{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:08:43Z","timestamp":1791590923644,"version":"4.3.4"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.bone.2019.115153","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T02:54:15Z","timestamp":1573527255000},"page":"115153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Inhibition of osteoclasts differentiation by CDC2-induced NFATc1 phosphorylation"],"prefix":"10.1016","volume":"131","author":[{"given":"Hye-min","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangku","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanmi","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho-Jin","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyeol","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joonsung","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjoo","family":"Cha-Molstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8202-1205","authenticated-orcid":false,"given":"Sung-Kyun","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Hyuk","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Ja","family":"Ryoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Blenis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Gu","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Seog","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Tae","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nak-Kyun","family":"Soung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo Yeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"23","key":"10.1016\/j.bone.2019.115153_bb0005","doi-asserted-by":"crossref","first-page":"13361","DOI":"10.1073\/pnas.95.23.13361","article-title":"Bone homeostasis","volume":"95","author":"Rodan","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"33","key":"10.1016\/j.bone.2019.115153_bb0010","doi-asserted-by":"crossref","first-page":"25103","DOI":"10.1074\/jbc.R109.041087","article-title":"Cellular and molecular mechanisms of bone remodeling","volume":"285","author":"Raggatt","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bone.2019.115153_bb0015","doi-asserted-by":"crossref","first-page":"233","DOI":"10.11005\/jbm.2014.21.4.233","article-title":"Regulation of NFATc1 in osteoclast differentiation","volume":"21","author":"Kim","year":"2014","journal-title":"Journal of Bone Metabolism"},{"key":"10.1016\/j.bone.2019.115153_bb0020","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1196\/annals.1402.071","article-title":"The role of NFAT in osteoclast formation","volume":"1116","author":"Takayanagi","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"6","key":"10.1016\/j.bone.2019.115153_bb0025","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nri1632","article-title":"NFAT proteins: key regulators of T-cell development and function","volume":"5","author":"Macian","year":"2005","journal-title":"Nat. Rev. Immunol."},{"issue":"18","key":"10.1016\/j.bone.2019.115153_bb0030","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1101\/gad.1102703","article-title":"Transcriptional regulation by calcium, calcineurin, and NFAT","volume":"17","author":"Hogan","year":"2003","journal-title":"Genes Dev."},{"issue":"1","key":"10.1016\/j.bone.2019.115153_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2003.10.008","article-title":"Calcineurin signaling and NFAT activation in cardiovascular and skeletal muscle development","volume":"266","author":"Schulz","year":"2004","journal-title":"Dev. Biol."},{"issue":"7109","key":"10.1016\/j.bone.2019.115153_bb0040","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nature05097","article-title":"Calcineurin\/NFAT signalling regulates pancreatic beta-cell growth and function","volume":"443","author":"Heit","year":"2006","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.bone.2019.115153_bb0045","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cell.2007.11.047","article-title":"NFATc1 balances quiescence and proliferation of skin stem cells","volume":"132","author":"Horsley","year":"2008","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.bone.2019.115153_bb0050","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/nm1270","article-title":"NFAT and Osterix cooperatively regulate bone formation","volume":"11","author":"Koga","year":"2005","journal-title":"Nat. Med."},{"issue":"7093","key":"10.1016\/j.bone.2019.115153_bb0055","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nature04678","article-title":"NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21","volume":"441","author":"Arron","year":"2006","journal-title":"Nature"},{"issue":"5308","key":"10.1016\/j.bone.2019.115153_bb0060","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1126\/science.275.5308.1930","article-title":"Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3","volume":"275","author":"Beals","year":"1997","journal-title":"Science"},{"issue":"7093","key":"10.1016\/j.bone.2019.115153_bb0065","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/nature04631","article-title":"A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT","volume":"441","author":"Gwack","year":"2006","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.bone.2019.115153_bb0070","doi-asserted-by":"crossref","first-page":"4184","DOI":"10.1128\/MCB.24.10.4184-4195.2004","article-title":"A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1","volume":"24","author":"Okamura","year":"2004","journal-title":"Mol. Cell. Biol."},{"issue":"8","key":"10.1016\/j.bone.2019.115153_bb0075","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1359\/JBMR.040321","article-title":"RANKL coordinates cell cycle withdrawal and differentiation in osteoclasts through the cyclin-dependent kinase inhibitors p27KIP1 and p21CIP1","volume":"19","author":"Sankar","year":"2004","journal-title":"Journal of Bone and Mineral Research\u202f: The Official Journal of the American Society for Bone and Mineral Research"},{"issue":"7","key":"10.1016\/j.bone.2019.115153_bb0080","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1359\/jbmr.2004.19.7.1128","article-title":"Osteoclast differentiation by RANKL requires NF-kappaB-mediated downregulation of cyclin-dependent kinase 6 (Cdk6)","volume":"19","author":"Ogasawara","year":"2004","journal-title":"Journal of Bone and Mineral Research\u202f: The Official Journal of the American Society for Bone and Mineral Research"},{"issue":"6117","key":"10.1016\/j.bone.2019.115153_bb0085","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/327031a0","article-title":"Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2","volume":"327","author":"Lee","year":"1987","journal-title":"Nature"},{"issue":"Pt 19","key":"10.1016\/j.bone.2019.115153_bb0090","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1242\/jcs.112.19.3361","article-title":"The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)\/M progression","volume":"112","author":"Wells","year":"1999","journal-title":"J. Cell Sci."},{"issue":"1","key":"10.1016\/j.bone.2019.115153_bb0095","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1128\/MCB.15.1.345","article-title":"Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2","volume":"15","author":"Desai","year":"1995","journal-title":"Mol. Cell. Biol."},{"issue":"15","key":"10.1016\/j.bone.2019.115153_bb0100","first-page":"5693","article-title":"Cyclin-dependent kinase 1 gene expression is associated with poor prognosis in gastric carcinoma","volume":"9","author":"Masuda","year":"2003","journal-title":"Clinical Cancer Research: An Official Journal of the American Association for Cancer Research"},{"issue":"9","key":"10.1016\/j.bone.2019.115153_bb0105","doi-asserted-by":"crossref","first-page":"4797","DOI":"10.1073\/pnas.96.9.4797","article-title":"A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts","volume":"96","author":"Rosania","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.bone.2019.115153_bb0110","doi-asserted-by":"crossref","first-page":"7143","DOI":"10.1128\/MCB.15.12.7143","article-title":"Plk is an M-phase-specific protein kinase and interacts with a kinesin-like protein, CHO1\/MKLP-1","volume":"15","author":"Lee","year":"1995","journal-title":"Mol. Cell. Biol."},{"issue":"5142","key":"10.1016\/j.bone.2019.115153_bb0115","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1126\/science.8266103","article-title":"Distinct roles for cyclin-dependent kinases in cell cycle control","volume":"262","author":"van den Heuvel","year":"1993","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.bone.2019.115153_bb0120","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.devcel.2009.02.004","article-title":"Plk1-dependent and -independent roles of an ODF2 splice variant, hCenexin1, at the centrosome of somatic cells","volume":"16","author":"Soung","year":"2009","journal-title":"Dev. Cell"},{"issue":"22","key":"10.1016\/j.bone.2019.115153_bb0125","doi-asserted-by":"crossref","first-page":"8316","DOI":"10.1128\/MCB.00671-06","article-title":"Requirement of hCenexin for proper mitotic functions of polo-like kinase 1 at the centrosomes","volume":"26","author":"Soung","year":"2006","journal-title":"Mol. Cell. Biol."},{"issue":"2","key":"10.1016\/j.bone.2019.115153_bb0130","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.devcel.2008.01.013","article-title":"CDK inhibitors: cell cycle regulators and beyond","volume":"14","author":"Besson","year":"2008","journal-title":"Dev. Cell"},{"issue":"9","key":"10.1016\/j.bone.2019.115153_bb0135","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.4161\/cc.28656","article-title":"Divide and differentiate: CDK\/Cyclins and the art of development","volume":"13","author":"Ishidate","year":"2014","journal-title":"Cell Cycle"},{"issue":"4","key":"10.1016\/j.bone.2019.115153_bb0140","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.devcel.2010.02.013","article-title":"Progressive activation of CyclinB1-Cdk1 coordinates entry to mitosis","volume":"18","author":"Gavet","year":"2010","journal-title":"Dev. Cell"},{"issue":"9","key":"10.1016\/j.bone.2019.115153_bb0145","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/nri2818","article-title":"NFAT, immunity and cancer: a transcription factor comes of age","volume":"10","author":"Muller","year":"2010","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.bone.2019.115153_bb0150","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.celrep.2016.05.083","article-title":"IkappaB kinase epsilon is an NFATc1 kinase that inhibits T cell immune response","volume":"16","author":"Zhang","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.bone.2019.115153_bb0155","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/bonekey.2013.179","article-title":"A bone to pick with zebrafish","volume":"2","author":"Mackay","year":"2013","journal-title":"BoneKEy reports"},{"issue":"5","key":"10.1016\/j.bone.2019.115153_bb0160","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s10735-012-9425-z","article-title":"The zebrafish scale as model to study the bone mineralization process","volume":"43","author":"Pasqualetti","year":"2012","journal-title":"J. Mol. Histol."},{"issue":"2","key":"10.1016\/j.bone.2019.115153_bb0165","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s10867-011-9247-3","article-title":"Ca\/P concentration ratio at different sites of normal and osteoporotic rabbit bones evaluated by Auger and energy dispersive X-ray spectroscopy","volume":"38","author":"Kourkoumelis","year":"2012","journal-title":"J. Biol. Phys."},{"issue":"1","key":"10.1016\/j.bone.2019.115153_bb0170","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1091\/mbc.3.1.13","article-title":"Role of phosphorylation in p34cdc2 activation: identification of an activating kinase","volume":"3","author":"Solomon","year":"1992","journal-title":"Mol. Biol. Cell"},{"issue":"Pt 12","key":"10.1016\/j.bone.2019.115153_bb0175","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1242\/jcs.115.12.2461","article-title":"From Cdc2 to Cdk1: when did the cell cycle kinase join its cyclin partner?","volume":"115","author":"Doree","year":"2002","journal-title":"J. Cell Sci."},{"issue":"25","key":"10.1016\/j.bone.2019.115153_bb0180","doi-asserted-by":"crossref","first-page":"26475","DOI":"10.1074\/jbc.M313973200","article-title":"Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos","volume":"279","author":"Matsuo","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2019.115153_bb0185","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.bbrep.2015.12.011","article-title":"The inhibitors of cyclin-dependent kinases and GSK-3beta enhance osteoclastogenesis","volume":"5","author":"Akiba","year":"2016","journal-title":"Biochemistry and biophysics reports"},{"issue":"7","key":"10.1016\/j.bone.2019.115153_bb0190","doi-asserted-by":"crossref","first-page":"731","DOI":"10.2174\/0929867003374723","article-title":"FK506, an immunosuppressant targeting calcineurin function","volume":"7","author":"Dumont","year":"2000","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bone.2019.115153_bb0195","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/230386","article-title":"Cyclosporine: a review","volume":"2012","author":"Tedesco","year":"2012","journal-title":"Journal of transplantation"},{"issue":"2","key":"10.1016\/j.bone.2019.115153_bb0200","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.canlet.2015.03.005","article-title":"Nuclear factor of activated T cells in cancer development and treatment","volume":"361","author":"Shou","year":"2015","journal-title":"Cancer Lett."},{"issue":"5948","key":"10.1016\/j.bone.2019.115153_bb0205","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1126\/science.1172867","article-title":"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution","volume":"325","author":"Holt","year":"2009","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.bone.2019.115153_bb0210","first-page":"188","article-title":"Danio rerio: the Janus of the bone from embryo to scale","volume":"12","author":"Mariotti","year":"2015","journal-title":"Clinical Cases in Mineral and Bone Metabolism: The Official Journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases"},{"issue":"Pt 4","key":"10.1016\/j.bone.2019.115153_bb0215","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1046\/j.1469-7580.1997.19040545.x","article-title":"Scale development in zebrafish (Danio rerio)","volume":"190","author":"Sire","year":"1997","journal-title":"J. Anat."},{"issue":"4","key":"10.1016\/j.bone.2019.115153_bb0220","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1017\/S0007114509992121","article-title":"Low calcium:phosphorus ratio in habitual diets affects serum parathyroid hormone concentration and calcium metabolism in healthy women with adequate calcium intake","volume":"103","author":"Kemi","year":"2010","journal-title":"Br. J. Nutr."},{"issue":"11","key":"10.1016\/j.bone.2019.115153_bb0225","doi-asserted-by":"crossref","first-page":"9633","DOI":"10.3390\/nu7115492","article-title":"Intakes of calcium and phosphorus and calculated calcium-to-phosphorus ratios of older adults: NHANES 2005\u20132006 data","volume":"7","author":"Adatorwovor","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.bone.2019.115153_bb0230","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1016\/S0092-8674(02)00699-2","article-title":"NFAT signaling: choreographing the social lives of cells","volume":"109","author":"Crabtree","year":"2002","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.bone.2019.115153_bb0235","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.cardiores.2004.01.021","article-title":"Calcineurin-NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs","volume":"63","author":"Molkentin","year":"2004","journal-title":"Cardiovasc. Res."},{"issue":"4","key":"10.1016\/j.bone.2019.115153_bb0240","doi-asserted-by":"crossref","first-page":"C915","DOI":"10.1152\/ajpcell.2000.279.4.C915","article-title":"The calcineurin-NFAT pathway and muscle fiber-type gene expression","volume":"279","author":"Swoap","year":"2000","journal-title":"American Journal of Physiology. Cell Physiology"},{"issue":"10","key":"10.1016\/j.bone.2019.115153_bb0245","first-page":"135","article-title":"Roscovitine in cancer and other diseases","volume":"3","author":"Cicenas","year":"2015","journal-title":"Annals of translational medicine"},{"key":"10.1016\/j.bone.2019.115153_bb0250","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s40842-016-0033-9","article-title":"Update on medical treatment for Cushing's disease","volume":"2","author":"Cuevas-Ramos","year":"2016","journal-title":"Clinical diabetes and endocrinology"},{"issue":"10","key":"10.1016\/j.bone.2019.115153_bb0255","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1634\/theoncologist.11-10-1121","article-title":"Bone loss and fracture risk associated with cancer therapy","volume":"11","author":"Guise","year":"2006","journal-title":"Oncologist"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328219304478?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328219304478?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:46:18Z","timestamp":1757612778000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328219304478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":51,"alternative-id":["S8756328219304478"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2019.115153","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of osteoclasts differentiation by CDC2-induced NFATc1 phosphorylation","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2019.115153","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115153"}}