{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T17:08:48Z","timestamp":1758042528189,"version":"3.44.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.bone.2020.115767","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T19:18:57Z","timestamp":1605986337000},"page":"115767","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Vitamin D supplementation improves bone mineralisation independent of dietary phosphate in male X-linked hypophosphatemic (Hyp) mice"],"prefix":"10.1016","volume":"143","author":[{"given":"Kate R.","family":"Barratt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca K.","family":"Sawyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald J.","family":"Atkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rene","family":"St-Arnaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul H.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.bone.2020.115767_bb0005","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1210\/en.2003-0255","article-title":"Disordered regulation of renal 25-hydroxyvitamin D-1alpha-hydroxylase gene expression by phosphorus in X-linked hypophosphatemic (hyp) mice","volume":"144","author":"Azam","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2020.115767_bb0010","doi-asserted-by":"crossref","first-page":"496514","DOI":"10.1186\/1687-9856-2009-496514","article-title":"Fibroblast growth factor 23 (FGF23) and disorders of phosphate metabolism","volume":"2009","author":"Saito","year":"2009","journal-title":"Int. J. Pediatr. Endocrinol."},{"issue":"1","key":"10.1016\/j.bone.2020.115767_bb0015","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s12018-014-9155-8","article-title":"Osteocyte communication with the kidney via the production of FGF23: remote control of phosphate homeostasis","volume":"12","author":"Ito","year":"2014","journal-title":"Clin. Rev. Bone Min. Metab."},{"issue":"4","key":"10.1016\/j.bone.2020.115767_bb0020","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1590\/S0004-27302006000400025","article-title":"Hypophosphatemic rickets and osteomalacia","volume":"50","author":"De Menezes Filho","year":"2006","journal-title":"Arq. Bras. Endocrinol. Metabol."},{"issue":"8","key":"10.1016\/j.bone.2020.115767_bb0025","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1210\/jc.2003-030036","article-title":"Early treatment improves growth and biochemical and radiographic outcome in X-linked hypophosphatemic rickets","volume":"88","author":"Makitie","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.bone.2020.115767_bb0030","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/jbmr.2783","article-title":"1,25-Dihydroxyvitamin D alone improves skeletal growth, microarchitecture, and strength in a murine model of XLH, despite enhanced FGF23 expression","volume":"31","author":"Liu","year":"2016","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2020.115767_bb0035","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/BF02411227","article-title":"Bone response to phosphate and vitamin D metabolites in the hypophosphatemic mouse model","volume":"34","author":"Marie","year":"1982","journal-title":"Calcif. Tissue Int."},{"issue":"6","key":"10.1016\/j.bone.2020.115767_bb0040","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1111\/jpc.14941","article-title":"Global consensus on nutritional rickets: implications for Australia","volume":"56","author":"Siafarikas","year":"2020","journal-title":"J. Paediatr. Child Health"},{"key":"10.1016\/j.bone.2020.115767_bb0045","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bonr.2017.02.001","article-title":"High dose dietary vitamin D3 increases bone mass and strength in mice","volume":"6","author":"Williamson","year":"2017","journal-title":"Bone Rep."},{"issue":"6","key":"10.1016\/j.bone.2020.115767_bb0050","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1023\/A:1020884312053","article-title":"Food intake, water intake, and drinking spout side preference of 28 mouse strains","volume":"32","author":"Bachmanov","year":"2002","journal-title":"Behav. Genet."},{"issue":"3\u20135","key":"10.1016\/j.bone.2020.115767_bb0055","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.jsbmb.2006.12.086","article-title":"25-Hydroxyvitamin D requirement for maintaining skeletal health utilising a Sprague-Dawley rat model","volume":"103","author":"Anderson","year":"2007","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"11","key":"10.1016\/j.bone.2020.115767_bb0060","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1359\/jbmr.080616","article-title":"Vitamin D depletion induces RANKL-mediated osteoclastogenesis and bone loss in a rodent model","volume":"23","author":"Anderson","year":"2008","journal-title":"J. Bone Miner. Res."},{"issue":"12","key":"10.1016\/j.bone.2020.115767_bb0065","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1093\/jn\/137.12.2608","article-title":"High dietary vitamin D prevents hypocalcemia and osteomalacia in CYP27B1 knockout mice","volume":"137","author":"Rowling","year":"2007","journal-title":"J. Nutr."},{"issue":"2","key":"10.1016\/j.bone.2020.115767_bb0070","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1172\/JCI81928","article-title":"CYP24 inhibition as a therapeutic target in FGF23-mediated renal phosphate wasting disorders","volume":"126","author":"Bai","year":"2016","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.bone.2020.115767_bb0075","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1210\/endo.134.4.8137741","article-title":"Increased renal 25-hydroxyvitamin D3-24-hydroxylase messenger ribonucleic acid and immunoreactive protein in phosphate-deprived Hyp mice: a mechanism for accelerated 1,25-dihydroxyvitamin D3 catabolism in X-linked hypophosphatemic rickets","volume":"134","author":"Roy","year":"1994","journal-title":"Endocrinology"},{"issue":"11","key":"10.1016\/j.bone.2020.115767_bb0080","doi-asserted-by":"crossref","first-page":"5269","DOI":"10.1210\/en.2004-0233","article-title":"Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders","volume":"145","author":"Bai","year":"2004","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.bone.2020.115767_bb0085","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1111\/j.1523-1755.2005.00506.x","article-title":"Effect of fibroblast growth factor-23 on phosphate transport in proximal tubules","volume":"68","author":"Baum","year":"2005","journal-title":"Kidney Int."},{"issue":"7","key":"10.1016\/j.bone.2020.115767_bb0090","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1210\/en.2003-1768","article-title":"Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis","volume":"145","author":"Larsson","year":"2004","journal-title":"Endocrinology"},{"issue":"Pt 1","key":"10.1016\/j.bone.2020.115767_bb0095","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1042\/BJ20041799","article-title":"Role of the vitamin D receptor in FGF23 action on phosphate metabolism","volume":"390","author":"Inoue","year":"2005","journal-title":"Biochem. J."},{"issue":"5","key":"10.1016\/j.bone.2020.115767_bb0100","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s00424-003-1084-1","article-title":"Effect of hydrolysis-resistant FGF23-R179Q on dietary phosphate regulation of the renal type-II Na\/Pi transporter","volume":"446","author":"Segawa","year":"2003","journal-title":"Pflugers Arch."},{"issue":"3","key":"10.1016\/j.bone.2020.115767_bb0105","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1359\/JBMR.0301264","article-title":"FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis","volume":"19","author":"Shimada","year":"2004","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.bone.2020.115767_bb0110","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.bbrc.2003.12.102","article-title":"FGF-23 transgenic mice demonstrate hypophosphatemic rickets with reduced expression of sodium phosphate cotransporter type IIa","volume":"314","author":"Shimada","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bone.2020.115767_bb0115","doi-asserted-by":"crossref","first-page":"113139","DOI":"10.1016\/j.jpba.2020.113139","article-title":"Active vitamin D and vitamin D analogs stimulate fibroblast growth factor 23 production in osteocyte-like cells via the vitamin D receptor","volume":"182","author":"Yashiro","year":"2020","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"6","key":"10.1016\/j.bone.2020.115767_bb0125","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/j.bone.2007.02.024","article-title":"Metabolism of vitamin D3 in human osteoblasts: evidence for autocrine and paracrine activities of 1 alpha,25-dihydroxyvitamin D3","volume":"40","author":"Atkins","year":"2007","journal-title":"Bone"},{"issue":"3\u20135","key":"10.1016\/j.bone.2020.115767_bb0130","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.jsbmb.2006.12.084","article-title":"RNAi-mediated silencing of CYP27B1 abolishes 1,25(OH)2D3 synthesis and reduces osteocalcin and CYP24 mRNA expression in human osteosarcoma (HOS) cells","volume":"103","author":"Anderson","year":"2007","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.bone.2020.115767_bb0135","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.mce.2011.05.024","article-title":"Vitamin D metabolism within bone cells: effects on bone structure and strength","volume":"347","author":"Anderson","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.bone.2020.115767_bb0140","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jsbmb.2010.03.021","article-title":"Bone CYP27B1 gene expression is increased with high dietary calcium and in mineralising osteoblasts","volume":"121","author":"Anderson","year":"2010","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.bone.2020.115767_bb0145","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.bone.2019.07.026","article-title":"Vitamin D sterols increase FGF23 expression by stimulating osteoblast and osteocyte maturation in CKD bone","volume":"127","author":"Pereira","year":"2019","journal-title":"Bone"},{"key":"10.1016\/j.bone.2020.115767_bb0155","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jsbmb.2018.07.012","article-title":"Generation of 1,25-dihydroxyvitamin D3 in Cyp27b1 knockout mice by treatment with 25-hydroxyvitamin D3 rescued their rachitic phenotypes","volume":"185","author":"Nishikawa","year":"2019","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.bone.2020.115767_bb0160","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.bone.2017.06.019","article-title":"Comparison of calcimimetic R568 and calcitriol in mineral homeostasis in the Hyp mouse, a murine homolog of X-linked hypophosphatemia","volume":"103","author":"Leifheit-Nestler","year":"2017","journal-title":"Bone"},{"key":"10.1016\/j.bone.2020.115767_bb0170","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jsbmb.2013.10.003","article-title":"The local production of 1,25(OH)2D3 promotes osteoblast and osteocyte maturation","volume":"144","author":"Turner","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"8","key":"10.1016\/j.bone.2020.115767_bb0175","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1172\/JCI98093","article-title":"Optimal bone fracture repair requires 24R,25-dihydroxyvitamin D3 and its effector molecule FAM57B2","volume":"128","author":"Martineau","year":"2018","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.bone.2020.115767_bb0180","first-page":"2382","article-title":"24,25 Dihydroxyvitamin D supplementation corrects hyperparathyroidism and improves skeletal abnormalities in X-linked hypophosphatemic rickets-a clinical research centre study","volume":"81","author":"Carpenter","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.bone.2020.115767_bb0185","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/jcb.22111","article-title":"Inorganic phosphate modulates responsiveness to 24,25(OH)2D3 in chondrogenic ATDC5 cells","volume":"107","author":"Denison","year":"2009","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.bone.2020.115767_bb0190","doi-asserted-by":"crossref","first-page":"R13","DOI":"10.1530\/EC-13-0103","article-title":"Therapeutic management of hypophosphatemic rickets from infancy to adulthood","volume":"3","author":"Linglart","year":"2014","journal-title":"Endocr. Connect."},{"issue":"3","key":"10.1016\/j.bone.2020.115767_bb0195","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1172\/JCI110110","article-title":"Healing of rickets with phosphate supplementation in the hypophosphatemic male mouse","volume":"67","author":"Marie","year":"1981","journal-title":"J. Clin. Invest."},{"issue":"11","key":"10.1016\/j.bone.2020.115767_bb9000","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.3390\/jcm8111988","article-title":"Elevated serum 25-hydroxyvitamin D levels are associated with improved bone formation and micro-structural measures in elderly hip fracture patients","volume":"8","author":"Sharma","year":"2019","journal-title":"J. Clin. Med."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632822030555X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632822030555X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:52:40Z","timestamp":1757613160000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S875632822030555X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":37,"alternative-id":["S875632822030555X"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2020.115767","relation":{},"ISSN":["8756-3282"],"issn-type":[{"type":"print","value":"8756-3282"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin D supplementation improves bone mineralisation independent of dietary phosphate in male X-linked hypophosphatemic (Hyp) mice","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2020.115767","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115767"}}