{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:57:58Z","timestamp":1792699078205,"version":"4.5.0"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.bone.2020.115777","type":"journal-article","created":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T02:24:43Z","timestamp":1606530283000},"page":"115777","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Investigating the causal effect of fibroblast growth factor 23 on osteoporosis and cardiometabolic disorders: A Mendelian randomization study"],"prefix":"10.1016","volume":"143","author":[{"given":"Maki","family":"Yokomoto-Umakoshi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironobu","family":"Umakoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Miyazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Ogata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuichi","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bone.2020.115777_bb0005","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1359\/JBMR.0301264","article-title":"FGF-23 is a potent regulator of vitamin D and phosphate homeostasis","volume":"19","author":"Shimada","year":"2004","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2020.115777_bb0010","doi-asserted-by":"crossref","unstructured":"Yamashita T, Yoshioka M, Itoh N. Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain Biochem Biophys Res Commun. 2000; 277(2):494\u20138.","DOI":"10.1006\/bbrc.2000.3696"},{"key":"10.1016\/j.bone.2020.115777_bb0015","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00467-009-1384-6","article-title":"FGF-23 in bone biology","volume":"25","author":"Wesseling-Perry","year":"2010","journal-title":"Pediatr. Nephrol."},{"issue":"1","key":"10.1016\/j.bone.2020.115777_bb0020","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1210\/en.2010-0800","article-title":"Minireview: fibroblast growth factor 23 in phosphate homeostasis and bone metabolism","volume":"152","author":"Hori","year":"2011","journal-title":"Endocrinology"},{"issue":"12","key":"10.1016\/j.bone.2020.115777_bb0025","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/ki.2011.47","article-title":"Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease","volume":"79","author":"Isakova","year":"2011","journal-title":"Kidney Int."},{"issue":"5","key":"10.1016\/j.bone.2020.115777_bb0030","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1055\/a-1151-2342","article-title":"FGF23 beyond the kidney: a new bone mass regulator in the general population","volume":"52","author":"Bilha","year":"2020","journal-title":"Horm. Metab. Res."},{"issue":"8","key":"10.1016\/j.bone.2020.115777_bb0035","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1210\/jc.2013-1152","article-title":"Fibroblast growth factor 23, bone mineral density, and risk of hip fracture among older adults: the cardiovascular health study","volume":"98","author":"Jovanovich","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2020.115777_bb0040","doi-asserted-by":"crossref","first-page":"4454","DOI":"10.1002\/jcb.26101","article-title":"Relationship of fibroblast growth factor 23 (FGF-23) serum levels with low bone mass in postmenopausal women","volume":"118","author":"Shen","year":"2017","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bone.2020.115777_bb0045","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/jbmr.263","article-title":"Serum fibroblast growth factor-23 (FGF-23) and fracture risk in elderly men","volume":"26","author":"Mirza","year":"2011","journal-title":"J Bone Min Res"},{"issue":"11","key":"10.1016\/j.bone.2020.115777_bb0050","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1002\/jbmr.1985","article-title":"Osteoporotic Fractures in Men (MrOS) Study Group. Association of serum fibroblast growth factor 23 (FGF23) and incident fractures in older men: the Osteoporotic Fractures in Men (MrOS) study","volume":"28","author":"Lane","year":"2013","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.bone.2020.115777_bb0055","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1002\/jbmr.2750","article-title":"Ix JH; Health ABC Study. Associations of FGF23 with change in bone mineral density and fracture risk in older individuals","volume":"31","author":"Isakova","year":"2016","journal-title":"J. Bone Miner. Res."},{"issue":"11","key":"10.1016\/j.bone.2020.115777_bb0060","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.tem.2018.08.006","article-title":"FGF23 beyond phosphotropic hormone","volume":"29","author":"Takashi","year":"2018","journal-title":"Trends Endocrinol. Metab."},{"issue":"11","key":"10.1016\/j.bone.2020.115777_bb0065","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1172\/JCI46122","article-title":"FGF23 induces left ventricular hypertrophy","volume":"121","author":"Faul","year":"2011","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.bone.2020.115777_bb0070","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.cmet.2015.09.002","article-title":"Activation of cardiac fibroblast growth factor receptor 4 causes left ventricular hypertropy","volume":"22","author":"Grabner","year":"2015","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.bone.2020.115777_bb0075","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/ki.2013.332","article-title":"Fibroblast growth factor 23 accelerates phosphate-induced vascular calcification in the absence of Klotho deficiency","volume":"85","author":"Jimbo","year":"2014","journal-title":"Kidney Int."},{"issue":"6","key":"10.1016\/j.bone.2020.115777_bb0080","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cmet.2012.11.001","article-title":"Circulating fibroblast growth factors as metabolic regulators\u2014a critical appraisal","volume":"16","author":"Angelin","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.bone.2020.115777_bb0085","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1210\/en.2011-1878","article-title":"Long-term Fgf23 deficiency does not influence aging, glucose homeostasis, or fat metabolism in mice with a nonfunctioning vitamin D receptor","volume":"153","author":"Streicher","year":"2012","journal-title":"Endocrinology"},{"issue":"6","key":"10.1016\/j.bone.2020.115777_bb0090","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1056\/NEJMoa0706130","article-title":"Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis","volume":"359","author":"Guti\u00e9rrez","year":"2008","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.bone.2020.115777_bb0095","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1001\/jamacardio.2018.0139","article-title":"Association of fibroblast growth factor 23 with risk of incident coronary disease in community-dwelling adults","volume":"3","author":"Panwar","year":"2018","journal-title":"JAMA Cardiol."},{"issue":"10","key":"10.1016\/j.bone.2020.115777_bb0100","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1093\/ndt\/gfp205","article-title":"Relationship between circulating FGF23 and total body atherosclerosis in the community","volume":"24","author":"Mirza","year":"2009","journal-title":"Nephrol. Dial. Transplant."},{"issue":"3","key":"10.1016\/j.bone.2020.115777_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0122885","article-title":"Associations of fibroblast growth factor-23 with markers of inflammation, insulin resistance, and obesity in adults","volume":"10","author":"Hanks","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bone.2020.115777_bb0110","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1161\/ATVBAHA.110.214619","article-title":"Circulating fibroblast growth factor-23 is associated with fat mass and dyslipidemia in two independent cohorts of elderly individuals","volume":"31","author":"Mirza","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1","key":"10.1016\/j.bone.2020.115777_bb0115","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1161\/HYPERTENSIONAHA.120.14703","article-title":"Fibroblast growth factor 23 and blood pressure in older adults: the health, aging, and body composition study","volume":"76","author":"Drew","year":"2020","journal-title":"Hypertension."},{"issue":"1","key":"10.1016\/j.bone.2020.115777_bb0120","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s00774-019-01027-7","article-title":"Circulating FGF23 is not associated with cardiac dysfunction, atherosclerosis, infection or inflammation in hemodialysis patients","volume":"38","author":"Takashi","year":"2020","journal-title":"J. Bone Miner. Metab."},{"issue":"5","key":"10.1016\/j.bone.2020.115777_bb0125","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.ahj.2011.02.012","article-title":"Plasma fibroblast growth factor 23, parathyroid hormone, phosphorus, and risk of coronary heart disease","volume":"161","author":"Taylor","year":"2011","journal-title":"Am. Heart J."},{"issue":"7","key":"10.1016\/j.bone.2020.115777_bb0130","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1681\/ASN.2017121334","article-title":"Fibroblast growth factor-23 and risks of cardiovascular and noncardiovascular diseases: a meta-analysis","volume":"29","author":"Marthi","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bone.2020.115777_bb0135","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.2337\/dc13-2235","article-title":"FGF23 in type 2 diabetic patients: relationship with bone metabolism and vascular disease","volume":"37","author":"Reyes-Garcia","year":"2014","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bone.2020.115777_bb0140","doi-asserted-by":"crossref","first-page":"994","DOI":"10.2337\/dc11-2235","article-title":"Earlier onset and greater severity of disordered mineral metabolism in diabetic patients with chronic kidney disease","volume":"35","author":"Wahl","year":"2012","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.bone.2020.115777_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ije\/dyg070","article-title":"\u2018Mendelian randomization\u2019: can genetic epidemiology contribute to understanding environmental determinants of disease?","volume":"32","author":"Davey Smith","year":"2003","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.bone.2020.115777_bb0150","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1146\/annurev-genom-090314-050016","article-title":"Mendelian randomization: new applications in the coming age of hypothesis-free causality","volume":"16","author":"Evans","year":"2015","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"issue":"10","key":"10.1016\/j.bone.2020.115777_bb0155","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1681\/ASN.2018020192","article-title":"Genetic variants associated with circulating fibroblast growth factor 23","volume":"29","author":"Robinson-Cohen","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bone.2020.115777_bb0160","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/oxfordjournals.aje.a115184","article-title":"Investigators: the Atherosclerosis Risk in Communities (ARIC) study: design and objectives","volume":"129","author":"The ARIC","year":"1989","journal-title":"The ARIC investigators. Am J Epidemiol."},{"key":"10.1016\/j.bone.2020.115777_bb0165","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00198-003-1560-7","article-title":"Peak bone mineral density at the hip is linked to chromosomes 14q and 15q","volume":"15","author":"Peacock","year":"2004","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2020.115777_bb0170","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1359\/jbmr.060110","article-title":"Free testosterone is an independent predictor ofBMD and prevalent fractures in elderly men: MrOS Sweden","volume":"21","author":"Mellstr\u00f6m","year":"2006","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2020.115777_bb0175","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1093\/aje\/kwf113","article-title":"Multi-ethnic study of atherosclerosis:objectives and design","volume":"156","author":"Bild","year":"2002","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.bone.2020.115777_bb0180","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s00223-002-2159-2","article-title":"Association of the collagen type 1 (COL1A 1) Sp1 binding site polymorphism to femoral neck bone mineral density and wrist fracture in 1044 elderly Swedish women","volume":"74","author":"Gerdhem","year":"2004","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2020.115777_bb0185","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/1047-2797(91)90005-W","article-title":"The cardiovascular health study: design and rationale","volume":"1","author":"Fried","year":"1991","journal-title":"Ann. Epidemiol."},{"issue":"21","key":"10.1016\/j.bone.2020.115777_bb0190","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1093\/bioinformatics\/btv402","article-title":"LDlink: a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants","volume":"31","author":"Machiela","year":"2015","journal-title":"Bioinformatics."},{"key":"10.1016\/j.bone.2020.115777_bb0195","doi-asserted-by":"crossref","unstructured":"Nath AP, Ritchie SC, Grinberg NF, Tang HH, Huang QQ, Teo SM, et al. Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy. Am J Hum Genet. 2019 5;105(6):1076\u20131090.","DOI":"10.1016\/j.ajhg.2019.10.001"},{"issue":"D1","key":"10.1016\/j.bone.2020.115777_bb0200","doi-asserted-by":"crossref","first-page":"D896","DOI":"10.1093\/nar\/gkw1133","article-title":"The new NHGRI-EBI catalog of published genome-wide association studies (GWAS catalog)","volume":"45","author":"MacArthur","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"7571","key":"10.1016\/j.bone.2020.115777_bb0205","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature14878","article-title":"Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture","volume":"526","author":"Zheng","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bone.2020.115777_bb0210","unstructured":"Elsworth, BL, Mitchell, R, Raistrick, CA, Paternoster, L, Hemani, G, Gaunt, TR (2017): MRC IEU UK Biobank GWAS pipeline version. (https:\/\/doi.org\/10.5523\/bris.2fahpksont1zi26xosyamqo8rr)."},{"key":"10.1016\/j.bone.2020.115777_bb0215","unstructured":"UK biobank (Neale lab) the round 2 results (released 1st August 2018). (http:\/\/www.nealelab.is\/uk-biobank\/0)."},{"issue":"8","key":"10.1016\/j.bone.2020.115777_bb0220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0237237","article-title":"Genome-wide association analysis of pulse wave velocity traits provide new insights into the causal relationship between arterial stiffness and blood pressure","volume":"15","author":"Rode","year":"2020","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.bone.2020.115777_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0233728","article-title":"Genome-wide analysis of carotid plaque burden suggests a role of IL5 in men","volume":"15","author":"Pott","year":"2020","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.bone.2020.115777_bb0230","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1161\/CIRCRESAHA.117.312086","article-title":"Identification of 64 novel genetic loci provides an expanded view on the genetic architecture of coronary artery disease","volume":"122","author":"van der Harst","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.bone.2020.115777_bb0235","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/ng.520","article-title":"New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk","volume":"42","author":"Dupuis","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bone.2020.115777_bb0240","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/ng.2797","article-title":"Discovery and refinement of loci associated with lipid levels","volume":"45","author":"Willer","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bone.2020.115777_bb0245","article-title":"The MR-base collaboration","volume":"7","author":"Hemani","year":"2018","journal-title":"The MR-Base platform supports systematic causal inference across the human phenome. eLife"},{"issue":"7","key":"10.1016\/j.bone.2020.115777_bb0250","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s10654-015-0011-z","article-title":"Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors","volume":"30","author":"Burgess","year":"2015","journal-title":"Eur. J. Epidemiol."},{"issue":"11","key":"10.1016\/j.bone.2020.115777_bb0255","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1002\/sim.6835","article-title":"Combining information on multiple instrumental variables in Mendelian randomization: comparison of allele score and summarized data methods","volume":"35","author":"Burgess","year":"2016","journal-title":"Stat. Med."},{"issue":"21","key":"10.1016\/j.bone.2020.115777_bb0260","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1002\/sim.6522","article-title":"Detecting pleiotropy in Mendelian randomization studies with summary data and a continuous outcome","volume":"34","author":"Greco","year":"2015","journal-title":"Stat. Med."},{"key":"10.1016\/j.bone.2020.115777_bb0265","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1002\/sim.7221","article-title":"A framework for the investigation of pleiotropy in two-sample summary data Mendelian randomization","volume":"36","author":"Bowden","year":"2017","journal-title":"Stat. Med."},{"key":"10.1016\/j.bone.2020.115777_bb0270","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/gepi.21965","article-title":"Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet. Epidemiol."},{"key":"10.1016\/j.bone.2020.115777_bb0275","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10654-017-0255-x","article-title":"Interpreting findings from Mendelian randomization using the MR-egger method","volume":"32","author":"Burgess","year":"2017","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.bone.2020.115777_bb0280","doi-asserted-by":"crossref","unstructured":"Morandi A, Di Sessa A, Zusi C, Umano GR, El Mazloum D, Fornari E, Miraglia Del Giudice E, Targher G, Maffeis C. Non-alcoholic fatty liver disease and estimated insulin resistance in obese youth: a Mendelian randomization analysis. J Clin Endocrinol Metab. 2020 dgaa583. doi: https:\/\/doi.org\/10.1210\/clinem\/dgaa583.","DOI":"10.1210\/clinem\/dgaa583"},{"key":"10.1016\/j.bone.2020.115777_bb0285","doi-asserted-by":"crossref","unstructured":"Staley JR, Blackshaw J, Kamat MA, Ellis S, Surendran P, Sun BB, Paul DS, Freitag D, Burgess S, Danesh J, Young R, Butterworth AS. PhenoScanner: a database of human genotype-phenotype associations. Bioinformatics. 2016 15;32(20):3207\u20133209.","DOI":"10.1093\/bioinformatics\/btw373"},{"key":"10.1016\/j.bone.2020.115777_bb0290","doi-asserted-by":"crossref","unstructured":"Kamat MA, Blackshaw JA, Young R, Surendran P, Burgess S, Danesh J, Butterworth AS, Staley JR, PhenoScanner V2: an expanded tool for searching human genotype-phenotype associations. Bioinformatics. 2019 1;35(22):4851\u20134853.","DOI":"10.1093\/bioinformatics\/btz469"},{"key":"10.1016\/j.bone.2020.115777_bb0295","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1002\/sim.7492","article-title":"Extending the MR Egger method for multivariable Mendelian randomization to correct for both measured and unmeasured pleiotropy","volume":"36","author":"Rees","year":"2017","journal-title":"Stat. Med."},{"key":"10.1016\/j.bone.2020.115777_bb0300","doi-asserted-by":"crossref","first-page":"45040","DOI":"10.1038\/srep45040","article-title":"1000 genomes-based meta-analysis identifies 10 novel loci for kidney function","volume":"7","author":"Gorski","year":"2017","journal-title":"Sci. Rep."},{"issue":"7538","key":"10.1016\/j.bone.2020.115777_bb0305","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nature14177","article-title":"Genetic studies of body mass index yield new insights for obesity biology","volume":"518","author":"Locke","year":"2015","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.bone.2020.115777_bb0310","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1093\/ije\/dyx034","article-title":"MendelianRandomization: an R package for performing Mendelianrandomization analyses using summarized data","volume":"46","author":"Yavorska","year":"2017","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.bone.2020.115777_bb0315","series-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2013"},{"key":"10.1016\/j.bone.2020.115777_bb0320","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1007\/s00198-008-0780-2","article-title":"Relation between fibroblast growth factor-23, body weight and bone mineral density in elderly men","author":"Marsell","year":"2009","journal-title":"Osteoporos. Int."},{"issue":"5","key":"10.1016\/j.bone.2020.115777_bb0325","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1210\/jc.2006-0572","article-title":"Relationship of obesity with osteoporosis","volume":"92","author":"Zhao","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2020.115777_bb0330","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1080\/07435800.2016.1242604","article-title":"Patients with FGF23-related hypophosphatemic rickets\/osteomalacia do not present with left ventricular hypertrophy","volume":"42","author":"Takashi","year":"2017","journal-title":"Endocr. Res."},{"issue":"7","key":"10.1016\/j.bone.2020.115777_bb0335","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.016041","article-title":"Clinical potential of targeting fibroblast growth factor-23 and \u03b1Klotho in the treatment of uremic cardiomyopathy","volume":"9","author":"Law","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.bone.2020.115777_bb0340","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.bone.2014.10.013","article-title":"FGF23 gene variation and its association with phosphate homeostasis and bone mineral density in Finnish children and adolescents","volume":"71","author":"Pekkinen","year":"2015","journal-title":"Bone."},{"key":"10.1016\/j.bone.2020.115777_bb0345","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3389\/fpubh.2020.00467","article-title":"Higher fibroblast growth factor 23 levels are causally associated with lower bone mineral density of heel and femoral neck: evidence from two-sample mendelian randomization analysis","volume":"8","author":"Wang","year":"2020","journal-title":"Front. Public Health"},{"issue":"6","key":"10.1016\/j.bone.2020.115777_bb0350","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1359\/jbmr.080220","article-title":"Overexpression of fibroblast growth factor 23 suppresses osteoblast differentiation and matrix mineralization in vitro","volume":"23","author":"Wang","year":"2008","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.bone.2020.115777_bb0355","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00223-012-9683-5","article-title":"1,25-dihydroxyvitamin D(3) regulation of fibroblast growth factor-23 expression in bone cells: evidence for primary and secondary mechanisms modulated by leptin and interleukin-6","volume":"92","author":"Saini","year":"2013","journal-title":"Calcif. Tissue Int."},{"issue":"1","key":"10.1016\/j.bone.2020.115777_bb0360","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.kint.2016.01.024","article-title":"Direct inhibition of osteoblastic Wnt pathway by fibroblast growth factor 23 contributes to bone loss in chronic kidney disease","volume":"90","author":"Carrillo-L\u00f3pez","year":"2016","journal-title":"Kidney Int."},{"issue":"8","key":"10.1016\/j.bone.2020.115777_bb0365","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1007\/s00198-019-04996-7","article-title":"High FGF23 levels are associated with impaired trabecular bone microarchitecture in patients with osteoporosis","volume":"30","author":"Rupp","year":"2019","journal-title":"Osteoporos. Int."},{"issue":"1","key":"10.1016\/j.bone.2020.115777_bb0370","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1037\/0033-2909.112.1.155","article-title":"A power primer","volume":"112","author":"Cohen","year":"1992","journal-title":"Psychol. Bull."},{"issue":"11","key":"10.1016\/j.bone.2020.115777_bb0375","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1210\/jc.2011-1239","article-title":"Iron modifies plasma FGF23 differently in autosomal dominant hypophosphatemic rickets and healthy humans","volume":"96","author":"Imel","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.bone.2020.115777_bb0380","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/ki.2015.290","article-title":"Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production","volume":"89","author":"David","year":"2016","journal-title":"Kidney Int."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328220305652?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328220305652?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:57:42Z","timestamp":1757613462000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328220305652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":76,"alternative-id":["S8756328220305652"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2020.115777","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigating the causal effect of fibroblast growth factor 23 on osteoporosis and cardiometabolic disorders: A Mendelian randomization study","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2020.115777","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115777"}}