{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T20:32:14Z","timestamp":1777062734172,"version":"3.51.4"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.bone.2020.115521","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T03:05:26Z","timestamp":1593745526000},"page":"115521","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["Role of Prx1-expressing skeletal cells and Prx1-expression in fracture repair"],"prefix":"10.1016","volume":"139","author":[{"given":"Alessandra","family":"Esposito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tieshi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Spagnoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2020.115521_bb0005","doi-asserted-by":"crossref","unstructured":"Morshed S, Corrales L, Genant H, Miclau T, 3rd. Outcome assessment in clinical trials of fracture-healing. J. Bone Joint Surg. Am. 2008;90 Suppl 1:62\u20137.","DOI":"10.2106\/JBJS.G.01556"},{"key":"10.1016\/j.bone.2020.115521_bb0010","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1146\/annurev-cellbio-100913-013132","article-title":"\u201cMesenchymal\u201d stem cells","volume":"30","author":"Bianco","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.bone.2020.115521_bb0015","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nm.3028","article-title":"The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine","volume":"19","author":"Bianco","year":"2013","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.bone.2020.115521_bb0020","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.stem.2008.03.002","article-title":"Mesenchymal stem cells: revisiting history, concepts, and assays","volume":"2","author":"Bianco","year":"2008","journal-title":"Cell Stem Cell"},{"issue":"12","key":"10.1016\/j.bone.2020.115521_bb0025","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1002\/jor.22181","article-title":"Current insights on the regenerative potential of the periosteum: molecular, cellular, and endogenous engineering approaches","volume":"30","author":"Colnot","year":"2012","journal-title":"J. Orthop. Res."},{"issue":"3","key":"10.1016\/j.bone.2020.115521_bb0030","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.bbrc.2009.06.059","article-title":"Mice expressing GFP and CreER in osteochondro progenitor cells in the periosteum","volume":"386","author":"Kawanami","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.bone.2020.115521_bb0035","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.devcel.2010.07.010","article-title":"Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels","volume":"19","author":"Maes","year":"2010","journal-title":"Dev. Cell"},{"issue":"3","key":"10.1016\/j.bone.2020.115521_bb0040","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.devcel.2014.03.013","article-title":"Osterix marks distinct waves of primitive and definitive stromal progenitors during bone marrow development","volume":"29","author":"Mizoguchi","year":"2014","journal-title":"Dev. Cell"},{"issue":"6","key":"10.1016\/j.bone.2020.115521_bb0045","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1007\/s00774-015-0711-1","article-title":"Identification of a progenitor cell population destined to form fracture fibrocartilage callus in Dickkopf-related protein 3-green fluorescent protein reporter mice","volume":"34","author":"Mori","year":"2016","journal-title":"J. Bone Miner. Metab."},{"issue":"4","key":"10.1016\/j.bone.2020.115521_bb0050","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1007\/s00774-013-0429-x","article-title":"Periosteal cells are a major source of soft callus in bone fracture","volume":"31","author":"Murao","year":"2013","journal-title":"J. Bone Miner. Metab."},{"issue":"7725","key":"10.1016\/j.bone.2020.115521_bb0055","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41586-018-0554-8","article-title":"Discovery of a periosteal stem cell mediating intramembranous bone formation","volume":"562","author":"Debnath","year":"2018","journal-title":"Nature."},{"issue":"1","key":"10.1016\/j.bone.2020.115521_bb0060","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41467-018-03124-z","article-title":"Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin","volume":"9","author":"Duchamp de Lageneste","year":"2018","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.bone.2020.115521_bb0065","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1002\/jbmr.2548","article-title":"BMP2 regulation of CXCL12 cellular, temporal, and spatial expression is essential during fracture repair","volume":"30","author":"Myers","year":"2015","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2020.115521_bb0070","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s007760050010","article-title":"Role of fracture hematoma and periosteum during fracture healing in rats: interaction of fracture hematoma and the periosteum in the initial step of the healing process","volume":"5","author":"Ozaki","year":"2000","journal-title":"J. Orthop. Sci."},{"issue":"5","key":"10.1016\/j.bone.2020.115521_bb0075","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/00005131-199906000-00006","article-title":"Regulation of osteoblast levels during bone healing","volume":"13","author":"Olmedo","year":"1999","journal-title":"J. Orthop. Trauma"},{"issue":"19","key":"10.1016\/j.bone.2020.115521_bb0080","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.1242\/dev.125.19.3831","article-title":"Prx1 and Prx2 in skeletogenesis: roles in the craniofacial region, inner ear and limbs","volume":"125","author":"ten Berge","year":"1998","journal-title":"Development."},{"issue":"10","key":"10.1016\/j.bone.2020.115521_bb0085","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1002\/dvdy.22092","article-title":"Prx1 and Prx2 cooperatively regulate the morphogenesis of the medial region of the mandibular process","volume":"238","author":"Balic","year":"2009","journal-title":"Dev. Dyn."},{"issue":"10","key":"10.1016\/j.bone.2020.115521_bb0090","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1101\/gad.9.10.1237","article-title":"The paired-like homeo box gene MHox is required for early events of skeletogenesis in multiple lineages","volume":"9","author":"Martin","year":"1995","journal-title":"Genes Dev."},{"issue":"3","key":"10.1016\/j.bone.2020.115521_bb0095","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/dvdy.20412","article-title":"Opposing roles of two isoforms of the Prx1 homeobox gene in chondrogenesis","volume":"233","author":"Peterson","year":"2005","journal-title":"Dev. Dyn."},{"issue":"2","key":"10.1016\/j.bone.2020.115521_bb0100","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/ajmg.10672","article-title":"Agnathia-otocephaly complex: report of three cases with involvement of two different Carnegie stages","volume":"112","author":"Schiffer","year":"2002","journal-title":"Am. J. Med. Genet."},{"issue":"3","key":"10.1016\/j.bone.2020.115521_bb0105","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.bbrc.2006.09.079","article-title":"Analyzing the cellular contribution of bone marrow to fracture healing using bone marrow transplantation in mice","volume":"350","author":"Colnot","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"16","key":"10.1016\/j.bone.2020.115521_bb0110","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.217828","article-title":"Primary cilia are necessary for Prx1-expressing cells to contribute to postnatal skeletogenesis","volume":"131","author":"Moore","year":"2018","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bone.2020.115521_bb0115","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.bone.2013.10.016","article-title":"Prx1 and 3.2kb Col1a1 promoters target distinct bone cell populations in transgenic mice","volume":"58","author":"Ouyang","year":"2014","journal-title":"Bone."},{"issue":"4","key":"10.1016\/j.bone.2020.115521_bb0120","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.stemcr.2017.03.002","article-title":"Postnatal calvarial skeletal stem cells expressing PRX1 reside exclusively in the calvarial sutures and are required for bone regeneration","volume":"8","author":"Wilk","year":"2017","journal-title":"Stem Cell Reports."},{"issue":"1","key":"10.1016\/j.bone.2020.115521_bb0125","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/jbmr.203","article-title":"Identification of the homeobox protein Prx1 (MHox, Prrx-1) as a regulator of osterix expression and mediator of tumor necrosis factor \u03b1 action in osteoblast differentiation","volume":"26","author":"Lu","year":"2011","journal-title":"Journal of bone and mineral research\u202f: the official journal of the American Society for Bone and Mineral Research."},{"issue":"5","key":"10.1016\/j.bone.2020.115521_bb0130","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1074\/jbc.M112.440370","article-title":"The transcription factor paired-related homeobox 1 (Prrx1) inhibits adipogenesis by activating transforming growth factor-beta (TGFbeta) signaling","volume":"288","author":"Du","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.bone.2020.115521_bb0135","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.1523\/JNEUROSCI.4586-12.2013","article-title":"Paired related homeobox protein 1 is a regulator of stemness in adult neural stem\/progenitor cells","volume":"33","author":"Shimozaki","year":"2013","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.bone.2020.115521_bb0140","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1002\/jcb.23068","article-title":"Cell-based gene therapy for repair of critical size defects in the rat fibula","volume":"112","author":"Lazard","year":"2011","journal-title":"J. Cell. Biochem."},{"issue":"2","key":"10.1016\/j.bone.2020.115521_bb0145","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.gene.2012.09.130","article-title":"Chondrocyte BMP2 signaling plays an essential role in bone fracture healing","volume":"512","author":"Mi","year":"2013","journal-title":"Gene."},{"issue":"Suppl. 1","key":"10.1016\/j.bone.2020.115521_bb0150","doi-asserted-by":"crossref","first-page":"S34","DOI":"10.1016\/S0020-1383(13)70008-1","article-title":"Clinical applications of growth factors in bone injuries: experience with BMPs","volume":"44","author":"Ronga","year":"2013","journal-title":"Injury."},{"issue":"12","key":"10.1016\/j.bone.2020.115521_bb0155","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/ng1916","article-title":"BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing","volume":"38","author":"Tsuji","year":"2006","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.bone.2020.115521_bb0160","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00264-008-0691-z","article-title":"Regional and cellular localisation of BMPs and their inhibitors\u2019 expression in human fractures","volume":"33","author":"Kwong","year":"2009","journal-title":"Int. Orthop."},{"issue":"2","key":"10.1016\/j.bone.2020.115521_bb0165","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1016\/j.athoracsur.2007.11.006","article-title":"Treatment of chronic nonunion of a sternal fracture with bone morphogenetic protein","volume":"85","author":"Morgan","year":"2008","journal-title":"Ann. Thorac. Surg."},{"issue":"6","key":"10.1016\/j.bone.2020.115521_bb0170","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1002\/jor.20794","article-title":"Altered relative expression of BMPs and BMP inhibitors in cartilaginous areas of human fractures progressing towards nonunion","volume":"27","author":"Kwong","year":"2009","journal-title":"J. Orthop. Res."},{"issue":"5","key":"10.1016\/j.bone.2020.115521_bb0175","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00109-014-1123-8","article-title":"CXC chemokine ligand 12 (CXCL12) and its receptor CXCR4","volume":"92","author":"Nagasawa","year":"2014","journal-title":"J Mol Med (Berl)."},{"key":"10.1016\/j.bone.2020.115521_bb0180","article-title":"Isolation of blood-vessel-derived multipotent precursors from human skeletal muscle","volume":"90","author":"Chen","year":"2014","journal-title":"J. Vis. Exp."},{"issue":"7","key":"10.1016\/j.bone.2020.115521_bb0185","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1182\/blood-2008-10-184754","article-title":"Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization","volume":"114","author":"Christopher","year":"2009","journal-title":"Blood."},{"key":"10.1016\/j.bone.2020.115521_bb0190","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0091-679X(08)00013-7","article-title":"Purification and long-term culture of multipotent progenitor cells affiliated with the walls of human blood vessels: myoendothelial cells and pericytes","volume":"86","author":"Crisan","year":"2008","journal-title":"Methods Cell Biol."},{"issue":"3","key":"10.1016\/j.bone.2020.115521_bb0195","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.stem.2008.07.003","article-title":"A perivascular origin for mesenchymal stem cells in multiple human organs","volume":"3","author":"Crisan","year":"2008","journal-title":"Cell Stem Cell"},{"issue":"3","key":"10.1016\/j.bone.2020.115521_bb0200","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.immuni.2010.08.017","article-title":"The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche","volume":"33","author":"Omatsu","year":"2010","journal-title":"Immunity."},{"issue":"7\u20138","key":"10.1016\/j.bone.2020.115521_bb0205","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1089\/ten.tea.2011.0187","article-title":"Modulation of stromal cell-derived factor-1\/CXC chemokine receptor 4 axis enhances rhBMP-2-induced ectopic bone formation","volume":"18","author":"Wise","year":"2012","journal-title":"Tissue Eng Part A."},{"issue":"7308","key":"10.1016\/j.bone.2020.115521_bb0210","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nature09262","article-title":"Mesenchymal and haematopoietic stem cells form a unique bone marrow niche","volume":"466","author":"Mendez-Ferrer","year":"2010","journal-title":"Nature."},{"issue":"9","key":"10.1016\/j.bone.2020.115521_bb0215","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1096\/fj.12-225763","article-title":"CXCL12\/CXCR4 signaling in the osteoblast regulates the mesenchymal stem cell and osteoclast lineage populations","volume":"27","author":"Shahnazari","year":"2013","journal-title":"FASEB J."},{"issue":"5","key":"10.1016\/j.bone.2020.115521_bb0220","first-page":"2656","article-title":"Stromal cell-derived factor-1alpha and transforming growth factor-beta1 synergistically facilitate migration and chondrogenesis of synovium-derived stem cells through MAPK pathways","volume":"9","author":"Wang","year":"2017","journal-title":"Am. J. Transl. Res."},{"issue":"3","key":"10.1016\/j.bone.2020.115521_bb0225","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1128\/AAC.40.3.750","article-title":"Antiviral efficacy in vivo of the anti-human immunodeficiency virus bicyclam SDZ SID 791 (JM 3100), an inhibitor of infectious cell entry","volume":"40","author":"Datema","year":"1996","journal-title":"Antimicrob. Agents Chemother."},{"issue":"6","key":"10.1016\/j.bone.2020.115521_bb0230","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1128\/AAC.44.6.1667-1673.2000","article-title":"Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers","volume":"44","author":"Hendrix","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"issue":"6","key":"10.1016\/j.bone.2020.115521_bb0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011316","article-title":"Selective enhancement of donor hematopoietic cell engraftment by the CXCR4 antagonist AMD3100 in a mouse transplantation model","volume":"5","author":"Kang","year":"2010","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.bone.2020.115521_bb0240","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1128\/AAC.40.3.755","article-title":"Use of standardized SCID-hu Thy\/Liv mouse model for preclinical efficacy testing of anti-human immunodeficiency virus type 1 compounds","volume":"40","author":"Rabin","year":"1996","journal-title":"Antimicrob. Agents Chemother."},{"issue":"4","key":"10.1016\/j.bone.2020.115521_bb0245","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/MOH.0b013e328338b7d5","article-title":"Update on clinical experience with AMD3100, an SDF-1\/CXCL12-CXCR4 inhibitor, in mobilization of hematopoietic stem and progenitor cells","volume":"17","author":"Pusic","year":"2010","journal-title":"Curr. Opin. Hematol."},{"issue":"7","key":"10.1016\/j.bone.2020.115521_bb0250","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.4049\/jimmunol.180.7.4742","article-title":"Homeostasis and effector function of lymphopenia-induced \u201cmemory-like\u201d T cells in constitutively T cell-depleted mice","volume":"180","author":"Voehringer","year":"2008","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.bone.2020.115521_bb0255","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nn.2467","article-title":"A robust and high-throughput Cre reporting and characterization system for the whole mouse brain","volume":"13","author":"Madisen","year":"2010","journal-title":"Nat. Neurosci."},{"issue":"3","key":"10.1016\/j.bone.2020.115521_bb0260","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/gene.20132","article-title":"Generation of a Bmp2 conditional null allele","volume":"42","author":"Ma","year":"2005","journal-title":"Genesis."},{"issue":"8","key":"10.1016\/j.bone.2020.115521_bb0265","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1002\/stem.103","article-title":"Regenerative effects of transplanted mesenchymal stem cells in fracture healing","volume":"27","author":"Granero-Molto","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.bone.2020.115521_bb0270","doi-asserted-by":"crossref","unstructured":"Granero-Molt\u00f3 F, Myers TJ, Weis JA, Longobardi L, Li T, Yan Y, et al. Mesenchymal stem cells expressing insulin-like growth factor-I (MSCIGF) promote fracture healing and restore new bone formation in Irs1 knockout mice: analyses of MSCIGF autocrine and paracrine regenerative effects. Stem cells (Dayton, Ohio). 2011;29(10):1537\u201348.","DOI":"10.1002\/stem.697"},{"issue":"7","key":"10.1016\/j.bone.2020.115521_bb0275","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro-computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2020.115521_bb0280","article-title":"High-precision analysis of subchondral sclerosis as an early and progressive marker of post-traumatic osteoarthritis using micro-computed tomography","volume":"2013","author":"Temple","year":"2013","journal-title":"Annual Meeting American Society for Bone and Mineral Research"},{"key":"10.1016\/j.bone.2020.115521_bb0285","article-title":"High-resolution micro-computed tomography of articular cartilage and subchondral bone changes in mouse models of osteoarthritis","volume":"2013","author":"Temple","year":"2013","journal-title":"Osteoarthritits Research Society International (OARSI) Annual Meeting"},{"key":"10.1016\/j.bone.2020.115521_bb0290","article-title":"Fundamental biomechanics in bone tissue engineering","volume":"55","author":"Wang","year":"2009","journal-title":"Synthesis Lectures on Tissue Engineering Morgan & Claypool Publishers"},{"issue":"2","key":"10.1016\/j.bone.2020.115521_bb0295","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00441-004-1006-3","article-title":"Bone marrow subendosteal microenvironment harbours functionally distinct haemosupportive stromal cell populations","volume":"319","author":"Balduino","year":"2005","journal-title":"Cell Tissue Res."},{"issue":"19","key":"10.1016\/j.bone.2020.115521_bb0300","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1016\/j.yexcr.2012.07.009","article-title":"Molecular signature and in vivo behavior of bone marrow endosteal and subendosteal stromal cell populations and their relevance to hematopoiesis","volume":"318","author":"Balduino","year":"2012","journal-title":"Exp. Cell Res."},{"issue":"4","key":"10.1016\/j.bone.2020.115521_bb0305","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0008-6363(96)00063-6","article-title":"Pericytes in the microvasculature","volume":"32","author":"Hirschi","year":"1996","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.bone.2020.115521_bb0310","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016816","article-title":"Nestin-GFP transgene reveals neural precursor cells in adult skeletal muscle","volume":"6","author":"Birbrair","year":"2011","journal-title":"PLoS One"},{"issue":"16","key":"10.1016\/j.bone.2020.115521_bb0315","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1089\/scd.2012.0647","article-title":"Role of pericytes in skeletal muscle regeneration and fat accumulation","volume":"22","author":"Birbrair","year":"2013","journal-title":"Stem Cells Dev."},{"issue":"3","key":"10.1016\/j.bone.2020.115521_bb0320","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/ncb1542","article-title":"Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells","volume":"9","author":"Dellavalle","year":"2007","journal-title":"Nat. Cell Biol."},{"issue":"9","key":"10.1016\/j.bone.2020.115521_bb0325","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1038\/nprot.2008.142","article-title":"Isolation of a slowly adhering cell fraction containing stem cells from murine skeletal muscle by the preplate technique","volume":"3","author":"Gharaibeh","year":"2008","journal-title":"Nat. Protoc."},{"issue":"2","key":"10.1016\/j.bone.2020.115521_bb0330","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.cell.2007.08.025","article-title":"Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment","volume":"131","author":"Sacchetti","year":"2007","journal-title":"Cell."},{"key":"10.1016\/j.bone.2020.115521_bb0335","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1196\/annals.1349.006","article-title":"The vascular wall as a source of stem cells","volume":"1044","author":"Tavian","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"1","key":"10.1016\/j.bone.2020.115521_bb0340","first-page":"1","article-title":"Muscle-bone interactions during fracture healing","volume":"15","author":"Davis","year":"2015","journal-title":"J. Musculoskelet. Neuronal Interact."},{"issue":"5","key":"10.1016\/j.bone.2020.115521_bb0345","doi-asserted-by":"crossref","DOI":"10.1002\/jbm4.10127","article-title":"PDGF modulates BMP2-induced osteogenesis in periosteal progenitor cells","volume":"3","author":"Wang","year":"2019","journal-title":"JBMR Plus."},{"key":"10.1016\/j.bone.2020.115521_bb0350","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41536-018-0063-2","article-title":"Relative contributions of adipose-resident CD146(+) pericytes and CD34(+) adventitial progenitor cells in bone tissue engineering","volume":"4","author":"Wang","year":"2019","journal-title":"NPJ Regen Med."},{"issue":"2","key":"10.1016\/j.bone.2020.115521_bb0355","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1359\/jbmr.081003","article-title":"Skeletal cell fate decisions within periosteum and bone marrow during bone regeneration","volume":"24","author":"Colnot","year":"2009","journal-title":"J. Bone Miner. Res."},{"issue":"6","key":"10.1016\/j.bone.2020.115521_bb0360","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1089\/ten.teb.2011.0243","article-title":"Cell sources for bone tissue engineering: insights from basic science","volume":"17","author":"Colnot","year":"2011","journal-title":"Tissue Eng Part B Rev."},{"key":"10.1016\/j.bone.2020.115521_bb0365","doi-asserted-by":"crossref","first-page":"591","DOI":"10.3389\/fphys.2019.00591","article-title":"Prx1 expressing cells are required for periodontal regeneration of the mouse incisor","volume":"10","author":"Bassir","year":"2019","journal-title":"Front. Physiol."},{"issue":"2","key":"10.1016\/j.bone.2020.115521_bb0370","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/stem.780","article-title":"In vivo fate mapping identifies mesenchymal progenitor cells","volume":"30","author":"Grcevic","year":"2012","journal-title":"Stem Cells"},{"issue":"5","key":"10.1016\/j.bone.2020.115521_bb0375","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1002\/jbmr.2140","article-title":"Analysis of alphaSMA-labeled progenitor cell commitment identifies notch signaling as an important pathway in fracture healing","volume":"29","author":"Matthews","year":"2014","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.bone.2020.115521_bb0380","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1172\/JCI80672","article-title":"NOTCH signaling in skeletal progenitors is critical for fracture repair","volume":"126","author":"Wang","year":"2016","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.bone.2020.115521_bb0385","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/jor.20518","article-title":"Fluorescence molecular tomography enables in vivo visualization and quantification of nonunion fracture repair induced by genetically engineered mesenchymal stem cells","volume":"26","author":"Zilberman","year":"2008","journal-title":"J. Orthop. Res."},{"issue":"7","key":"10.1016\/j.bone.2020.115521_bb0390","article-title":"The Prrx1 limb enhancer marks an adult subpopulation of injury-responsive dermal fibroblasts","volume":"8","author":"Currie","year":"2019","journal-title":"Biol. Open"},{"issue":"5","key":"10.1016\/j.bone.2020.115521_bb0395","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/jbmr.3668","article-title":"Mechanical loading promotes the expansion of primitive osteoprogenitors and organizes matrix and vascular morphology in long bone defects","volume":"34","author":"Liu","year":"2019","journal-title":"J. Bone Miner. Res."},{"issue":"5","key":"10.1016\/j.bone.2020.115521_bb0400","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/jcp.25641","article-title":"Osteogenic differentiation of periosteal cells during fracture healing","volume":"232","author":"Wang","year":"2017","journal-title":"J. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.bone.2020.115521_bb0405","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/(SICI)1526-968X(200004)26:4<225::AID-GENE10>3.0.CO;2-F","article-title":"Identification of a prx1 limb enhancer","volume":"26","author":"Martin","year":"2000","journal-title":"Genesis."},{"issue":"1\u20132","key":"10.1016\/j.bone.2020.115521_bb0410","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.cell.2014.11.042","article-title":"Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential","volume":"160","author":"Worthley","year":"2015","journal-title":"Cell."},{"issue":"4","key":"10.1016\/j.bone.2020.115521_bb0415","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/ncb3139","article-title":"The suture provides a niche for mesenchymal stem cells of craniofacial bones","volume":"17","author":"Zhao","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bone.2020.115521_bb0420","doi-asserted-by":"crossref","unstructured":"Ivanova A, Signore M, Caro N, Greene ND, Copp AJ, Martinez-Barbera JP. In vivo genetic ablation by Cre-mediated expression of diphtheria toxin fragment A. Genesis (New York, NY: 2000). 2005;43(3):129\u201335.","DOI":"10.1002\/gene.20162"},{"issue":"5","key":"10.1016\/j.bone.2020.115521_bb0425","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.devcel.2014.11.005","article-title":"Variations in the efficiency of lineage marking and ablation confound distinctions between myogenic cell populations","volume":"31","author":"Comai","year":"2014","journal-title":"Dev. Cell"},{"issue":"1\u20132","key":"10.1016\/j.bone.2020.115521_bb0430","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2014.12.002","article-title":"Identification and specification of the mouse skeletal stem cell","volume":"160","author":"Chan","year":"2015","journal-title":"Cell."},{"issue":"32","key":"10.1016\/j.bone.2020.115521_bb0435","doi-asserted-by":"crossref","first-page":"9920","DOI":"10.1073\/pnas.1513066112","article-title":"Identification and characterization of an injury-induced skeletal progenitor","volume":"112","author":"Marecic","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"10","key":"10.1016\/j.bone.2020.115521_bb0440","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1002\/jor.21105","article-title":"Long bone fracture repair in mice harboring GFP reporters for cells within the osteoblastic lineage","volume":"28","author":"Ushiku","year":"2010","journal-title":"J. Orthop. Res."},{"issue":"1","key":"10.1016\/j.bone.2020.115521_bb0445","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/jbmr.3839","article-title":"American Society for Bone and Mineral Research-orthopaedic research society joint task force report on cell-based therapies","volume":"35","author":"O\u2019Keefe","year":"2019","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2020.115521_bb0450","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.bone.2008.08.120","article-title":"Gene expression profile of the bone microenvironment in human fragility fracture bone","volume":"44","author":"Hopwood","year":"2009","journal-title":"Bone."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632822030301X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632822030301X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:48:49Z","timestamp":1757612929000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S875632822030301X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":90,"alternative-id":["S875632822030301X"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2020.115521","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of Prx1-expressing skeletal cells and Prx1-expression in fracture repair","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2020.115521","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115521"}}