{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:51:52Z","timestamp":1790351512119,"version":"4.1.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.bone.2020.115656","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T20:58:15Z","timestamp":1600981095000},"page":"115656","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Genetic pathways disrupted by ENPP1 deficiency provide insight into mechanisms of osteoporosis, osteomalacia, and paradoxical mineralization"],"prefix":"10.1016","volume":"142","author":[{"given":"Nathan D.","family":"Maulding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dillon","family":"Kavanagh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Zimmerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfilippo","family":"Coppola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas O.","family":"Carpenter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel K.","family":"Jue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetrios T.","family":"Braddock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"22","key":"10.1016\/j.bone.2020.115656_bb0005","doi-asserted-by":"crossref","first-page":"21155","DOI":"10.1074\/jbc.M413183200","article-title":"Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate","volume":"280","author":"van Meeteren","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"35","key":"10.1016\/j.bone.2020.115656_bb0010","doi-asserted-by":"crossref","first-page":"25822","DOI":"10.1074\/jbc.M605142200","article-title":"Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid","volume":"281","author":"Tanaka","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"18","key":"10.1016\/j.bone.2020.115656_bb0015","first-page":"6938","article-title":"Autotaxin (NPP-2), a metastasis-enhancing motogen, is an angiogenic factor","volume":"61","author":"Nam","year":"2001","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.bone.2020.115656_bb0020","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/(SICI)1097-4547(19980801)53:3<343::AID-JNR8>3.0.CO;2-A","article-title":"Lysophosphatidic acid stimulates actomyosin contraction in astrocytes","volume":"53","author":"Manning","year":"1998","journal-title":"J. Neurosci. Res."},{"issue":"2","key":"10.1016\/j.bone.2020.115656_bb0025","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1083\/jcb.200204026","article-title":"Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production","volume":"158","author":"Umezu-Goto","year":"2002","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.bone.2020.115656_bb0030","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/sj.onc.1203263","article-title":"Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells","volume":"19","author":"Nam","year":"2000","journal-title":"Oncogene."},{"issue":"3","key":"10.1016\/j.bone.2020.115656_bb0035","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s11060-007-9480-6","article-title":"Autotaxin: a secreted autocrine\/paracrine factor that promotes glioma invasion","volume":"86","author":"Hoelzinger","year":"2008","journal-title":"J. Neuro-Oncol."},{"issue":"10","key":"10.1016\/j.bone.2020.115656_bb0040","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1158\/1535-7163.MCT-08-0463","article-title":"Identification of small-molecule inhibitors of autotaxin that inhibit melanoma cell migration and invasion","volume":"7","author":"Saunders","year":"2008","journal-title":"Mol. Cancer Ther."},{"issue":"6","key":"10.1016\/j.bone.2020.115656_bb0045","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.ccr.2009.03.027","article-title":"Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases","volume":"15","author":"Liu","year":"2009","journal-title":"Cancer Cell"},{"issue":"25","key":"10.1016\/j.bone.2020.115656_bb0050","doi-asserted-by":"crossref","first-page":"17492","DOI":"10.1074\/jbc.M601803200","article-title":"Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid","volume":"281","author":"Kishi","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bone.2020.115656_bb0055","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/956","article-title":"Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine","volume":"19","author":"Okawa","year":"1998","journal-title":"Nat. Genet."},{"issue":"6","key":"10.1016\/j.bone.2020.115656_bb0060","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1007\/s004390050993","article-title":"Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL)","volume":"104","author":"Nakamura","year":"1999","journal-title":"Hum. Genet."},{"issue":"2","key":"10.1016\/j.bone.2020.115656_bb0065","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ajhg.2010.01.010","article-title":"Autosomal-recessive hypophosphatemic rickets is associated with an inactivation mutation in the ENPP1 gene","volume":"86","author":"Levy-Litan","year":"2010","journal-title":"Am. J. Hum. Genet."},{"issue":"2","key":"10.1016\/j.bone.2020.115656_bb0070","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ajhg.2010.01.006","article-title":"Loss-of-function ENPP1 mutations cause both generalized arterial calcification of infancy and autosomal-recessive hypophosphatemic rickets","volume":"86","author":"Lorenz-Depiereux","year":"2010","journal-title":"Am. J. Hum. Genet."},{"issue":"4","key":"10.1016\/j.bone.2020.115656_bb0075","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/ng1221","article-title":"Mutations in ENPP1 are associated with \u2018idiopathic\u2019 infantile arterial calcification","volume":"34","author":"Rutsch","year":"2003","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.bone.2020.115656_bb0080","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0002-9440(10)63996-X","article-title":"PC-1 nucleoside triphosphate pyrophosphohydrolase deficiency in idiopathic infantile arterial calcification","volume":"158","author":"Rutsch","year":"2001","journal-title":"Am. J. Pathol."},{"issue":"5","key":"10.1016\/j.bone.2020.115656_bb0085","first-page":"1227","article-title":"Mutant Enpp1asj mice as a model for generalized arterial calcification of infancy","volume":"6","author":"Li","year":"2013","journal-title":"Dis. Model. Mech."},{"issue":"22","key":"10.1016\/j.bone.2020.115656_bb0090","doi-asserted-by":"crossref","first-page":"4432","DOI":"10.1182\/blood-2012-04-425215","article-title":"NPP4 is a procoagulant enzyme on the surface of vascular endothelium","volume":"120","author":"Albright","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.bone.2020.115656_bb0095","doi-asserted-by":"crossref","first-page":"10006","DOI":"10.1038\/ncomms10006","article-title":"ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy","volume":"6","author":"Albright","year":"2015","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.bone.2020.115656_bb0100","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1093\/rheumatology\/kes089","article-title":"Novel compound heterozygous mutations in ENPP1 cause hypophosphataemic rickets with anterior spinal ligament ossification","volume":"51","author":"Mehta","year":"2012","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.bone.2020.115656_bb0105","article-title":"Clinical and biochemical phenotypes in a family with ENPP1 mutations","author":"Kotwal","year":"2019","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.bone.2020.115656_bb0110","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.bone.2011.06.029","article-title":"A patient with hypophosphatemic rickets and ossification of posterior longitudinal ligament caused by a novel homozygous mutation in ENPP1 gene","volume":"49","author":"Saito","year":"2011","journal-title":"Bone."},{"issue":"1","key":"10.1016\/j.bone.2020.115656_bb0115","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1359\/jbmr.2002.17.1.138","article-title":"Nucleotide pyrophosphatase gene polymorphism associated with ossification of the posterior longitudinal ligament of the spine","volume":"17","author":"Koshizuka","year":"2002","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2020.115656_bb0120","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ajhg.2011.11.020","article-title":"Generalized arterial calcification of infancy and pseudoxanthoma elasticum can be caused by mutations in either ENPP1 or ABCC6","volume":"90","author":"Nitschke","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bone.2020.115656_bb0125","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3389\/fgene.2012.00302","article-title":"Generalized arterial calcification of infancy and pseudoxanthoma elasticum: two sides of the same coin","volume":"3","author":"Nitschke","year":"2012","journal-title":"Front. Genet."},{"issue":"1","key":"10.1016\/j.bone.2020.115656_bb0130","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/ajmg.a.33162","article-title":"An unusual severe vascular case of pseudoxanthoma elasticum presenting as generalized arterial calcification of infancy","volume":"152A","author":"Le Boulanger","year":"2010","journal-title":"Am. J. Med. Genet. A"},{"issue":"3","key":"10.1016\/j.bone.2020.115656_bb0135","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/jid.2013.370","article-title":"Mutations in the ABCC6 gene as a cause of generalized arterial calcification of infancy: genotypic overlap with pseudoxanthoma elasticum","volume":"134","author":"Li","year":"2014","journal-title":"The Journal of investigative dermatology"},{"issue":"2","key":"10.1016\/j.bone.2020.115656_bb0140","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/76109","article-title":"Mutations in ABCC6 cause pseudoxanthoma elasticum","volume":"25","author":"Bergen","year":"2000","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.bone.2020.115656_bb0145","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/76102","article-title":"Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum","volume":"25","author":"Le Saux","year":"2000","journal-title":"Nat. Genet."},{"issue":"11","key":"10.1016\/j.bone.2020.115656_bb0150","doi-asserted-by":"crossref","first-page":"6001","DOI":"10.1073\/pnas.100041297","article-title":"Pseudoxanthoma elasticum: mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter","volume":"97","author":"Ringpfeil","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"50","key":"10.1016\/j.bone.2020.115656_bb0155","doi-asserted-by":"crossref","first-page":"20206","DOI":"10.1073\/pnas.1319582110","article-title":"ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release","volume":"110","author":"Jansen","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.bone.2020.115656_bb0160","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1161\/ATVBAHA.114.304017","article-title":"ABCC6-mediated ATP secretion by the liver is the main source of the mineralization inhibitor inorganic pyrophosphate in the systemic circulation-brief report","volume":"34","author":"Jansen","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bone.2020.115656_bb0165","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.bone.2017.06.017","article-title":"Early arterial calcification does not correlate with bone loss in pseudoxanthoma elasticum","volume":"103","author":"Martin","year":"2017","journal-title":"Bone."},{"key":"10.1016\/j.bone.2020.115656_bb0170","article-title":"Human heterozygous ENPP1 deficiency is associated with early onset osteoporosis, a phenotype recapitulated in a mouse model of Enpp1 deficiency","author":"Oheim","year":"2019","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2020.115656_bb0175","author":"Andrews"},{"issue":"D1","key":"10.1016\/j.bone.2020.115656_bb0180","doi-asserted-by":"crossref","first-page":"D754","DOI":"10.1093\/nar\/gkx1098","article-title":"Ensembl 2018","volume":"46","author":"Zerbino","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.bone.2020.115656_bb0185","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"issue":"15","key":"10.1016\/j.bone.2020.115656_bb0190","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"issue":"12","key":"10.1016\/j.bone.2020.115656_bb0195","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"issue":"W1","key":"10.1016\/j.bone.2020.115656_bb0200","doi-asserted-by":"crossref","first-page":"W83","DOI":"10.1093\/nar\/gkw199","article-title":"g:Profiler-a web server for functional interpretation of gene lists (2016 update)","volume":"44","author":"Reimand","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.bone.2020.115656_bb0205","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B Methodol."},{"issue":"1\u20132","key":"10.1016\/j.bone.2020.115656_bb0210","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0166-4328(01)00297-2","article-title":"Controlling the false discovery rate in behavior genetics research","volume":"125","author":"Benjamini","year":"2001","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bone.2020.115656_bb0215","author":"Butts"},{"issue":"5","key":"10.1016\/j.bone.2020.115656_bb0220","doi-asserted-by":"crossref","first-page":"3819","DOI":"10.1002\/jcb.26332","article-title":"The participation of fibroblast growth factor 23 (FGF23) in the progression of osteoporosis via JAK\/STAT pathway","volume":"119","author":"Xu","year":"2018","journal-title":"J. Cell. Biochem."},{"issue":"3","key":"10.1016\/j.bone.2020.115656_bb0225","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.maturitas.2014.04.013","article-title":"Wnt signaling and osteoporosis","volume":"78","author":"Manolagas","year":"2014","journal-title":"Maturitas"},{"issue":"6","key":"10.1016\/j.bone.2020.115656_bb0230","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1210\/jcem.87.6.8621","article-title":"Genetic control of susceptibility to osteoporosis","volume":"87","author":"Ralston","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"21","key":"10.1016\/j.bone.2020.115656_bb0235","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.2174\/1381612043383773","article-title":"Growth factors and bone formation in osteoporosis: roles for fibroblast growth factor and transforming growth factor beta","volume":"10","author":"Fromigue","year":"2004","journal-title":"Curr. Pharm. Des."},{"issue":"2","key":"10.1016\/j.bone.2020.115656_bb0240","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s11914-012-0103-6","article-title":"Effects of bone matrix proteins on fracture and fragility in osteoporosis","volume":"10","author":"Sroga","year":"2012","journal-title":"Curr Osteoporos Rep."},{"issue":"1","key":"10.1016\/j.bone.2020.115656_bb0245","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.bone.2008.03.020","article-title":"Matrix metalloproteinases and bone","volume":"43","author":"Krane","year":"2008","journal-title":"Bone."},{"issue":"5","key":"10.1016\/j.bone.2020.115656_bb0250","article-title":"Hedgehog signaling regulates osteoblast differentiation in zebrafish larvae through modulation of autophagy","volume":"8","author":"Hu","year":"2019","journal-title":"Biol Open"},{"issue":"5","key":"10.1016\/j.bone.2020.115656_bb0255","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.tem.2016.03.006","article-title":"Osteoporosis and bone mass disorders: from gene pathways to treatments","volume":"27","author":"Rivadeneira","year":"2016","journal-title":"Trends Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.bone.2020.115656_bb0260","doi-asserted-by":"crossref","first-page":"267","DOI":"10.4184\/asj.2011.5.4.267","article-title":"Ossification of the posterior longitudinal ligament: a review of literature","volume":"5","author":"Choi","year":"2011","journal-title":"Asian Spine J."},{"issue":"8","key":"10.1016\/j.bone.2020.115656_bb0265","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1096\/fj.10-177816","article-title":"Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling","volume":"25","author":"Martin","year":"2011","journal-title":"FASEB J."},{"issue":"Suppl","key":"10.1016\/j.bone.2020.115656_bb0270","first-page":"157","article-title":"A new breed of mouse showing multiple osteochondral lesions\u2014twy mouse","volume":"21","author":"Hosoda","year":"1981","journal-title":"Ryumachi."},{"issue":"3","key":"10.1016\/j.bone.2020.115656_bb0275","doi-asserted-by":"crossref","DOI":"10.3171\/2010.12.FOCUS10271","article-title":"Ossification of the posterior longitudinal ligament: genetics and pathophysiology","volume":"30","author":"Stapleton","year":"2011","journal-title":"Neurosurg. Focus."},{"issue":"5","key":"10.1016\/j.bone.2020.115656_bb0280","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/s002239900455","article-title":"Regional variations in the progression of bone loss in two different mouse osteopenia models","volume":"62","author":"Kobayashi","year":"1998","journal-title":"Calcif. Tissue Int."},{"issue":"3","key":"10.1016\/j.bone.2020.115656_bb0285","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s002239900610","article-title":"Calcitonin simultaneously regulates both periosteal hyperostosis and trabecular osteopenia in the spinal hyperostotic mouse (twy\/twy) in vivo","volume":"64","author":"Okawa","year":"1999","journal-title":"Calcif. Tissue Int."},{"issue":"9","key":"10.1016\/j.bone.2020.115656_bb0290","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1359\/jbmr.090417","article-title":"New variants in the Enpp1 and Ptpn6 genes cause low BMD, crystal-related arthropathy, and vascular calcification","volume":"24","author":"Babij","year":"2009","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.bone.2020.115656_bb0295","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032177","article-title":"Altered bone development and an increase in FGF-23 expression in Enpp1(\u2212\/\u2212) mice","volume":"7","author":"Mackenzie","year":"2012","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.bone.2020.115656_bb0300","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1002\/jbmr.118","article-title":"Wnt10b deficiency results in age-dependent loss of bone mass and progressive reduction of mesenchymal progenitor cells","volume":"25","author":"Stevens","year":"2010","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.bone.2020.115656_bb0305","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1530\/JOE-18-0020","article-title":"Inducible Wnt16 inactivation: WNT16 regulates cortical bone thickness in adult mice","volume":"237","author":"Ohlsson","year":"2018","journal-title":"J. Endocrinol."},{"issue":"4","key":"10.1016\/j.bone.2020.115656_bb0315","doi-asserted-by":"crossref","first-page":"342","DOI":"10.4062\/biomolther.2019.043","article-title":"Molecular pathophysiology of Ossification of the Posterior Longitudinal Ligament (OPLL)","volume":"27","author":"Nam","year":"2019","journal-title":"Biomol Ther (Seoul)"},{"issue":"5","key":"10.1016\/j.bone.2020.115656_bb0320","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1177\/2192568218801015","article-title":"Increase of the serum FGF-23 in ossification of the posterior longitudinal ligament","volume":"9","author":"Kawaguchi","year":"2019","journal-title":"Global Spine J."},{"issue":"5","key":"10.1016\/j.bone.2020.115656_bb0325","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0174881","article-title":"Serum biomarkers in patients with ossification of the posterior longitudinal ligament (OPLL): inflammation in OPLL","volume":"12","author":"Kawaguchi","year":"2017","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.bone.2020.115656_bb0335","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1007\/s00198-019-04996-7","article-title":"High FGF23 levels are associated with impaired trabecular bone microarchitecture in patients with osteoporosis","volume":"30","author":"Rupp","year":"2019","journal-title":"Osteoporos. Int."},{"issue":"24","key":"10.1016\/j.bone.2020.115656_bb0340","doi-asserted-by":"crossref","first-page":"798","DOI":"10.21037\/atm.2019.12.73","article-title":"Plasma inorganic pyrophosphate and alkaline phosphatase in patients with pseudoxanthoma elasticum","volume":"7","author":"Sanchez-Tevar","year":"2019","journal-title":"Ann Transl Med."},{"issue":"1","key":"10.1016\/j.bone.2020.115656_bb0345","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/ndt\/gfp362","article-title":"Plasma pyrophosphate and vascular calcification in chronic kidney disease","volume":"25","author":"O\u2019Neill","year":"2010","journal-title":"Nephrol. Dial. Transplant."},{"issue":"1","key":"10.1016\/j.bone.2020.115656_bb0350","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.kint.2016.01.024","article-title":"Direct inhibition of osteoblastic Wnt pathway by fibroblast growth factor 23 contributes to bone loss in chronic kidney disease","volume":"90","author":"Carrillo-Lopez","year":"2016","journal-title":"Kidney Int."},{"key":"10.1016\/j.bone.2020.115656_bb0355","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.yjmcc.2019.07.008","article-title":"Wnt1 inhibits vascular smooth muscle cell calcification by promoting ANKH expression","volume":"135","author":"Chen","year":"2019","journal-title":"J. Mol. Cell. Cardiol."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328220304361?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328220304361?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:49:10Z","timestamp":1757612950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328220304361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":69,"alternative-id":["S8756328220304361"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2020.115656","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic pathways disrupted by ENPP1 deficiency provide insight into mechanisms of osteoporosis, osteomalacia, and paradoxical mineralization","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2020.115656","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115656"}}