{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T03:57:27Z","timestamp":1776743847818,"version":"3.51.2"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81430089"],"award-info":[{"award-number":["81430089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603214"],"award-info":[{"award-number":["81603214"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673490"],"award-info":[{"award-number":["81673490"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972036"],"award-info":[{"award-number":["81972036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007046","name":"Wuhan University","doi-asserted-by":"publisher","award":["TFJC2018001"],"award-info":[{"award-number":["TFJC2018001"]}],"id":[{"id":"10.13039\/501100007046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC 1001300"],"award-info":[{"award-number":["2017YFC 1001300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.bone.2020.115245","type":"journal-article","created":{"date-parts":[[2020,1,18]],"date-time":"2020-01-18T01:46:37Z","timestamp":1579311997000},"page":"115245","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Subchondral bone dysplasia partly participates in prenatal dexamethasone induced-osteoarthritis susceptibility in female offspring rats"],"prefix":"10.1016","volume":"133","author":[{"given":"Hao","family":"Xiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingkui","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinxian","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangfan","family":"Shangguan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Magdalou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5300-8661","authenticated-orcid":false,"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8778-1457","authenticated-orcid":false,"given":"Liaobin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2020.115245_bb0005","doi-asserted-by":"crossref","first-page":"246","DOI":"10.15585\/mmwr.mm6609e1","article-title":"Vital signs: prevalence of doctor-diagnosed arthritis and arthritis-attributable activity limitation \u2014 United States, 2013\u20132015","volume":"66","author":"Barbour","year":"2017","journal-title":"MMWR Morb. Mortal. Wkly Rep."},{"key":"10.1016\/j.bone.2020.115245_bb0010","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1002\/art.39692","article-title":"Updated projected prevalence of self-reported doctor-diagnosed arthritis and arthritis-attributable activity limitation among US adults, 2015\u20132040","volume":"68","author":"Hootman","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.bone.2020.115245_bb0015","doi-asserted-by":"crossref","first-page":"S847","DOI":"10.1007\/s00198-012-2162-z","article-title":"Subchondral bone and osteoarthritis: biological and cellular aspects","volume":"23","author":"Henrotin","year":"2012","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2020.115245_bb0020","doi-asserted-by":"crossref","first-page":"62","DOI":"10.5606\/ehc.2016.14","article-title":"Is there crosstalk between subchondral bone, cartilage, and meniscus in the pathogenesis of osteoarthritis?","volume":"27","author":"Atik","year":"2016","journal-title":"Eklem Hastalik Cerrahisi"},{"key":"10.1016\/j.bone.2020.115245_bb0025","doi-asserted-by":"crossref","first-page":"R152","DOI":"10.1186\/ar3103","article-title":"Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis","volume":"12","author":"Bellido","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.bone.2020.115245_bb0030","doi-asserted-by":"crossref","DOI":"10.1038\/boneres.2016.28","article-title":"Bone-cartilage crosstalk: a conversation for understanding osteoarthritis","volume":"4","author":"Findlay","year":"2016","journal-title":"Bone Res"},{"key":"10.1016\/j.bone.2020.115245_bb0035","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1007\/s00198-009-1071-2","article-title":"Micro-CT and mechanical evaluation of subchondral trabecular bone structure between postmenopausal women with osteoarthritis and osteoporosis","volume":"21","author":"Zhang","year":"2010","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2020.115245_bb0040","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1016\/j.joca.2017.09.008","article-title":"Association between radiography-based subchondral bone structure and MRI-based cartilage composition in postmenopausal women with mild osteoarthritis","volume":"25","author":"Hirvasniemi","year":"2017","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2020.115245_bb0045","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/jor.21054","article-title":"Effects of estrogen deficiency and low bone mineral density on healthy knee cartilage in rabbits","volume":"28","author":"Castaneda","year":"2010","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2020.115245_bb0050","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.12659\/MSM.916254","article-title":"Estrogen modulates cartilage and subchondral bone remodeling in an ovariectomized rat model of postmenopausal osteoarthritis","volume":"25","author":"Xu","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.bone.2020.115245_bb0055","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/ahe.12341","article-title":"Trabecular and subchondral bone development of the talus and distal tibia from foal to adult in the warmblood horse","volume":"47","author":"Gorissen","year":"2018","journal-title":"Anat. Histol. Embryol."},{"key":"10.1016\/j.bone.2020.115245_bb0060","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1166\/jbn.2019.2735","article-title":"Bone marrow mesenchymal stem cells and endothelial progenitor cells co-culture enhances large segment bone defect repair","volume":"15","author":"Peng","year":"2019","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.bone.2020.115245_bb0065","doi-asserted-by":"crossref","first-page":"593","DOI":"10.2174\/1381612825666190326143814","article-title":"Antenatal corticosteroids for fetal lung maturity \u2014 too much of a good thing?","volume":"25","author":"Hrabalkova","year":"2019","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bone.2020.115245_bb0070","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ejogrb.2018.12.025","article-title":"Antenatal corticosteroid therapy: historical and scientific basis to improve preterm birth management","volume":"234","author":"Briceno-Perez","year":"2019","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.bone.2020.115245_bb0075","first-page":"186","article-title":"Challenges in prenatal treatment with dexamethasone","volume":"16","author":"McCann-Crosby","year":"2018","journal-title":"Pediatr. Endocrinol. Rev."},{"key":"10.1016\/j.bone.2020.115245_bb0080","first-page":"485","article-title":"Antenatal dexamethasone and decreased birth weight","volume":"97","author":"Bloom","year":"2001","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.bone.2020.115245_bb0085","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1111\/bph.13506","article-title":"Mitogen-inducible gene-6 partly mediates the inhibitory effects of prenatal dexamethasone exposure on endochondral ossification in long bones of fetal rats","volume":"173","author":"Zhang","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bone.2020.115245_bb0090","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/s41419-018-0701-z","article-title":"Increased H3K27ac level of ACE mediates the intergenerational effect of low peak bone mass induced by prenatal dexamethasone exposure in male offspring rats","volume":"9","author":"Xiao","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bone.2020.115245_bb0095","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1016\/j.joca.2010.05.030","article-title":"The OARSI histopathology initiative \u2014 recommendations for histological assessments of osteoarthritis in the rat","volume":"18","author":"Gerwin","year":"2010","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2020.115245_bb0100","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jbmr.1805","article-title":"Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee","volume":"28","author":"Dempster","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2020.115245_bb0105","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro-computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2020.115245_bb0110","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/bdrc.21058","article-title":"TGFbeta signaling in cartilage development and maintenance","volume":"102","author":"Wang","year":"2014","journal-title":"Birth Defects Res C Embryo Today"},{"key":"10.1016\/j.bone.2020.115245_bb0115","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1002\/art.10862","article-title":"Weight from birth to 53\u00a0years: a longitudinal study of the influence on clinical hand osteoarthritis","volume":"48","author":"Sayer","year":"2003","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bone.2020.115245_bb0120","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1017\/S2040174414000373","article-title":"Further evidence of the developmental origins of osteoarthritis: results from the Hertfordshire Cohort Study","volume":"5","author":"Clynes","year":"2014","journal-title":"J. Dev. Orig. Health Dis."},{"key":"10.1016\/j.bone.2020.115245_bb0125","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/acr.22475","article-title":"Association of low birth weight and preterm birth with the incidence of knee and hip arthroplasty for osteoarthritis","volume":"67","author":"Hussain","year":"2015","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.bone.2020.115245_bb0130","doi-asserted-by":"crossref","DOI":"10.1038\/srep17746","article-title":"Prenatal caffeine exposure induces a poor quality of articular cartilage in male adult offspring rats via cholesterol accumulation in cartilage","volume":"5","author":"Luo","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bone.2020.115245_bb0135","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1096\/fj.15-274399","article-title":"Intrauterine low-functional programming of IGF1 by prenatal nicotine exposure mediates the susceptibility to osteoarthritis in female adult rat offspring","volume":"30","author":"Tie","year":"2016","journal-title":"FASEB J."},{"key":"10.1016\/j.bone.2020.115245_bb0140","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.reprotox.2015.12.010","article-title":"Prenatal nicotine exposure induces poor articular cartilage quality in female adult offspring fed a high-fat diet and the intrauterine programming mechanisms","volume":"60","author":"Tie","year":"2016","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.bone.2020.115245_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2017.10.020","article-title":"Low-functional programming of the CREB\/BDNF\/TrkB pathway mediates cognitive impairment in male offspring after prenatal dexamethasone exposure","volume":"283","author":"Dong","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.bone.2020.115245_bb0150","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1210\/en.2018-00044","article-title":"Prenatal dexamethasone exposure induced ovarian developmental toxicity and transgenerational effect in rat offspring","volume":"159","author":"Lv","year":"2018","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2020.115245_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2018.06.005","article-title":"Decreased H3K9ac level of StAR mediated testicular dysplasia induced by prenatal dexamethasone exposure in male offspring rats","volume":"408","author":"Liu","year":"2018","journal-title":"Toxicology"},{"key":"10.1016\/j.bone.2020.115245_bb0160","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.pathophys.2017.02.005","article-title":"IL-10 and TGF-beta: roles in chondroprotective effects of glucosamine in experimental osteoarthritis?","volume":"24","author":"Waly","year":"2017","journal-title":"Pathophysiology"},{"key":"10.1016\/j.bone.2020.115245_bb0165","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s00223-015-9991-7","article-title":"Characterising bone material composition and structure in the ovariectomized (OVX) rat model of osteoporosis","volume":"97","author":"Mathavan","year":"2015","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2020.115245_bb0170","article-title":"Secondary alterations in bone mineralisation and trabecular thickening occur after long-term estrogen deficiency in ovariectomised rat tibiae, which do not coincide with initial rapid bone loss","author":"O\u2019Sullivan","year":"2019","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2020.115245_bb0175","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/jbmr.1785","article-title":"Glucocorticoid effects on changes in bone mineral density and cortical structure in childhood nephrotic syndrome","volume":"28","author":"Tsampalieros","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2020.115245_bb0180","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1439-0396.2008.00909.x","article-title":"Bone development of suckling piglets after prenatal, neonatal or perinatal treatment with dexamethasone","volume":"94","author":"Sliwa","year":"2010","journal-title":"J Anim Physiol Anim Nutr (Berl)"},{"key":"10.1016\/j.bone.2020.115245_bb0185","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a008334","article-title":"Development of the endochondral skeleton","volume":"5","author":"Long","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bone.2020.115245_bb0190","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00427-016-0567-y","article-title":"Evolutionary origin of endochondral ossification: the transdifferentiation hypothesis","volume":"227","author":"Cervantes-Diaz","year":"2017","journal-title":"Dev. Genes Evol."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328220300259?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328220300259?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:40:07Z","timestamp":1762659607000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328220300259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":38,"alternative-id":["S8756328220300259"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2020.115245","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Subchondral bone dysplasia partly participates in prenatal dexamethasone induced-osteoarthritis susceptibility in female offspring rats","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2020.115245","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115245"}}