{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T23:40:08Z","timestamp":1784850008943,"version":"3.55.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.bone.2020.115468","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T05:06:03Z","timestamp":1591333563000},"page":"115468","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Cartilage -specific knockout of Sirt1 significantly reduces bone quality and catch-up growth efficiency"],"prefix":"10.1016","volume":"138","author":[{"given":"Biana","family":"Shtaif","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meytal","family":"Bar-Maisels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yankel","family":"Gabet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Hiram-Bab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Yackobovitch-Gavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Phillip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2163-2176","authenticated-orcid":false,"given":"Galia","family":"Gat-Yablonski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.bone.2020.115468_bb0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004820","article-title":"Chondrocytes transdifferentiate into osteoblasts in endochondral bone during development, postnatal growth and fracture healing in mice","volume":"10","author":"Zhou","year":"2014","journal-title":"PLoS Genet."},{"issue":"5","key":"10.1016\/j.bone.2020.115468_bb0010","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1242\/bio.201411031","article-title":"Dual pathways to endochondral osteoblasts: a novel chondrocyte-derived osteoprogenitor cell identified in hypertrophic cartilage","volume":"4","author":"Park","year":"2015","journal-title":"Biol Open"},{"issue":"12","key":"10.1016\/j.bone.2020.115468_bb0015","doi-asserted-by":"crossref","first-page":"6871","DOI":"10.1073\/pnas.121180498","article-title":"Effects of estrogen on growth plate senescence and epiphyseal fusion","volume":"98","author":"Weise","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.bone.2020.115468_bb0020","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.bone.2006.12.066","article-title":"Tamoxifen induces permanent growth arrest through selective induction of apoptosis in growth plate chondrocytes in cultured rat metatarsal bones","volume":"40","author":"Chagin","year":"2007","journal-title":"Bone"},{"issue":"8","key":"10.1016\/j.bone.2020.115468_bb0025","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1210\/en.2013-2175","article-title":"Evidence that estrogen hastens epiphyseal fusion and cessation of longitudinal bone growth by irreversibly depleting the number of resting zone progenitor cells in female rabbits","volume":"155","author":"Nilsson","year":"2014","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.bone.2020.115468_bb0030","first-page":"552","article-title":"Altered hypertrophic chondrocyte kinetics in GDF-5 deficient murine tibial growth plates","volume":"22","author":"Mikic","year":"2004","journal-title":"J. Orthop. Res."},{"issue":"4","key":"10.1016\/j.bone.2020.115468_bb0035","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3109\/08977194.2015.1082557","article-title":"Growth without growth hormone: can growth and differentiation factor 5 be the mediator?","volume":"33","author":"Shtaif","year":"2015","journal-title":"Growth Factors"},{"issue":"3","key":"10.1016\/j.bone.2020.115468_bb0040","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1677\/joe.0.1760331","article-title":"Growth retardation induced by dexamethasone is associated with increased apoptosis of the growth plate chondrocytes","volume":"176","author":"Chrysis","year":"2003","journal-title":"J. Endocrinol."},{"issue":"1\u20132","key":"10.1016\/j.bone.2020.115468_bb0045","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0303-7207(99)00037-4","article-title":"Hormone regulation of chondrocyte differentiation and endochondral bone formation","volume":"151","author":"Stevens","year":"1999","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.bone.2020.115468_bb0050","series-title":"A Century of Trends in Adult Human Height","author":"Bentham","year":"2016"},{"issue":"1","key":"10.1016\/j.bone.2020.115468_bb0055","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1038\/s41598-018-21517-4","article-title":"MicroRNA contents in matrix vesicles produced by growth plate chondrocytes are cell maturation dependent","volume":"8","author":"Lin","year":"2018","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.bone.2020.115468_bb0060","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1016\/j.jnutbio.2011.09.010","article-title":"MicroRNAs in the growth plate are responsive to nutritional cues: association between miR-140 and SIRT1","volume":"23","author":"Pando","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.bone.2020.115468_bb0065","doi-asserted-by":"crossref","unstructured":"K. Tatton-Brown, S. Seal, E. Ruark, J. Harmer, E. Ramsay, S. Del Vecchio Duarte, A. Zachariou, S. Hanks, E. O'Brien, L. Aksglaede, D. Baralle, T. Dabir, B. Gener, D. Goudie, T. Homfray, A. Kumar, D.T. Pilz, A. Selicorni, I.K. Temple, L. Van Maldergem, N. Yachelevich, C. Childhood Overgrowth, R. van Montfort, N. Rahman, Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability, Nat. Genet. 46(4) (2014) 385\u20138.","DOI":"10.1038\/ng.2917"},{"issue":"10","key":"10.1016\/j.bone.2020.115468_bb0070","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1096\/fj.09-133215","article-title":"A novel domain in histone deacetylase 1 and 2 mediates repression of cartilage-specific genes in human chondrocytes","volume":"23","author":"Hong","year":"2009","journal-title":"FASEB J."},{"issue":"4","key":"10.1016\/j.bone.2020.115468_bb0075","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cell.2004.10.024","article-title":"Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis","volume":"119","author":"Vega","year":"2004","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.bone.2020.115468_bb0080","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/jid.2008.179","article-title":"SIRT1 promotes differentiation of normal human keratinocytes","volume":"129","author":"Blander","year":"2009","journal-title":"J Invest Dermatol"},{"issue":"3","key":"10.1016\/j.bone.2020.115468_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0193921","article-title":"The dynamic shuttling of SIRT1 between cytoplasm and nuclei in bronchial epithelial cells by single and repeated cigarette smoke exposure","volume":"13","author":"Yanagisawa","year":"2018","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.bone.2020.115468_bb0090","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1159\/000369718","article-title":"Modulation of SIRT1-Foxo1 signaling axis by resveratrol: implications in skeletal muscle aging and insulin resistance","volume":"35","author":"Sin","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"issue":"9","key":"10.1016\/j.bone.2020.115468_bb0095","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1002\/pmic.200401305","article-title":"Panorama Ab microarray cell signaling kit: a unique tool for protein expression analysis","volume":"5","author":"Kopf","year":"2005","journal-title":"Proteomics"},{"issue":"16","key":"10.1016\/j.bone.2020.115468_bb0100","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1016\/j.febslet.2008.06.005","article-title":"Regulation of SIRT1 protein levels by nutrient availability","volume":"582","author":"Kanfi","year":"2008","journal-title":"FEBS Lett."},{"issue":"19","key":"10.1016\/j.bone.2020.115468_bb0105","doi-asserted-by":"crossref","first-page":"10794","DOI":"10.1073\/pnas.1934713100","article-title":"Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice","volume":"100","author":"Cheng","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.bone.2020.115468_bb0110","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1017\/S0007114516001781","article-title":"Skeletal effect of casein and whey protein intake during catch-up growth in young male Sprague-Dawley rats","volume":"116","author":"Masarwi","year":"2016","journal-title":"Br. J. Nutr."},{"issue":"2","key":"10.1016\/j.bone.2020.115468_bb0115","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<145::AID-GENE14>3.0.CO;2-C","article-title":"Col2a1-directed expression of Cre recombinase in differentiating chondrocytes in transgenic mice","volume":"26","author":"Ovchinnikov","year":"2000","journal-title":"Genesis"},{"issue":"7","key":"10.1016\/j.bone.2020.115468_bb0120","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1136\/annrheumdis-2012-202620","article-title":"Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice","volume":"73","author":"Matsuzaki","year":"2014","journal-title":"Ann. Rheum. Dis."},{"issue":"3","key":"10.1016\/j.bone.2020.115468_bb0125","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1530\/JOE-14-0486","article-title":"Bone quality is affected by food restriction and by nutrition-induced catch-up growth","volume":"223","author":"Pando","year":"2014","journal-title":"J. Endocrinol."},{"issue":"6","key":"10.1016\/j.bone.2020.115468_bb0130","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.peptides.2009.02.019","article-title":"Restrain of bone growth by estrogen-mimetic peptide-1 (EMP-1): a micro-computed tomographic study","volume":"30","author":"Kasher","year":"2009","journal-title":"Peptides"},{"issue":"4","key":"10.1016\/j.bone.2020.115468_bb0135","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/jbmr.321","article-title":"The osteoblast: an insulin target cell controlling glucose homeostasis","volume":"26","author":"Clemens","year":"2011","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.bone.2020.115468_bb0140","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.molmet.2013.08.004","article-title":"In vivo analysis of the contribution of bone resorption to the control of glucose metabolism in mice","volume":"2","author":"Lacombe","year":"2013","journal-title":"Mol Metab"},{"issue":"11","key":"10.1016\/j.bone.2020.115468_bb0145","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.2337\/db16-0053","article-title":"Regulation of glucose handling by the skeleton: insights from mouse and human studies","volume":"65","author":"Liu","year":"2016","journal-title":"Diabetes"},{"issue":"26","key":"10.1016\/j.bone.2020.115468_bb0150","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1056\/NEJMra1905136","article-title":"Effects of intermittent fasting on health, aging, and disease","volume":"381","author":"de Cabo","year":"2019","journal-title":"N. Engl. J. Med."},{"issue":"5682","key":"10.1016\/j.bone.2020.115468_bb0155","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1126\/science.1099196","article-title":"Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase","volume":"305","author":"Cohen","year":"2004","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.bone.2020.115468_bb0160","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1128\/MCB.23.1.38-54.2003","article-title":"The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis","volume":"23","author":"McBurney","year":"2003","journal-title":"Mol. Cell. Biol."},{"issue":"6","key":"10.1016\/j.bone.2020.115468_bb0165","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.jbspin.2013.01.001","article-title":"Sirt1-deficient mice exhibit an altered cartilage phenotype","volume":"80","author":"Gabay","year":"2013","journal-title":"Joint Bone Spine"},{"issue":"22","key":"10.1016\/j.bone.2020.115468_bb0170","doi-asserted-by":"crossref","first-page":"8614","DOI":"10.1074\/jbc.M117.809822","article-title":"Sirtuin-1 (SIRT1) stimulates growth-plate chondrogenesis by attenuating the PERK-eIF-2alpha-CHOP pathway in the unfolded protein response","volume":"293","author":"Kang","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.bone.2020.115468_bb0175","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1210\/en.2019-00427","article-title":"Cartilage ablation of Sirt1 causes inhibition of growth plate chondrogenesis by hyperactivation of mTORC1 signaling","volume":"160","author":"Jin","year":"2019","journal-title":"Endocrinology"},{"issue":"32","key":"10.1016\/j.bone.2020.115468_bb0180","doi-asserted-by":"crossref","first-page":"22048","DOI":"10.1074\/jbc.M114.568790","article-title":"Sirtuin-1 (SIRT1) is required for promoting chondrogenic differentiation of mesenchymal stem cells","volume":"289","author":"Buhrmann","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bone.2020.115468_bb0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035712","article-title":"Resveratrol mediated modulation of Sirt-1\/Runx2 promotes osteogenic differentiation of mesenchymal stem cells: potential role of Runx2 deacetylation","volume":"7","author":"Shakibaei","year":"2012","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.bone.2020.115468_bb0190","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1177\/0022034518781509","article-title":"Overexpressed Sirt1 in MSCs promotes dentin formation in Bmi1-deficient mice","volume":"97","author":"Wang","year":"2018","journal-title":"J. Dent. Res."},{"issue":"4","key":"10.1016\/j.bone.2020.115468_bb0195","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s00011-004-1341-6","article-title":"Effect of resveratrol in experimental osteoarthritis in rabbits","volume":"54","author":"Elmali","year":"2005","journal-title":"Inflamm. Res."},{"issue":"2","key":"10.1016\/j.bone.2020.115468_bb0200","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3177\/jnsv.46.78","article-title":"Resveratrol attenuates ovariectomy-induced hypertension and bone loss in stroke-prone spontaneously hypertensive rats","volume":"46","author":"Mizutani","year":"2000","journal-title":"J. Nutr. Sci. Vitaminol. (Tokyo)"},{"issue":"10","key":"10.1016\/j.bone.2020.115468_bb0205","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.mad.2005.04.006","article-title":"The Sirt1 deacetylase modulates the insulin-like growth factor signaling pathway in mammals","volume":"126","author":"Lemieux","year":"2005","journal-title":"Mech. Ageing Dev."},{"issue":"13","key":"10.1016\/j.bone.2020.115468_bb0210","doi-asserted-by":"crossref","first-page":"8373","DOI":"10.1074\/jbc.M114.602763","article-title":"Sirtuin 1 is a negative regulator of parathyroid hormone stimulation of matrix metalloproteinase 13 expression in osteoblastic cells: role of sirtuin 1 in the action of PTH on osteoblasts","volume":"290","author":"Fei","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.bone.2020.115468_bb0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0185236","article-title":"SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis","volume":"12","author":"Zainabadi","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2020.115468_bb0220","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41413-018-0021-z","article-title":"The art of building bone: emerging role of chondrocyte-to-osteoblast transdifferentiation in endochondral ossification","volume":"6","author":"Aghajanian","year":"2018","journal-title":"Bone Res"},{"issue":"15","key":"10.1016\/j.bone.2020.115468_bb0225","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1016\/j.cub.2017.06.040","article-title":"SIRT1 functions as a negative regulator of eukaryotic poly(A)RNA transport","volume":"27","author":"Shan","year":"2017","journal-title":"Curr. Biol."},{"issue":"8","key":"10.1016\/j.bone.2020.115468_bb0230","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.18632\/aging.101009","article-title":"Quantitative proteomics of rat livers shows that unrestricted feeding is stressful for proteostasis with implications on life span","volume":"8","author":"Gat-Yablonski","year":"2016","journal-title":"Aging (Albany NY)"},{"issue":"10","key":"10.1016\/j.bone.2020.115468_bb0235","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/ncb1962","article-title":"Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis","volume":"11","author":"Saito","year":"2009","journal-title":"Nat. Cell Biol."},{"issue":"6","key":"10.1016\/j.bone.2020.115468_bb0240","doi-asserted-by":"crossref","first-page":"4809","DOI":"10.1074\/jbc.M110.152900","article-title":"Endoplasmic reticulum stress response mediated by the PERK-eIF2(alpha)-ATF4 pathway is involved in osteoblast differentiation induced by BMP2","volume":"286","author":"Saito","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.bone.2020.115468_bb0245","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/ncb1963","article-title":"Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation","volume":"11","author":"Murakami","year":"2009","journal-title":"Nat. Cell Biol."},{"issue":"6","key":"10.1016\/j.bone.2020.115468_bb0250","doi-asserted-by":"crossref","first-page":"9267","DOI":"10.18632\/oncotarget.14035","article-title":"Reducing Smad3\/ATF4 was essential for Sirt1 inhibiting ER stress-induced apoptosis in mice brown adipose tissue","volume":"8","author":"Liu","year":"2017","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.bone.2020.115468_bb0255","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/cdd.2016.138","article-title":"SIRT1 protects the heart from ER stress-induced cell death through eIF2alpha deacetylation","volume":"24","author":"Prola","year":"2017","journal-title":"Cell Death Differ."},{"issue":"4","key":"10.1016\/j.bone.2020.115468_bb0260","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1136\/ard.2011.200504","article-title":"Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice","volume":"71","author":"Gabay","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bone.2020.115468_bb0265","doi-asserted-by":"crossref","first-page":"343","DOI":"10.2741\/4105","article-title":"Towards elucidating the role of SirT1 in osteoarthritis","volume":"18","author":"Dvir-Ginzberg","year":"2013","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"4","key":"10.1016\/j.bone.2020.115468_bb0270","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/jor.21284","article-title":"Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions","volume":"29","author":"Fujita","year":"2011","journal-title":"J. Orthop. Res."},{"issue":"1","key":"10.1016\/j.bone.2020.115468_bb0275","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s13018-016-0477-8","article-title":"The expression of SIRT1 in articular cartilage of patients with knee osteoarthritis and its correlation with disease severity","volume":"11","author":"Li","year":"2016","journal-title":"J. Orthop. Surg. Res."},{"issue":"2","key":"10.1016\/j.bone.2020.115468_bb0280","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1074\/jbc.M109.058628","article-title":"Ionizing radiation induces cellular senescence of articular chondrocytes via negative regulation of SIRT1 by p38 kinase","volume":"285","author":"Hong","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.bone.2020.115468_bb0285","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1002\/art.24864","article-title":"SIRT1 regulation of apoptosis of human chondrocytes","volume":"60","author":"Takayama","year":"2009","journal-title":"Arthritis Rheum."},{"issue":"5","key":"10.1016\/j.bone.2020.115468_bb0290","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1002\/art.27369","article-title":"SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway","volume":"62","author":"Gagarina","year":"2010","journal-title":"Arthritis Rheum."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328220302489?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328220302489?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:50:58Z","timestamp":1757613058000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328220302489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":58,"alternative-id":["S8756328220302489"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2020.115468","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cartilage -specific knockout of Sirt1 significantly reduces bone quality and catch-up growth efficiency","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2020.115468","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115468"}}