{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:56:43Z","timestamp":1773212203825,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005689","name":"G\u00f6teborgs L\u00e4kares\u00e4llskap","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005689","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006636","name":"Forskningsr\u00e5det om H\u00e4lsa, Arbetsliv och V\u00e4lf\u00e4rd","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006636","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.bone.2020.115768","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T19:19:01Z","timestamp":1605986341000},"page":"115768","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Low-level cadmium exposure is associated with decreased cortical thickness, cortical area and trabecular bone volume fraction in elderly men: The MrOS Sweden study"],"prefix":"10.1016","volume":"143","author":[{"given":"Maria","family":"Wallin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Barregard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerd","family":"Sallsten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Lundh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Sundh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattias","family":"Lorentzon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claes","family":"Ohlsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Mellstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bone.2020.115768_bb0005","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1359\/jbmr.2000.15.2.322","article-title":"Osteoporosis in elderly men and women: effects of dietary calcium, physical activity, and body mass index","volume":"15","author":"Nguyen","year":"2000","journal-title":"J. Bone Miner. Res."},{"issue":"9156","key":"10.1016\/j.bone.2020.115768_bb0010","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/S0140-6736(98)09075-8","article-title":"Mortality after all major types of osteoporotic fracture in men and women: an observational study","volume":"353","author":"Center","year":"1999","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.bone.2020.115768_bb0015","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.bone.2007.11.001","article-title":"A reference standard for the description of osteoporosis","volume":"42","author":"Kanis","year":"2008","journal-title":"Bone."},{"issue":"1","key":"10.1016\/j.bone.2020.115768_bb0020","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s40279-013-0100-7","article-title":"Bone quality: the determinants of bone strength and fragility","volume":"44","author":"Fonseca","year":"2014","journal-title":"Sports Med."},{"issue":"1","key":"10.1016\/j.bone.2020.115768_bb0025","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S2213-8587(18)30308-5","article-title":"Cortical and trabecular bone microarchitecture as an independent predictor of incident fracture risk in older women and men in the Bone Microarchitecture International Consortium (BoMIC): a prospective study","volume":"7","author":"Samelson","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"2","key":"10.1016\/j.bone.2020.115768_bb0030","first-page":"516","article-title":"Cortical bone area predicts incident fractures independently of areal bone mineral density in older men","volume":"102","author":"Ohlsson","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"9","key":"10.1016\/j.bone.2020.115768_bb0035","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1002\/jbmr.2509","article-title":"Increased cortical porosity in older men with fracture","volume":"30","author":"Sundh","year":"2015","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2020.115768_bb0040","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.2903\/j.efsa.2012.2551","article-title":"Cadmium dietary exposure in the European population","volume":"10","author":"EFSA","year":"2012","journal-title":"EFSA J."},{"issue":"Suppl. 1","key":"10.1016\/j.bone.2020.115768_bb0045","first-page":"1","article-title":"Health effects of cadmium exposure\u2014a review of the literature and a risk estimate","volume":"24","author":"Jarup","year":"1998","journal-title":"Scand. J. Work Environ. Health"},{"key":"10.1016\/j.bone.2020.115768_bb0050","series-title":"Handbook on the Toxicology of Metals","first-page":"667","article-title":"Cadmium","volume":"2","author":"Nordberg","year":"2015"},{"issue":"6","key":"10.1016\/j.bone.2020.115768_bb0055","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1289\/ehp.8763","article-title":"Cadmium-induced effects on bone in a population-based study of women","volume":"114","author":"Akesson","year":"2006","journal-title":"Environ. Health Perspect."},{"issue":"5","key":"10.1016\/j.bone.2020.115768_bb0060","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.ijheh.2015.03.010","article-title":"Investigation of the relationship between low environmental exposure to metals and bone mineral density, bone resorption and renal function","volume":"218","author":"Callan","year":"2015","journal-title":"Int. J. Hyg. Environ. Health"},{"issue":"1","key":"10.1016\/j.bone.2020.115768_bb0065","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s12011-013-9862-x","article-title":"Do cadmium, lead, and aluminum in drinking water increase the risk of hip fractures? A NOREPOS study","volume":"157","author":"Dahl","year":"2014","journal-title":"Biol. Trace Elem. Res."},{"issue":"3","key":"10.1016\/j.bone.2020.115768_bb0070","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/jbmr.224","article-title":"Long-term cadmium exposure and the association with bone mineral density and fractures in a population-based study among women","volume":"26","author":"Engstrom","year":"2011","journal-title":"J. Bone Miner. Res."},{"issue":"6","key":"10.1016\/j.bone.2020.115768_bb0075","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.bone.2012.03.018","article-title":"Associations between dietary cadmium exposure and bone mineral density and risk of osteoporosis and fractures among women","volume":"50","author":"Engstrom","year":"2012","journal-title":"Bone."},{"issue":"10","key":"10.1016\/j.bone.2020.115768_bb0080","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1289\/ehp.11452","article-title":"Urinary cadmium and osteoporosis in U.S. women \u226550 years of age: NHANES 1988-1994 and 1999-2004","volume":"116","author":"Gallagher","year":"2008","journal-title":"Environ. Health Perspect."},{"issue":"5","key":"10.1016\/j.bone.2020.115768_bb0085","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s00038-013-0488-8","article-title":"Environmental cadmium exposure and osteoporosis: a review","volume":"58","author":"James","year":"2013","journal-title":"Int. J. Public Health"},{"issue":"2","key":"10.1016\/j.bone.2020.115768_bb0090","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00223-013-9796-5","article-title":"Hip fracture risk and cadmium in erythrocytes: a nested case-control study with prospectively collected samples","volume":"94","author":"Sommar","year":"2014","journal-title":"Calcif. Tissue Int."},{"issue":"7","key":"10.1016\/j.bone.2020.115768_bb0095","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1002\/jbmr.386","article-title":"Dietary cadmium exposure and fracture incidence among men: a population-based prospective cohort study","volume":"26","author":"Thomas","year":"2011","journal-title":"J. Bone Miner. Res."},{"issue":"8","key":"10.1016\/j.bone.2020.115768_bb0100","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1007\/s00198-009-1111-y","article-title":"Urinary cadmium, osteopenia, and osteoporosis in the US population","volume":"21","author":"Wu","year":"2010","journal-title":"Osteoporos. Int."},{"issue":"4","key":"10.1016\/j.bone.2020.115768_bb0105","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/jbmr.2743","article-title":"Low-level cadmium exposure is associated with decreased bone mineral density and increased risk of incident fractures in elderly men: the MrOS Sweden study","volume":"31","author":"Wallin","year":"2016","journal-title":"J. Bone Miner. Res."},{"issue":"10","key":"10.1016\/j.bone.2020.115768_bb0110","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000002932","article-title":"Cadmium exposure and risk of any fracture: a PRISMA-compliant systematic review and meta-analysis","volume":"95","author":"Cheng","year":"2016","journal-title":"Medicine (Baltimore)"},{"issue":"5","key":"10.1016\/j.bone.2020.115768_bb0115","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1289\/ehp.1307110","article-title":"Non-renal effects and the risk assessment of environmental cadmium exposure","volume":"122","author":"Akesson","year":"2014","journal-title":"Environ. Health Perspect."},{"issue":"8","key":"10.1016\/j.bone.2020.115768_bb0120","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1007\/s00198-017-4047-7","article-title":"Increased blood cadmium levels were not associated with increased fracture risk but with increased total mortality in women: the Malmo Diet and Cancer Study","volume":"28","author":"Moberg","year":"2017","journal-title":"Osteoporos. Int."},{"issue":"3","key":"10.1016\/j.bone.2020.115768_bb0125","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.taap.2009.05.015","article-title":"Cadmium osteotoxicity in experimental animals: mechanisms and relationship to human exposures","volume":"238","author":"Bhattacharyya","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bone.2020.115768_bb0130","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.fct.2013.08.017","article-title":"Environmental level of cadmium exposure stimulates osteoclasts formation in male rats","volume":"60","author":"Chen","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bone.2020.115768_bb0135","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.etap.2017.07.007","article-title":"Emodin suppresses cadmium-induced osteoporosis by inhibiting osteoclast formation","volume":"54","author":"Chen","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"11","key":"10.1016\/j.bone.2020.115768_bb0140","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1258\/ebm.2011.011104","article-title":"Effects of cadmium on bone microstructure and serum tartrate-resistant acid phosphatase 5b in male rats","volume":"236","author":"Chen","year":"2011","journal-title":"Exp. Biol. Med. (Maywood)"},{"issue":"1","key":"10.1016\/j.bone.2020.115768_bb0145","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s12011-015-0447-8","article-title":"CT imaging biomarkers of bone damage induced by environmental level of cadmium exposure in male rats","volume":"170","author":"Tang","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"issue":"3","key":"10.1016\/j.bone.2020.115768_bb0150","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1006\/taap.2000.8908","article-title":"Uncoupling between bone formation and resorption in ovariectomized rats with chronic cadmium exposure","volume":"164","author":"Uriu","year":"2000","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"3\u20134","key":"10.1016\/j.bone.2020.115768_bb0155","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.fct.2011.12.034","article-title":"Assessment of dietary cadmium exposure in Sweden and population health concern including scenario analysis","volume":"50","author":"Sand","year":"2012","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.bone.2020.115768_bb0160","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.envres.2009.10.010","article-title":"Cadmium, mercury, and lead in kidney cortex of living kidney donors: impact of different exposure sources","volume":"110","author":"Barregard","year":"2010","journal-title":"Environ. Res."},{"issue":"3","key":"10.1016\/j.bone.2020.115768_bb0165","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.taap.2013.02.009","article-title":"The relationship between cadmium in kidney and cadmium in urine and blood in an environmentally exposed population","volume":"268","author":"Akerstrom","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bone.2020.115768_bb0170","series-title":"Cortical Porosity \u2013 Its Regulation and Association With Fracture","author":"Sundh","year":"2017"},{"key":"10.1016\/j.bone.2020.115768_bb0175","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.bone.2010.05.034","article-title":"Reproducibility of direct quantitative measures of cortical bone microarchitecture of the distal radius and tibia by HR-pQCT","volume":"47","author":"Burghardt","year":"2010","journal-title":"Bone."},{"issue":"10","key":"10.1016\/j.bone.2020.115768_bb0180","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1359\/jbmr.080518","article-title":"Older men with low serum estradiol and high serum SHBG have an increased risk of fractures","volume":"23","author":"Mellstrom","year":"2008","journal-title":"J. Bone Miner. Res."},{"issue":"Pt 6","key":"10.1016\/j.bone.2020.115768_bb0185","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1177\/0004563212474939","article-title":"Holotranscobalamin is not influenced by decreased renal function in elderly men: the MrOS Sweden study","volume":"50","author":"Lewerin","year":"2013","journal-title":"Ann. Clin. Biochem."},{"issue":"5","key":"10.1016\/j.bone.2020.115768_bb0190","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/joim.12587","article-title":"Increased cortical porosity in women with hip fracture","volume":"281","author":"Sundh","year":"2017","journal-title":"J. Intern. Med."},{"issue":"2","key":"10.1016\/j.bone.2020.115768_bb0195","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1185\/03007990802707626","article-title":"Endocrine and metabolic effects of smoking cessation","volume":"25","author":"Berlin","year":"2009","journal-title":"Curr. Med. Res. Opin."},{"issue":"8","key":"10.1016\/j.bone.2020.115768_bb0200","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1002\/jbmr.4014","article-title":"Smoking-induced risk of osteoporosis is partly mediated by cadmium from tobacco smoke: the MrOS Sweden study","volume":"35","author":"Li","year":"2020","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.bone.2020.115768_bb0205","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.etap.2009.04.010","article-title":"Effects of cadmium on osteoblasts and osteoclasts in vitro","volume":"28","author":"Chen","year":"2009","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.bone.2020.115768_bb0210","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13028-014-0064-0","article-title":"Changes in compact bone microstructure of rats subchronically exposed to cadmium","volume":"56","author":"Duranova","year":"2014","journal-title":"Acta Vet. Scand."},{"issue":"7","key":"10.1016\/j.bone.2020.115768_bb0215","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.etp.2016.06.001","article-title":"Effect of cadmium on bone tissue in growing animals","volume":"68","author":"Rodriguez","year":"2016","journal-title":"Exp. Toxicol. Pathol."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328220305561?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328220305561?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:52:45Z","timestamp":1757613165000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328220305561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":43,"alternative-id":["S8756328220305561"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2020.115768","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low-level cadmium exposure is associated with decreased cortical thickness, cortical area and trabecular bone volume fraction in elderly men: The MrOS Sweden study","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2020.115768","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115768"}}