{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T09:46:40Z","timestamp":1789897600406,"version":"4.0.1"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T00:00:00Z","timestamp":1613001600000},"content-version":"am","delay-in-days":316,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001793","name":"Queensland University of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.bone.2020.115223","type":"journal-article","created":{"date-parts":[[2020,1,11]],"date-time":"2020-01-11T02:19:44Z","timestamp":1578709184000},"page":"115223","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Assessment of romosozumab efficacy in the treatment of postmenopausal osteoporosis: Results from a mechanistic PK-PD mechanostat model of bone remodeling"],"prefix":"10.1016","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7897-197X","authenticated-orcid":false,"given":"Madge","family":"Martin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Sansalone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.L.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9963-1616","authenticated-orcid":false,"given":"Mark R.","family":"Forwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Pivonka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bone.2020.115223_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ar.1092190104","article-title":"Bone \u201cmass\u201d and the \u201cmechanostat\u201d: a proposal","volume":"219","author":"Frost","year":"1987","journal-title":"Anat. Rec."},{"issue":"6","key":"10.1016\/j.bone.2020.115223_bb0010","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1084\/jem.20031454","article-title":"Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist","volume":"199","author":"van Bezooijen","year":"2004","journal-title":"J. Exp. Med."},{"issue":"23","key":"10.1016\/j.bone.2020.115223_bb0015","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.1093\/emboj\/cdg599","article-title":"Osteocyte control of bone formation via sclerostin, a novel BMP antagonist","volume":"22","author":"Winkler","year":"2003","journal-title":"EMBO J."},{"issue":"6","key":"10.1016\/j.bone.2020.115223_bb0020","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1177\/1759720X16670154","article-title":"Bone modeling and remodeling: potential as therapeutic targets for the treatment of osteoporosis","volume":"8","author":"Langdahl","year":"2016","journal-title":"Ther. Adv. Musculoskel. Dis."},{"issue":"4","key":"10.1016\/j.bone.2020.115223_bb0025","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.bone.2007.12.224","article-title":"Osteocytes, mechanosensing and Wnt signaling","volume":"42","author":"Bonewald","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.bone.2020.115223_bb0030","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/j.bone.2010.01.022","article-title":"Sclerostin is an important target for stimulating bone formation, restoring bone mass and enhancing fracture healing","volume":"46","author":"Ke","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.bone.2020.115223_bb0035","article-title":"Sclerostin Antagonism in adult rodents, via monoclonal antibody mediated blockade, increases bone mineral density and implicates sclerostin as a key regulator of bone mass during adulthood","volume":"19","author":"Warmington","year":"2004","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2020.115223_bb0040","article-title":"Anti-sclerostin antibody increases markers of bone formation in healthy postmenopausal women","volume":"22","author":"Padhi","year":"2007","journal-title":"J. Bone Miner. Res."},{"issue":"9","key":"10.1016\/j.bone.2020.115223_bb0045","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1002\/jbmr.3454","article-title":"Sclerostin neutralizing antibody treatment enhances bone formation but does not rescue mechanically induced delayed healing","volume":"33","author":"Kruck","year":"2018","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.bone.2020.115223_bb0050","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s40265-019-01072-6","article-title":"Romosozumab: first global approval","volume":"79","author":"Markham","year":"2019","journal-title":"Drugs"},{"issue":"8","key":"10.1016\/j.bone.2020.115223_bb0055","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1002\/jbmr.3452","article-title":"Effects of 24 months of treatment with romosozumab followed by 12 months of denosumab or placebo in postmenopausal women with low bone mineral density: a randomized, double-blind, Phase 2, Parallel Group Study","volume":"33","author":"McClung","year":"2018","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.bone.2020.115223_bb0060","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s10928-014-9372-2","article-title":"Incorporating target-mediated drug disposition in a minimal physiologically-based pharmacokinetic model for monoclonal antibodies","volume":"41","author":"Cao","year":"2014","journal-title":"J. Pharmacokinet. Pharmacodyn."},{"issue":"6","key":"10.1016\/j.bone.2020.115223_bb0065","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/psp4.41","article-title":"A tutorial on target-mediated drug disposition (TMDD) models","volume":"4","author":"Dua","year":"2015","journal-title":"CPT Pharmacometrics Syst. Pharmacol."},{"issue":"9","key":"10.1016\/j.bone.2020.115223_bb0070","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/psp4.12013","article-title":"Connecting the dots: linking osteocyte activity and therapeutic modulation of sclerostin by extending a multiscale systems model","volume":"4","author":"Eudy","year":"2015","journal-title":"CPT Pharmacometrics Syst. Pharmacol."},{"key":"10.1016\/j.bone.2020.115223_bb0075","series-title":"American Conference on Pharmacokinetics, Arlington, Virginia, USA","first-page":"W","article-title":"Population pharmacokinetics and pharmacodynamics of blosozumab","author":"Tang","year":"2015"},{"issue":"2","key":"10.1016\/j.bone.2020.115223_bb0080","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.bone.2008.03.025","article-title":"Model structure and control of bone remodeling: a theoretical study","volume":"43","author":"Pivonka","year":"2008","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.bone.2020.115223_bb0085","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jtbi.2009.09.021","article-title":"Theoretical investigation of the role of the RANK-RANKL-OPG system in bone remodeling","volume":"262","author":"Pivonka","year":"2010","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.bone.2020.115223_bb0090","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cma.2012.10.015","article-title":"Coupling systems biology with multiscale mechanics, for computer simulations of bone remodeling","volume":"254","author":"Scheiner","year":"2013","journal-title":"Comput. Methods Appl. Mech. Eng."},{"key":"10.1016\/j.bone.2020.115223_bb0095","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1007\/s10237-019-01158-w","article-title":"Mechanobiological osteocyte feedback drives mechanostat regulation of bone in a multiscale computational model","volume":"18","author":"Martin","year":"2019","journal-title":"Biomech. Model. Mechanobiol."},{"key":"10.1016\/j.bone.2020.115223_bb0100","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.bone.2019.04.022","article-title":"Effects of long-term treatment of denosumab on bone mineral density: insights from an in-silico model of bone mineralization","volume":"125","author":"Mart\u00ednez-Reina","year":"2019","journal-title":"Bone"},{"issue":"10102","key":"10.1016\/j.bone.2020.115223_bb0105","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/S0140-6736(17)31613-6","article-title":"Romosozumab (sclerostin monoclonal antibody) versus teriparatide in postmenopausal women with osteoporosis transitioning from oral bisphosphonate therapy: a randomised, open-label, phase 3 trial","volume":"390","author":"Langdahl","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.bone.2020.115223_bb0110","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bone.2017.07.005","article-title":"Romosozumab increases bone mineral density in postmenopausal Japanese women with osteoporosis: a phase 2 study","volume":"103","author":"Ishibashi","year":"2017","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.bone.2020.115223_bb0115","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/jbmr.173","article-title":"Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody","volume":"26","author":"Padhi","year":"2011","journal-title":"J. Bone Miner. Res."},{"issue":"8","key":"10.1016\/j.bone.2020.115223_bb0120","first-page":"553","article-title":"MONOGRAPH","volume":"39","author":"Paton","year":"2014","journal-title":"Drugs Future"},{"key":"10.1016\/j.bone.2020.115223_bb0125","unstructured":"Evenity [Prescribing Information], Thousand Oaks, California, 2019, https:\/\/www.pi.amgen.com\/~\/media\/amgen\/repositorysites\/pi-amgen-com\/evenity\/evenity{_}pi{_}hcp{_}english.ashx."},{"key":"10.1016\/j.bone.2020.115223_bb0130","first-page":"220","article-title":"A thermodynamic model of bone remodelling: the influence of dynamic loading together with biochemical control","volume":"10","author":"Klika","year":"2010","journal-title":"J. Musculoskelet. Neuronal Interact."},{"issue":"2","key":"10.1016\/j.bone.2020.115223_bb0135","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S8756-3282(03)00157-1","article-title":"Mathematical model predicts a critical role for osteoclast autocrine regulation in the control of bone remodeling","volume":"33","author":"Komarova","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.bone.2020.115223_bb0140","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.1109\/IEMBS.2006.260532","article-title":"Mathematical modeling and analysis of force induced bone growth","volume":"1","author":"Maldonado","year":"2006","journal-title":"Conf. Proc. IEEE Eng. Med. Biol. Soc."},{"key":"10.1016\/j.bone.2020.115223_bb0145","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.bone.2017.11.009","article-title":"A mathematical multiscale model of bone remodeling, accounting for pore space-specific mechanosensation","volume":"107","author":"Pastrama","year":"2018","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.bone.2020.115223_bb0150","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jtbi.2004.03.023","article-title":"Modeling the interactions between osteoblast and osteoclast activities in bone remodeling","volume":"229","author":"Lemaire","year":"2004","journal-title":"J. Theor. Biol."},{"issue":"2","key":"10.1016\/j.bone.2020.115223_bb0155","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1210\/en.2003-0726","article-title":"Nitric oxide regulates receptor activator of nuclear factor-\u03baB ligand and osteoprotegerin expression in bone marrow stromal cells","volume":"145","author":"Fan","year":"2004","journal-title":"Endocrinology"},{"issue":"6","key":"10.1016\/j.bone.2020.115223_bb0160","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1359\/jbmr.1998.13.6.1039","article-title":"Role of nitric oxide and prostaglandins in mechanically induced bone formation","volume":"13","author":"Chow","year":"1998","journal-title":"J. Bone Miner. Res."},{"issue":"7","key":"10.1016\/j.bone.2020.115223_bb0165","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1359\/jbmr.1999.14.7.1123","article-title":"Mechanical strain stimulates nitric oxide production by rapid activation of endothelial nitric oxide synthase in osteocytes","volume":"14","author":"Zaman","year":"1999","journal-title":"J. Bone Miner. Res."},{"issue":"5","key":"10.1016\/j.bone.2020.115223_bb0170","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1210\/jc.2010-0067","article-title":"Increased sclerostin serum levels associated with bone formation and resorption markers in patients with immobilization-induced bone loss","volume":"95","author":"Gaudio","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"27","key":"10.1016\/j.bone.2020.115223_bb0175","doi-asserted-by":"crossref","first-page":"16744","DOI":"10.1074\/jbc.M114.628313","article-title":"The Wnt inhibitor sclerostin is up-regulated by mechanical unloading in osteocytes in vitro","volume":"290","author":"Spatz","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.bone.2020.115223_bb0180","doi-asserted-by":"crossref","first-page":"5866","DOI":"10.1074\/jbc.M705092200","article-title":"Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost\/sclerostin","volume":"283","author":"Robling","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"20","key":"10.1016\/j.bone.2020.115223_bb0185","doi-asserted-by":"crossref","first-page":"19883","DOI":"10.1074\/jbc.M413274200","article-title":"Sclerostin binds to LRP5\/6 and antagonizes canonical Wnt signaling","volume":"280","author":"Li","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.bone.2020.115223_bb0190","doi-asserted-by":"crossref","first-page":"9172","DOI":"10.1074\/jbc.M109.092130","article-title":"Reconstitution of a Frizzled8-Wnt3a-LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6","volume":"285","author":"Bourhis","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2020.115223_bb0195","article-title":"IUPHAR BPS Guide to Pharmacology","year":"2019","journal-title":"Romosozumab"},{"key":"10.1016\/j.bone.2020.115223_bb0200","series-title":"Cell Interaction","first-page":"169","article-title":"A systems approach to understanding bone cell interactions in health and disease","author":"Pivonka","year":"2012"},{"issue":"4","key":"10.1016\/j.bone.2020.115223_bb0205","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1136\/jcp.2010.086595","article-title":"Osteoprotegerin, RANKL and bone turnover in postmenopausal osteoporosis","volume":"64","author":"Jabbar","year":"2011","journal-title":"J. Clin. Pathol."},{"issue":"7","key":"10.1016\/j.bone.2020.115223_bb0210","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1177\/154405910608500703","article-title":"Bone remodeling in post-menopausal osteoporosis","volume":"85","author":"Lerner","year":"2006","journal-title":"J. Dent. Res."},{"issue":"SUPPL.1","key":"10.1016\/j.bone.2020.115223_bb0215","first-page":"1","article-title":"Role of RANKL inhibition in osteoporosis","volume":"9","author":"McClung","year":"2007","journal-title":"Arthritis Res. Ther."},{"issue":"12","key":"10.1016\/j.bone.2020.115223_bb0220","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1002\/jbmr.479","article-title":"Determinants of serum sclerostin in healthy pre- and postmenopausal women","volume":"26","author":"Ardawi","year":"2011","journal-title":"J. Bone Miner. Res."},{"issue":"3","key":"10.1016\/j.bone.2020.115223_bb0225","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/jbmr.1773","article-title":"Changes in bone sclerostin levels in mice after ovariectomy vary independently of changes in serum sclerostin levels","volume":"28","author":"Jastrzebski","year":"2013","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2020.115223_bb0230","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1359\/jbmr.2000.15.1.13","article-title":"Trabecular bone microarchitecture, bone mineral density, and vertebral fractures in male osteoporosis","volume":"15","author":"Legrand","year":"2000","journal-title":"J. Bone Miner. Res."},{"issue":"11","key":"10.1016\/j.bone.2020.115223_bb0235","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1016\/j.jbiomech.2006.11.022","article-title":"Densitometric, morphometric and mechanical distributions in the human proximal femur","volume":"40","author":"Nazarian","year":"2007","journal-title":"J. Biomech."},{"issue":"1","key":"10.1016\/j.bone.2020.115223_bb0240","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1210\/jcem-70-1-83","article-title":"The relative contributions of age and years since menopause to postmenopausal bone loss","volume":"70","author":"Nordin","year":"1990","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2020.115223_bb0245","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1196\/annals.1402.018","article-title":"Osteocytes as dynamic multifunctional cells","volume":"1116","author":"Bonewald","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"2","key":"10.1016\/j.bone.2020.115223_bb0250","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.bone.2012.10.013","article-title":"Mechanosensation and transduction in osteocytes","volume":"54","author":"Klein-Nulend","year":"2013","journal-title":"Bone"},{"issue":"sup1","key":"10.1016\/j.bone.2020.115223_bb0255","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1080\/10255842.2012.713683","article-title":"Parametric study of interstitial fluid flow in the bone lacuno-canalicular network","volume":"15","author":"Lemaire","year":"2012","journal-title":"Comput. Methods Biomech. Biomed. Engin."},{"issue":"11","key":"10.1016\/j.bone.2020.115223_bb0260","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.ijengsci.2008.06.001","article-title":"Electro-mechanics of bone remodelling","volume":"46","author":"Ramtani","year":"2008","journal-title":"Int. J. Eng. Sci."},{"issue":"3","key":"10.1016\/j.bone.2020.115223_bb0265","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s10237-012-0422-7","article-title":"Interstitial fluid flow within bone canaliculi and electro-chemo-mechanical features of the canalicular milieu","volume":"12","author":"Sansalone","year":"2013","journal-title":"Biomech. Model. Mechanobiol."},{"key":"10.1016\/j.bone.2020.115223_bb0270","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10237-015-0704-y","article-title":"Poromicromechanics reveals that physiological bone strains induce osteocyte-stimulating lacunar pressure","volume":"15","author":"Scheiner","year":"2016","journal-title":"Biomech. Model. Mechanobiol."},{"issue":"7","key":"10.1016\/j.bone.2020.115223_bb0275","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1210\/jcem.87.7.8654","article-title":"Ethnic variation in bone density in premenopausal and early perimenopausal women: effects of anthropometric and lifestyle factors","volume":"87","author":"Finkelstein","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2020.115223_bb0280","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bone.2014.07.031","article-title":"Temporal changes in systemic and local expression of bone turnover markers during six months of sclerostin antibody administration to ovariectomized rats","volume":"67","author":"Stolina","year":"2014","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.bone.2020.115223_bb0285","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.bone.2009.08.053","article-title":"A physiologically based mathematical model of integrated calcium homeostasis and bone remodeling","volume":"46","author":"Peterson","year":"2010","journal-title":"Bone"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632822030003X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632822030003X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:48:40Z","timestamp":1757612920000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S875632822030003X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":57,"alternative-id":["S875632822030003X"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2020.115223","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessment of romosozumab efficacy in the treatment of postmenopausal osteoporosis: Results from a mechanistic PK-PD mechanostat model of bone remodeling","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2020.115223","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115223"}}