{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T12:19:15Z","timestamp":1788956355977,"version":"build-2803163510"},"reference-count":173,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.bone.2020.115455","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T22:22:42Z","timestamp":1590618162000},"page":"115455","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Secreted BMP antagonists and their role in cancer and bone metastases"],"prefix":"10.1016","volume":"137","author":[{"given":"Grace M.","family":"Todd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8683-4070","authenticated-orcid":false,"given":"Marko","family":"Hyv\u00f6nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek P.","family":"Brazil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"ten Dijke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2020.115455_bb0005","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1016\/j.febslet.2012.05.028","article-title":"Structural studies of the TGF-\u03b2s and their receptors - insights into evolution of the TGF-\u03b2 superfamily","volume":"586","author":"Hinck","year":"2012","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bone.2020.115455_bb0010","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/978-1-4471-5451-8_114","article-title":"Bone: formation by autoinduction","author":"Wall","year":"2014","journal-title":"Class. Pap. Orthop."},{"key":"10.1016\/j.bone.2020.115455_bb0015","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cytogfr.2015.12.009","article-title":"Bone morphogenetic proteins in inflammation, glucose homeostasis and adipose tissue energy metabolism","volume":"27","author":"Grgurevic","year":"2016","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.bone.2020.115455_bb0020","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1161\/01.RES.00000175571.53833.6c","article-title":"Bone morphogenetic proteins in vascular calcification","volume":"97","author":"Hruska","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.bone.2020.115455_bb0025","doi-asserted-by":"crossref","first-page":"a021899","DOI":"10.1101\/cshperspect.a021899","article-title":"Bone morphogenetic proteins","volume":"8","author":"Katagiri","year":"2018","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bone.2020.115455_bb0030","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.tcb.2014.12.004","article-title":"BMP signalling: agony and antagony in the family","volume":"25","author":"Brazil","year":"2015","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bone.2020.115455_bb0035","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/path.5170","article-title":"Bone morphogenetic protein receptor signal transduction in human disease","volume":"247","author":"Gomez-Puerto","year":"2019","journal-title":"J. Pathol."},{"key":"10.1016\/j.bone.2020.115455_bb0040","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1681\/ASN.2005020193","article-title":"Roles of insulin receptor substrates in insulin-induced stimulation of renal proximal bicarbonate absorption","volume":"16","author":"Zheng","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bone.2020.115455_bb0045","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/46794","article-title":"Silencing of TGF-\u03b2 signalling by the pseudoreceptor BAMBI","volume":"401","author":"Onichtchouk","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.bone.2020.115455_bb0050","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/abbs\/gmx126","article-title":"TGF-\u03b2 family co-receptor function and signaling","volume":"50","author":"Nickel","year":"2018","journal-title":"Acta Biochim. Biophys. Sin. Shanghai"},{"key":"10.1016\/j.bone.2020.115455_bb0055","doi-asserted-by":"crossref","first-page":"4141","DOI":"10.1158\/0008-5472.CAN-09-4466","article-title":"Matrix metalloproteinase-14 (MT1-MMP)-mediated endoglin shedding inhibits tumor angiogenesis","volume":"70","author":"Hawinkels","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.bone.2020.115455_bb0060","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bcmd.2007.06.023","article-title":"Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site","volume":"40","author":"Lin","year":"2008","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.bone.2020.115455_bb0065","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.tcb.2010.01.008","article-title":"Extracellular BMP-antagonist regulation in development and disease: tied up in knots","volume":"20","author":"Walsh","year":"2010","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bone.2020.115455_bb0070","doi-asserted-by":"crossref","first-page":"52","DOI":"10.2106\/00004623-200300003-00010","article-title":"Structural basis of BMP signaling inhibition by Noggin, a novel twelve-membered cystine knot protein","volume":"85","author":"Groppe","year":"2003","journal-title":"J. Bone Jt. Surg. - Ser. A"},{"key":"10.1016\/j.bone.2020.115455_bb0075","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/pro.2485","article-title":"The DAN family: modulators of TGF-\u03b2 signaling and beyond","volume":"23","author":"Nolan","year":"2014","journal-title":"Protein Sci."},{"key":"10.1016\/j.bone.2020.115455_bb0080","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.1093\/ndt\/gfs381","article-title":"Inhibitors\/antagonists of TGF-\u03b2 system in kidney fibrosis","volume":"27","author":"Yanagita","year":"2012","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bone.2020.115455_bb0085","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/bs.vh.2015.06.004","article-title":"The bone morphogenetic proteins and their antagonists","volume":"99","author":"Mulloy","year":"2015","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.bone.2020.115455_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/me.2003-0227","article-title":"Comparative genomic analysis of the eight-membered ring cystine knot-containing bone morphogenetic protein antagonists","volume":"18","author":"Avsian-Kretchmer","year":"2004","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.bone.2020.115455_bb0095","first-page":"1","article-title":"Binding between crossveinless-2 and chordin von willebrand factor type c domains promotes bmp signaling by blocking chordin activity","volume":"5","author":"Zhang","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2020.115455_bb0100","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.matbio.2018.08.006","article-title":"Internal cleavage and synergy with twisted gastrulation enhance BMP inhibition by BMPER","volume":"77","author":"Lockhart-Cairns","year":"2019","journal-title":"Matrix Biol."},{"key":"10.1016\/j.bone.2020.115455_bb0105","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1083\/jcb.130.1.217","article-title":"Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects","volume":"130","author":"Yamashita","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bone.2020.115455_bb0110","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/nature01245","article-title":"Structural basis of BMP signalling inhibition by the cystine knot protein noggin","volume":"420","author":"Groppe","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bone.2020.115455_bb0115","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cytogfr.2015.11.005","article-title":"Structural insights into BMP receptors: specificity, activation and inhibition","volume":"27","author":"Yadin","year":"2016","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.bone.2020.115455_bb0120","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1016\/j.celrep.2016.07.046","article-title":"Structure of Gremlin-2 in complex with GDF5 gives insight into DAN-family-mediated BMP antagonism","volume":"16","author":"Nolan","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.bone.2020.115455_bb0125","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.str.2013.06.005","article-title":"Structure of protein related to Dan and Cerberus: insights into the mechanism of bone morphogenetic protein antagonism","volume":"21","author":"Nolan","year":"2013","journal-title":"Structure"},{"key":"10.1016\/j.bone.2020.115455_bb0130","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1042\/BCJ20160254","article-title":"Structure of Gremlin-1 and analysis of its interaction with BMP-2","volume":"473","author":"Kisonaite","year":"2016","journal-title":"Biochem. J."},{"key":"10.1016\/j.bone.2020.115455_bb0135","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.devcel.2008.02.017","article-title":"Crystal structure analysis reveals how the Chordin family member Crossveinless 2 blocks BMP-2 receptor binding","volume":"14","author":"Zhang","year":"2008","journal-title":"Dev. Cell"},{"issue":"1\u201312","key":"10.1016\/j.bone.2020.115455_bb0140","article-title":"DHA inhibits Gremlin-1-induced epithelial-to-mesenchymal transition via ERK suppression in human breast cancer cells","volume":"40","author":"Sung","year":"2020","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.bone.2020.115455_bb0145","doi-asserted-by":"crossref","DOI":"10.1038\/nsmb.3016","article-title":"Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein","volume":"22","author":"Healey","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bone.2020.115455_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules22050713","article-title":"Heparin, heparan sulphate and the TGF-\u03b2 cytokine superfamily","volume":"22","author":"Rider","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.bone.2020.115455_bb0155","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1432-1033.1996.0295n.x","article-title":"Human bone morphogenetic protein 2 contains a heparin-binding site which modifies its biological activity","volume":"237","author":"Ruppert","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bone.2020.115455_bb0160","doi-asserted-by":"crossref","first-page":"14371","DOI":"10.1074\/jbc.RA118.003191","article-title":"Domains with highest heparan sulfate-binding affinity reside at opposite ends in BMP2\/4 versus BMP5\/6\/7:implications for function","volume":"293","author":"Billings","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"e6","key":"10.1016\/j.bone.2020.115455_bb0165","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.devcel.2017.03.002","article-title":"Serum proteases potentiate BMP-induced cell cycle re-entry of dedifferentiating muscle cells during newt limb regeneration","volume":"40","author":"Wagner","year":"2017","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bone.2020.115455_bb0170","doi-asserted-by":"crossref","first-page":"51289","DOI":"10.1074\/jbc.M408129200","article-title":"Cell-surface heparan sulfate proteoglycans potentiate chordin antagonism of bone morphogenetic protein signaling and are necessary for cellular uptake of chordin","volume":"279","author":"Jasuja","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2020.115455_bb0175","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1042\/BCJ20161050","article-title":"Analysis and identification of the Grem2 heparin\/heparan sulfate-binding motif","volume":"474","author":"Kattamuri","year":"2017","journal-title":"Biochem. J."},{"key":"10.1016\/j.bone.2020.115455_bb0180","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1074\/jbc.M109151200","article-title":"Heparan sulfate proteoglycans retain noggin at the cell surface. A potential mechanism for shaping bone morphogenetic protein gradients","volume":"277","author":"Paine-Saunders","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2020.115455_bb0185","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.devcel.2008.06.013","article-title":"Crossveinless-2 is a BMP feedback inhibitor that binds Chordin\/BMP to regulate xenopus embryonic patterning","volume":"15","author":"Ambrosio","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bone.2020.115455_bb0190","doi-asserted-by":"crossref","first-page":"12169","DOI":"10.1074\/jbc.M109.087197","article-title":"Identification of a key residue mediating bone morphogenetic protein (BMP)-6 resistance to noggin inhibition allows for engineered BMPs with superior agonist activity","volume":"285","author":"Song","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2020.115455_bb0195","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1083\/jcb.201612169","article-title":"DAN (NBL1) promotes collective neural crest migration by restraining uncontrolled invasion","volume":"216","author":"McLennan","year":"2017","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bone.2020.115455_bb0200","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1006\/bbrc.2000.3758","article-title":"Overexpression of DAN causes a growth suppression in p53-deficient SAOS-2 cells","volume":"278","author":"Hanaoka","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bone.2020.115455_bb0205","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1096\/fj.05-4126com","article-title":"Chordin is underexpressed in ovarian tumors and reduces tumor cell motility","volume":"20","author":"Moll","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.bone.2020.115455_bb0210","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1515\/bmc.2010.026","article-title":"Secreted bone morphogenetic protein antagonists of the Chordin family","volume":"1","author":"Itoh","year":"2010","journal-title":"Biomol. Concepts"},{"key":"10.1016\/j.bone.2020.115455_bb0215","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.yexmp.2011.10.004","article-title":"BMP activated Smad signaling strongly promotes migration and invasion of hepatocellular carcinoma cells","volume":"92","author":"Maegdefrau","year":"2012","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.bone.2020.115455_bb0220","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1158\/0008-5472.448.65.2","article-title":"Bone morphogenic proteins are overexpressed in malignant melanoma and promote cell invasion and migration","volume":"65","author":"Rothhammer","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.bone.2020.115455_bb0225","doi-asserted-by":"crossref","first-page":"4024","DOI":"10.1038\/onc.2008.42","article-title":"Autocrine induction of invasion and metastasis by tumor-associated trypsin inhibitor in human colon cancer cells","volume":"27","author":"Gouyer","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.bone.2020.115455_bb0230","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1172\/JCI40676","article-title":"Epimorphin deletion protects mice from inflammation-induced colon carcinogenesis and alters stem cell niche myofibroblast secretion","volume":"120","author":"Shaker","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bone.2020.115455_bb0235","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1007\/s13277-015-3988-8","article-title":"BMP pathway suppression is an early event in inflammation-driven colon neoplasmatogenesis of uPA-deficient mice","volume":"37","author":"Karagiannis","year":"2016","journal-title":"Tumor Biol."},{"key":"10.1016\/j.bone.2020.115455_bb0240","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1677\/JOE-08-0226","article-title":"Bone morphogenetic protein 6 (BMP6) and BMP7 inhibit estrogen-induced proliferation of breast cancer cells by suppressing p38 mitogen-activated protein kinase activation","volume":"199","author":"Takahasi","year":"2008","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bone.2020.115455_bb0245","doi-asserted-by":"crossref","first-page":"12426","DOI":"10.1074\/jbc.M707117200","article-title":"GLI2-specific transcriptional activation of the bone morphogenetic protein\/activin antagonist follistatin in human epidermal cells","volume":"283","author":"Eichberger","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2020.115455_bb0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12964-015-0104-z","article-title":"Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B","volume":"13","author":"Olsen","year":"2015","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.bone.2020.115455_bb0255","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1210\/en.2003-0968","article-title":"Novel action of Activin and bone morphogenetic protein in regulating aldosterone production by human adrenocortical cells","volume":"145","author":"Suzuki","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2020.115455_bb0260","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/S0006-291X(03)01052-0","article-title":"Involvement of activin\/BMP system in development of human pituitary gonadotropinomas and nonfunctioning adenomas","volume":"306","author":"Takeda","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bone.2020.115455_bb0265","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1677\/JOE-07-0138","article-title":"Effects of peroxisome proliferator-activated receptor activation on gonadotropin transcription and cell mitosis induced by bone morphogenetic proteins in mouse gonadotrope L\u03b2T2 cells","volume":"194","author":"Takeda","year":"2007","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bone.2020.115455_bb0270","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.bbrc.2008.09.031","article-title":"Induction of follistatin precedes gastric transformation in gastrin deficient mice","volume":"376","author":"Kang","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bone.2020.115455_bb0275","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.lungcan.2019.03.020","article-title":"Predictive value of serum protein levels in patients with advanced non-small cell lung cancer treated with nivolumab","volume":"132","author":"Oyanagi","year":"2019","journal-title":"Lung Cancer"},{"key":"10.1016\/j.bone.2020.115455_bb0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-213X-2-8","article-title":"A transcriptional response to Wnt protein in human embryonic carcinomacells","volume":"2","author":"Willert","year":"2002","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.bone.2020.115455_bb0285","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.molonc.2014.04.004","article-title":"Expression patterns of bone morphogenetic protein antagonists in colorectal cancer desmoplastic invasion fronts","volume":"8","author":"Karagiannis","year":"2014","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.bone.2020.115455_bb0290","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003876","article-title":"Eleven candidate susceptibility genes for common familial colorectal cancer","volume":"9","author":"Gylfe","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bone.2020.115455_bb0295","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1089\/dna.2018.4188","article-title":"TWSG1 is a novel tumor suppressor in gastric cancer","volume":"37","author":"Yuan","year":"2018","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.bone.2020.115455_bb0300","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1136\/jclinpath-2011-200577","article-title":"Twisted gastrulation expression in cholangiocellular and hepatocellular carcinoma","volume":"65","author":"Johnston","year":"2012","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.bone.2020.115455_bb0305","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.7150\/jca.18482","article-title":"Twisted gastrulation BMP signaling modulator 1 regulates papillary thyroid cancer cell motility and proliferation","volume":"8","author":"Xia","year":"2017","journal-title":"J. Cancer"},{"key":"10.1016\/j.bone.2020.115455_bb0310","doi-asserted-by":"crossref","first-page":"5664","DOI":"10.1128\/MCB.23.16.5664-5679.2003","article-title":"BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation","volume":"23","author":"Moser","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bone.2020.115455_bb0315","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.cell.2012.06.035","article-title":"The BMP inhibitor coco reactivates breast cancer cells at lung metastatic sites","volume":"150","author":"Gao","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bone.2020.115455_bb0320","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nature10212","article-title":"Microenvironmental regulation of stem cells in intestinal homeostasis and cancer","volume":"474","author":"Medema","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bone.2020.115455_bb0325","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00535-012-0614-z","article-title":"Expression of gremlin 1 correlates with increased angiogenesis and progression-free survival in patients with pancreatic neuroendocrine tumors","volume":"48","author":"Chen","year":"2013","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.bone.2020.115455_bb0330","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1111\/j.1349-7006.2012.02252.x","article-title":"Combinatorial use of bone morphogenetic protein 6, noggin and SOST significantly predicts cancer progression","volume":"103","author":"Yuen","year":"2012","journal-title":"Cancer Sci."},{"key":"10.1016\/j.bone.2020.115455_bb0335","first-page":"1400","article-title":"The expression patterns of gremlin 1 and noggin in normal adult and tumor tissues","volume":"6","author":"Laurila","year":"2013","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.bone.2020.115455_bb0340","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/labinvest.2008.55","article-title":"Aggressive melanoma cells escape from BMP7-mediated autocrine growth inhibition through coordinated Noggin upregulation","volume":"88","author":"Hsu","year":"2008","journal-title":"Lab. Investig."},{"key":"10.1016\/j.bone.2020.115455_bb0345","doi-asserted-by":"crossref","first-page":"4801","DOI":"10.1128\/MCB.17.8.4801","article-title":"Identification of drm, a novel gene whose expression is suppressed in transformed cells and which can inhibit growth of normal but not transformed cells in culture","volume":"17","author":"Topol","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bone.2020.115455_bb0350","doi-asserted-by":"crossref","first-page":"8785","DOI":"10.1074\/jbc.275.12.8785","article-title":"Biosynthesis, post-translation modification, and functional characterization of Drm\/gremlin","volume":"275","author":"Topol","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2020.115455_bb0355","doi-asserted-by":"crossref","first-page":"5515","DOI":"10.1242\/dev.126.23.5515","article-title":"The BMP antagonist gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb","volume":"126","author":"Merino","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.bone.2020.115455_bb0360","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/ng1178","article-title":"Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning","volume":"34","author":"Khokha","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bone.2020.115455_bb0365","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1242\/dev.02861","article-title":"Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF\/WNT11 feedback signalling during kidney branching morphogenesis","volume":"134","author":"Michos","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.bone.2020.115455_bb0370","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.cell.2014.11.042","article-title":"Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential","volume":"160","author":"Worthley","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.bone.2020.115455_bb0375","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/S0006-291X(02)00828-8","article-title":"Drm\/gremlin transcriptionally activates p21Cip1 via a novel mechanism and inhibits neoplastic transformation","volume":"295","author":"Chen","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bone.2020.115455_bb0380","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2407-6-74","article-title":"The bone morphogenetic protein antagonist gremlin I is overexpressed in human cancers and interacts with YWHAH protein","volume":"6","author":"Namkoong","year":"2006","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bone.2020.115455_bb0385","first-page":"58","article-title":"The bone morphogenetic protein antagonist gremlin is overexpressed in human malignant mesothelioma","volume":"27","author":"Wang","year":"2012","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.bone.2020.115455_bb0390","series-title":"Gremlin in the Pathogenesis of Hepatocellular Carcinoma Complicating Chronic Hepatitis C: An Immunohistochemical and PCR Study of Human Liver Biopsies","first-page":"390","volume":"5","author":"Guimei","year":"2012"},{"key":"10.1016\/j.bone.2020.115455_bb0395","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1101\/gad.235515.113","article-title":"Glioma cancer stem cells secrete Gremlin1 to promote their maintenance within the tumor hierarchy","volume":"28","author":"Yan","year":"2014","journal-title":"Genes Dev."},{"key":"10.1016\/j.bone.2020.115455_bb0400","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/1440-1681.12697","article-title":"Gremlin1 promotes carcinogenesis of glioma in vitro","volume":"44","author":"Guan","year":"2017","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.bone.2020.115455_bb0405","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3892\/or.2015.4367","article-title":"Clinical significance of Gremlin 1 in cervical cancer and its effects on cancer stem cell maintenance","volume":"35","author":"Sato","year":"2016","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.bone.2020.115455_bb0410","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ebiom.2018.02.017","article-title":"Reciprocal modulation of mesenchymal stem cells and tumor cells promotes lung cancer metastasis","volume":"29","author":"Fregni","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bone.2020.115455_bb0415","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1159\/000491060","article-title":"Gremlin1 delivered by mesenchymal stromal cells promoted epithelial-mesenchymal transition in human esophageal squamous cell carcinoma","volume":"47","author":"Hong","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bone.2020.115455_bb0420","series-title":"Fibroblast-Derived Gremlin1 Localises to Epithelial Cells at the Base of the Intestinal Crypt","first-page":"4630","volume":"10","author":"Dutton","year":"2019"},{"key":"10.1016\/j.bone.2020.115455_bb0425","doi-asserted-by":"crossref","first-page":"10070","DOI":"10.1038\/s41598-018-28297-x","article-title":"Pirfenidone decreases mesothelioma cell proliferation and migration via inhibition of ERK and AKT and regulates mesothelioma tumor microenvironment in vivo","volume":"8","author":"Li","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bone.2020.115455_bb0430","doi-asserted-by":"crossref","first-page":"15418","DOI":"10.1073\/pnas.0707210104","article-title":"Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors","volume":"104","author":"Kosinski","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bone.2020.115455_bb0435","doi-asserted-by":"crossref","first-page":"5583","DOI":"10.1002\/jcb.27842","article-title":"Knockdown GREM1 suppresses cell growth, angiogenesis, and epithelial-mesenchymal transition in colon cancer","volume":"120","author":"Liu","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bone.2020.115455_bb0440","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1182\/blood-2006-06-032276","article-title":"Bone morphogenic protein antagonist Drm\/gremlin is a novel proangiogenic factor","volume":"109","author":"Stabile","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bone.2020.115455_bb0445","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s10456-012-9309-6","article-title":"Involvement of \u03b1v\u03b23 integrin in gremlin-induced angiogenesis","volume":"16","author":"Ravelli","year":"2013","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bone.2020.115455_bb0450","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1371\/journal.pgen.1002105","article-title":"Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer","volume":"7","author":"Tomlinson","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bone.2020.115455_bb0455","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/ng.2263","article-title":"Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1","volume":"44","author":"Jaeger","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bone.2020.115455_bb0460","first-page":"1","article-title":"Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche","volume":"21","author":"Davis","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.bone.2020.115455_bb0465","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-21525-4","article-title":"Molecular characterization of colorectal adenomas with and without malignancy reveals distinguishing genome, transcriptome and methylome alterations","volume":"8","author":"Druliner","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bone.2020.115455_bb0470","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.molonc.2013.04.002","article-title":"Enrichment map profiling of the cancer invasion front suggests regulation of colorectal cancer progression by the bone morphogenetic protein antagonist, gremlin-1","volume":"7","author":"Karagiannis","year":"2013","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.bone.2020.115455_bb0475","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.celrep.2014.07.020","article-title":"A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding","volume":"8","author":"Lewis","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.bone.2020.115455_bb0480","doi-asserted-by":"crossref","first-page":"61318","DOI":"10.18632\/oncotarget.18095","article-title":"A functional variant in GREM1 confers risk for colorectal cancer by disrupting a hsa-miR-185-3p binding site","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"issue":"3642\u20133650","key":"10.1016\/j.bone.2020.115455_bb0485","article-title":"Identification and verification of differentially expressed microRNAs and their target genes for the diagnosis of esophageal cancer","volume":"16","author":"Cai","year":"2018","journal-title":"Oncol. Lett."},{"issue":"147","key":"10.1016\/j.bone.2020.115455_bb0490","article-title":"Overexpression of mircoRNA - 137 inhibits cervical cancer cell invasion , migration and epithelial \u2013 mesenchymal transition by suppressing the TGF-\u03b2\/Smad pathway via binding to GREM1","volume":"19","author":"Miao","year":"2019","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.bone.2020.115455_bb0495","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/sj.bjc.6602837","article-title":"DNA methylation-associated inactivation of TGF\u03b2-related genes DRM\/Gremlin, RUNX3, and HPP1 in human cancers","volume":"93","author":"Suzuki","year":"2005","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bone.2020.115455_bb0500","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s13402-014-0189-1","article-title":"Validation of DNA promoter hypermethylation biomarkers in breast cancer - a short report","volume":"37","author":"De Groot","year":"2014","journal-title":"Cell. Oncol."},{"key":"10.1016\/j.bone.2020.115455_bb0505","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s10549-015-3276-8","article-title":"Methylation profiling of 48 candidate genes in tumor and matched normal tissues from breast cancer patients","volume":"149","author":"Li","year":"2015","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.bone.2020.115455_bb0510","doi-asserted-by":"crossref","first-page":"575","DOI":"10.2353\/ajpath.2010.090442","article-title":"Prognostic significance of Gremlin1 (GREM1) promoter CpG island hypermethylation in clear cell renal cell carcinoma","volume":"176","author":"Van Vlodrop","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bone.2020.115455_bb0515","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1136\/gutjnl-2018-317645","article-title":"Cancer cell niche factors secreted from cancer-associated fibroblast by loss of H3K27me3","volume":"69","author":"Maeda","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.bone.2020.115455_bb0520","article-title":"Gremlin-1 induces BMP-independent tumor cell proliferation, migration, and invasion","volume":"7","author":"Kim","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2020.115455_bb0525","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1038\/onc.2009.493","article-title":"Identification of candidate tumour suppressor genes frequently methylated in renal cell carcinoma","volume":"29","author":"Morris","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.bone.2020.115455_bb0535","series-title":"Gremlin 1 Promotes Breast Cancer Progression","first-page":"1","author":"Ren","year":"2019"},{"key":"10.1016\/j.bone.2020.115455_bb0540","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12964-019-0467-7","article-title":"GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients","volume":"17","author":"Neckmann","year":"2019","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.bone.2020.115455_bb0545","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.humpath.2016.12.018","article-title":"Prognostic significance of stromal GREM1 expression in colorectal cancer","volume":"62","author":"Jang","year":"2017","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.bone.2020.115455_bb0550","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/his.13006","article-title":"Gremlin1 expression associates with serrated pathway and favourable prognosis in colorectal cancer","volume":"69","author":"Pelli","year":"2016","journal-title":"Histopathology"},{"key":"10.1016\/j.bone.2020.115455_bb0555","doi-asserted-by":"crossref","first-page":"49","DOI":"10.21873\/cgp.20167","article-title":"Increased expression of GrEmliN1 promotes proliferation and epithelial mesenchymal transition in gastric cancer cells and correlates with poor prognosis of patients with gastric cancer","volume":"17","author":"Zhiwei","year":"2020","journal-title":"CANCER GENOMICS PROTEOMICS"},{"issue":"2445\u20132457","key":"10.1016\/j.bone.2020.115455_bb0560","article-title":"Overexpression of gremlin 1 by sonic hedgehog signaling promotes pancreatic cancer progression","volume":"53","author":"Yu","year":"2018","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bone.2020.115455_bb0565","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0159010","article-title":"Gremlin-1 overexpression in mouse lung reduces silica-induced lymphocyte recruitment - a link to idiopathic pulmonary fibrosis through negative correlation with CXCL10 chemokine","volume":"11","author":"Koli","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2020.115455_bb0570","doi-asserted-by":"crossref","first-page":"14842","DOI":"10.1073\/pnas.0606857103","article-title":"Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation","volume":"103","author":"Sneddon","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1\u201313","key":"10.1016\/j.bone.2020.115455_bb0575","article-title":"GREM1 is expressed in the cancer-associated myofibroblasts of basal cell carcinomas","volume":"12","author":"Kim","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2020.115455_bb0580","doi-asserted-by":"crossref","first-page":"29349","DOI":"10.1074\/jbc.M603833200","article-title":"BMP4 activation and secretion are negatively regulated by an intracellular gremlin-BMP4 interaction","volume":"281","author":"Sun","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2020.115455_bb0585","doi-asserted-by":"crossref","first-page":"5914","DOI":"10.4049\/jimmunol.173.10.5914","article-title":"Cutting edge: bone morphogenetic protein antagonists Drm\/Gremlin and Dan interact with slits and act as negative regulators of monocyte chemotaxis","volume":"173","author":"Chen","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.bone.2020.115455_bb0590","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1074\/jbc.M117.804021","article-title":"Identification of direct negative crosstalk between the SLIT2 and bone morphogenetic protein-gremlin signaling pathways","volume":"293","author":"Tumelty","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2020.115455_bb0595","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1182\/blood-2010-06-291930","article-title":"Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2","volume":"116","author":"Mitola","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bone.2020.115455_bb0600","doi-asserted-by":"crossref","first-page":"35353","DOI":"10.18632\/oncotarget.9286","article-title":"Monomeric gremlin is a novel vascular endothelial growth factor receptor-2 antagonist","volume":"7","author":"Grillo","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.bone.2020.115455_bb0605","article-title":"EXPRESS: Gremlin1 blocks vascular endothelial growth factor signalling in the pulmonary microvascular endothelium","volume":"4","author":"Rowan","year":"2018","journal-title":"Pulmonary Circulation"},{"key":"10.1016\/j.bone.2020.115455_bb0610","doi-asserted-by":"crossref","first-page":"18041","DOI":"10.1074\/jbc.AC119.010148","article-title":"No evidence of Gremlin1-mediated activation of VEGFR2 signaling in endothelial cells","volume":"294","author":"Dutton","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2020.115455_bb0615","first-page":"321","article-title":"Bone metastases: An overview","volume":"11","author":"Macedo","year":"2017","journal-title":"Oncol. Rev."},{"key":"10.1016\/j.bone.2020.115455_bb0620","doi-asserted-by":"crossref","first-page":"8276","DOI":"10.1158\/0008-5472.CAN-04-2251","article-title":"Bone morphogenetic protein (BMP)-6 signaling and BMP antagonist noggin in prostate cancer","volume":"64","author":"Haudenschild","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.bone.2020.115455_bb0625","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.critrevonc.2005.03.011","article-title":"Management of bone metastases in cancer: a review","volume":"56","author":"Selvaggi","year":"2005","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.bone.2020.115455_bb0630","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/00006454-199103000-00027","article-title":"Hypothesis revisited","volume":"10","author":"Fidler","year":"1991","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.bone.2020.115455_bb0635","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.omto.2017.10.002","article-title":"The dual role of bone morphogenetic proteins in cancer","volume":"8","author":"Bach","year":"2018","journal-title":"Mol. Ther. - Oncolytics"},{"key":"10.1016\/j.bone.2020.115455_bb0640","doi-asserted-by":"crossref","first-page":"8274","DOI":"10.1158\/0008-5472.CAN-05-1891","article-title":"Bone morphogenetic protein-6 promotes osteoblastic prostate cancer bone metastases through a dual mechanism","volume":"65","author":"Dai","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.bone.2020.115455_bb0645","doi-asserted-by":"crossref","first-page":"R349","DOI":"10.1530\/ERC-17-0139","article-title":"Bone morphogenetic proteins, breast cancer, and bone metastases: striking the right balance","volume":"24","author":"Zabkiewicz","year":"2017","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.bone.2020.115455_bb0650","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2353\/ajpath.2007.070168","article-title":"BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo","volume":"171","author":"Buijs","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bone.2020.115455_bb0655","doi-asserted-by":"crossref","first-page":"8742","DOI":"10.1158\/0008-5472.CAN-06-2490","article-title":"Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer","volume":"67","author":"Buijs","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.bone.2020.115455_bb0660","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1038\/onc.2011.400","article-title":"The BMP2\/7 heterodimer inhibits the human breast cancer stem cell subpopulation and bone metastases formation","volume":"31","author":"Buijs","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.bone.2020.115455_bb0665","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.bone.2005.12.018","article-title":"Noggin regulation of bone morphogenetic protein (BMP) 2\/7 heterodimer activity in vitro","volume":"39","author":"Zhu","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.bone.2020.115455_bb0670","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1084\/jem.20110840","article-title":"Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone","volume":"208","author":"Kobayashi","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bone.2020.115455_bb0675","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/annonc\/mdm453","article-title":"Bone morphogenetic protein 7 expression associates with bone metastasis in breast carcinomas","volume":"19","author":"Alarmo","year":"2008","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.bone.2020.115455_bb0680","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0173322","article-title":"The effect of bone morphogenetic protein-2 on osteosarcoma metastasis","volume":"12","author":"Gill","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2020.115455_bb0685","doi-asserted-by":"crossref","first-page":"6322","DOI":"10.1038\/onc.2008.232","article-title":"Bone morphogenetic protein signaling enhances invasion and bone metastasis of breast cancer cells through Smad pathway","volume":"27","author":"Katsuno","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.bone.2020.115455_bb0690","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.canlet.2016.03.008","article-title":"The impact of bone morphogenetic protein 4 (BMP4) on breast cancer metastasis in a mouse xenograft model","volume":"375","author":"Ampuja","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bone.2020.115455_bb0695","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/bab.1619","article-title":"The BMP antagonist Noggin is produced by osteoblasts in response to the presence of prostate cancer cells","volume":"65","author":"AlShaibi","year":"2018","journal-title":"Biotechnol. Appl. Biochem."},{"key":"10.1016\/j.bone.2020.115455_bb0700","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016078","article-title":"The role of the BMP signaling antagonist noggin in the development of prostate cancer osteolytic bone metastasis","volume":"6","author":"Secondini","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2020.115455_bb0705","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.bone.2005.07.015","article-title":"Overexpression of noggin inhibits BMP-mediated growth of osteolytic prostate cancer lesions","volume":"38","author":"Feeley","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.bone.2020.115455_bb0710","doi-asserted-by":"crossref","first-page":"160","DOI":"10.2353\/ajpath.2007.051276","article-title":"Lack of noggin expression by cancer cells is a determinant of the osteoblast response in bone metastases","volume":"170","author":"Schweninger","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bone.2020.115455_bb0715","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1158\/0008-5472.CAN-12-2862","article-title":"\u0394np63\u0391-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells","volume":"73","author":"Balboni","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.bone.2020.115455_bb0720","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0061256","article-title":"Bone morphogenetic protein type I receptor antagonists decrease growth and induce cell death of lung cancer cell lines","volume":"8","author":"Langenfeld","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2020.115455_bb0725","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1038\/onc.2014.189","article-title":"Inhibition of BMP signaling suppresses metastasis in mammary cancer","volume":"34","author":"Owens","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.bone.2020.115455_bb0730","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13046-019-1130-2","article-title":"Discovery of a natural small-molecule compound that suppresses tumor EMT, stemness and metastasis by inhibiting TGF\u03b2\/BMP signaling in triple-negative breast cancer","volume":"38","author":"Di","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bone.2020.115455_bb0735","doi-asserted-by":"crossref","unstructured":"Gudipati, S., M. R., Mankad, A., Pandya, H. & Jasrai, Y. . Molecular docking based screening of noggin inhibitors. Bioinformation 14, 015\u2013020 (2018).","DOI":"10.6026\/97320630014015"},{"key":"10.1016\/j.bone.2020.115455_bb0740","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.1111\/bph.12724","article-title":"Bone morphogenetic proteins and their antagonists: current and emerging clinical uses","volume":"171","author":"Ali","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bone.2020.115455_bb0745","series-title":"Crossveinless 2 Regulates Bone Morphogenetic Protein 9 in Human and Mouse Vascular Endothelium","first-page":"5037","volume":"119","author":"Yao","year":"2012"},{"key":"10.1016\/j.bone.2020.115455_bb0750","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nm1217","article-title":"Kielin\/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease","volume":"11","author":"Lin","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.bone.2020.115455_bb0755","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.tibs.2008.07.006","article-title":"The CCN family of proteins: structure \u2013 function relationships","volume":"33","author":"Holbourn","year":"2008","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bone.2020.115455_bb0760","doi-asserted-by":"crossref","first-page":"12516","DOI":"10.1074\/jbc.M117.788992","article-title":"Structural analyses of von Willebrand factor C domains of collagen 2A and CCN3 reveal an alternative mode of binding to bone morphogenetic protein-2","volume":"292","author":"Xu","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2020.115455_bb0765","first-page":"2785","article-title":"Identification of human DAN gene, mapping to the putative neuroblastoma tumor suppressor locus","volume":"9","author":"Enomoto","year":"1994","journal-title":"Oncogene"},{"key":"10.1016\/j.bone.2020.115455_bb0770","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1074\/jbc.RA118.006817","article-title":"High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds","volume":"294","author":"Bradford","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2020.115455_bb0775","doi-asserted-by":"crossref","first-page":"41614","DOI":"10.1074\/jbc.M110.153890","article-title":"Distinct modes of inhibition by Sclerostin on bone morphogenetic protein and Wnt signaling pathways","volume":"285","author":"Krause","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2020.115455_bb0780","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.bonr.2018.06.007","article-title":"Bisphosphonate conjugation for bone specific drug targeting","volume":"9","author":"Farrell","year":"2018","journal-title":"Bone Reports"},{"key":"10.1016\/j.bone.2020.115455_bb0785","doi-asserted-by":"crossref","first-page":"14951","DOI":"10.18632\/oncotarget.7498","article-title":"The BMP inhibitor DAND5 in serum predicts poor survival in breast cancer","volume":"7","author":"Chi","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.bone.2020.115455_bb0790","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s00408-015-9735-5","article-title":"Intrinsic BMP antagonist Gremlin-1 as a novel circulating marker in pulmonary arterial hypertension","volume":"193","author":"Wellbrock","year":"2015","journal-title":"Lung"},{"key":"10.1016\/j.bone.2020.115455_bb0795","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2337\/db19-0701","article-title":"The novel adipokine gremlin 1 antagonizes insulin action and is increased in type 2 diabetes and NAFLD \/ NASH","volume":"69","author":"Hedjazifar","year":"2019","journal-title":"Diabetes"},{"key":"10.1016\/j.bone.2020.115455_bb0800","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-09491-5","article-title":"Excessive mechanical loading promotes osteoarthritis through the gremlin-1\u2013NF-\u03baB pathway","volume":"10","author":"Chang","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bone.2020.115455_bb0805","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1038\/onc.2011.473","article-title":"Bone morphogenetic protein modulator BMPER is highly expressed in malignant tumors and controls invasive cell behavior","volume":"31","author":"Heinke","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.bone.2020.115455_bb0810","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1128\/MCB.00600-15","article-title":"Chordin-like 1 suppresses bone morphogenetic protein 4-induced breast cancer cell migration and invasion","volume":"36","author":"Cyr-Depauw","year":"2016","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bone.2020.115455_bb0815","doi-asserted-by":"crossref","first-page":"4759","DOI":"10.1074\/jbc.M114.628412","article-title":"& Thompson, T. B. (2015). Structure of neuroblastoma suppressor of tumorigenicity 1 (NBL1): insights for the functional variability across bone morphogenetic protein (BMP) antagonists","volume":"290","author":"Nolan","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2020.115455_bb0820","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-53671-8","article-title":"Follistatin impacts tumor angiogenesis and outcome in thymic epithelial tumors","volume":"9","author":"Janik","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bone.2020.115455_bb0825","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1159\/000485759","article-title":"Fstl1 promotes glioma growth through the BMP4\/Smad1\/5\/8 signaling pathway","volume":"44","author":"Jin","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bone.2020.115455_bb0830","doi-asserted-by":"crossref","first-page":"5886","DOI":"10.1158\/0008-5472.CAN-17-1411","article-title":"FSTL1 promotes metastasis and chemoresistance in esophageal squamous cell carcinoma through NF\u03baB-BMP signaling cross-talk","volume":"77","author":"Lau","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.bone.2020.115455_bb0835","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042264","article-title":"Gremlin is overexpressed in lung adenocarcinoma and increases cell growth and proliferation in normal lung cells","volume":"7","author":"Mulvihill","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2020.115455_bb0845","doi-asserted-by":"crossref","first-page":"98280","DOI":"10.18632\/oncotarget.21550","article-title":"Gremlin-1 is a key regulator of the invasive cell phenotype in mesothelioma","volume":"8","author":"Yin","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bone.2020.115455_bb0850","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1515\/hsz-2014-0221","article-title":"Bone morphogenetic protein antagonist gremlin-1 regulates colon cancer progression","volume":"396","author":"Karagiannis","year":"2015","journal-title":"Biol. Chem."},{"key":"10.1016\/j.bone.2020.115455_bb0855","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s12253-010-9307-1","article-title":"Activation of the PI3K\/Akt pathway mediates bone morphogenetic protein 2-induced invasion of pancreatic cancer cells Panc-1","volume":"17","author":"Chen","year":"2011","journal-title":"Pathol Oncol Res"},{"key":"10.1016\/j.bone.2020.115455_bb0860","doi-asserted-by":"crossref","first-page":"21346","DOI":"10.1074\/jbc.M112.355834","article-title":"Identification of NOG as a specific breast cancer bone metastasis-supporting gene","volume":"287","author":"Tarragona","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2020.115455_bb0865","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.2353\/ajpath.2009.090163","article-title":"Bone morphogenetic protein antagonist noggin promotes skin tumorigenesis via stimulation of the Wnt and Shh signaling pathways","volume":"175","author":"Sharov","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bone.2020.115455_bb0870","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142058","article-title":"SOST inhibits prostate cancer invasion","volume":"10","author":"Hudson","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2020.115455_bb0875","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jmb.2012.10.003","article-title":"Members of the DAN Family Are BMP Antagonists That Form Highly Stable Noncovalent Dimers","volume":"424","author":"Kattamuri","year":"2012","journal-title":"J Mol. Biol."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328220302350?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328220302350?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:54:36Z","timestamp":1757613276000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328220302350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":173,"alternative-id":["S8756328220302350"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2020.115455","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Secreted BMP antagonists and their role in cancer and bone metastases","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2020.115455","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115455"}}