{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T22:01:43Z","timestamp":1769637703517,"version":"3.49.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.bone.2020.115324","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T13:00:23Z","timestamp":1584622823000},"page":"115324","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Large osteocyte lacunae in iliac crest infantile bone are not associated with impaired mineral distribution or signs of osteocytic osteolysis"],"prefix":"10.1016","volume":"135","author":[{"given":"Nico Maximilian","family":"Jandl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"von Kroge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"St\u00fcrznickel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anke","family":"Baranowsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kilian Elia","family":"Stockhausen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert","family":"Mushumba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank Timo","family":"Beil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"P\u00fcschel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Amling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1058-1307","authenticated-orcid":false,"given":"Tim","family":"Rolvien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bone.2020.115324_bb0005","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/jbmr.320","article-title":"The amazing osteocyte","volume":"26","author":"Bonewald","year":"2011","journal-title":"J. Bone Miner. Res."},{"issue":"8","key":"10.1016\/j.bone.2020.115324_bb0010","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1002\/jbmr.3167","article-title":"Osteocytes acidify their microenvironment in response to PTHrP in vitro and in lactating mice in vivo","volume":"32","author":"Jahn","year":"2017","journal-title":"J. Bone Miner. Res."},{"issue":"5","key":"10.1016\/j.bone.2020.115324_bb0015","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s11914-019-00522-0","article-title":"Physicochemical niche conditions and mechanosensing by osteocytes and myocytes","volume":"17","author":"Jin","year":"2019","journal-title":"Curr Osteoporos Rep"},{"issue":"5","key":"10.1016\/j.bone.2020.115324_bb0020","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1002\/jbmr.1567","article-title":"Demonstration of osteocytic perilacunar\/canalicular remodeling in mice during lactation","volume":"27","author":"Qing","year":"2012","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2020.115324_bb0025","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bone.2017.06.022","article-title":"Vitamin D regulates osteocyte survival and perilacunar remodeling in human and murine bone","volume":"103","author":"Rolvien","year":"2017","journal-title":"Bone"},{"issue":"4","key":"10.1016\/j.bone.2020.115324_bb0030","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1152\/physrev.00014.2014","article-title":"Bone development and mineral homeostasis in the fetus and neonate: roles of the calciotropic and phosphotropic hormones","volume":"94","author":"Kovacs","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bone.2020.115324_bb0035","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1042\/bj0820056","article-title":"Changes in the composition of the human femur during growth","volume":"82","author":"Dickerson","year":"1962","journal-title":"Biochem. J."},{"key":"10.1016\/j.bone.2020.115324_bb0040","series-title":"Bone Repair Biomaterials","first-page":"15","article-title":"Biology","author":"Fuchs","year":"2019"},{"issue":"6","key":"10.1016\/j.bone.2020.115324_bb0045","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1111\/j.1474-9726.2010.00633.x","article-title":"Decrease in the osteocyte lacunar density accompanied by hypermineralized lacunar occlusion reveals failure and delay of remodeling in aged human bone","volume":"9","author":"Busse","year":"2010","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.bone.2020.115324_bb0050","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00223-013-9790-y","article-title":"Osteocytes: master orchestrators of bone","volume":"94","author":"Schaffler","year":"2014","journal-title":"Calcif. Tissue Int."},{"issue":"1","key":"10.1016\/j.bone.2020.115324_bb0055","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00223-013-9774-y","article-title":"Osteocyte-driven bone remodeling","volume":"94","author":"Bellido","year":"2014","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2020.115324_bb0060","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.bone.2019.05.036","article-title":"Recovery of bone mineralization and quality during asfotase alfa treatment in an adult patient with infantile-onset hypophosphatasia","volume":"127","author":"Rolvien","year":"2019","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.bone.2020.115324_bb0065","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/jbmr.2980","article-title":"A novel ANO5 mutation causing gnathodiaphyseal dysplasia with high bone turnover osteosclerosis","volume":"32","author":"Rolvien","year":"2017","journal-title":"J. Bone Miner. Res."},{"issue":"6","key":"10.1016\/j.bone.2020.115324_bb0070","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.bone.2009.02.021","article-title":"Normative data on mineralization density distribution in iliac bone biopsies of children, adolescents and young adults","volume":"44","author":"Fratzl-Zelman","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.bone.2020.115324_bb0075","first-page":"1238","article-title":"Histological measure of the volume and resorption of bone joints","volume":"12","author":"Bordier","year":"1964","journal-title":"Pathol Biol"},{"issue":"1","key":"10.1016\/j.bone.2020.115324_bb0080","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jbmr.1805","article-title":"Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee","volume":"28","author":"Dempster","year":"2013","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.bone.2020.115324_bb0085","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S8756-3282(98)00112-4","article-title":"Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsies","volume":"23","author":"Roschger","year":"1998","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.bone.2020.115324_bb0090","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1038\/s41598-018-19803-2","article-title":"Early bone tissue aging in human auditory ossicles is accompanied by excessive hypermineralization, osteocyte death and micropetrosis","volume":"8","author":"Rolvien","year":"2018","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.bone.2020.115324_bb0095","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0021-9290(94)90010-8","article-title":"A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses","volume":"27","author":"Weinbaum","year":"1994","journal-title":"J. Biomech."},{"issue":"5","key":"10.1016\/j.bone.2020.115324_bb0100","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1096\/fasebj.9.5.7896017","article-title":"Sensitivity of osteocytes to biomechanical stress in vitro","volume":"9","author":"Klein-Nulend","year":"1995","journal-title":"FASEB J."},{"issue":"5","key":"10.1016\/j.bone.2020.115324_bb0105","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1359\/jbmr.2002.17.5.907","article-title":"Spatial distribution of Bax and Bcl-2 in osteocytes after bone fatigue: complementary roles in bone remodeling regulation?","volume":"17","author":"Verborgt","year":"2002","journal-title":"J. Bone Miner. Res."},{"issue":"6","key":"10.1016\/j.bone.2020.115324_bb0110","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1359\/jbmr.080207","article-title":"Apoptotic bodies convey activity capable of initiating osteoclastogenesis and localized bone destruction","volume":"23","author":"Kogianni","year":"2008","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2020.115324_bb0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ecl.2016.09.003","article-title":"The role of the osteocyte in bone and nonbone disease","volume":"46","author":"Bonewald","year":"2017","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"issue":"1","key":"10.1016\/j.bone.2020.115324_bb0120","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00223-017-0332-x","article-title":"Clinical significance of DXA and HR-pQCT in autosomal dominant osteopetrosis (ADO II)","volume":"102","author":"Butscheidt","year":"2018","journal-title":"Calcif. Tissue Int."},{"issue":"8","key":"10.1016\/j.bone.2020.115324_bb0125","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1002\/jbmr.3730","article-title":"Mechanical competence and bone quality develop during skeletal growth","volume":"34","author":"Zimmermann","year":"2019","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2020.115324_bb0130","doi-asserted-by":"crossref","first-page":"a1518","DOI":"10.1136\/bmj.a1518","article-title":"Patterns of skeletal fractures in child abuse: systematic review","volume":"337","author":"Kemp","year":"2008","journal-title":"BMJ"},{"issue":"7","key":"10.1016\/j.bone.2020.115324_bb0135","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1359\/jbmr.080303","article-title":"Vigorous physical activity increases fracture risk in children irrespective of bone mass: a prospective study of the independent risk factors for fractures in healthy children","volume":"23","author":"Clark","year":"2008","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.bone.2020.115324_bb0140","first-page":"145","article-title":"Histomorphometric study on the osteocyte lacuno-canalicular network in animals of different species. I. Woven-fibered and parallel-fibered bones","volume":"103","author":"Remaggi","year":"1998","journal-title":"Ital. J. Anat. Embryol."},{"issue":"3","key":"10.1016\/j.bone.2020.115324_bb0145","first-page":"121","article-title":"Histomorphometric study on the osteocyte lacuno-canalicular network in animals of different species. II. Parallel-fibered and lamellar bones","volume":"104","author":"Ferretti","year":"1999","journal-title":"Ital. J. Anat. Embryol."},{"issue":"5","key":"10.1016\/j.bone.2020.115324_bb0150","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.bone.2004.07.002","article-title":"Osteocyte density in woven bone","volume":"35","author":"Hernandez","year":"2004","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.bone.2020.115324_bb0155","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/ajpa.20491","article-title":"An investigation of skeletal indicators of vitamin D deficiency in adults: effective markers for interpreting past living conditions and pollution levels in 18th and 19th century Birmingham, England","volume":"132","author":"Brickley","year":"2007","journal-title":"Am. J. Phys. Anthropol."},{"issue":"4","key":"10.1016\/j.bone.2020.115324_bb0160","first-page":"330","article-title":"Effects of nanomechanical bone tissue properties on bone tissue strain: implications for osteocyte mechanotransduction","volume":"8","author":"Nicolella","year":"2008","journal-title":"J. Musculoskelet. Neuronal Interact."},{"issue":"4","key":"10.1016\/j.bone.2020.115324_bb0165","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1002\/jbmr.3044","article-title":"Lactation-induced changes in the volume of osteocyte lacunar-canalicular space alter mechanical properties in cortical bone tissue","volume":"32","author":"Kaya","year":"2017","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2020.115324_bb0170","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0021-9290(00)00163-9","article-title":"Machine vision photogrammetry: a technique for measurement of microstructural strain in cortical bone","volume":"34","author":"Nicolella","year":"2001","journal-title":"J. Biomech."},{"issue":"9","key":"10.1016\/j.bone.2020.115324_bb0175","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/j.jbiomech.2005.04.032","article-title":"Osteocyte lacunae tissue strain in cortical bone","volume":"39","author":"Nicolella","year":"2006","journal-title":"J. Biomech."},{"issue":"10","key":"10.1016\/j.bone.2020.115324_bb0180","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1016\/j.jbiomech.2006.10.040","article-title":"Tissue strain amplification at the osteocyte lacuna: a microstructural finite element analysis","volume":"40","author":"Bonivtch","year":"2007","journal-title":"J. Biomech."},{"issue":"2","key":"10.1016\/j.bone.2020.115324_bb0185","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s11914-015-0256-1","article-title":"Osteocyte shape and mechanical loading","volume":"13","author":"van Oers","year":"2015","journal-title":"Curr Osteoporos Rep"},{"issue":"7","key":"10.1016\/j.bone.2020.115324_bb0190","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/j.jbiomech.2008.01.031","article-title":"Round versus flat: bone cell morphology, elasticity, and mechanosensing","volume":"41","author":"Bacabac","year":"2008","journal-title":"J. Biomech."},{"issue":"6","key":"10.1016\/j.bone.2020.115324_bb0195","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00223-018-0463-8","article-title":"Mechanical loading differentially affects osteocytes in fibulae from lactating mice compared to osteocytes in virgin mice: possible role for lacuna size","volume":"103","author":"Hemmatian","year":"2018","journal-title":"Calcif. Tissue Int."},{"issue":"2","key":"10.1016\/j.bone.2020.115324_bb0200","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.bone.2009.04.238","article-title":"Osteocyte morphology in human tibiae of different bone pathologies with different bone mineral density\u2014is there a role for mechanosensing?","volume":"45","author":"van Hove","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.bone.2020.115324_bb0205","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.bone.2018.04.018","article-title":"Inter-site variability of the osteocyte lacunar network in the cortical bone underpins fracture susceptibility of the superolateral femoral neck","volume":"112","author":"Rolvien","year":"2018","journal-title":"Bone"},{"key":"10.1016\/j.bone.2020.115324_bb0210","doi-asserted-by":"crossref","DOI":"10.1002\/jbmr.3970","article-title":"Long-term immobilization in elderly females causes a specific pattern of cortical bone and osteocyte deterioration different from postmenopausal osteoporosis","author":"Rolvien","year":"2020","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.bone.2020.115324_bb0215","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/jbmr.2340","article-title":"Modifications to nano- and microstructural quality and the effects on mechanical integrity in Paget\u2019s disease of bone","volume":"30","author":"Zimmermann","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2020.115324_bb0220","doi-asserted-by":"crossref","first-page":"441","DOI":"10.22203\/eCM.v024a31","article-title":"Changes to the cell, tissue and architecture levels in cranial suture synostosis reveal a problem of timing in bone development","volume":"24","author":"Regelsberger","year":"2012","journal-title":"Eur Cell Mater"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328220301046?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328220301046?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:46:40Z","timestamp":1757612800000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328220301046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":44,"alternative-id":["S8756328220301046"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2020.115324","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Large osteocyte lacunae in iliac crest infantile bone are not associated with impaired mineral distribution or signs of osteocytic osteolysis","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2020.115324","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115324"}}