{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:08:04Z","timestamp":1791378484376,"version":"4.3.2"},"reference-count":166,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T00:00:00Z","timestamp":1591401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008762","name":"Genome Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004923","name":"AFM-T\u00e9l\u00e9thon","doi-asserted-by":"publisher","award":["22379"],"award-info":[{"award-number":["22379"]}],"id":[{"id":"10.13039\/501100004923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007054","name":"Meso Scale Diagnostics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["106169\/ZZ14\/Z"],"award-info":[{"award-number":["106169\/ZZ14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000092","name":"Ontario Genomics Institute","doi-asserted-by":"publisher","award":["OGI-055"],"award-info":[{"award-number":["OGI-055"]}],"id":[{"id":"10.13039\/501100000092","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009744","name":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009744","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012524","name":"Nederlandse Federatie van Universitair Medische Centra","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012524","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009945","name":"Merck KGaA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009945","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.bone.2020.115472","type":"journal-article","created":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T18:29:51Z","timestamp":1591468191000},"page":"115472","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":124,"special_numbering":"C","title":["Bone morphogenetic protein receptors: Structure, function and targeting by selective small molecule kinase inhibitors"],"prefix":"10.1016","volume":"138","author":[{"given":"Gonzalo","family":"Sanchez-Duffhues","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Jose","family":"Goumans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl-Henrik","family":"Heldin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"ten Dijke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3698","key":"10.1016\/j.bone.2020.115472_bb0005","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1126\/science.150.3698.893","article-title":"Bone: formation by autoinduction","volume":"150","author":"Urist","year":"1965","journal-title":"Science"},{"issue":"24","key":"10.1016\/j.bone.2020.115472_bb0010","doi-asserted-by":"crossref","first-page":"9484","DOI":"10.1073\/pnas.85.24.9484","article-title":"Purification and characterization of other distinct bone-inducing factors","volume":"85","author":"Wang","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4885","key":"10.1016\/j.bone.2020.115472_bb0015","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1126\/science.3201241","article-title":"Novel regulators of bone formation: molecular clones and activities","volume":"242","author":"Wozney","year":"1988","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.bone.2020.115472_bb0020","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a021873","article-title":"TGF-\u03b2 and the TGF-\u03b2 family: context-dependent roles in cell and tissue physiology","volume":"8","author":"Morikawa","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bone.2020.115472_bb0025","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cytogfr.2015.11.004","article-title":"Common mechanisms in development and disease: BMP signaling in craniofacial development","volume":"27","author":"Graf","year":"2016","journal-title":"Cytokine Growth Factor Rev."},{"issue":"14","key":"10.1016\/j.bone.2020.115472_bb0030","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/j.febslet.2012.04.030","article-title":"BMP signaling in vascular diseases","volume":"586","author":"Cai","year":"2012","journal-title":"FEBS Lett."},{"issue":"6","key":"10.1016\/j.bone.2020.115472_bb0035","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a021899","article-title":"Bone morphogenetic proteins","volume":"8","author":"Katagiri","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"6","key":"10.1016\/j.bone.2020.115472_bb0040","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/0092-8674(91)90549-E","article-title":"Expression cloning of an activin receptor, a predicted transmembrane serine kinase","volume":"65","author":"Mathews","year":"1991","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.bone.2020.115472_bb0045","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0092-8674(92)90209-U","article-title":"Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine\/threonine kinase receptors","volume":"68","author":"Attisano","year":"1992","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.bone.2020.115472_bb0050","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/aja.1001960207","article-title":"Developmental expression of four novel serine\/threonine kinase receptors homologous to the activin\/transforming growth factor-\u03b2 type II receptor family","volume":"196","author":"He","year":"1993","journal-title":"Dev. Dyn."},{"issue":"25","key":"10.1016\/j.bone.2020.115472_bb0055","doi-asserted-by":"crossref","first-page":"16985","DOI":"10.1016\/S0021-9258(17)32506-1","article-title":"Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4","volume":"269","author":"ten Dijke","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.bone.2020.115472_bb0060","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1128\/MCB.15.7.3479","article-title":"Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs","volume":"15","author":"Liu","year":"1995","journal-title":"Mol. Cell. Biol."},{"issue":"17","key":"10.1016\/j.bone.2020.115472_bb0065","doi-asserted-by":"crossref","first-page":"7632","DOI":"10.1073\/pnas.92.17.7632","article-title":"Cloning and characterization of a human type II receptor for bone morphogenetic proteins","volume":"92","author":"Rosenzweig","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.bone.2020.115472_bb0070","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1083\/jcb.130.1.217","article-title":"Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects","volume":"130","author":"Yamashita","year":"1995","journal-title":"J. Cell Biol."},{"issue":"38","key":"10.1016\/j.bone.2020.115472_bb0075","doi-asserted-by":"crossref","first-page":"22522","DOI":"10.1074\/jbc.270.38.22522","article-title":"Identification of a human type II receptor for bone morphogenetic protein-4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptors","volume":"270","author":"Nohno","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"33","key":"10.1016\/j.bone.2020.115472_bb0080","doi-asserted-by":"crossref","first-page":"20533","DOI":"10.1016\/S0021-9258(17)30535-5","article-title":"Distinct transforming growth factor-\u03b2 (TGF-\u03b2) receptor subsets as determinants of cellular responsiveness to three TGF-\u03b2 isoforms","volume":"265","author":"Cheifetz","year":"1990","journal-title":"J. Biol. Chem."},{"issue":"30","key":"10.1016\/j.bone.2020.115472_bb0085","doi-asserted-by":"crossref","first-page":"18518","DOI":"10.1016\/S0021-9258(17)44782-X","article-title":"Concomitant loss of transforming growth factor (TGF)-\u03b2 receptor types I and II in TGF-\u03b2-resistant cell mutants implicates both receptor types in signal transduction","volume":"265","author":"Laiho","year":"1990","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bone.2020.115472_bb0090","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/path.5170","article-title":"Bone morphogenetic protein receptor signal transduction in human disease","volume":"247","author":"Gomez-Puerto","year":"2019","journal-title":"J. Pathol."},{"issue":"4","key":"10.1016\/j.bone.2020.115472_bb0095","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0092-8674(00)81250-7","article-title":"MADR1, a MAD-related protein that functions in BMP2 signaling pathways","volume":"85","author":"Hoodless","year":"1996","journal-title":"Cell"},{"issue":"6583","key":"10.1016\/j.bone.2020.115472_bb0100","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/381620a0","article-title":"A human Mad protein acting as a BMP-regulated transcriptional activator","volume":"381","author":"Liu","year":"1996","journal-title":"Nature"},{"issue":"6603","key":"10.1016\/j.bone.2020.115472_bb0105","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/383832a0","article-title":"Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways","volume":"383","author":"Lagna","year":"1996","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bone.2020.115472_bb0110","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0960-9822(06)00123-0","article-title":"The tumor suppressor Smad4\/DPC 4 as a central mediator of Smad function","volume":"7","author":"Zhang","year":"1997","journal-title":"Curr. Biol."},{"issue":"7","key":"10.1016\/j.bone.2020.115472_bb0115","doi-asserted-by":"crossref","first-page":"4883","DOI":"10.1074\/jbc.M111023200","article-title":"Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter","volume":"277","author":"Korchynskyi","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.bone.2020.115472_bb0120","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1093\/emboj\/17.11.3091","article-title":"Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene","volume":"17","author":"Dennler","year":"1998","journal-title":"EMBO J."},{"issue":"4","key":"10.1016\/j.bone.2020.115472_bb0125","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S1097-2765(00)80061-1","article-title":"Human Smad3 and Smad4 are sequence-specific transcription activators","volume":"1","author":"Zawel","year":"1998","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.bone.2020.115472_bb0130","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/nm.3468","article-title":"An activin receptor IIA ligand trap corrects ineffective erythropoiesis in \u03b2-thalassemia","volume":"20","author":"Dussiot","year":"2014","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.bone.2020.115472_bb0135","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1172\/JCI133678","article-title":"Biological basis for efficacy of activin receptor ligand traps in myelodysplastic syndromes","volume":"130","author":"Verma","year":"2020","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.bone.2020.115472_bb0140","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1158\/1078-0432.CCR-15-0743","article-title":"Activin receptor-like kinase 1 ligand trap reduces microvascular density and improves chemotherapy efficiency to various solid tumors","volume":"22","author":"Hawinkels","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bone.2020.115472_bb0145","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.bone.2017.09.004","article-title":"Structural basis for the potent and selective binding of LDN-212854 to the BMP receptor kinase ALK2","volume":"109","author":"Williams","year":"2018","journal-title":"Bone"},{"issue":"9","key":"10.1016\/j.bone.2020.115472_bb0150","doi-asserted-by":"crossref","first-page":"5876","DOI":"10.1074\/jbc.M706029200","article-title":"Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome","volume":"283","author":"Kotzsch","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.bone.2020.115472_bb0155","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nsmb756","article-title":"Molecular recognition of BMP-2 and BMP receptor IA","volume":"11","author":"Keller","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"14","key":"10.1016\/j.bone.2020.115472_bb0160","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1016\/j.febslet.2012.02.043","article-title":"Promiscuity and specificity in BMP receptor activation","volume":"586","author":"Mueller","year":"2012","journal-title":"FEBS Lett."},{"issue":"Pt 6","key":"10.1016\/j.bone.2020.115472_bb0165","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1242\/jcs.002949","article-title":"BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis","volume":"120","author":"Scharpfenecker","year":"2007","journal-title":"J. Cell Sci."},{"issue":"Pt 20","key":"10.1016\/j.bone.2020.115472_bb0170","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1242\/jcs.112.20.3519","article-title":"Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation","volume":"112","author":"Ebisawa","year":"1999","journal-title":"J. Cell Sci."},{"issue":"7","key":"10.1016\/j.bone.2020.115472_bb0175","doi-asserted-by":"crossref","first-page":"5330","DOI":"10.1074\/jbc.M102750200","article-title":"The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways","volume":"277","author":"Nohe","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.bone.2020.115472_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/cells8121579","article-title":"Specification of BMP signaling","volume":"8","author":"Nickel","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.bone.2020.115472_bb0185","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cytogfr.2015.11.005","article-title":"Structural insights into BMP receptors: specificity, activation and inhibition","volume":"27","author":"Yadin","year":"2016","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.bone.2020.115472_bb0190","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cytogfr.2015.12.005","article-title":"BMP signaling in vascular biology and dysfunction","volume":"27","author":"de Vinuesa","year":"2016","journal-title":"Cytokine Growth Factor Rev."},{"issue":"28","key":"10.1016\/j.bone.2020.115472_bb0195","doi-asserted-by":"crossref","first-page":"10963","DOI":"10.1074\/jbc.RA118.002968","article-title":"A heterodimer formed by bone morphogenetic protein 9 (BMP9) and BMP10 provides most BMP biological activity in plasma","volume":"293","author":"Tillet","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2020.115472_bb0200","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.48872","article-title":"BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis","volume":"8","author":"Kim","year":"2019","journal-title":"Elife"},{"issue":"3","key":"10.1016\/j.bone.2020.115472_bb0205","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1006\/bbrc.1995.1712","article-title":"Potent ectopic bone-inducing activity of bone morphogenetic protein-4\/7 heterodimer","volume":"210","author":"Aono","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.bone.2020.115472_bb0210","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.spinee.2017.07.171","article-title":"BMP-2\/7 heterodimer strongly induces bone regeneration in the absence of increased soft tissue inflammation","volume":"18","author":"Kaito","year":"2018","journal-title":"Spine J."},{"issue":"Pt 8","key":"10.1016\/j.bone.2020.115472_bb0215","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1242\/jcs.114.8.1483","article-title":"Synergistic effects of different bone morphogenetic protein type I receptors on alkaline phosphatase induction","volume":"114","author":"Aoki","year":"2001","journal-title":"J. Cell Sci."},{"issue":"5","key":"10.1016\/j.bone.2020.115472_bb0220","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/ncb1870","article-title":"Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis","volume":"11","author":"Little","year":"2009","journal-title":"Nat. Cell Biol."},{"issue":"5","key":"10.1016\/j.bone.2020.115472_bb0225","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.tcb.2014.12.004","article-title":"BMP signalling: agony and antagony in the family","volume":"25","author":"Brazil","year":"2015","journal-title":"Trends Cell Biol."},{"issue":"1","key":"10.1016\/j.bone.2020.115472_bb0230","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1042\/BST20160263","article-title":"Extracellular regulation of BMP signaling: welcome to the matrix","volume":"45","author":"Sedlmeier","year":"2017","journal-title":"Biochem. Soc. Trans."},{"issue":"1","key":"10.1016\/j.bone.2020.115472_bb0235","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/abbs\/gmx126","article-title":"TGF-\u03b2 family co-receptor function and signaling","volume":"50","author":"Nickel","year":"2018","journal-title":"Acta Biochim. Biophys. Sin. Shanghai"},{"issue":"1","key":"10.1016\/j.bone.2020.115472_bb0240","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10456-008-9101-9","article-title":"Endoglin in angiogenesis and vascular diseases","volume":"11","author":"ten Dijke","year":"2008","journal-title":"Angiogenesis"},{"issue":"5","key":"10.1016\/j.bone.2020.115472_bb0245","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.tcb.2016.11.009","article-title":"RGMs: structural insights, molecular regulation, and downstream signaling","volume":"27","author":"Siebold","year":"2017","journal-title":"Trends Cell Biol."},{"issue":"2","key":"10.1016\/j.bone.2020.115472_bb0250","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1182\/blood-2007-07-100677","article-title":"Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis","volume":"111","author":"Silvestri","year":"2008","journal-title":"Blood"},{"issue":"13","key":"10.1016\/j.bone.2020.115472_bb0255","doi-asserted-by":"crossref","first-page":"3866","DOI":"10.1093\/emboj\/16.13.3866","article-title":"Mechanism of TGF-\u03b2 receptor inhibition by FKBP12","volume":"16","author":"Chen","year":"1997","journal-title":"EMBO J."},{"issue":"9","key":"10.1016\/j.bone.2020.115472_bb0260","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1091\/mbc.12.9.2881","article-title":"Transforming growth factor \u03b2 receptor signaling and endocytosis are linked through a COOH terminal activation motif in the type I receptor","volume":"12","author":"Garamszegi","year":"2001","journal-title":"Mol. Biol. Cell"},{"issue":"10","key":"10.1016\/j.bone.2020.115472_bb0265","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022079","article-title":"Transcriptional control by the SMADs","volume":"8","author":"Hill","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"12","key":"10.1016\/j.bone.2020.115472_bb0270","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022087","article-title":"Posttranslational regulation of Smads","volume":"8","author":"Xu","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"2","key":"10.1016\/j.bone.2020.115472_bb0275","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.ceb.2007.02.015","article-title":"Negative regulation of TGF-\u03b2 receptor\/Smad signal transduction","volume":"19","author":"Itoh","year":"2007","journal-title":"Curr. Opin. Cell Biol."},{"issue":"2","key":"10.1016\/j.bone.2020.115472_bb0280","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3109\/03009734.2012.654858","article-title":"Key role for ubiquitin protein modification in TGF-\u03b2 signal transduction","volume":"117","author":"De Boeck","year":"2012","journal-title":"Ups. J. Med. Sci."},{"issue":"2","key":"10.1016\/j.bone.2020.115472_bb0285","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0092-8674(00)00114-8","article-title":"Cell signaling by receptor tyrosine kinases","volume":"103","author":"Schlessinger","year":"2000","journal-title":"Cell"},{"issue":"6242","key":"10.1016\/j.bone.2020.115472_bb0290","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaa5838","article-title":"EMBRYO DEVELOPMENT. BMP gradients: a paradigm for morphogen-mediated developmental patterning","volume":"348","author":"Bier","year":"2015","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.bone.2020.115472_bb0295","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022053","article-title":"Signaling receptors for TGF-\u03b2 family members","volume":"8","author":"Heldin","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"14","key":"10.1016\/j.bone.2020.115472_bb0300","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1101\/gad.12.14.2144","article-title":"Determinants of specificity in TGF-\u03b2 signal transduction","volume":"12","author":"Chen","year":"1998","journal-title":"Genes Dev."},{"issue":"1\u20132","key":"10.1016\/j.bone.2020.115472_bb0305","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0303-7207(01)00522-6","article-title":"Intracellular and extracellular control of activin function by novel regulatory molecules","volume":"180","author":"Tsuchida","year":"2001","journal-title":"Mol. Cell. Endocrinol."},{"issue":"2","key":"10.1016\/j.bone.2020.115472_bb0310","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022129","article-title":"Non-Smad signaling pathways of the TGF-\u03b2 family","volume":"9","author":"Zhang","year":"2017","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"2","key":"10.1016\/j.bone.2020.115472_bb0315","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a031989","article-title":"Bone morphogenetic proteins in vascular homeostasis and disease","volume":"10","author":"Goumans","year":"2018","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"2","key":"10.1016\/j.bone.2020.115472_bb0320","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/ng0696-189","article-title":"Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2","volume":"13","author":"Johnson","year":"1996","journal-title":"Nat. Genet."},{"issue":"12","key":"10.1016\/j.bone.2020.115472_bb0325","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1136\/jmg.40.12.865","article-title":"Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia","volume":"40","author":"Harrison","year":"2003","journal-title":"J. Med. Genet."},{"issue":"1","key":"10.1016\/j.bone.2020.115472_bb0330","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13073-019-0685-z","article-title":"Novel risk genes and mechanisms implicated by exome sequencing of 2572 individuals with pulmonary arterial hypertension","volume":"11","author":"Zhu","year":"2019","journal-title":"Genome Med."},{"issue":"5","key":"10.1016\/j.bone.2020.115472_bb0335","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/ng1783","article-title":"A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva","volume":"38","author":"Shore","year":"2006","journal-title":"Nat. Genet."},{"issue":"44","key":"10.1016\/j.bone.2020.115472_bb0340","doi-asserted-by":"crossref","first-page":"36990","DOI":"10.1074\/jbc.M112.365932","article-title":"Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva","volume":"287","author":"Chaikuad","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2020.115472_bb0345","first-page":"1","article-title":"Variable signaling activity by FOP ACVR1 mutations","author":"Haupt","year":"2017","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.bone.2020.115472_bb0350","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1359\/jbmr.091110","article-title":"ALK2 R206H mutation linked to fibrodysplasia ossificans progressiva confers constitutive activity to the BMP type I receptor and sensitizes mesenchymal cells to BMP-induced osteoblast differentiation and bone formation","volume":"25","author":"van Dinther","year":"2010","journal-title":"J. Bone Miner. Res."},{"issue":"11","key":"10.1016\/j.bone.2020.115472_bb0355","first-page":"3462","article-title":"The fibrodysplasia ossificans progressiva R206H ACVR1 mutation activates BMP-independent chondrogenesis and zebrafish embryo ventralization","volume":"119","author":"Shen","year":"2009","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.bone.2020.115472_bb0360","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/ng.2970","article-title":"ACVR1 mutations and the genomic landscape of pediatric diffuse glioma","volume":"46","author":"Zadeh","year":"2014","journal-title":"Nat. Genet."},{"issue":"5","key":"10.1016\/j.bone.2020.115472_bb0365","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/ng.2950","article-title":"Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma","volume":"46","author":"Fontebasso","year":"2014","journal-title":"Nat. Genet."},{"issue":"5","key":"10.1016\/j.bone.2020.115472_bb0370","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/ng.2925","article-title":"Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma","volume":"46","author":"Taylor","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bone.2020.115472_bb0375","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.bone.2017.10.027","article-title":"Variable signaling activity by FOP ACVR1 mutations","volume":"109","author":"Haupt","year":"2018","journal-title":"Bone"},{"issue":"17","key":"10.1016\/j.bone.2020.115472_bb0380","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1158\/0008-5472.CAN-14-1298","article-title":"ACVR1 mutations in DIPG: lessons learned from FOP","volume":"74","author":"Taylor","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.bone.2020.115472_bb0385","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s42003-019-0420-8","article-title":"ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma","volume":"2","author":"Carvalho","year":"2019","journal-title":"Commun. Biol."},{"issue":"1","key":"10.1016\/j.bone.2020.115472_bb0390","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/s41467-019-08823-9","article-title":"ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis","volume":"10","author":"Hoeman","year":"2019","journal-title":"Nat. Commun."},{"issue":"24","key":"10.1016\/j.bone.2020.115472_bb0395","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.1161\/CIRCULATIONAHA.108.843714","article-title":"Dominant-negative ALK2 allele associates with congenital heart defects","volume":"119","author":"Smith","year":"2009","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.bone.2020.115472_bb0400","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/ejhg.2010.224","article-title":"ALK2 mutation in a patient with Down\u2019s syndrome and a congenital heart defect","volume":"19","author":"Joziasse","year":"2011","journal-title":"Eur. J. Hum. Genet."},{"issue":"C","key":"10.1016\/j.bone.2020.115472_bb0405","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.bone.2017.10.009","article-title":"Clinical-pathological correlations in three patients with fibrodysplasia ossificans progressiva","volume":"109","author":"Wentworth","year":"2018","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.bone.2020.115472_bb0410","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/88919","article-title":"Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis","volume":"28","author":"Howe","year":"2001","journal-title":"Nat. Genet."},{"issue":"7","key":"10.1016\/j.bone.2020.115472_bb0415","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1136\/gut.2006.116913","article-title":"Risk of colorectal cancer in juvenile polyposis","volume":"56","author":"Brosens","year":"2007","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.bone.2020.115472_bb0420","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.jss.2013.01.015","article-title":"BMPR1A mutations in juvenile polyposis affect cellular localization","volume":"184","author":"Howe","year":"2013","journal-title":"J. Surg. Res."},{"issue":"1","key":"10.1016\/j.bone.2020.115472_bb0425","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1038\/s41598-019-39648-7","article-title":"A familial congenital heart disease with a possible multigenic origin involving a mutation in BMPR1A","volume":"9","author":"Demal","year":"2019","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.bone.2020.115472_bb0430","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1399-0004.2011.01763.x","article-title":"Juvenile polyposis and other intestinal polyposis syndromes with microdeletions of chromosome 10q22-23","volume":"81","author":"Dahdaleh","year":"2012","journal-title":"Clin. Genet."},{"issue":"11","key":"10.1016\/j.bone.2020.115472_bb0435","doi-asserted-by":"crossref","first-page":"e969","DOI":"10.1002\/mgg3.969","article-title":"Homozygous missense variant in BMPR1A resulting in BMPR signaling disruption and syndromic features","volume":"7","author":"Russell","year":"2019","journal-title":"Mol. Genet. Genomic Med."},{"issue":"4","key":"10.1016\/j.bone.2020.115472_bb0440","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1136\/jmg.2004.023564","article-title":"A homozygous BMPR1B mutation causes a new subtype of acromesomelic chondrodysplasia with genital anomalies","volume":"42","author":"Demirhan","year":"2005","journal-title":"J. Med. Genet."},{"issue":"3","key":"10.1016\/j.bone.2020.115472_bb0445","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/ahg.12233","article-title":"A novel homozygous variant in BMPR1B underlies acromesomelic dysplasia Hunter-Thompson type","volume":"82","author":"Ullah","year":"2018","journal-title":"Ann. Hum. Genet."},{"issue":"12","key":"10.1016\/j.bone.2020.115472_bb0450","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1038\/ejhg.2015.38","article-title":"Two novel disease-causing variants in BMPR1B are associated with brachydactyly type A1","volume":"23","author":"Racacho","year":"2015","journal-title":"Eur. J. Hum. Genet."},{"issue":"6","key":"10.1016\/j.bone.2020.115472_bb0455","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/bdra.23354","article-title":"Novel mutation in the BMPR1B gene (R486L) in a Polish family and further delineation of the phenotypic features of BMPR1B-related brachydactyly","volume":"103","author":"Badura-Stronka","year":"2015","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"issue":"6","key":"10.1016\/j.bone.2020.115472_bb0460","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1253\/circj.CJ-11-1281","article-title":"Missense mutations of the BMPR1B (ALK6) gene in childhood idiopathic pulmonary arterial hypertension","volume":"76","author":"Chida","year":"2012","journal-title":"Circ. J."},{"issue":"1","key":"10.1016\/j.bone.2020.115472_bb0465","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1038\/s41467-018-03672-4","article-title":"Identification of rare sequence variation underlying heritable pulmonary arterial hypertension","volume":"9","author":"Graf","year":"2018","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bone.2020.115472_bb0470","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01900-2018","article-title":"Pathophysiology of the right ventricle and of the pulmonary circulation in pulmonary hypertension: an update","volume":"53","author":"Vonk Noordegraaf","year":"2019","journal-title":"Eur. Respir. J."},{"issue":"1","key":"10.1016\/j.bone.2020.115472_bb0475","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1038\/s41598-017-02074-8","article-title":"Molecular and functional characterization of the BMPR2 gene in pulmonary arterial hypertension","volume":"7","author":"Pousada","year":"2017","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.bone.2020.115472_bb0480","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1111\/jcmm.13425","article-title":"Functional assessment of the BMPR2 gene in lymphoblastoid cell lines from Graves\u2019 disease patients","volume":"22","author":"Pousada","year":"2018","journal-title":"J. Cell. Mol. Med."},{"issue":"12","key":"10.1016\/j.bone.2020.115472_bb0485","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1002\/humu.22904","article-title":"Pulmonary arterial hypertension: a current perspective on established and emerging molecular genetic defects","volume":"36","author":"Machado","year":"2015","journal-title":"Hum. Mutat."},{"issue":"5366","key":"10.1016\/j.bone.2020.115472_bb0490","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1126\/science.280.5366.1086","article-title":"Mutations in the SMAD4\/DPC4 gene in juvenile polyposis","volume":"280","author":"Howe","year":"1998","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.bone.2020.115472_bb0495","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1053\/j.gastro.2008.02.059","article-title":"The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers","volume":"134","author":"Kodach","year":"2008","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.bone.2020.115472_bb0500","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/ng1294-345","article-title":"Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1","volume":"8","author":"McAllister","year":"1994","journal-title":"Nat. Genet."},{"issue":"4","key":"10.1016\/j.bone.2020.115472_bb0505","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/(SICI)1098-1004(1998)11:4<286::AID-HUMU6>3.0.CO;2-B","article-title":"Mutation and expression analysis of the endoglin gene in hereditary hemorrhagic telangiectasia reveals null alleles","volume":"11","author":"Gallione","year":"1998","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.bone.2020.115472_bb0510","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fgene.2015.00001","article-title":"Hereditary hemorrhagic telangiectasia: genetics and molecular diagnostics in a new era","volume":"6","author":"McDonald","year":"2015","journal-title":"Front. Genet."},{"issue":"2","key":"10.1016\/j.bone.2020.115472_bb0515","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1136\/jmg.2005.030833","article-title":"Hereditary haemorrhagic telangiectasia: current views on genetics and mechanisms of disease","volume":"43","author":"Abdalla","year":"2006","journal-title":"J. Med. Genet."},{"issue":"33","key":"10.1016\/j.bone.2020.115472_bb0520","doi-asserted-by":"crossref","first-page":"29820","DOI":"10.1074\/jbc.M503511200","article-title":"Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor","volume":"280","author":"Babitt","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"14","key":"10.1016\/j.bone.2020.115472_bb0525","doi-asserted-by":"crossref","first-page":"14122","DOI":"10.1074\/jbc.M410034200","article-title":"DRAGON, a bone morphogenetic protein co-receptor","volume":"280","author":"Samad","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.bone.2020.115472_bb0530","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/ng1777","article-title":"Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression","volume":"38","author":"Babitt","year":"2006","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.bone.2020.115472_bb0535","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1053\/j.gastro.2010.06.013","article-title":"Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment","volume":"139","author":"Pietrangelo","year":"2010","journal-title":"Gastroenterology"},{"issue":"12","key":"10.1016\/j.bone.2020.115472_bb0540","doi-asserted-by":"crossref","first-page":"4669","DOI":"10.1182\/blood-2004-01-0072","article-title":"Genetic abnormalities and juvenile hemochromatosis: mutations of the HJV gene encoding hemojuvelin","volume":"103","author":"Lee","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bone.2020.115472_bb0545","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fphar.2014.00104","article-title":"Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasis","volume":"5","author":"Core","year":"2014","journal-title":"Front. Pharmacol."},{"issue":"7","key":"10.1016\/j.bone.2020.115472_bb0550","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/gt.2011.152","article-title":"Restoration of normal BMP signaling levels and osteogenic differentiation in FOP mesenchymal progenitor cells by mutant allele-specific targeting","volume":"19","author":"Kaplan","year":"2012","journal-title":"Gene Ther."},{"issue":"7","key":"10.1016\/j.bone.2020.115472_bb0555","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069096","article-title":"Antisense-oligonucleotide mediated exon skipping in activin-receptor-like kinase 2: inhibiting the receptor that is overactive in fibrodysplasia ossificans progressiva","volume":"8","author":"Shi","year":"2013","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.bone.2020.115472_bb0560","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050958","article-title":"The role of the 3\u2032UTR region in the regulation of the ACVR1\/Alk-2 gene expression","volume":"7","author":"Mura","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.bone.2020.115472_bb0565","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1242\/dmm.023929","article-title":"High-throughput screening for modulators of ACVR1transcription: discovery of potential therapeutics for fibrodysplasia ossificans progressiva","volume":"9","author":"Cappato","year":"2016","journal-title":"Dis. Model. Mech."},{"issue":"11","key":"10.1016\/j.bone.2020.115472_bb0570","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.213512","article-title":"BMPR2 inhibits activin and BMP signaling via wild-type ALK2","volume":"131","author":"Olsen","year":"2018","journal-title":"J. Cell Sci."},{"issue":"2","key":"10.1016\/j.bone.2020.115472_bb0575","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1124\/mol.105.017483","article-title":"Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression","volume":"69","author":"Jinnin","year":"2006","journal-title":"Mol. Pharmacol."},{"issue":"1","key":"10.1016\/j.bone.2020.115472_bb0580","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1021\/cb300610s","article-title":"Kinase drug discovery\u2014what\u2019s next in the field?","volume":"8","author":"Cohen","year":"2013","journal-title":"ACS Chem. Biol."},{"issue":"19","key":"10.1016\/j.bone.2020.115472_bb0585","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1101\/gad.10.19.2452","article-title":"Genetic analysis of dorsoventral pattern formation in the zebrafish: requirement of a BMP-like ventralizing activity and its dorsal repressor","volume":"10","author":"Hammerschmidt","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/j.bone.2020.115472_bb0590","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/978-1-4939-7598-3_12","article-title":"Compound C\/Dorsomorphin: its use and misuse as an AMPK inhibitor","volume":"1732","author":"Dasgupta","year":"2018","journal-title":"Methods Mol. Biol."},{"issue":"19","key":"10.1016\/j.bone.2020.115472_bb0595","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1016\/S0960-894X(02)00525-5","article-title":"Synthesis and initial SAR studies of 3,6-disubstituted pyrazolo[1,5-a]pyrimidines: a new class of KDR kinase inhibitors","volume":"12","author":"Fraley","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"15","key":"10.1016\/j.bone.2020.115472_bb0600","doi-asserted-by":"crossref","first-page":"4388","DOI":"10.1016\/j.bmcl.2008.06.052","article-title":"Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors","volume":"18","author":"Cuny","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"12","key":"10.1016\/j.bone.2020.115472_bb0605","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1038\/nm.1888","article-title":"BMP type I receptor inhibition reduces heterotopic [corrected] ossification","volume":"14","author":"Yu","year":"2008","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.bone.2020.115472_bb0610","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/ki.2014.223","article-title":"BMP type I receptor inhibition attenuates endothelial dysfunction in mice with chronic kidney disease","volume":"87","author":"Kajimoto","year":"2015","journal-title":"Kidney Int."},{"issue":"3","key":"10.1016\/j.bone.2020.115472_bb0615","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1161\/ATVBAHA.111.242594","article-title":"Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis","volume":"32","author":"Derwall","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.bone.2020.115472_bb0620","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1161\/ATVBAHA.111.240101","article-title":"Pharmacological suppression of hepcidin increases macrophage cholesterol efflux and reduces foam cell formation and atherosclerosis","volume":"32","author":"Saeed","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"15","key":"10.1016\/j.bone.2020.115472_bb0625","doi-asserted-by":"crossref","first-page":"5194","DOI":"10.1158\/0008-5472.CAN-10-4374","article-title":"BMP4 promotes prostate tumor growth in bone through osteogenesis","volume":"71","author":"Lee","year":"2011","journal-title":"Cancer Res."},{"issue":"11","key":"10.1016\/j.bone.2020.115472_bb0630","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/j.cellsig.2011.06.019","article-title":"The specificities of small molecule inhibitors of the TGFss and BMP pathways","volume":"23","author":"Vogt","year":"2011","journal-title":"Cell. Signal."},{"issue":"2","key":"10.1016\/j.bone.2020.115472_bb0635","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1021\/cb9002865","article-title":"In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors","volume":"5","author":"Hao","year":"2010","journal-title":"ACS Chem. Biol."},{"issue":"43","key":"10.1016\/j.bone.2020.115472_bb0640","doi-asserted-by":"crossref","first-page":"15835","DOI":"10.1073\/pnas.0605224103","article-title":"Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination","volume":"103","author":"Vedadi","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.bone.2020.115472_bb0645","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0062721","article-title":"A new class of small molecule inhibitor of BMP signaling","volume":"8","author":"Sanvitale","year":"2013","journal-title":"PLoS One"},{"issue":"19","key":"10.1016\/j.bone.2020.115472_bb0650","doi-asserted-by":"crossref","first-page":"7900","DOI":"10.1021\/jm501177w","article-title":"Structure\u2013activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants","volume":"57","author":"Mohedas","year":"2014","journal-title":"J. Med. Chem."},{"issue":"11","key":"10.1016\/j.bone.2020.115472_bb0655","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1016\/j.bmcl.2013.03.113","volume":"23","author":"Engers","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"6","key":"10.1016\/j.bone.2020.115472_bb0660","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1021\/cb300655w","article-title":"Development of an ALK2-biased BMP type I receptor kinase inhibitor","volume":"8","author":"Mohedas","year":"2013","journal-title":"ACS Chem. Biol."},{"issue":"8","key":"10.1016\/j.bone.2020.115472_bb0665","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1016\/j.ymthe.2017.01.008","article-title":"Strategic targeting of multiple BMP receptors prevents trauma-induced heterotopic ossification","volume":"25","author":"Agarwal","year":"2017","journal-title":"Mol. Ther."},{"issue":"27","key":"10.1016\/j.bone.2020.115472_bb0670","doi-asserted-by":"crossref","first-page":"3672","DOI":"10.1038\/s41388-018-0156-9","article-title":"Novel bone morphogenetic protein receptor inhibitor JL5 suppresses tumor cell survival signaling and induces regression of human lung cancer","volume":"37","author":"Newman","year":"2018","journal-title":"Oncogene"},{"issue":"9","key":"10.1016\/j.bone.2020.115472_bb0675","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s00894-018-3789-2","article-title":"Identification of small molecule inhibitors of ALK2: a virtual screening, density functional theory, and molecular dynamics simulations study","volume":"24","author":"Kausar","year":"2018","journal-title":"J. Mol. Model."},{"issue":"43","key":"10.1016\/j.bone.2020.115472_bb0680","doi-asserted-by":"crossref","first-page":"29651","DOI":"10.1074\/jbc.M114.591388","article-title":"In vivo inhibition of RIPK2 kinase alleviates inflammatory disease","volume":"289","author":"Tigno-Aranjuez","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.bone.2020.115472_bb0685","doi-asserted-by":"crossref","DOI":"10.1002\/jbm4.10230","article-title":"Development of macrocycle kinase inhibitors for ALK2 using fibrodysplasia ossificans progressiva-derived endothelial cells","volume":"3","author":"Sanchez-Duffhues","year":"2019","journal-title":"JBMR Plus"},{"issue":"16","key":"10.1016\/j.bone.2020.115472_bb0690","doi-asserted-by":"crossref","first-page":"7261","DOI":"10.1021\/acs.jmedchem.8b00782","article-title":"Novel quinazolinone inhibitors of ALK2 flip between alternate binding modes: structure-activity relationship, structural characterization, kinase profiling, and cellular proof of concept","volume":"61","author":"Hudson","year":"2018","journal-title":"J. Med. Chem."},{"issue":"10","key":"10.1016\/j.bone.2020.115472_bb0695","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.1016\/j.bmcl.2012.04.013","article-title":"Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring","volume":"22","author":"Boys","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"3","key":"10.1016\/j.bone.2020.115472_bb0700","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1124\/jpet.114.216903","article-title":"Specific activin receptor-like kinase 3 inhibitors enhance liver regeneration","volume":"351","author":"Tsugawa","year":"2014","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bone.2020.115472_bb0705","first-page":"236133","article-title":"LJ000328, a novel ALK2\/3 kinase inhibitor, represses hepcidin and significantly improves the phenotype of IRIDA","author":"Belot","year":"2019","journal-title":"Haematologica"},{"issue":"10","key":"10.1016\/j.bone.2020.115472_bb0710","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.bbagrm.2013.08.002","article-title":"Serum regulation of Id1 expression by a BMP pathway and BMP responsive element","volume":"1829","author":"Lewis","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"10","key":"10.1016\/j.bone.2020.115472_bb0715","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1038\/leu.2012.96","article-title":"Using combination therapy to override stromal-mediated chemoresistance in mutant FLT3-positive AML: synergism between FLT3 inhibitors, dasatinib\/multi-targeted inhibitors and JAK inhibitors","volume":"26","author":"Weisberg","year":"2012","journal-title":"Leukemia"},{"issue":"5","key":"10.1016\/j.bone.2020.115472_bb0720","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.stemcr.2018.10.007","article-title":"An mTOR signaling modulator suppressed heterotopic ossification of fibrodysplasia ossificans progressiva","volume":"11","author":"Hino","year":"2018","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.bone.2020.115472_bb0725","doi-asserted-by":"crossref","first-page":"e10567","DOI":"10.15252\/emmm.201910567","article-title":"Inhibition of phosphatidylinositol 3-kinase alpha (PI3Kalpha) prevents heterotopic ossification","volume":"11","author":"Valer","year":"2019","journal-title":"EMBO Mol. Med."},{"issue":"4","key":"10.1016\/j.bone.2020.115472_bb0730","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/nm.2334","article-title":"Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-gamma agonists","volume":"17","author":"Shimono","year":"2011","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.bone.2020.115472_bb0735","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1124\/jpet.109.156554","volume":"331","author":"Goto","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"3","key":"10.1016\/j.bone.2020.115472_bb0740","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.ccell.2020.02.002","article-title":"Mutant ACVR1 arrests glial cell differentiation to drive tumorigenesis in pediatric gliomas","volume":"37","author":"Fortin","year":"2020","journal-title":"Cancer Cell"},{"issue":"543","key":"10.1016\/j.bone.2020.115472_bb0745","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaz5660","article-title":"ACTRIIA-fc rebalances activin\/GDF versus BMP signaling in pulmonary hypertension","volume":"12","author":"Yung","year":"2020","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"10.1016\/j.bone.2020.115472_bb0750","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1084\/jem.20091309","article-title":"Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis","volume":"207","author":"Cunha","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bone.2020.115472_bb0755","first-page":"1","article-title":"ACVR1-fc suppresses BMP signaling and chondro-osseous differentiation in an in vitro model of fibrodysplasia ossificans progressiva","author":"Pang","year":"2016","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.bone.2020.115472_bb0760","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.chembiol.2017.10.011","article-title":"Small-molecule kinase downregulators","volume":"25","author":"Jones","year":"2018","journal-title":"Cell Chem. Biol."},{"issue":"8","key":"10.1016\/j.bone.2020.115472_bb0765","doi-asserted-by":"crossref","first-page":"3600","DOI":"10.1172\/JCI65592","article-title":"FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension","volume":"123","author":"Spiekerkoetter","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"24","key":"10.1016\/j.bone.2020.115472_bb0770","doi-asserted-by":"crossref","first-page":"4786","DOI":"10.1093\/hmg\/ddx358","article-title":"Tacrolimus rescues the signaling and gene expression signature of endothelial ALK1 loss-of-function and improves HHT vascular pathology","volume":"26","author":"Ruiz","year":"2017","journal-title":"Hum. Mol. Genet."},{"issue":"4","key":"10.1016\/j.bone.2020.115472_bb0775","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.ccell.2014.09.001","article-title":"Hedgehog signaling restrains bladder cancer progression by eliciting stromal production of urothelial differentiation factors","volume":"26","author":"Shin","year":"2014","journal-title":"Cancer Cell"},{"issue":"5","key":"10.1016\/j.bone.2020.115472_bb0780","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.chembiol.2019.01.011","article-title":"Activation of BMP signaling by FKBP12 ligands synergizes with inhibition of CXCR4 to accelerate wound healing","volume":"26","author":"Peiffer","year":"2019","journal-title":"Cell Chem. Biol."},{"issue":"9","key":"10.1016\/j.bone.2020.115472_bb0785","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1021\/acschembio.7b00527","article-title":"Ventromorphins: a new class of small molecule activators of the canonical BMP signaling pathway","volume":"12","author":"Genthe","year":"2017","journal-title":"ACS Chem. Biol."},{"issue":"3","key":"10.1016\/j.bone.2020.115472_bb0790","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0059045","article-title":"Identification of small molecule activators of BMP signaling","volume":"8","author":"Vrijens","year":"2013","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.bone.2020.115472_bb0795","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1074\/jbc.RA118.006817","article-title":"High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds","volume":"294","author":"Bradford","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"32","key":"10.1016\/j.bone.2020.115472_bb0800","doi-asserted-by":"crossref","first-page":"8245","DOI":"10.1016\/j.biomaterials.2010.07.042","article-title":"Differentiation of pre-osteoblast cells on poly(ethylene terephthalate) grafted with RGD and\/or BMPs mimetic peptides","volume":"31","author":"Zouani","year":"2010","journal-title":"Biomaterials"},{"issue":"23","key":"10.1016\/j.bone.2020.115472_bb0805","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20235877","article-title":"CK2.3, a mimetic peptide of the BMP type I receptor, increases activity in osteoblasts over BMP2","volume":"20","author":"Weidner","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bone.2020.115472_bb0810","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-49758-x","article-title":"A bone morphogenetic protein (BMP)-derived peptide based on the type I receptor-binding site modifies cell-type dependent BMP signalling","volume":"9","author":"Tong","year":"2019","journal-title":"Sci. Rep."},{"issue":"Suppl. 25","key":"10.1016\/j.bone.2020.115472_bb0815","doi-asserted-by":"crossref","first-page":"D13","DOI":"10.1016\/j.jacc.2013.10.035","article-title":"Genetics and genomics of pulmonary arterial hypertension","volume":"62","author":"Soubrier","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.bone.2020.115472_bb0820","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nchembio.2007.54","article-title":"Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism","volume":"4","author":"Yu","year":"2008","journal-title":"Nat. Chem. Biol."},{"issue":"22","key":"10.1016\/j.bone.2020.115472_bb0825","doi-asserted-by":"crossref","first-page":"6465","DOI":"10.1021\/jm060434q","article-title":"N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src\/Abl kinase inhibitor","volume":"49","author":"Hennequin","year":"2006","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.bone.2020.115472_bb0830","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1042\/BJ20110502","article-title":"A drug targeting only p110alpha can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types","volume":"438","author":"Jamieson","year":"2011","journal-title":"Biochem. J."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328220302520?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328220302520?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:41:45Z","timestamp":1762659705000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328220302520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":166,"alternative-id":["S8756328220302520"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2020.115472","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bone morphogenetic protein receptors: Structure, function and targeting by selective small molecule kinase inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2020.115472","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2020 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115472"}}