{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:19:40Z","timestamp":1792653580065,"version":"4.5.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.bone.2020.115436","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T12:32:00Z","timestamp":1589805120000},"page":"115436","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Aberrant structure of fibrillar collagen and elevated levels of advanced glycation end products typify delayed fracture healing in the diet-induced obesity mouse model"],"prefix":"10.1016","volume":"137","author":[{"given":"Deepak Kumar","family":"Khajuria","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Elfar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory S.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadia","family":"Kamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reyad A.","family":"Elbarbary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2020.115436_bb0005","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrrheum.2014.164","article-title":"Fracture healing: mechanisms and interventions","volume":"11","author":"Einhorn","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bone.2020.115436_bb0010","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/jor.23460","article-title":"Fracture healing physiology and the quest for therapies for delayed healing and nonunion","volume":"35","author":"Kostenuik","year":"2017","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2020.115436_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2018.00006","article-title":"The impact of type 2 diabetes on bone fracture healing","volume":"9","author":"Marin","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)."},{"key":"10.1016\/j.bone.2020.115436_bb0020","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3109\/17453674.2012.747054","article-title":"Patient-related risk factors for fracture-healing complications in the United Kingdom General Practice Research Database","volume":"83","author":"Hernandez","year":"2012","journal-title":"Acta Orthop."},{"key":"10.1016\/j.bone.2020.115436_bb0025","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1001\/jama.2009.2014","article-title":"CLINICIAN\u2019S CORNER among US adults , 1999\u20132008","volume":"303","author":"Flegal","year":"2013","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.bone.2020.115436_bb0030","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/jor.24170","article-title":"Cellular biology of fracture healing","volume":"37","author":"Bahney","year":"2019","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2020.115436_bb0035","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrrheum.2012.1","article-title":"Fracture healing under healthy and inflammatory conditions","volume":"8","author":"Claes","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bone.2020.115436_bb0040","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.bone.2016.02.020","article-title":"Inflammation, fracture and bone repair","volume":"86","author":"Loi","year":"2016","journal-title":"Bone"},{"key":"10.1016\/j.bone.2020.115436_bb0045","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.injury.2011.03.031","article-title":"The biology of fracture healing","volume":"42","author":"Marsell","year":"2011","journal-title":"Injury"},{"key":"10.1016\/j.bone.2020.115436_bb0050","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1242\/dev.130807","article-title":"Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes","volume":"144","author":"Hu","year":"2017","journal-title":"Dev"},{"key":"10.1016\/j.bone.2020.115436_bb0055","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s11914-015-0286-8","article-title":"Diabetes and its effect on bone and fracture healing","volume":"13","author":"Jiao","year":"2015","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bone.2020.115436_bb0060","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1002\/jbmr.3379","article-title":"Inhibition of CaMKK2 enhances fracture healing by stimulating Indian hedgehog signaling and accelerating endochondral ossification","volume":"33","author":"Williams","year":"2018","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2020.115436_bb0065","article-title":"Delayed fracture healing and increased callus adiposity in a C57BL\/6J murine model of obesity-associated type 2 diabetes mellitus","volume":"9","author":"Brown","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2020.115436_bb0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0106159","article-title":"The development of diet-induced obesity and glucose intolerance in C57Bl\/6 mice on a high-fat diet consists of distinct phases","volume":"9","author":"Williams","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2020.115436_bb0075","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1242\/dev.139253","article-title":"Deposition of collagen type I onto skeletal endothelium reveals a new role for blood vessels in regulating bone morphology","volume":"143","author":"Ben Shoham","year":"2016","journal-title":"Dev"},{"key":"10.1016\/j.bone.2020.115436_bb0080","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s00223-015-9984-6","article-title":"The mineral\u2013collagen interface in bone","volume":"97","author":"Stock","year":"2015","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2020.115436_bb0085","article-title":"The role of confined collagen geometry in decreasing nucleation energy barriers to intrafibrillar mineralization","volume":"9","author":"Kim","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bone.2020.115436_bb0090","article-title":"Dietary advanced glycation end-product consumption leads to mechanical stiffening of murine intervertebral discs","volume":"11","author":"Krishnamoorthy","year":"2018","journal-title":"DMM Dis. Model. Mech."},{"key":"10.1016\/j.bone.2020.115436_bb0095","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1038\/nbt894","article-title":"Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms","volume":"21","author":"Campagnola","year":"2003","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bone.2020.115436_bb0100","doi-asserted-by":"crossref","first-page":"7075","DOI":"10.1073\/pnas.0832308100","article-title":"Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation","volume":"100","author":"Zipfel","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bone.2020.115436_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18081772","article-title":"Imaging collagen in scar tissue: developments in second harmonic generation microscopy for biomedical applications","volume":"18","author":"Mosta\u00e7o-Guidolin","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bone.2020.115436_bb0110","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2474-12-26","article-title":"Second harmonic generation analysis of early Achilles tendinosis in response to in vivo mechanical loading","volume":"12","author":"Abraham","year":"2011","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.bone.2020.115436_bb0115","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/jor.21291","article-title":"Sodium cromolyn reduces expression of CTGF, ADAMTS1, and TIMP3 and modulates post-injury patellar tendon morphology","volume":"29","author":"Sharma","year":"2011","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2020.115436_bb0120","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/jbmr.3668","article-title":"Mechanical loading promotes the expansion of primitive osteoprogenitors and organizes matrix and vascular morphology in long bone defects","volume":"34","author":"Liu","year":"2019","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2020.115436_bb0125","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/jor.21220","article-title":"Scleraxis expression is coordinately regulated in a murine model of patellar tendon injury","volume":"29","author":"Scott","year":"2011","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2020.115436_bb0130","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jsb.2012.05.004","article-title":"Quantitative assessment of forward and backward second harmonic three dimensional images of collagen type I matrix remodeling in a stimulated cellular environment","volume":"180","author":"Abraham","year":"2012","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.bone.2020.115436_bb0135","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.actbio.2013.11.024","article-title":"Lysyl oxidase-mediated collagen crosslinks may be assessed as markers of functional properties of tendon tissue formation","volume":"10","author":"Marturano","year":"2014","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bone.2020.115436_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046057","article-title":"Female mice are protected against high-fat diet induced metabolic syndrome and increase the regulatory T cell population in adipose tissue","volume":"7","author":"Pettersson","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2020.115436_bb0145","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/oby.2009.273","article-title":"Sex differences in high-fat diet-induced obesity, metabolic alterations and learning, and synaptic plasticity deficits in mice","volume":"18","author":"Hwang","year":"2010","journal-title":"Obesity"},{"key":"10.1016\/j.bone.2020.115436_bb0150","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1002\/jcp.22819","article-title":"Aryl hydrocarbon receptor-mediated impairment of chondrogenesis and fracture healing by cigarette smoke and benzo(\u03b1)pyrene","volume":"227","author":"Kung","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bone.2020.115436_bb0155","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro-computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2020.115436_bb0160","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1016\/j.jbiomech.2007.04.004","article-title":"Micro-computed tomography prediction of biomechanical strength in murine structural bone grafts","volume":"40","author":"Reynolds","year":"2007","journal-title":"J. Biomech."},{"key":"10.1016\/j.bone.2020.115436_bb0165","series-title":"Bio-Distribution of near Infrared Imaging Agent Loaded Targeted Drug Nanoparticle Carriers in Highly Fibrotic Pancreatic Tumor Determined Using Multiphoton and Harmonic Generation Imaging","first-page":"55","volume":"1049729","author":"Abraham","year":"2018"},{"key":"10.1016\/j.bone.2020.115436_bb0170","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jsb.2010.04.006","article-title":"Extracellular matrix remodeling of lung alveolar walls in three dimensional space identified using second harmonic generation and multiphoton excitation fluorescence","volume":"171","author":"Abraham","year":"2010","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.bone.2020.115436_bb0175","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ab.2016.11.018","article-title":"Extraction of high-quality RNA from human articular cartilage","volume":"518","author":"Le Bleu","year":"2017","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bone.2020.115436_bb0180","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1002\/jbio.201500150","article-title":"Analysis of forward and backward second harmonic generation images to probe the nanoscale structure of collagen within bone and cartilage","volume":"8","author":"Houle","year":"2015","journal-title":"J. Biophotonics"},{"key":"10.1016\/j.bone.2020.115436_bb0185","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/jor.22838","article-title":"Type III collagen modulates fracture callus bone formation and early remodeling","volume":"33","author":"Miedel","year":"2015","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2020.115436_bb0190","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.203950","article-title":"The triple helix of collagens - an ancient protein structure that enabled animal multicellularity and tissue evolution","volume":"131","author":"Fidler","year":"2018","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bone.2020.115436_bb0195","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14913","article-title":"Molecular level detection and localization of mechanical damage in collagen enabled by collagen hybridizing peptides","volume":"8","author":"Zitnay","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bone.2020.115436_bb0200","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.actbio.2017.01.079","article-title":"Molecular assessment of collagen denaturation in decellularized tissues using a collagen hybridizing peptide","volume":"53","author":"Hwang","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bone.2020.115436_bb0205","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s11914-016-0332-1","article-title":"Advanced glycation end products, diabetes, and bone strength","volume":"14","author":"Yamamoto","year":"2016","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bone.2020.115436_bb0210","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.bone.2018.10.010","article-title":"Changes in bone matrix properties with aging","volume":"120","author":"Burr","year":"2019","journal-title":"Bone"},{"key":"10.1016\/j.bone.2020.115436_bb0215","doi-asserted-by":"crossref","first-page":"7329","DOI":"10.1016\/S0021-9258(20)89449-6","article-title":"Immunochemical approach to characterize advanced glycation end products of the Maillard reaction: evidence for the presence of a common structure","volume":"266","author":"Horiuchi","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2020.115436_bb0220","doi-asserted-by":"crossref","first-page":"10872","DOI":"10.1021\/bi00034a021","article-title":"N\u03b5-(Carboxymethyl)lysine is a dominant advanced glycation end product (AGE) antigen in tissue proteins","volume":"34","author":"Reddy","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/j.bone.2020.115436_bb0225","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1080\/15321810903188136","article-title":"Characterization of anti-advanced glycation end product antibodies to nonenzymatically lysine-derived and arginine-derived glycated products","volume":"30","author":"Choi","year":"2009","journal-title":"J. Immunoass. Immunochem."},{"key":"10.1016\/j.bone.2020.115436_bb0230","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1369\/jhc.2009.953273","article-title":"Use of human vascular tissue microarrays for measurement of advanced glycation endproducts","volume":"57","author":"Halushka","year":"2009","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.bone.2020.115436_bb0235","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1681\/ASN.2008050555","article-title":"Reactive immunization suppresses advanced glycation and mitigates diabetic nephropathy","volume":"20","author":"Shcheglova","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bone.2020.115436_bb0240","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1002\/jor.22695","article-title":"Effect of isolated hyperglycemia on native mechanical and biologic shoulder joint properties in a rat model","volume":"32","author":"Thomas","year":"2014","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2020.115436_bb0245","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/path.4485","article-title":"AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival","volume":"235","author":"Rodriguez-Teja","year":"2015","journal-title":"J. Pathol."},{"key":"10.1016\/j.bone.2020.115436_bb0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12931-016-0460-2","article-title":"Increased AGE-RAGE ratio in idiopathic pulmonary fibrosis","volume":"17","author":"Machahua","year":"2016","journal-title":"Respir. Res."},{"key":"10.1016\/j.bone.2020.115436_bb0255","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.jse.2015.10.015","article-title":"Advanced glycation end products in idiopathic frozen shoulders","volume":"25","author":"Hwang","year":"2016","journal-title":"J. Shoulder Elb. Surg."},{"key":"10.1016\/j.bone.2020.115436_bb0260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-16499-8","article-title":"Advanced glycation endproducts link inflammatory cues to upregulation of galectin-1 in diabetic retinopathy","volume":"7","author":"Kanda","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bone.2020.115436_bb0265","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1002\/jbmr.59","article-title":"TNF-\u03b1 mediates diabetes-enhanced chondrocyte apoptosis during fracture healing and stimulates chondrocyte apoptosis through FOXO1","volume":"25","author":"Kayal","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2020.115436_bb0270","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.2337\/db18-0340","article-title":"FOXO1 deletion reverses the effect of diabetic-induced impaired fracture healing","volume":"67","author":"Alharbi","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.bone.2020.115436_bb0275","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/dmrr.537","article-title":"Influence of diabetic metabolic state on fracture healing in spontaneously diabetic rats","volume":"21","author":"Follak","year":"2005","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.bone.2020.115436_bb0280","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2478\/v10136-012-0018-7","article-title":"Effects of insulin therapy on fracture healing and expression of VEGF in diabetic rats","volume":"11","author":"Wang","year":"2013","journal-title":"J. Appl. Biomed."},{"key":"10.1016\/j.bone.2020.115436_bb0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13018-018-0837-7","article-title":"Effects of obesity on the healing of bone fracture in mice","volume":"13","author":"Gao","year":"2018","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.bone.2020.115436_bb0290","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s00125-014-3470-y","article-title":"Diabetes reduces mesenchymal stem cells in fracture healing through a TNF\u03b1-mediated mechanism","volume":"58","author":"Ko","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.bone.2020.115436_bb0295","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3390\/ijms11020407","article-title":"The fibrillar collagen family","volume":"11","author":"Exposito","year":"2010","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bone.2020.115436_bb0300","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep13378","article-title":"Imaging fibrosis and separating collagens using second harmonic generation and phasor approach to fluorescence lifetime imaging","volume":"5","author":"Ranjit","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bone.2020.115436_bb0305","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1210\/js.2019-00160","article-title":"Advanced glycation end products (AGEs), receptor for AGEs, diabetes, and bone: review of the literature","volume":"3","author":"Asadipooya","year":"2019","journal-title":"J. Endocr. Soc."},{"key":"10.1016\/j.bone.2020.115436_bb0310","doi-asserted-by":"crossref","first-page":"28189","DOI":"10.1074\/jbc.M115.669499","article-title":"Advanced glycation end products affect osteoblast proliferation and function by modulating autophagy via the receptor of advanced glycation end products\/raf protein\/mitogen-activated protein kinase\/extracellular signalregulated kinase kinase\/extracellular","volume":"290","author":"Meng","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2020.115436_bb0315","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.stem.2017.02.009","article-title":"Adipocyte accumulation in the bone marrow during obesity and aging impairs stem cell-based hematopoietic and bone regeneration","volume":"20","author":"Ambrosi","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bone.2020.115436_bb0320","doi-asserted-by":"crossref","first-page":"48967","DOI":"10.1074\/jbc.M108196200","article-title":"Chelating activity of advanced glycation end-product inhibitors","volume":"276","author":"Price","year":"2001","journal-title":"J. Biol. Chem."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328220302167?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328220302167?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:51:15Z","timestamp":1757613075000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328220302167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":64,"alternative-id":["S8756328220302167"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2020.115436","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aberrant structure of fibrillar collagen and elevated levels of advanced glycation end products typify delayed fracture healing in the diet-induced obesity mouse model","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2020.115436","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115436"}}