{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:10:12Z","timestamp":1778944212559,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R03 DE019190"],"award-info":[{"award-number":["R03 DE019190"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["T32 AR007505"],"award-info":[{"award-number":["T32 AR007505"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR068361"],"award-info":[{"award-number":["R01 AR068361"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR7505-30"],"award-info":[{"award-number":["AR7505-30"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.bone.2020.115733","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T23:39:58Z","timestamp":1604446798000},"page":"115733","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["The master developmental regulator Jab1\/Cops5\/Csn5 is essential for proper bone growth and survival in mice"],"prefix":"10.1016","volume":"143","author":[{"given":"William E.","family":"Samsa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murali K.","family":"Mamidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan S.","family":"Hausman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay A.","family":"Bashur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward M.","family":"Greenfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bone.2020.115733_bb0005","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1177\/0004563218759371","article-title":"The bone remodelling cycle","volume":"55","author":"Kenkre","year":"2018","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.bone.2020.115733_bb0010","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bone.2018.05.017","article-title":"The hematopoietic stem cell niche: what's so special about bone?","volume":"119","author":"Frisch","year":"2019","journal-title":"Bone."},{"issue":"4","key":"10.1016\/j.bone.2020.115733_bb0015","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrendo.2016.12","article-title":"BMP signalling in skeletal development, disease and repair","volume":"12","author":"Salazar","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"issue":"570","key":"10.1016\/j.bone.2020.115733_bb0020","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aav5183","article-title":"Specificity, versatility, and control of TGF-beta family signaling","volume":"12","author":"Derynck","year":"2019","journal-title":"Sci. Signal."},{"issue":"6","key":"10.1016\/j.bone.2020.115733_bb0025","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1002\/jcp.25696","article-title":"Roles of multifunctional COP9 signalosome complex in cell fate and implications for drug discovery","volume":"232","author":"Li","year":"2017","journal-title":"J. Cell. Physiol."},{"issue":"11","key":"10.1016\/j.bone.2020.115733_bb0030","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1111\/j.1365-2443.2009.01349.x","article-title":"Mammalian COP9 signalosome","volume":"14","author":"Kato","year":"2009","journal-title":"Genes Cells"},{"key":"10.1016\/j.bone.2020.115733_bb0035","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3389\/fphar.2018.00135","article-title":"Jab1\/COPS5 as a novel biomarker for diagnosis, prognosis, therapy prediction and therapeutic tools for human cancer","volume":"9","author":"Liu","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"6599","key":"10.1016\/j.bone.2020.115733_bb0040","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/383453a0","article-title":"A new group of conserved coactivators that increase the specificity of AP-1 transcription factors","volume":"383","author":"Claret","year":"1996","journal-title":"Nature."},{"issue":"25","key":"10.1016\/j.bone.2020.115733_bb0045","doi-asserted-by":"crossref","first-page":"17457","DOI":"10.1074\/jbc.M601857200","article-title":"Jab1 induces the cytoplasmic localization and degradation of p53 in coordination with Hdm2","volume":"281","author":"Oh","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bone.2020.115733_bb0050","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1074\/jbc.C100442200","article-title":"Jab1 interacts directly with HIF-1alpha and regulates its stability","volume":"277","author":"Bae","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bone.2020.115733_bb0055","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/embo-reports\/kvf024","article-title":"Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation","volume":"3","author":"Wan","year":"2002","journal-title":"EMBO Rep."},{"issue":"6","key":"10.1016\/j.bone.2020.115733_bb0060","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1128\/MCB.24.6.2251-2262.2004","article-title":"Jab1\/CSN5, a component of the COP9 signalosome, regulates transforming growth factor beta signaling by binding to Smad7 and promoting its degradation","volume":"24","author":"Kim","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bone.2020.115733_bb0065","article-title":"Signaling pathways regulating cartilage growth plate formation and activity","author":"Samsa","year":"2016","journal-title":"Semin. Cell Dev. Biol."},{"issue":"Pt 1","key":"10.1016\/j.bone.2020.115733_bb0070","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1242\/jcs.113795","article-title":"The transcriptional co-regulator Jab1 is crucial for chondrocyte differentiation in vivo","volume":"126","author":"Chen","year":"2013","journal-title":"J. Cell Sci."},{"issue":"11","key":"10.1016\/j.bone.2020.115733_bb0075","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1002\/jcp.24602","article-title":"Loss of jab1 in osteochondral progenitor cells severely impairs embryonic limb development in mice","volume":"229","author":"Bashur","year":"2014","journal-title":"J. Cell. Physiol."},{"issue":"16","key":"10.1016\/j.bone.2020.115733_bb0080","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1242\/dev.02480","article-title":"Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors","volume":"133","author":"Rodda","year":"2006","journal-title":"Development."},{"issue":"2","key":"10.1016\/j.bone.2020.115733_bb0085","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1084\/jem.20070725","article-title":"Targeted inactivation of the COP9 signalosome impairs multiple stages of T cell development","volume":"205","author":"Panattoni","year":"2008","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.bone.2020.115733_bb0090","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/5007","article-title":"Generalized lacZ expression with the ROSA26 Cre reporter strain","volume":"21","author":"Soriano","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bone.2020.115733_bb0095","doi-asserted-by":"crossref","DOI":"10.1038\/s41388-020-1320-6","article-title":"The crucial p53-dependent oncogenic role of JAB1 in osteosarcoma in vivo","author":"Samsa","year":"2020","journal-title":"Oncogene"},{"issue":"50","key":"10.1016\/j.bone.2020.115733_bb0100","doi-asserted-by":"crossref","first-page":"19004","DOI":"10.1073\/pnas.0605170103","article-title":"Dominance of SOX9 function over RUNX2 during skeletogenesis","volume":"103","author":"Zhou","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.bone.2020.115733_bb0105","first-page":"1056","article-title":"Targeted and sustained Sox9 expression in mouse hypertrophic chondrocytes causes severe and spontaneous osteoarthritis by perturbing cartilage homeostasis","volume":"12","author":"Liang","year":"2020","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.bone.2020.115733_bb0110","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1242\/jcs.108.12.3677","article-title":"A 182 bp fragment of the mouse pro alpha 1(II) collagen gene is sufficient to direct chondrocyte expression in transgenic mice","volume":"108","author":"Zhou","year":"1995","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bone.2020.115733_bb0115","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.bone.2016.01.006","article-title":"Deficiency of circadian clock protein BMAL1 in mice results in a low bone mass phenotype","volume":"84","author":"Samsa","year":"2016","journal-title":"Bone."},{"issue":"2","key":"10.1016\/j.bone.2020.115733_bb0120","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s00223-011-9550-9","article-title":"Ectopic expression of SOX9 in osteoblasts alters bone mechanical properties","volume":"90","author":"Liang","year":"2012","journal-title":"Calcif. Tissue Int."},{"issue":"9","key":"10.1016\/j.bone.2020.115733_bb0125","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/0021-9290(96)00020-6","article-title":"Calcium buffering is required to maintain bone stiffness in saline solution","volume":"29","author":"Gustafson","year":"1996","journal-title":"J. Biomech."},{"key":"10.1016\/j.bone.2020.115733_bb0130","doi-asserted-by":"crossref","DOI":"10.1364\/JOSAA.1.000612","article-title":"Practical cone-beam algorithm","author":"Feldkamp","year":"1984","journal-title":"J. Opt. Soc. Am. A"},{"issue":"4","key":"10.1016\/j.bone.2020.115733_bb0135","first-page":"225","article-title":"Fast cone-beam CT image reconstruction using GPU hardware","volume":"16","author":"Yan","year":"2008","journal-title":"J. X-ray Sci. Technol."},{"issue":"7","key":"10.1016\/j.bone.2020.115733_bb0140","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro-computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2020.115733_bb0145","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.actbio.2015.03.027","article-title":"Long bone maturation is driven by pore closing: a quantitative tomography investigation of structural formation in young C57BL\/6 mice","volume":"22","author":"Bortel","year":"2015","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.bone.2020.115733_bb0150","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11248-014-9828-6","article-title":"Skeletal defects in Osterix-Cre transgenic mice","volume":"24","author":"Huang","year":"2015","journal-title":"Transgenic Res."},{"issue":"1","key":"10.1016\/j.bone.2020.115733_bb0155","doi-asserted-by":"crossref","first-page":"e85161","DOI":"10.1371\/journal.pone.0085161","article-title":"Osx-Cre targets multiple cell types besides osteoblast lineage in postnatal mice","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.bone.2020.115733_bb0160","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s11248-011-9581-z","article-title":"Decreased body weight in young Osterix-Cre transgenic mice results in delayed cortical bone expansion and accrual","volume":"21","author":"Davey","year":"2012","journal-title":"Transgenic Res."},{"issue":"2","key":"10.1016\/j.bone.2020.115733_bb0165","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00223-014-9945-5","article-title":"Osterix-Cre transgene causes craniofacial bone development defect","volume":"96","author":"Wang","year":"2015","journal-title":"Calcif. Tissue Int."},{"issue":"22","key":"10.1016\/j.bone.2020.115733_bb0170","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1182\/blood.2019000530","article-title":"Asrij\/OCIAD1 suppresses CSN5-mediated p53 degradation and maintains mouse hematopoietic stem cell quiescence","volume":"133","author":"Sinha","year":"2019","journal-title":"Blood."},{"issue":"43","key":"10.1016\/j.bone.2020.115733_bb0175","doi-asserted-by":"crossref","first-page":"29011","DOI":"10.1074\/jbc.M804539200","article-title":"Stable form of JAB1 enhances proliferation and maintenance of hematopoietic progenitors","volume":"283","author":"Mori","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bone.2020.115733_bb0180","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1083\/jcb.96.1.191","article-title":"In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria","volume":"96","author":"Sudo","year":"1983","journal-title":"J. Cell Biol."},{"issue":"7","key":"10.1016\/j.bone.2020.115733_bb0185","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/cdd.2015.168","article-title":"Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?","volume":"23","author":"Chen","year":"2016","journal-title":"Cell Death Differ."},{"issue":"2","key":"10.1016\/j.bone.2020.115733_bb0190","first-page":"168","article-title":"Molecular mechanism of Runx2-dependent bone development","volume":"43","author":"Komori","year":"2020","journal-title":"Mol. Cells."},{"issue":"1\u20132","key":"10.1016\/j.bone.2020.115733_bb0195","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s11010-013-1823-3","article-title":"Characterization of a unique motif in LIM mineralization protein-1 that interacts with jun activation-domain-binding protein 1","volume":"385","author":"Sangadala","year":"2014","journal-title":"Mol. Cell. Biochem."},{"issue":"5","key":"10.1016\/j.bone.2020.115733_bb0200","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.bbadis.2013.01.015","article-title":"X-linked intellectual disability gene CUL4B targets Jab1\/CSN5 for degradation and regulates bone morphogenetic protein signaling","volume":"1832","author":"He","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"8","key":"10.1016\/j.bone.2020.115733_bb0205","first-page":"9279","article-title":"Reverse correlation of Jab1 and Smad4 in PANC-1 cells involved in the pathogenesis of pancreatic cancer","volume":"8","author":"Li","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"1","key":"10.1016\/j.bone.2020.115733_bb0210","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.stemcr.2019.05.017","article-title":"TGF-beta signaling plays an essential role in the lineage specification of mesenchymal stem\/progenitor cells in fetal bone marrow","volume":"13","author":"Abou-Ezzi","year":"2019","journal-title":"Stem Cell Rep."},{"issue":"12","key":"10.1016\/j.bone.2020.115733_bb0215","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1002\/art.22261","article-title":"Jun activation domain-binding protein 1 binds Smad5 and inhibits bone morphogenetic protein signaling","volume":"54","author":"Haag","year":"2006","journal-title":"Arthritis Rheum."},{"issue":"9","key":"10.1016\/j.bone.2020.115733_bb0220","doi-asserted-by":"crossref","DOI":"10.3390\/cells8090969","article-title":"TGFbeta\/BMP signaling pathway in cartilage homeostasis","volume":"8","author":"Thielen","year":"2019","journal-title":"Cells."},{"issue":"2","key":"10.1016\/j.bone.2020.115733_bb0225","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.bone.2011.06.030","article-title":"New factors controlling the balance between osteoblastogenesis and adipogenesis","volume":"50","author":"Abdallah","year":"2012","journal-title":"Bone."},{"issue":"8","key":"10.1016\/j.bone.2020.115733_bb0230","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/onc.2016.271","article-title":"Stat3 contributes to cancer progression by regulating Jab1\/Csn5 expression","volume":"36","author":"Pan","year":"2017","journal-title":"Oncogene."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328220305214?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328220305214?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T14:14:08Z","timestamp":1778940848000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328220305214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":46,"alternative-id":["S8756328220305214"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2020.115733","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The master developmental regulator Jab1\/Cops5\/Csn5 is essential for proper bone growth and survival in mice","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2020.115733","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115733"}}