{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:20:36Z","timestamp":1787170836571,"version":"build-2736575974"},"reference-count":181,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.bone.2020.115434","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T22:44:42Z","timestamp":1589582682000},"page":"115434","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Transcriptional, epigenetic and microRNA regulation of growth plate"],"prefix":"10.1016","volume":"137","author":[{"given":"Ryo","family":"Nakamichi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Kurimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Tabata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirosi","family":"Asahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bone.2020.115434_bb0005","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/BF00174948","article-title":"The membranous skeleton: the role of cell condensations in vertebrate skeletogenesis","volume":"186","author":"Hall","year":"1992","journal-title":"Anat. Embryol. (Berl)"},{"issue":"6937","key":"10.1016\/j.bone.2020.115434_bb0010","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/nature01657","article-title":"Developmental regulation of the growth plate","volume":"423","author":"Kronenberg","year":"2003","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.bone.2020.115434_bb0015","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.devcel.2010.07.010","article-title":"Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels","volume":"19","author":"Maes","year":"2010","journal-title":"Dev. Cell"},{"issue":"33","key":"10.1016\/j.bone.2020.115434_bb0020","doi-asserted-by":"crossref","first-page":"12097","DOI":"10.1073\/pnas.1302703111","article-title":"Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation","volume":"111","author":"Yang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.bone.2020.115434_bb0025","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/8792","article-title":"Sox 9 is required for cartilage formation","volume":"22","author":"Bi","year":"1999","journal-title":"Nat. Genet."},{"issue":"6506","key":"10.1016\/j.bone.2020.115434_bb0030","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/372525a0","article-title":"Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene","volume":"372","author":"Foster","year":"1994","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.bone.2020.115434_bb0035","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/0092-8674(94)90041-8","article-title":"Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9","volume":"79","author":"Wagner","year":"1994","journal-title":"Cell"},{"issue":"21","key":"10.1016\/j.bone.2020.115434_bb0040","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1101\/gad.1017802","article-title":"The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6","volume":"16","author":"Akiyama","year":"2002","journal-title":"Genes Dev."},{"issue":"2","key":"10.1016\/j.bone.2020.115434_bb0045","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/ng0697-174","article-title":"SOX9 directly regulates the type-II collagen gene","volume":"16","author":"Bell","year":"1997","journal-title":"Nat. Genet."},{"issue":"4","key":"10.1016\/j.bone.2020.115434_bb0050","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1128\/MCB.17.4.2336","article-title":"SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene","volume":"17","author":"Lefebvre","year":"1997","journal-title":"Mol. Cell. Biol."},{"issue":"1","key":"10.1016\/j.bone.2020.115434_bb0055","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1006\/dbio.1996.8487","article-title":"SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse","volume":"183","author":"Ng","year":"1997","journal-title":"Dev. Biol."},{"issue":"24","key":"10.1016\/j.bone.2020.115434_bb0060","doi-asserted-by":"crossref","first-page":"14989","DOI":"10.1074\/jbc.273.24.14989","article-title":"Three high mobility group-like sequences within a 48-base pair enhancer of the Col2a1 gene are required for cartilage-specific expression in vivo","volume":"273","author":"Zhou","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"19","key":"10.1016\/j.bone.2020.115434_bb0065","doi-asserted-by":"crossref","first-page":"5718","DOI":"10.1093\/emboj\/17.19.5718","article-title":"A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene","volume":"17","author":"Lefebvre","year":"1998","journal-title":"EMBO J."},{"issue":"6","key":"10.1016\/j.bone.2020.115434_bb0070","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1242\/dev.045203","article-title":"SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification","volume":"137","author":"Hattori","year":"2010","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.bone.2020.115434_bb0075","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.devcel.2011.12.024","article-title":"Sox9 directs hypertrophic maturation and blocks osteoblast differentiation of growth plate chondrocytes","volume":"22","author":"Dy","year":"2012","journal-title":"Dev. Cell"},{"issue":"50","key":"10.1016\/j.bone.2020.115434_bb0080","doi-asserted-by":"crossref","first-page":"19004","DOI":"10.1073\/pnas.0605170103","article-title":"Dominance of SOX9 function over RUNX2 during skeletogenesis","volume":"103","author":"Zhou","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.bone.2020.115434_bb0085","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.devcel.2011.12.024","article-title":"Sox9 directs hypertrophic maturation and blocks osteoblast differentiation of growth plate chondrocytes","volume":"22","author":"Dy","year":"2012","journal-title":"Dev. Cell"},{"issue":"11","key":"10.1016\/j.bone.2020.115434_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002356","article-title":"SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression","volume":"7","author":"Leung","year":"2011","journal-title":"PLoS Genet."},{"issue":"9","key":"10.1016\/j.bone.2020.115434_bb0095","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1101\/gad.1171104","article-title":"Interactions between Sox9 and beta-catenin control chondrocyte differentiation","volume":"18","author":"Akiyama","year":"2004","journal-title":"Genes Dev."},{"issue":"2","key":"10.1016\/j.bone.2020.115434_bb0100","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S1534-5807(01)00003-X","article-title":"The transcription factors L-Sox5 and Sox6 are essential for cartilage formation","volume":"1","author":"Smits","year":"2001","journal-title":"Dev. Cell"},{"issue":"5","key":"10.1016\/j.bone.2020.115434_bb0105","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1083\/jcb.200312045","article-title":"Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate","volume":"164","author":"Smits","year":"2004","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.bone.2020.115434_bb0110","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1399-0004.2007.00736.x","article-title":"Two novel translocation breakpoints upstream of SOX9 define borders of the proximal and distal breakpoint cluster region in campomelic dysplasia","volume":"71","author":"Leipoldt","year":"2007","journal-title":"Clin. Genet."},{"key":"10.1016\/j.bone.2020.115434_bb0115","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1471-2350-14-50","article-title":"The clinical impact of chromosomal rearrangements with breakpoints upstream of the SOX9 gene: two novel de novo balanced translocations associated with acampomelic campomelic dysplasia","volume":"14","author":"Fonseca","year":"2013","journal-title":"BMC Med. Genet."},{"issue":"3","key":"10.1016\/j.bone.2020.115434_bb0120","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/ng.329","article-title":"Highly conserved non-coding elements on either side of SOX9 associated with Pierre Robin sequence","volume":"41","author":"Benko","year":"2009","journal-title":"Nat. Genet."},{"issue":"8","key":"10.1016\/j.bone.2020.115434_bb0125","doi-asserted-by":"crossref","first-page":"4459","DOI":"10.1093\/nar\/gkt140","article-title":"A far-upstream (\u221270 kb) enhancer mediates Sox9 auto-regulation in somatic tissues during development and adult regeneration","volume":"41","author":"Mead","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.bone.2020.115434_bb0130","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.ydbio.2005.11.013","article-title":"Long-range upstream and downstream enhancers control distinct subsets of the complex spatiotemporal Sox9 expression pattern","volume":"291","author":"Bagheri-Fam","year":"2006","journal-title":"Dev. Biol."},{"issue":"11","key":"10.1016\/j.bone.2020.115434_bb0135","doi-asserted-by":"crossref","first-page":"5394","DOI":"10.1093\/nar\/gkv426","article-title":"The SOX9 upstream region prone to chromosomal aberrations causing campomelic dysplasia contains multiple cartilage enhancers","volume":"43","author":"Yao","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.bone.2020.115434_bb0140","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.devcel.2018.07.024","article-title":"Combinatorial CRISPR\/Cas 9 approach to elucidate a far-upstream enhancer complex for tissue-specific Sox9 expression","volume":"46","author":"Mochizuki","year":"2018","journal-title":"Dev. Cell"},{"issue":"2","key":"10.1016\/j.bone.2020.115434_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006610","article-title":"Mesoderm-specific stat 3 deletion affects expression of Sox9 yielding Sox9-dependent phenotypes","volume":"13","author":"Hall","year":"2017","journal-title":"PLoS Genet."},{"issue":"5275","key":"10.1016\/j.bone.2020.115434_bb0150","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1126\/science.273.5275.613","article-title":"Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein","volume":"273","author":"Vortkamp","year":"1996","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.bone.2020.115434_bb0155","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1242\/dev.129.12.2977","article-title":"PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps","volume":"129","author":"Kobayashi","year":"2002","journal-title":"Development"},{"issue":"4","key":"10.1016\/j.bone.2020.115434_bb0160","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.matbio.2006.12.002","article-title":"Misexpression of Sox9 in mouse limb bud mesenchyme induces polydactyly and rescues hypodactyly mice","volume":"26","author":"Akiyama","year":"2007","journal-title":"Matrix Biol."},{"issue":"16","key":"10.1016\/j.bone.2020.115434_bb0165","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1101\/gad.13.16.2072","article-title":"Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation","volume":"13","author":"St-Jacques","year":"1999","journal-title":"Genes Dev."},{"issue":"1","key":"10.1016\/j.bone.2020.115434_bb0170","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ydbio.2007.01.031","article-title":"PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms","volume":"305","author":"Mau","year":"2007","journal-title":"Dev. Biol."},{"issue":"14","key":"10.1016\/j.bone.2020.115434_bb0175","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1242\/dev.126.14.3205","article-title":"Gli proteins encode context-dependent positive and negative functions: implications for development and disease","volume":"126","author":"Ruiz i Altaba","year":"1999","journal-title":"Development"},{"issue":"4","key":"10.1016\/j.bone.2020.115434_bb0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007346","article-title":"Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions","volume":"14","author":"Tan","year":"2018","journal-title":"PLoS Genet."},{"issue":"9","key":"10.1016\/j.bone.2020.115434_bb0185","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nrrheum.2015.84","article-title":"The role of hedgehog signalling in skeletal health and disease","volume":"11","author":"Alman","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"issue":"23","key":"10.1016\/j.bone.2020.115434_bb0190","doi-asserted-by":"crossref","first-page":"5249","DOI":"10.1242\/dev.02097","article-title":"Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation","volume":"132","author":"Koziel","year":"2005","journal-title":"Development (Cambridge, England)"},{"issue":"8","key":"10.1016\/j.bone.2020.115434_bb0195","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1128\/MCB.01089-09","article-title":"Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation","volume":"30","author":"Wen","year":"2010","journal-title":"Mol. Cell. Biol."},{"issue":"9","key":"10.1016\/j.bone.2020.115434_bb0200","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1128\/MCB.26.9.3365-3377.2006","article-title":"Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation","volume":"26","author":"Pan","year":"2006","journal-title":"Mol. Cell. Biol."},{"issue":"12","key":"10.1016\/j.bone.2020.115434_bb0205","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1242\/dev.052126","article-title":"Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors","volume":"137","author":"Wang","year":"2010","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.bone.2020.115434_bb0210","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1172\/JCI11706","article-title":"Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development","volume":"107","author":"Chung","year":"2001","journal-title":"J. Clin. Invest."},{"issue":"14","key":"10.1016\/j.bone.2020.115434_bb0215","doi-asserted-by":"crossref","first-page":"9924","DOI":"10.1074\/jbc.M112.409342","article-title":"Hedgehog-Gli activators direct osteo-chondrogenic function of bone morphogenetic protein toward osteogenesis in the perichondrium","volume":"288","author":"Hojo","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.bone.2020.115434_bb0220","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1093\/hmg\/ddm061","article-title":"SOX9cre1, a cis-acting regulatory element located 1.1 Mb upstream of SOX9, mediates its enhancement through the SHH pathway","volume":"16","author":"Bien-Willner","year":"2007","journal-title":"Hum. Mol. Genet."},{"issue":"24","key":"10.1016\/j.bone.2020.115434_bb0225","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1242\/dev.041624","article-title":"The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization","volume":"136","author":"Joeng","year":"2009","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.bone.2020.115434_bb0230","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.yexcr.2003.10.021","article-title":"Impaired endochondral bone development and osteopenia in Gli2-deficient mice","volume":"294","author":"Miao","year":"2004","journal-title":"Exp. Cell Res."},{"issue":"7","key":"10.1016\/j.bone.2020.115434_bb0235","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1101\/gad.1902910","article-title":"The output of hedgehog signaling is controlled by the dynamic association between suppressor of fused and the Gli proteins","volume":"24","author":"Humke","year":"2010","journal-title":"Genes Dev."},{"issue":"11","key":"10.1016\/j.bone.2020.115434_bb0240","doi-asserted-by":"crossref","first-page":"4316","DOI":"10.1128\/MCB.02183-05","article-title":"Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP","volume":"26","author":"Temp\u00e9","year":"2006","journal-title":"Mol. Cell. Biol."},{"issue":"1","key":"10.1016\/j.bone.2020.115434_bb0245","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1073\/pnas.0509927103","article-title":"Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing","volume":"103","author":"Wang","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"19","key":"10.1016\/j.bone.2020.115434_bb0250","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.1242\/dev.02025","article-title":"Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development","volume":"132","author":"Hilton","year":"2005","journal-title":"Development"},{"issue":"5","key":"10.1016\/j.bone.2020.115434_bb0255","first-page":"475","article-title":"Tricho-rhino-phalangeal syndrome","volume":"21","author":"Giedion","year":"1966","journal-title":"Helvetica Paediatrica Acta"},{"issue":"3","key":"10.1016\/j.bone.2020.115434_bb0260","first-page":"249","article-title":"Autosomal-dominant transmission of the tricho-rhino-phalangeal syndrome. Report of 4 unrelated families, review of 60 cases","volume":"28","author":"Giedion","year":"1973","journal-title":"Helvetica Paediatrica Acta"},{"issue":"1","key":"10.1016\/j.bone.2020.115434_bb0265","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/71717","article-title":"Mutations in a new gene, encoding a zinc-finger protein, cause tricho-rhino-phalangeal syndrome type I","volume":"24","author":"Momeni","year":"2000","journal-title":"Nat. Genet."},{"issue":"22","key":"10.1016\/j.bone.2020.115434_bb0270","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1093\/hmg\/ddn247","article-title":"A position effect on TRPS1 is associated with Ambras syndrome in humans and the Koala phenotype in mice","volume":"17","author":"Fantauzzo","year":"2008","journal-title":"Hum. Mol. Genet."},{"issue":"2","key":"10.1016\/j.bone.2020.115434_bb0275","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.ydbio.2007.10.001","article-title":"Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling","volume":"312","author":"Suemoto","year":"2007","journal-title":"Dev. Biol."},{"issue":"24","key":"10.1016\/j.bone.2020.115434_bb0280","doi-asserted-by":"crossref","first-page":"8592","DOI":"10.1128\/MCB.22.24.8592-8600.2002","article-title":"Deletion of the GATA domain of TRPS1 causes an absence of facial hair and provides new insights into the bone disorder in inherited tricho-rhino-phalangeal syndromes","volume":"22","author":"Malik","year":"2002","journal-title":"Mol. Cell. Biol."},{"issue":"14","key":"10.1016\/j.bone.2020.115434_bb0285","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1093\/hmg\/ddn125","article-title":"Uncoupling of chondrocyte differentiation and perichondrial mineralization underlies the skeletal dysplasia in tricho-rhino-phalangeal syndrome","volume":"17","author":"Napierala","year":"2008","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.bone.2020.115434_bb0290","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.bone.2008.03.009","article-title":"Trps1 deficiency enlarges the proliferative zone of growth plate cartilage by upregulation of Pthrp","volume":"43","author":"Nishioka","year":"2008","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.bone.2020.115434_bb0295","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ydbio.2009.01.012","article-title":"Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3","volume":"328","author":"Wuelling","year":"2009","journal-title":"Dev. Biol."},{"issue":"46","key":"10.1016\/j.bone.2020.115434_bb0300","doi-asserted-by":"crossref","first-page":"31690","DOI":"10.1074\/jbc.M109.052316","article-title":"Identification of the GATA factor TRPS1 as a repressor of the osteocalcin promoter","volume":"284","author":"Piscopo","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bone.2020.115434_bb0305","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ydbio.2019.09.012","article-title":"Wnt5a is a transcriptional target of Gli3 and Trps1 at the onset of chondrocyte hypertrophy","volume":"457","author":"Wuelling","year":"2020","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bone.2020.115434_bb0310","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1146\/annurev.biochem.66.1.807","article-title":"Transcriptional regulation by cyclic AMP","volume":"66","author":"Montminy","year":"1997","journal-title":"Annu. Rev. Biochem."},{"issue":"4","key":"10.1016\/j.bone.2020.115434_bb0315","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/0092-8674(89)90013-5","article-title":"Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133","volume":"59","author":"Gonzalez","year":"1989","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.bone.2020.115434_bb0320","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0092-8674(92)90162-6","article-title":"The regulation of transcription by phosphorylation","volume":"70","author":"Hunter","year":"1992","journal-title":"Cell"},{"issue":"23","key":"10.1016\/j.bone.2020.115434_bb0325","doi-asserted-by":"crossref","first-page":"7892","DOI":"10.1128\/MCB.21.23.7892-7900.2001","article-title":"Chromatin-dependent cooperativity between constitutive and inducible activation domains in CREB","volume":"21","author":"Asahara","year":"2001","journal-title":"Mol. Cell. Biol."},{"issue":"2","key":"10.1016\/j.bone.2020.115434_bb0330","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.molcel.2003.08.013","article-title":"TORCs: transducers of regulated CREB activity","volume":"12","author":"Conkright","year":"2003","journal-title":"Mol. Cell"},{"issue":"3","key":"10.1016\/j.bone.2020.115434_bb0335","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nrm3072","article-title":"CREB and the CRTC co-activators: sensors for hormonal and metabolic signals","volume":"12","author":"Altarejos","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.bone.2020.115434_bb0340","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cell.2004.09.015","article-title":"The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector","volume":"119","author":"Screaton","year":"2004","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.bone.2020.115434_bb0345","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.tem.2018.08.004","article-title":"Salt-inducible kinases: physiology, regulation by cAMP, and therapeutic potential","volume":"29","author":"Wein","year":"2018","journal-title":"Trends Endocrinol. Metab."},{"issue":"1\u20132","key":"10.1016\/j.bone.2020.115434_bb0350","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0303-7207(01)00696-7","article-title":"The expanding family of CREB\/CREM transcription factors that are involved with spermatogenesis","volume":"187","author":"Don","year":"2002","journal-title":"Mol. Cell. Endocrinol."},{"issue":"8","key":"10.1016\/j.bone.2020.115434_bb0355","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35085068","article-title":"Transcriptional regulation by the phosphorylation-dependent factor CREB","volume":"2","author":"Mayr","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.bone.2020.115434_bb0360","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1242\/dev.128.4.541","article-title":"The CREB family of activators is required for endochondral bone development","volume":"128","author":"Long","year":"2001","journal-title":"Development"},{"issue":"8","key":"10.1016\/j.bone.2020.115434_bb0365","doi-asserted-by":"crossref","first-page":"4481","DOI":"10.1073\/pnas.95.8.4481","article-title":"Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein","volume":"95","author":"Rudolph","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.bone.2020.115434_bb0370","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1128\/MCB.18.2.967","article-title":"A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos","volume":"18","author":"Ahn","year":"1998","journal-title":"Mol. Cell. Biol."},{"issue":"6","key":"10.1016\/j.bone.2020.115434_bb0375","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1083\/jcb.126.6.1611","article-title":"Parathyroid hormone-related peptide-depleted mice show abnormal epiphyseal cartilage development and altered endochondral bone formation","volume":"126","author":"Amizuka","year":"1994","journal-title":"J. Cell Biol."},{"issue":"15","key":"10.1016\/j.bone.2020.115434_bb0380","doi-asserted-by":"crossref","first-page":"11639","DOI":"10.1074\/jbc.M006564200","article-title":"PTHrP modulates chondrocyte differentiation through AP-1 and CREB signaling","volume":"276","author":"Ionescu","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"7730","key":"10.1016\/j.bone.2020.115434_bb0385","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s41586-018-0662-5","article-title":"Resting zone of the growth plate houses a unique class of skeletal stem cells","volume":"563","author":"Mizuhashi","year":"2018","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bone.2020.115434_bb0390","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.devcel.2010.09.008","article-title":"ZFP521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes","volume":"19","author":"Correa","year":"2010","journal-title":"Dev. Cell"},{"issue":"5","key":"10.1016\/j.bone.2020.115434_bb0395","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.97903","article-title":"PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy","volume":"4","author":"Nishimori","year":"2019","journal-title":"JCI Insight"},{"issue":"7","key":"10.1016\/j.bone.2020.115434_bb0400","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1002\/j.1460-2075.1989.tb03610.x","article-title":"Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain","volume":"8","author":"Maekawa","year":"1989","journal-title":"EMBO J."},{"issue":"6783","key":"10.1016\/j.bone.2020.115434_bb0405","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/35012097","article-title":"ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation","volume":"405","author":"Kawasaki","year":"2000","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.bone.2020.115434_bb0410","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1093\/nar\/22.8.1463","article-title":"Different binding specificities and transactivation of variant CRE\u2019s by CREB complexes","volume":"22","author":"Benbrook","year":"1994","journal-title":"Nucleic Acids Res."},{"issue":"6562","key":"10.1016\/j.bone.2020.115434_bb0415","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/379262a0","article-title":"Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice","volume":"379","author":"Reimold","year":"1996","journal-title":"Nature"},{"issue":"25","key":"10.1016\/j.bone.2020.115434_bb0420","doi-asserted-by":"crossref","first-page":"17813","DOI":"10.1074\/jbc.274.25.17813","article-title":"Mouse ATF-2 null mutants display features of a severe type of meconium aspiration syndrome","volume":"274","author":"Maekawa","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bone.2020.115434_bb0425","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1073\/pnas.96.4.1433","article-title":"Identification of the cyclin D1 gene as a target of activating transcription factor 2 in chondrocytes","volume":"96","author":"Beier","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"17","key":"10.1016\/j.bone.2020.115434_bb0430","doi-asserted-by":"crossref","first-page":"12948","DOI":"10.1074\/jbc.275.17.12948","article-title":"Activating transcription factor 2 is necessary for maximal activity and serum induction of the cyclin A promoter in chondrocytes","volume":"275","author":"Beier","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bone.2020.115434_bb0435","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/jcb.21198","article-title":"Activating transcription factor 2 controls Bcl-2 promoter activity in growth plate chondrocytes","volume":"101","author":"Ma","year":"2007","journal-title":"J. Cell. Biochem."},{"issue":"3","key":"10.1016\/j.bone.2020.115434_bb0440","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0092-8674(04)00344-7","article-title":"ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for coffin-Lowry syndrome","volume":"117","author":"Yang","year":"2004","journal-title":"Cell"},{"issue":"24","key":"10.1016\/j.bone.2020.115434_bb0445","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.1242\/dev.043281","article-title":"Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription","volume":"136","author":"Wang","year":"2009","journal-title":"Development"},{"issue":"5","key":"10.1016\/j.bone.2020.115434_bb0450","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1128\/MCB.01552-06","article-title":"BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer","volume":"27","author":"Kondo","year":"2007","journal-title":"Mol. Cell. Biol."},{"issue":"43","key":"10.1016\/j.bone.2020.115434_bb0455","doi-asserted-by":"crossref","first-page":"36190","DOI":"10.1074\/jbc.M112.373746","article-title":"The endoplasmic reticulum stress transducer BBF2H7 suppresses apoptosis by activating the ATF5-MCL1 pathway in growth plate cartilage","volume":"287","author":"Izumi","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.bone.2020.115434_bb0460","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1182\/blood-2002-08-2652","article-title":"Evi3, a common retroviral integration site in murine B-cell lymphoma, encodes an EBFAZ-related Kruppel-like zinc finger protein","volume":"101","author":"Warming","year":"2003","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.bone.2020.115434_bb0465","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1182\/blood-2003-07-2388","article-title":"Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells","volume":"103","author":"Bond","year":"2004","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.bone.2020.115434_bb0470","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1523\/JNEUROSCI.17-11-04159.1997","article-title":"Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O\/E-1 to regulate gene expression: implications for olfactory neuronal development","volume":"17","author":"Tsai","year":"1997","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.bone.2020.115434_bb0475","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0092-8674(00)81561-5","article-title":"OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways","volume":"100","author":"Hata","year":"2000","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.bone.2020.115434_bb0480","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.bone.2008.11.011","article-title":"ZFP521 antagonizes Runx2, delays osteoblast differentiation in vitro, and promotes bone formation in vivo","volume":"44","author":"Wu","year":"2009","journal-title":"Bone"},{"issue":"9","key":"10.1016\/j.bone.2020.115434_bb0485","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1096\/fj.11-183277","article-title":"Deletion of ZFP521 rescues the growth plate phenotype in a mouse model of Jansen metaphyseal chondrodysplasia","volume":"25","author":"Seriwatanachai","year":"2011","journal-title":"FASEB J."},{"issue":"4","key":"10.1016\/j.bone.2020.115434_bb0490","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/(SICI)1097-0177(199904)214:4<279::AID-AJA1>3.0.CO;2-W","article-title":"Maturational disturbance of chondrocytes in Cbfa1-deficient mice","volume":"214","author":"Inada","year":"1999","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.bone.2020.115434_bb0495","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0925-4773(98)00210-X","article-title":"Regulation of chondrocyte differentiation by Cbfa1","volume":"80","author":"Kima FO","year":"1999","journal-title":"Mech. Dev."},{"issue":"5","key":"10.1016\/j.bone.2020.115434_bb0500","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0092-8674(00)80259-7","article-title":"Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development","volume":"89","author":"Otto","year":"1997","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.bone.2020.115434_bb0505","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0092-8674(00)80258-5","article-title":"Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts.","volume":"89","author":"Komori","year":"1997","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.bone.2020.115434_bb0510","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1101\/gad.1174704","article-title":"Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog","volume":"18","author":"Yoshida","year":"2004","journal-title":"Genes Dev."},{"issue":"4","key":"10.1016\/j.bone.2020.115434_bb0515","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1101\/gad.845101","article-title":"Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice","volume":"15","author":"Takeda","year":"2001","journal-title":"Genes Dev."},{"issue":"1","key":"10.1016\/j.bone.2020.115434_bb0520","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1083\/jcb.153.1.87","article-title":"Skeletal Malformations Caused by Overexpression of Cbfa1 or Its Dominant Negative Form in Chondrocytes.","volume":"153","author":"Ueta","year":"2001","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.bone.2020.115434_bb0525","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1006\/dbio.2002.0640","article-title":"Role of Runx genes in chondrocyte differentiation","volume":"245","author":"Stricker","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bone.2020.115434_bb0530","series-title":"Maturational Disturbance of Chondrocytes in Cbfa1-deficient Mice","first-page":"279","volume":"214","author":"Himeno","year":"1999"},{"issue":"11","key":"10.1016\/j.bone.2020.115434_bb0535","doi-asserted-by":"crossref","first-page":"5316","DOI":"10.1091\/mbc.e05-01-0084","article-title":"Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophy.","volume":"16","author":"James","year":"2005","journal-title":"Mol. Biol. Cell"},{"issue":"11","key":"10.1016\/j.bone.2020.115434_bb0540","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1359\/jbmr.090502","article-title":"Dose-dependent effects of Runx2 on bone development","volume":"24","author":"Zhang","year":"2009","journal-title":"J. Bone Miner. Res."},{"issue":"13","key":"10.1016\/j.bone.2020.115434_bb0545","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.yexcr.2009.03.008","article-title":"Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytes","volume":"315","author":"Yamashita","year":"2009","journal-title":"Exp. Cell Res."},{"issue":"2001","key":"10.1016\/j.bone.2020.115434_bb0550","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0925-4773(01)00428-2","article-title":"Tissue specific regulation of VEGF expression during bone development requires Cbfa1\/Runx2","volume":"106","author":"Elazar Zelzer","year":"2001","journal-title":"Mech. Dev."},{"issue":"6","key":"10.1016\/j.bone.2020.115434_bb0555","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1002\/jcb.10677","article-title":"Runx2\/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes","volume":"90","author":"Drissi","year":"2003","journal-title":"J. Cell. Biochem."},{"issue":"5","key":"10.1016\/j.bone.2020.115434_bb0560","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1083\/jcb.200211089","article-title":"Type X collagen gene regulation by Runx2 contributes directly to its hypertrophic chondrocyte-specific expression in vivo","volume":"162","author":"Zheng","year":"2003","journal-title":"J. Cell Biol."},{"issue":"7","key":"10.1016\/j.bone.2020.115434_bb0565","doi-asserted-by":"crossref","first-page":"5037","DOI":"10.1074\/jbc.275.7.5037","article-title":"Parathyroid hormone regulation of the rat Collagenase-3 promoter by protein kinase A-dependent transactivation of Core binding factor\u202f?1*","volume":"275","author":"Nagarajan Selvamurugan","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"44","key":"10.1016\/j.bone.2020.115434_bb0570","doi-asserted-by":"crossref","first-page":"31577","DOI":"10.1074\/jbc.274.44.31577","article-title":"Interaction and functional cooperation of PEBP2\/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter.","volume":"274","author":"Hanai","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"19","key":"10.1016\/j.bone.2020.115434_bb0575","doi-asserted-by":"crossref","first-page":"10549","DOI":"10.1073\/pnas.180309597","article-title":"A RUNX2\/PEBP2alpha A\/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia","volume":"97","author":"Zhang","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"13","key":"10.1016\/j.bone.2020.115434_bb0580","doi-asserted-by":"crossref","first-page":"8412","DOI":"10.1074\/jbc.M705578200","article-title":"Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal","volume":"283","author":"Javed","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bone.2020.115434_bb0585","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.devcel.2007.02.004","article-title":"MEF2C transcription factor controls chondrocyte hypertrophy and bone development","volume":"12","author":"Arnold","year":"2007","journal-title":"Dev. Cell"},{"issue":"9","key":"10.1016\/j.bone.2020.115434_bb0590","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1002\/jbmr.2240","article-title":"Dlx5 and mef2 regulate a novel runx2 enhancer for osteoblast-specific expression","volume":"29","author":"Kawane","year":"2014","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.bone.2020.115434_bb0595","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cell.2004.10.024","article-title":"Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis","volume":"119","author":"Vega","year":"2004","journal-title":"Cell"},{"issue":"21","key":"10.1016\/j.bone.2020.115434_bb0600","doi-asserted-by":"crossref","first-page":"5751","DOI":"10.1128\/MCB.00415-09","article-title":"Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A\/histone deacetylase 4\/MEF2 pathway","volume":"29","author":"Kozhemyakina","year":"2009","journal-title":"Mol. Cell. Biol."},{"issue":"12","key":"10.1016\/j.bone.2020.115434_bb0605","doi-asserted-by":"crossref","first-page":"5187","DOI":"10.1172\/JCI130126","article-title":"Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodeling","volume":"129","author":"Nishimori","year":"2019","journal-title":"J. Clin. Invest."},{"issue":"1993","key":"10.1016\/j.bone.2020.115434_bb0610","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1242\/dev.119.3.567","article-title":"KHK, Evelyn Grau and G\u00fcnther Sch\u00fctz. Postimplantation expression patterns indicate a role for the mouse forkhead\/HNF-3, and genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm","volume":"119","author":"Paula Monaghan","year":"1993","journal-title":"Development"},{"issue":"13","key":"10.1016\/j.bone.2020.115434_bb0615","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1093\/emboj\/16.13.3995","article-title":"Transcriptional regulation in endoderm development: characterization of an enhancer controlling Hnf3g expression by transgenesis and targeted mutagenesis","volume":"16","author":"Hiemisch GnStaKHK","year":"1997","journal-title":"EMBO J."},{"issue":"2","key":"10.1016\/j.bone.2020.115434_bb0620","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.modgep.2004.08.006","article-title":"Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissues","volume":"5","author":"Besnard","year":"2004","journal-title":"Gene Expr. Patterns"},{"issue":"7","key":"10.1016\/j.bone.2020.115434_bb0625","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1128\/MCB.18.7.4245","article-title":"Targeted disruption of the gene encoding hepatocyte nuclear factor 3? Results in reduced transcription of hepatocyte-specific genes","volume":"18","author":"Klaus","year":"1998","journal-title":"Mol. Cell. Biol."},{"issue":"46","key":"10.1016\/j.bone.2020.115434_bb0630","doi-asserted-by":"crossref","first-page":"42812","DOI":"10.1074\/jbc.M106344200","article-title":"Foxa3 (hepatocyte nuclear factor 3gamma) is required for the regulation of hepatic GLUT2 expression and the maintenance of glucose homeostasis during a prolonged fast","volume":"276","author":"Shen","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.bone.2020.115434_bb0635","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.devcel.2012.03.011","article-title":"FoxA family members are crucial regulators of the hypertrophic chondrocyte differentiation program","volume":"22","author":"Ionescu","year":"2012","journal-title":"Dev. Cell"},{"issue":"3","key":"10.1016\/j.bone.2020.115434_bb0640","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.cell.2012.01.021","article-title":"Hypoxia-inducible factors in physiology and medicine","volume":"148","author":"Semenza","year":"2012","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.bone.2020.115434_bb0645","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.devcel.2009.11.008","article-title":"The role of hypoxia in development of the mammalian embryo","volume":"17","author":"Dunwoodie","year":"2009","journal-title":"Dev. Cell"},{"issue":"3","key":"10.1016\/j.bone.2020.115434_bb0650","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1152\/physrev.1996.76.3.839","article-title":"Oxygen sensing and molecular adaptation to hypoxia","volume":"76","author":"Bunn","year":"1996","journal-title":"Physiol. Rev."},{"issue":"12","key":"10.1016\/j.bone.2020.115434_bb0655","doi-asserted-by":"crossref","first-page":"5510","DOI":"10.1073\/pnas.92.12.5510","article-title":"Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension","volume":"92","author":"Wang","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.bone.2020.115434_bb0660","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1432-1033.1997.t01-1-00155.x","article-title":"The mouse gene for hypoxia-inducible factor-1alpha--genomic organization, expression and characterization of an alternative first exon and 5\u2032 flanking sequence","volume":"246","author":"Wenger","year":"1997","journal-title":"Eur. J. Biochem."},{"issue":"5516","key":"10.1016\/j.bone.2020.115434_bb0665","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1126\/science.1059796","article-title":"Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation","volume":"292","author":"Jaakkola","year":"2001","journal-title":"Science"},{"issue":"5574","key":"10.1016\/j.bone.2020.115434_bb0670","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1126\/science.1073440","article-title":"Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling","volume":"296","author":"Min","year":"2002","journal-title":"Science"},{"issue":"7092","key":"10.1016\/j.bone.2020.115434_bb0675","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nature04871","article-title":"Hypoxia signalling in cancer and approaches to enforce tumour regression","volume":"441","author":"Pouyssegur","year":"2006","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bone.2020.115434_bb0680","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrc3183","article-title":"HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth and progression","volume":"12","author":"Keith","year":"2011","journal-title":"Nat. Rev. Cancer"},{"issue":"3","key":"10.1016\/j.bone.2020.115434_bb0685","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1083\/jcb.200612023","article-title":"Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development","volume":"177","author":"Provot","year":"2007","journal-title":"J. Cell Biol."},{"issue":"Pt 9","key":"10.1016\/j.bone.2020.115434_bb0690","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1242\/jcs.00385","article-title":"HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes","volume":"116","author":"Pfander","year":"2003","journal-title":"J. Cell Sci."},{"issue":"21","key":"10.1016\/j.bone.2020.115434_bb0695","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.1242\/dev.008441","article-title":"HIF1alpha regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis","volume":"134","author":"Amarilio","year":"2007","journal-title":"Development"},{"issue":"21","key":"10.1016\/j.bone.2020.115434_bb0700","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1101\/gad.934301","article-title":"Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival","volume":"15","author":"Schipani","year":"2001","journal-title":"Genes Dev."},{"issue":"9","key":"10.1016\/j.bone.2020.115434_bb0705","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1242\/dev.01053","article-title":"VEGFA is necessary for chondrocyte survival during bone development","volume":"131","author":"Zelzer","year":"2004","journal-title":"Development"},{"issue":"23","key":"10.1016\/j.bone.2020.115434_bb0710","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.1242\/dev.083881","article-title":"HIF1alpha is a central regulator of collagen hydroxylation and secretion under hypoxia during bone development","volume":"139","author":"Bentovim","year":"2012","journal-title":"Development"},{"issue":"5","key":"10.1016\/j.bone.2020.115434_bb0715","doi-asserted-by":"crossref","DOI":"10.1016\/j.devcel.2019.04.029","article-title":"Suppressing mitochondrial respiration is critical for hypoxia tolerance in the fetal growth plate","volume":"49","author":"Yao","year":"2019","journal-title":"Dev. Cell"},{"issue":"6","key":"10.1016\/j.bone.2020.115434_bb0720","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nm.2146","article-title":"Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development","volume":"16","author":"Saito","year":"2010","journal-title":"Nat. Med."},{"issue":"6","key":"10.1016\/j.bone.2020.115434_bb0725","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/nm.2153","article-title":"Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction","volume":"16","author":"Yang","year":"2010","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.bone.2020.115434_bb0730","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/nm0111-25","article-title":"Lack of HIF-2alpha in limb bud mesenchyme causes a modest and transient delay of endochondral bone development","volume":"17","author":"Araldi","year":"2011","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.bone.2020.115434_bb0735","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1074-5521(02)00092-3","article-title":"Deacetylase enzymes: biological functions and the use of small-molecule inhibitors","volume":"9","author":"Grozinger","year":"2002","journal-title":"Chem. Biol."},{"issue":"5","key":"10.1016\/j.bone.2020.115434_bb0740","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S0168-9525(03)00073-8","article-title":"Class II histone deacetylases: versatile regulators","volume":"19","author":"Verdin","year":"2003","journal-title":"Trends Genet."},{"issue":"12","key":"10.1016\/j.bone.2020.115434_bb0745","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1002\/jbmr.3236","article-title":"Histone deacetylase 3 deletion in mesenchymal progenitor cells hinders long bone development","volume":"32","author":"Feigenson","year":"2017","journal-title":"J. Bone Miner. Res."},{"issue":"40","key":"10.1016\/j.bone.2020.115434_bb0750","doi-asserted-by":"crossref","first-page":"41998","DOI":"10.1074\/jbc.M403702200","article-title":"Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation","volume":"279","author":"Schroeder","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bone.2020.115434_bb0755","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S1097-2765(01)00429-4","article-title":"Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT\/N-CoR","volume":"9","author":"Fischle","year":"2002","journal-title":"Mol. Cell"},{"issue":"440","key":"10.1016\/j.bone.2020.115434_bb0760","doi-asserted-by":"crossref","first-page":"ra79","DOI":"10.1126\/scisignal.aaf3273","article-title":"Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling","volume":"9","author":"Carpio","year":"2016","journal-title":"Sci. Signal."},{"issue":"3","key":"10.1016\/j.bone.2020.115434_bb0765","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1615\/CritRevEukarGeneExpr.v17.i3.20","article-title":"Histone deacetylase co-repressor complex control of Runx2 and bone formation","volume":"17","author":"Jensen","year":"2007","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"issue":"1","key":"10.1016\/j.bone.2020.115434_bb0770","doi-asserted-by":"crossref","first-page":"C33","DOI":"10.1152\/ajpcell.00348.2011","article-title":"Subcellular relocation of histone deacetylase 4 regulates growth plate chondrocyte differentiation through Ca2+\/calmodulin-dependent kinase IV","volume":"303","author":"Guan","year":"2012","journal-title":"Am. J. Phys. Cell Physiol."},{"issue":"2","key":"10.1016\/j.bone.2020.115434_bb0775","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.bbamcr.2014.11.003","article-title":"Mitogen-activated protein kinase p38 induces HDAC4 degradation in hypertrophic chondrocytes","volume":"1853","author":"Zhou","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.bone.2020.115434_bb0780","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1074\/jbc.M114.596247","article-title":"Histone deacetylase 7 (Hdac 7) suppresses chondrocyte proliferation and beta-catenin activity during endochondral ossification","volume":"290","author":"Bradley","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.bone.2020.115434_bb0785","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1091\/mbc.e10-07-0566","article-title":"Arid 5a cooperates with Sox9 to stimulate chondrocyte-specific transcription","volume":"22","author":"Amano","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bone.2020.115434_bb0790","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1038\/ncomms3850","article-title":"Arid5b facilitates chondrogenesis by recruiting the histone demethylase Phf2 to Sox9-regulated genes","volume":"4","author":"Hata","year":"2013","journal-title":"Nat. Commun."},{"issue":"7186","key":"10.1016\/j.bone.2020.115434_bb0795","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/nature06736","article-title":"SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin","volume":"452","author":"Michishita","year":"2008","journal-title":"Nature"},{"issue":"16","key":"10.1016\/j.bone.2020.115434_bb0800","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.4161\/cc.8.16.9367","article-title":"Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6","volume":"8","author":"Michishita","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bone.2020.115434_bb0805","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1038\/srep03022","article-title":"Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling","volume":"3","author":"Piao","year":"2013","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.bone.2020.115434_bb0810","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","article-title":"The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14","volume":"75","author":"Lee","year":"1993","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.bone.2020.115434_bb0815","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0092-8674(93)90530-4","article-title":"Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans","volume":"75","author":"Wightman","year":"1993","journal-title":"Cell"},{"issue":"7006","key":"10.1016\/j.bone.2020.115434_bb0820","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature02871","article-title":"The functions of animal micro RNAs","volume":"431","author":"Ambros","year":"2004","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bone.2020.115434_bb0825","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cell.2018.03.006","article-title":"Metazoan Micro RNAs","volume":"173","author":"Bartel","year":"2018","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.bone.2020.115434_bb0830","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1073\/pnas.0707900105","article-title":"Dicer-dependent pathways regulate chondrocyte proliferation and differentiation","volume":"105","author":"Kobayashi","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"10.1016\/j.bone.2020.115434_bb0835","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1101\/gad.1915510","article-title":"Micro RNA-140 plays dual roles in both cartilage development and homeostasis","volume":"24","author":"Miyaki","year":"2010","journal-title":"Genes Dev."},{"issue":"14","key":"10.1016\/j.bone.2020.115434_bb0840","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1128\/MCB.05178-11","article-title":"Chondrocyte-specific micro RNA-140 regulates endochondral bone development and targets Dnpep to modulate bone morphogenetic protein signaling","volume":"31","author":"Nakamura","year":"2011","journal-title":"Mol. Cell. Biol."},{"issue":"3","key":"10.1016\/j.bone.2020.115434_bb0845","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1089\/scd.2013.0209","article-title":"Micro RNA-140 targets RALA and regulates chondrogenic differentiation of human mesenchymal stem cells by translational enhancement of SOX9 and ACAN","volume":"23","author":"Karlsen","year":"2014","journal-title":"Stem Cells Dev."},{"issue":"17","key":"10.1016\/j.bone.2020.115434_bb0850","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.1016\/j.febslet.2006.06.080","article-title":"The cartilage specific micro RNA-140 targets histone deacetylase 4 in mouse cells","volume":"580","author":"Tuddenham","year":"2006","journal-title":"FEBS Lett."},{"issue":"6","key":"10.1016\/j.bone.2020.115434_bb0855","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/jbmr.2438","article-title":"Micro RNA-140 provides robustness to the regulation of hypertrophic chondrocyte differentiation by the PTHrP-HDAC4 pathway","volume":"30","author":"Papaioannou","year":"2015","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2020.115434_bb0860","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s12010-011-9404-y","article-title":"Sox9 is upstream of micro RNA-140 in cartilage","volume":"166","author":"Nakamura","year":"2012","journal-title":"Appl. Biochem. Biotechnol."},{"issue":"26","key":"10.1016\/j.bone.2020.115434_bb0865","doi-asserted-by":"crossref","first-page":"22206","DOI":"10.1074\/jbc.M112.343194","article-title":"L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity","volume":"287","author":"Yamashita","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.bone.2020.115434_bb0870","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/s41556-018-0077-4","article-title":"Dissecting the roles of miR-140 and its host gene","volume":"20","author":"Inui","year":"2018","journal-title":"Nat. Cell Biol."},{"issue":"4","key":"10.1016\/j.bone.2020.115434_bb0875","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41591-019-0353-2","article-title":"Gain-of-function mutation of microRNA-140 in human skeletal dysplasia","volume":"25","author":"Grigelioniene","year":"2019","journal-title":"Nat. Med."},{"issue":"19","key":"10.1016\/j.bone.2020.115434_bb0880","first-page":"3562","article-title":"miR-322 stabilizes MEK1 expression to inhibit RAF\/MEK\/ERK pathway activation in cartilage","volume":"144","author":"Bluhm","year":"2017","journal-title":"Development (Cambridge, England)"},{"issue":"4","key":"10.1016\/j.bone.2020.115434_bb0885","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.bbadis.2016.01.010","article-title":"miR-322 regulates insulin signaling pathway and protects against metabolic syndrome-induced cardiac dysfunction in mice","volume":"1862","author":"Marchand","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"16","key":"10.1016\/j.bone.2020.115434_bb0890","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1242\/dev.110254","article-title":"Crucial requirement of ERK\/MAPK signaling in respiratory tract development","volume":"141","author":"Boucherat","year":"2014","journal-title":"Development"},{"issue":"8","key":"10.1016\/j.bone.2020.115434_bb0895","first-page":"3514","article-title":"Regulation and expression of a growth arrest-specific gene (gas 5) during growth, differentiation, and development","volume":"12","author":"Coccia","year":"1992","journal-title":"Mol. Cell. Biol."},{"issue":"12","key":"10.1016\/j.bone.2020.115434_bb0900","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1002\/jor.22718","article-title":"A long non-coding RNA, GAS5, plays a critical role in the regulation of miR-21 during osteoarthritis","volume":"32","author":"Song","year":"2014","journal-title":"J. Orthop. Res."},{"issue":"1","key":"10.1016\/j.bone.2020.115434_bb0905","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12929-018-0424-6","article-title":"Long non-coding RNA gas 5 regulates proliferation and apoptosis in HCS-2\/8 cells and growth plate chondrocytes by controlling FGF1 expression via miR-21 regulation","volume":"25","author":"Liu","year":"2018","journal-title":"J. Biomed. Sci."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328220302143?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328220302143?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:50:02Z","timestamp":1757613002000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328220302143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":181,"alternative-id":["S8756328220302143"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2020.115434","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptional, epigenetic and microRNA regulation of growth plate","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2020.115434","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115434"}}