{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T22:23:56Z","timestamp":1769552636716,"version":"3.49.0"},"reference-count":239,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.bone.2020.115807","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T09:23:00Z","timestamp":1608110580000},"page":"115807","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Liver X receptors and skeleton: Current state-of-knowledge"],"prefix":"10.1016","volume":"144","author":[{"given":"Divya","family":"Goel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya","family":"Vohora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2020.115807_bb0005","first-page":"785","article-title":"Consensus development panel on osteoporosis prevention, diagnosis, and therapy. Osteoporosis prevention, diagnosis, and therapy","volume":"85","author":"JAMA","year":"2001","journal-title":"J. Am. Med. Assoc."},{"issue":"12","key":"10.1016\/j.bone.2020.115807_bb0010","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1007\/s00198-006-0172-4","article-title":"An estimate of the worldwide prevalence and disability associated with osteoporotic fractures","volume":"17","author":"Johnell","year":"2006","journal-title":"Osteoporos. Int."},{"issue":"4","key":"10.1016\/j.bone.2020.115807_bb0015","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s11914-012-0114-3","article-title":"Osteoporosis in Asia: a call to action","volume":"10","author":"Mithal","year":"2012","journal-title":"Current Osteoporosis Reports"},{"issue":"3","key":"10.1016\/j.bone.2020.115807_bb0020","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1359\/jbmr.061113","article-title":"Incidence and economic burden of osteoporosis-related fractures in the United States, 2005\u20132025","volume":"22","author":"Burge","year":"2007","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.bone.2020.115807_bb0025","first-page":"261","article-title":"Diagnosis and management of osteoporosis","volume":"92","author":"Jeremiah","year":"2015","journal-title":"Am. Fam. Physician"},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb0030","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/ageing\/afp221","article-title":"Excess mortality in men compared with women following a hip fracture. national analysis of comedications, comorbidity and survival","volume":"39","author":"Kannegaard","year":"2010","journal-title":"Age Ageing"},{"issue":"3","key":"10.1016\/j.bone.2020.115807_bb0035","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s11914-018-0435-y","article-title":"Epigenetics of skeletal diseases","volume":"16","author":"del Real","year":"2018","journal-title":"Current Osteoporosis Reports"},{"issue":"1","key":"10.1016\/j.bone.2020.115807_bb0040","doi-asserted-by":"crossref","DOI":"10.2196\/ijmr.8555","article-title":"Factors affecting bone mineral density among snowy region residents in Japan: analysis using multiple linear regression and Bayesian network model","volume":"7","author":"Suzuki","year":"2018","journal-title":"Interactive Journal of Medical Research"},{"issue":"1\u20132","key":"10.1016\/j.bone.2020.115807_bb0045","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s11657-013-0136-1","article-title":"Osteoporosis in the European Union: medical management, epidemiology and economic burden","volume":"8","author":"Hernlund","year":"2013","journal-title":"Arch. Osteoporos."},{"issue":"4","key":"10.1016\/j.bone.2020.115807_bb0050","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nrrheum.2011.23","article-title":"Advances in osteoclast biology: old findings and new insights from mouse models","volume":"7","author":"Edwards","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"issue":"1","key":"10.1016\/j.bone.2020.115807_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ecl.2016.09.003","article-title":"The role of the osteocyte in bone and nonbone disease","volume":"46","author":"Bonewald","year":"2017","journal-title":"Endocrinol. Metab. Clin."},{"key":"10.1016\/j.bone.2020.115807_bb0060","series-title":"In Endotext [Internet]","article-title":"The epidemiology and pathogenesis of osteoporosis","author":"Rosen","year":"2017"},{"issue":"12","key":"10.1016\/j.bone.2020.115807_bb0065","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.clinbiochem.2012.03.021","article-title":"An overview of the regulation of bone remodelling at the cellular level","volume":"45","author":"Kular","year":"2012","journal-title":"Clin. Biochem."},{"issue":"1","key":"10.1016\/j.bone.2020.115807_bb0070","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev-pathol-011110-130203","article-title":"Disorders of bone remodeling","volume":"6","author":"Feng","year":"2011","journal-title":"Annual Review of Pathology: Mechanisms of Disease"},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb0075","first-page":"70","article-title":"Bone remodelling and disorders of bone metabolism","volume":"27","author":"Peel","year":"2009","journal-title":"Surgery"},{"key":"10.1016\/j.bone.2020.115807_bb0080","doi-asserted-by":"crossref","DOI":"10.1038\/383728a0","article-title":"An Oxysterol signalling pathway mediated by the nuclear receptor LXR\u03b1","author":"Janowski","year":"1996","journal-title":"Nature."},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb0085","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0378-1119(94)90080-9","article-title":"NER, a new member of the gene family encoding the human steroid hormone nuclear receptor","volume":"147","author":"Shinar","year":"1994","journal-title":"Gene"},{"issue":"9","key":"10.1016\/j.bone.2020.115807_bb0090","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1101\/gad.9.9.1033","article-title":"LXR, a nuclear receptor that defines a distinct retinoid response pathway","volume":"9","author":"Willy","year":"1995","journal-title":"Genes Dev."},{"issue":"3","key":"10.1016\/j.bone.2020.115807_bb0095","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1172\/JCI27883","article-title":"Liver X receptors as integrators of metabolic and inflammatory signaling","volume":"116","author":"Zelcer","year":"2006","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.bone.2020.115807_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules22010088","article-title":"Ligands of therapeutic utility for the liver X receptors","volume":"22","author":"Komati","year":"2017","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb0105","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.bone.2010.08.018","article-title":"Short-term activation of liver X receptors inhibits osteoblasts but long-term activation does not have an impact on murine bone in vivo","volume":"48","author":"Prawitt","year":"2011","journal-title":"Bone"},{"issue":"38","key":"10.1016\/j.bone.2020.115807_bb0110","doi-asserted-by":"crossref","first-page":"33084","DOI":"10.1074\/jbc.M111.235937","article-title":"Activation of liver X receptor (LXR) inhibits receptor activator of nuclear factor \u039aB ligand (RANKL)-induced osteoclast differentiation in an LXR\u03b2-dependent mechanism","volume":"286","author":"Remen","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.bone.2020.115807_bb0115","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/S2213-8587(17)30188-2","article-title":"Osteoporosis treatment: recent developments and ongoing challenges","volume":"5","author":"Khosla","year":"2017","journal-title":"The Lancet Diabetes & Endocrinology"},{"issue":"1","key":"10.1016\/j.bone.2020.115807_bb0120","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1189\/jlb.1112601","article-title":"Liver X receptor activation inhibits osteoclastogenesis by suppressing NF-\u039aB activity and c-Fos induction and prevents inflammatory bone loss in mice","volume":"94","author":"Kim","year":"2013","journal-title":"J. Leukoc. Biol."},{"issue":"12","key":"10.1016\/j.bone.2020.115807_bb0125","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1002\/jbmr.1702","article-title":"Liver X receptors orchestrate osteoblast\/osteoclast crosstalk and counteract pathologic bone loss","volume":"27","author":"Kleyer","year":"2012","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2020.115807_bb0130","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1189\/jlb.0712339","article-title":"Activation of the liver X receptor-\u03b2 potently inhibits Osteoclastogenesis from lipopolysaccharide-exposed bone marrow-derived macrophages","volume":"93","author":"Remen","year":"2013","journal-title":"J. Leukoc. Biol."},{"issue":"23","key":"10.1016\/j.bone.2020.115807_bb0135","doi-asserted-by":"crossref","first-page":"4001","DOI":"10.1007\/s00018-010-0479-3","article-title":"Cellular communications in bone homeostasis and repair","volume":"67","author":"Nakahama","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"issue":"9","key":"10.1016\/j.bone.2020.115807_bb0140","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nrendo.2016.91","article-title":"Physiological and pathophysiological bone turnover \u2014 role of the immune system","volume":"12","author":"Weitzmann","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bone.2020.115807_bb0145","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1146\/annurev.cellbio.042308.113308","article-title":"Genetic control of bone formation","volume":"25","author":"Karsenty","year":"2009","journal-title":"Annual Review of Cell and Developmental"},{"issue":"8","key":"10.1016\/j.bone.2020.115807_bb0150","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1007\/s00198-008-0575-5","article-title":"Regulatory pathways revealing new approaches to the development of anabolic drugs for osteoporosis","volume":"19","author":"Martin","year":"2008","journal-title":"Osteoporos. Int."},{"issue":"3","key":"10.1016\/j.bone.2020.115807_bb0155","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/nrrheum.2015.160","article-title":"Navigating the bone marrow niche: translational insights and cancer-driven dysfunction","volume":"12","author":"Reagan","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"issue":"4","key":"10.1016\/j.bone.2020.115807_bb0160","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s007740070018","article-title":"Roles of macrophage-colony stimulating factor and osteoclast differentiation factor in osteoclastogenesis","volume":"18","author":"Tsurukai","year":"2000","journal-title":"J. Bone Miner. Metab."},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb0165","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","article-title":"Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation","volume":"93","author":"Lacey","year":"1998","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.bone.2020.115807_bb0170","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1586\/eem.09.38","article-title":"Bone signaling pathways and treatment of osteoporosis","volume":"4","author":"Gogakos","year":"2009","journal-title":"Expert. Rev. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.bone.2020.115807_bb0175","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/sj.emboj.7600564","article-title":"RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis","volume":"24","author":"Gohda","year":"2005","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.bone.2020.115807_bb0180","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1196\/annals.1402.071","article-title":"The role of NFAT in osteoclast formation","volume":"1116","author":"Takayanagi","year":"2007","journal-title":"Ann. N. Y. Acad. Sci"},{"issue":"4","key":"10.1016\/j.bone.2020.115807_bb0185","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s11154-010-9153-1","article-title":"Cellular mechanisms of bone remodeling","volume":"11","author":"Eriksen","year":"2010","journal-title":"Reviews in Endocrine and Metabolic Disorders"},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb0190","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/jcp.22159","article-title":"Regulation of adult bone turnover by sex steroids","volume":"224","author":"Frenkel","year":"2010","journal-title":"J. Cell. Physiol."},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb0195","first-page":"92","article-title":"Osteoporosis: a review of treatment options","volume":"43","author":"Tu","year":"2018","journal-title":"P and T"},{"issue":"7","key":"10.1016\/j.bone.2020.115807_bb0200","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1001\/jama.282.7.637","article-title":"Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators","volume":"282","author":"Ettinger","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.bone.2020.115807_bb0205","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1146\/annurev.cellbio.16.1.459","article-title":"The role of orphan nuclear receptors in the regulation of cholesterol homeostasis","volume":"16","author":"Repa","year":"2000","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb0210","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1517\/14728222.2011.547853","article-title":"Targeting liver X receptors in human health: deadlock or promising trail?","volume":"15","author":"Viennois","year":"2011","journal-title":"Expert Opin. Ther. Targets"},{"issue":"6","key":"10.1016\/j.bone.2020.115807_bb0215","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1210\/me.2002-0399","article-title":"Liver X receptors interact with corepressors to regulate gene expression","volume":"17","author":"Hu","year":"2003","journal-title":"Mol. Endocrinol."},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb0220","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4103\/0250-474X.41445","article-title":"Liver X receptor: a novel therapeutic target","volume":"70","author":"Patel","year":"2008","journal-title":"Indian J. Pharm. Sci."},{"issue":"17","key":"10.1016\/j.bone.2020.115807_bb0225","doi-asserted-by":"crossref","first-page":"6009","DOI":"10.1073\/pnas.0500299102","article-title":"Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors","volume":"102","author":"Codina","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb0230","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1210\/en.2016-1577","article-title":"Posttranslational modifications of lipid-activated nuclear receptors: focus on metabolism","volume":"158","author":"Becares","year":"2017","journal-title":"Endocrinology"},{"issue":"7","key":"10.1016\/j.bone.2020.115807_bb0235","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1172\/JCI24594","article-title":"Liver X receptors alpha and beta regulate renin expression in vivo","volume":"115","author":"Morello","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"7","key":"10.1016\/j.bone.2020.115807_bb0240","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1172\/JCI24594","article-title":"Liver X receptors \u03b1 and \u03b2 regulate renin expression in vivo","volume":"115","author":"Morello","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"15","key":"10.1016\/j.bone.2020.115807_bb0245","doi-asserted-by":"crossref","first-page":"8513","DOI":"10.1073\/pnas.100519097","article-title":"LXRalpha functions as a CAMP-responsive transcriptional regulator of gene expression","volume":"97","author":"Tamura","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"17","key":"10.1016\/j.bone.2020.115807_bb0250","doi-asserted-by":"crossref","first-page":"15252","DOI":"10.1074\/jbc.M208644200","article-title":"Identification of a novel set of genes regulated by a unique liver X receptor-\u03b1-mediated transcription mechanism","volume":"278","author":"Anderson","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.bone.2020.115807_bb0255","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/j.biotechadv.2018.03.003","article-title":"Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR","volume":"36","author":"Hiebl","year":"2018","journal-title":"Biotechnol. Adv."},{"issue":"1","key":"10.1016\/j.bone.2020.115807_bb0260","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/glia.22423","article-title":"Regulation of microglia activation and deactivation by nuclear receptors","volume":"61","author":"Saijo","year":"2013","journal-title":"Glia"},{"issue":"4","key":"10.1016\/j.bone.2020.115807_bb0265","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.cell.2006.06.049","article-title":"Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network","volume":"126","author":"Bookout","year":"2006","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb0270","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.cell.2007.09.012","article-title":"Systematic gene expression mapping clusters nuclear receptors according to their function in the brain","volume":"131","author":"Gofflot","year":"2007","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb0275","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1172\/JCI77186","article-title":"Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling","volume":"125","author":"Men\u00e9ndez-Guti\u00e9rrez","year":"2015","journal-title":"J. Clin. Invest."},{"issue":"8","key":"10.1016\/j.bone.2020.115807_bb0280","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1359\/jbmr.060503","article-title":"Cholesterol-sensing receptors, liver X receptor \u03b1 and \u03b2, have novel and distinct roles in osteoclast differentiation and activation","volume":"21","author":"Robertson","year":"2006","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb0285","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cell.2004.09.032","article-title":"LXR-dependent gene expression is important for macrophage survival and the innate immune response","volume":"119","author":"Joseph","year":"2004","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.bone.2020.115807_bb0290","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1124\/mol.106.031906","article-title":"Selective activation of liver X receptors by acanthoic acid-related diterpenes","volume":"71","author":"Traves","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bone.2020.115807_bb0295","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.chemphyslip.2017.02.006","article-title":"Role of the liver X receptors in skin physiology: putative pharmacological targets in human diseases","volume":"207","author":"Ouedraogo","year":"2017","journal-title":"Chem. Phys. Lipids"},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb0300","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.mce.2011.08.036","article-title":"Selective liver X receptor modulators (SLiMs): what use in human health?","volume":"351","author":"Viennois","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"issue":"11","key":"10.1016\/j.bone.2020.115807_bb0305","doi-asserted-by":"crossref","first-page":"7604","DOI":"10.1073\/pnas.112059299","article-title":"Synthetic LXR ligand inhibits the development of atherosclerosis in mice","volume":"99","author":"Joseph","year":"2002","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"17","key":"10.1016\/j.bone.2020.115807_bb0310","doi-asserted-by":"crossref","first-page":"5419","DOI":"10.1021\/jm050532w","article-title":"Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure","volume":"48","author":"Jaye","year":"2005","journal-title":"J. Med. Chem."},{"issue":"18","key":"10.1016\/j.bone.2020.115807_bb0315","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.1016\/j.bmcl.2015.07.047","article-title":"Discovery and structure-guided optimization of tert-butyl 6-(phenoxymethyl)-3-(trifluoromethyl) benzoates as liver X receptor agonists","volume":"25","author":"Matsui","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb0320","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.bmcl.2014.11.029","article-title":"Liver X receptor (LXR) partial agonists: biaryl pyrazoles and imidazoles displaying a preference for LXR\u03b2","volume":"25","author":"Kick","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"7","key":"10.1016\/j.bone.2020.115807_bb0325","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1021\/acs.jmedchem.5b02029","article-title":"Discovery of a novel, orally efficacious liver X receptor (LXR) \u03b2 agonist","volume":"59","author":"Zheng","year":"2016","journal-title":"J. Med. Chem."},{"issue":"20","key":"10.1016\/j.bone.2020.115807_bb0330","doi-asserted-by":"crossref","first-page":"5044","DOI":"10.1016\/j.bmcl.2016.08.089","article-title":"Brain penetrant liver X receptor (LXR) modulators based on a 2, 4, 5, 6-tetrahydropyrrolo [3, 4-c] pyrazole core","volume":"26","author":"Tice","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"1","key":"10.1016\/j.bone.2020.115807_bb0335","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1038\/s41598-018-20663-z","article-title":"Ouabagenin is a naturally occurring LXR ligand without causing hepatic steatosis as a side effect","volume":"8","author":"Tamura","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bone.2020.115807_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112240","article-title":"Discovery of new LXR\u03b2 agonists as glioblastoma inhibitors","volume":"194","author":"Chen","year":"2020","journal-title":"Eur. J. Med. Chem."},{"issue":"Suppl. 7","key":"10.1016\/j.bone.2020.115807_bb0345","first-page":"31","article-title":"Biological role of liver X receptors","volume":"59","author":"Baranowski","year":"2008","journal-title":"J. Physiol. Pharmacol."},{"issue":"1\u20132","key":"10.1016\/j.bone.2020.115807_bb0350","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11010-008-0001-5","article-title":"Lipid-activated transcription factors control bile acid glucuronidation","volume":"326","author":"Barbier","year":"2009","journal-title":"Mol. Cell. Biochem."},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb0355","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1073\/pnas.98.2.507","article-title":"LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes","volume":"98","author":"Laffitte","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"4","key":"10.1016\/j.bone.2020.115807_bb0360","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1210\/me.2003-0338","article-title":"Regulation of the aldo-keto reductase gene Akr1b7 by the nuclear oxysterol receptor LXR\u03b1 (liver X receptor-\u03b1) in the mouse intestine: putative role of LXRs in lipid detoxification processes","volume":"18","author":"Volle","year":"2004","journal-title":"Mol. Endocrinol."},{"issue":"4","key":"10.1016\/j.bone.2020.115807_bb0365","doi-asserted-by":"crossref","first-page":"895","DOI":"10.3892\/mmr.2012.758","article-title":"Role of liver X receptors in cholesterol efflux and inflammatory signaling (review)","volume":"5","author":"Zhu","year":"2012","journal-title":"Mol. Med. Rep."},{"issue":"4","key":"10.1016\/j.bone.2020.115807_bb0370","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1177\/0748730407302461","article-title":"Multiple mechanisms regulate circadian expression of the gene for cholesterol 7\u03b1-hydroxylase (Cyp7a), a key enzyme in hepatic bile acid biosynthesis","volume":"22","author":"Noshiro","year":"2007","journal-title":"J. Biol. Rhythm."},{"issue":"7","key":"10.1016\/j.bone.2020.115807_bb0375","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.tips.2012.03.013","article-title":"Liver X receptor biology and pharmacology: new pathways, challenges and opportunities","volume":"33","author":"Jakobsson","year":"2012","journal-title":"Trends Pharmacol. Sci."},{"issue":"8","key":"10.1016\/j.bone.2020.115807_bb0380","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/s41574-018-0037-x","article-title":"Liver X receptors in lipid signalling and membrane homeostasis","volume":"14","author":"Wang","year":"2018","journal-title":"Nature Reviews. Endocrinology"},{"issue":"7605","key":"10.1016\/j.bone.2020.115807_bb0385","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/nature17674","article-title":"Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis","volume":"534","author":"Sallam","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bone.2020.115807_bb0390","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.28766","article-title":"Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP","volume":"6","author":"Zhang","year":"2017","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.bone.2020.115807_bb0395","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1074\/jbc.M605023200","article-title":"The liver X receptor (LXR) and hepatic lipogenesis the carbohydrate-response element-binding protein is a target gene of LXR","volume":"282","author":"Cha","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.bone.2020.115807_bb0400","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/j.1600-0625.2009.00841.x","article-title":"Activators of PPARs and LXR decrease the adverse effects of exogenous glucocorticoids on the epidermis","volume":"18","author":"Demerjian","year":"2009","journal-title":"Exp. Dermatol."},{"issue":"25","key":"10.1016\/j.bone.2020.115807_bb0405","doi-asserted-by":"crossref","first-page":"10601","DOI":"10.1073\/pnas.0701096104","article-title":"Attenuation of Neuroinflammation and Alzheimer\u2019s disease pathology by liver x receptors","volume":"104","author":"Zelcer","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"3","key":"10.1016\/j.bone.2020.115807_bb0410","first-page":"956","article-title":"ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver","volume":"118","author":"Denechaud","year":"2008","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.bone.2020.115807_bb0415","doi-asserted-by":"crossref","first-page":"5419","DOI":"10.1073\/pnas.0830671100","article-title":"Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue","volume":"100","author":"Laffitte","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb0420","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.jiph.2019.09.008","article-title":"Role of LXR alpha in regulating expression of glucose transporter 4 in adipocytes\u2014investigation on improvement of health of diabetic patients","volume":"13","author":"Balasubramanian","year":"2020","journal-title":"Journal of Infection and Public Health"},{"key":"10.1016\/j.bone.2020.115807_bb0425","author":"Sohrabi"},{"issue":"4","key":"10.1016\/j.bone.2020.115807_bb0430","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s13238-014-0131-3","article-title":"Cholesterol metabolism and homeostasis in the brain","volume":"6","author":"Zhang","year":"2015","journal-title":"Protein & Cell"},{"issue":"18","key":"10.1016\/j.bone.2020.115807_bb0435","doi-asserted-by":"crossref","first-page":"12799","DOI":"10.1074\/jbc.M601019200","article-title":"24 (S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux","volume":"281","author":"Abildayeva","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.bone.2020.115807_bb0440","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1210\/mend.16.6.0835","article-title":"Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system","volume":"16","author":"Whitney","year":"2002","journal-title":"Mol. Endocrinol."},{"issue":"5","key":"10.1016\/j.bone.2020.115807_bb0445","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0092-8674(00)81432-4","article-title":"Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR\u03b1","volume":"93","author":"Peet","year":"1998","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.bone.2020.115807_bb0450","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1161\/01.CIR.0000026802.79202.96","article-title":"Accumulation of foam cells in liver X receptor-deficient mice","volume":"106","author":"Schuster","year":"2002","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.bone.2020.115807_bb0455","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/humu.1206","article-title":"Mutations in ATP-cassette binding proteins G5 (ABCG5) and G8 (ABCG8) causing sitosterolemia","volume":"18","author":"Hubacek","year":"2001","journal-title":"Hum. Mutat."},{"issue":"13","key":"10.1016\/j.bone.2020.115807_bb0460","doi-asserted-by":"crossref","first-page":"6482","DOI":"10.1158\/0008-5472.CAN-06-0632","article-title":"Inhibition of tumor growth and progression of LNCaP prostate cancer cells in athymic mice by androgen and liver X receptor agonist","volume":"66","author":"Chuu","year":"2006","journal-title":"Cancer Res."},{"issue":"21","key":"10.1016\/j.bone.2020.115807_bb0465","doi-asserted-by":"crossref","first-page":"7686","DOI":"10.1158\/0008-5472.CAN-04-2332","article-title":"Antiproliferative effect of liver X receptor agonists on LNCaP human prostate cancer cells","volume":"64","author":"Fukuchi","year":"2004","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.bone.2020.115807_bb0470","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S1734-1140(10)70239-5","article-title":"Liver X receptor (LXR) and the reproductive system - a potential novel target for therapeutic intervention","volume":"62","author":"Be\u0142towski","year":"2010","journal-title":"Pharmacol. Rep."},{"issue":"1\u20132","key":"10.1016\/j.bone.2020.115807_bb0475","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.mce.2006.03.044","article-title":"Reduced fertility and inability of oocytes to resume meiosis in mice deficient of the Lxr genes","volume":"256","author":"Steffensen","year":"2006","journal-title":"Mol. Cell. Endocrinol."},{"issue":"7","key":"10.1016\/j.bone.2020.115807_bb0480","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1172\/JCI28400","article-title":"Liver X receptors regulate adrenal cholesterol balance","volume":"116","author":"Cummins","year":"2006","journal-title":"J. Clin. Invest."},{"issue":"7","key":"10.1016\/j.bone.2020.115807_bb0485","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1210\/en.2008-1519","article-title":"Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice","volume":"150","author":"Mouzat","year":"2009","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb0490","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1677\/jme.1.01515","article-title":"Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions","volume":"33","author":"Frenoux","year":"2004","journal-title":"J. Mol. Endocrinol."},{"issue":"4","key":"10.1016\/j.bone.2020.115807_bb0495","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/j.1745-7262.2007.00301.x","article-title":"Liver X receptors and epididymal epithelium physiology","volume":"9","author":"Saez","year":"2007","journal-title":"Asian Journal of Andrology"},{"issue":"6","key":"10.1016\/j.bone.2020.115807_bb0500","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1210\/en.2004-1413","article-title":"The liver X receptor-\u03b2 is essential for maintaining cholesterol homeostasis in the testis","volume":"146","author":"Robertson","year":"2005","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.bone.2020.115807_bb0505","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1073\/pnas.1017884108","article-title":"Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity","volume":"108","author":"Korach-Andr\u00e9","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb0510","doi-asserted-by":"crossref","first-page":"E167","DOI":"10.1152\/ajpendo.00184.2009","article-title":"Separate and overlapping metabolic functions of LXR\u03b1 and LXR\u03b2 in C57Bl\/6 female mice","volume":"298","author":"Korach-Andr\u00e9","year":"2010","journal-title":"American Journal of Physiology-Endocrinology and Metabolism"},{"issue":"1","key":"10.1016\/j.bone.2020.115807_bb0515","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.atherosclerosis.2015.06.042","article-title":"Liver X receptors at the intersection of lipid metabolism and atherogenesis","volume":"242","author":"Lee","year":"2015","journal-title":"Atherosclerosis"},{"issue":"12","key":"10.1016\/j.bone.2020.115807_bb0520","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0145467","article-title":"Role of liver X receptor in AD pathophysiology","volume":"10","author":"Sandoval-Hern\u00e1ndez","year":"2015","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.bone.2020.115807_bb0525","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.bbrc.2005.12.137","article-title":"Niemann\u2013Pick C1 like 1 gene expression is down-regulated by LXR activators in the intestine","volume":"340","author":"Duval","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"21","key":"10.1016\/j.bone.2020.115807_bb0530","doi-asserted-by":"crossref","first-page":"18793","DOI":"10.1074\/jbc.M109927200","article-title":"Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors \u03b1 and \u03b2","volume":"277","author":"Repa","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"39","key":"10.1016\/j.bone.2020.115807_bb0535","doi-asserted-by":"crossref","first-page":"26332","DOI":"10.1074\/jbc.M804808200","article-title":"Regulation of cholesterologenesis by the oxysterol receptor, LXR\u03b1","volume":"283","author":"Wang","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bone.2020.115807_bb0540","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1677\/jme.1.01508","article-title":"Genome-wide expression profiling; a panel of mouse tissues discloses novel biological functions of liver X receptors in adrenals","volume":"33","author":"Steffensen","year":"2004","journal-title":"J. Mol. Endocrinol."},{"issue":"7","key":"10.1016\/j.bone.2020.115807_bb0545","doi-asserted-by":"crossref","first-page":"e59","DOI":"10.1161\/01.RES.0000163630.86796.17","article-title":"Liver x receptor agonists inhibit cytokine-induced osteopontin expression in macrophages through interference with activator protein-1 signaling pathways","volume":"96","author":"Ogawa","year":"2005","journal-title":"Circ. Res."},{"issue":"7","key":"10.1016\/j.bone.2020.115807_bb0550","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000981","article-title":"PPAR\u03b3 and LXR signaling inhibit dendritic cell-mediated HIV-1 capture and trans-infection","volume":"6","author":"Hanley","year":"2010","journal-title":"PLoS Pathog."},{"issue":"19","key":"10.1016\/j.bone.2020.115807_bb0555","doi-asserted-by":"crossref","first-page":"7049","DOI":"10.1523\/JNEUROSCI.6546-10.2011","article-title":"Critical role of astroglial apolipoprotein E and liver X receptor-\u03b1 expression for microglial A\u03b2 phagocytosis","volume":"31","author":"Terwel","year":"2011","journal-title":"J. Neurosci."},{"issue":"51","key":"10.1016\/j.bone.2020.115807_bb0560","doi-asserted-by":"crossref","first-page":"17813","DOI":"10.1073\/pnas.0407749101","article-title":"Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis","volume":"101","author":"Valledor","year":"2004","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb0565","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.immuni.2009.06.018","article-title":"Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR","volume":"31","author":"A-Gonzalez","year":"2009","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.bone.2020.115807_bb0570","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1757-2215-3-13","article-title":"Anti-proliferative effect of LXR agonist T0901317 in ovarian carcinoma cells","volume":"3","author":"Rough","year":"2010","journal-title":"Journal of Ovarian Research"},{"issue":"1","key":"10.1016\/j.bone.2020.115807_bb0575","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1046\/j.0022-202x.2001.01628.x","article-title":"Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-\u03b2 in murine epidermis","volume":"118","author":"K\u00f6m\u00fcves","year":"2002","journal-title":"J. Investig. Dermatol."},{"issue":"5","key":"10.1016\/j.bone.2020.115807_bb0580","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.cell.2014.01.038","article-title":"Broad-spectrum therapeutic suppression of metastatic melanoma through nuclear hormone receptor activation","volume":"156","author":"Pencheva","year":"2014","journal-title":"Cell"},{"issue":"32","key":"10.1016\/j.bone.2020.115807_bb0585","doi-asserted-by":"crossref","first-page":"13112","DOI":"10.1073\/pnas.1210833109","article-title":"Liver X receptor \u03b2 protects dopaminergic neurons in a mouse model of Parkinson disease","volume":"109","author":"Dai","year":"2012","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"1","key":"10.1016\/j.bone.2020.115807_bb0590","first-page":"1009","article-title":"Liver X receptor regulates rheumatoid arthritis fibroblast-like synoviocyte invasiveness, matrix metalloproteinase 2 activation, interleukin-6 and CXCL10","volume":"18","author":"Laragione","year":"2012","journal-title":"Molecular Medicine (Cambridge, Mass.)"},{"issue":"4","key":"10.1016\/j.bone.2020.115807_bb0595","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1002\/art.22528","article-title":"Liver X receptor is a therapeutic target in collagen-induced arthritis","volume":"56","author":"Chintalacharuvu","year":"2007","journal-title":"Arthritis Rheum."},{"issue":"5","key":"10.1016\/j.bone.2020.115807_bb0600","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1093\/rheumatology\/keq007","article-title":"Liver X receptor agonist prevents the evolution of collagen-induced arthritis in mice","volume":"49","author":"Park","year":"2010","journal-title":"Rheumatology (Oxford, England)"},{"issue":"13","key":"10.1016\/j.bone.2020.115807_bb0605","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.137230","article-title":"Selective LXR agonist DMHCA corrects retinal and bone marrow dysfunction in type 2 diabetes","volume":"5","author":"Vieira","year":"2020","journal-title":"JCI Insight"},{"issue":"23","key":"10.1016\/j.bone.2020.115807_bb0610","doi-asserted-by":"crossref","first-page":"20637","DOI":"10.1074\/jbc.M111.227082","article-title":"Cross-talk between the androgen receptor and the liver X receptor: implications for cholesterol homeostasis","volume":"286","author":"Krycer","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"October","key":"10.1016\/j.bone.2020.115807_bb0615","first-page":"165","article-title":"High cholesterol deteriorates bone health: new insights into molecular mechanisms","volume":"6","author":"Mandal","year":"2015","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bone.2020.115807_bb0620","doi-asserted-by":"crossref","unstructured":"Tavazoie, Masoud F, Ilana Pollack, Raissa Tanqueco, Benjamin N Ostendorf, Bernardo S Reis, Foster C Gonsalves, Isabel Kurth, et al. 2018. \u201cLXR\/ApoE Activation Restricts Innate Immune Suppression in Cancer.\u201d Cell 172 (4): 825\u2013840.e18. doi:https:\/\/doi.org\/10.1016\/j.cell.2017.12.026.","DOI":"10.1016\/j.cell.2017.12.026"},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb0625","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.bbrc.2020.04.137","article-title":"LXR activation radiosensitizes non-small cell lung cancer by restricting myeloid-derived suppressor cells","volume":"528","author":"Liang","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"issue":"18","key":"10.1016\/j.bone.2020.115807_bb0630","doi-asserted-by":"crossref","first-page":"11896","DOI":"10.1073\/pnas.182199799","article-title":"Identification of macrophage liver X receptors as inhibitors of atherosclerosis","volume":"99","author":"Tangirala","year":"2002","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"8","key":"10.1016\/j.bone.2020.115807_bb0635","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1161\/ATVBAHA.109.191197","article-title":"Liver x receptor signaling pathways and atherosclerosis","volume":"30","author":"Calkin","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"5","key":"10.1016\/j.bone.2020.115807_bb0640","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1046\/j.1523-1747.1999.00743.x","article-title":"Fetal epidermal differentiation and barrier development in vivo is accelerated by nuclear hormone receptor activators","volume":"113","author":"Hanley","year":"1999","journal-title":"J. Investig. Dermatol."},{"issue":"8","key":"10.1016\/j.bone.2020.115807_bb0645","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1073\/pnas.0911377107","article-title":"LXR modulation blocks prostaglandin E2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model","volume":"107","author":"Li","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb0650","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1124\/jpet.108.142687","article-title":"Antiatherosclerotic effects of a novel synthetic tissue-selective steroidal liver X receptor agonist in low-density lipoprotein receptor-deficient mice","volume":"327","author":"Peng","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"10","key":"10.1016\/j.bone.2020.115807_bb0655","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1194\/jlr.M400257-JLR200","article-title":"Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor","volume":"45","author":"Quinet","year":"2004","journal-title":"J. Lipid Res."},{"issue":"22","key":"10.1016\/j.bone.2020.115807_bb0660","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1101\/gad.850400","article-title":"Role of LXRs in control of lipogenesis","volume":"14","author":"Schultz","year":"2000","journal-title":"Genes Dev."},{"issue":"4","key":"10.1016\/j.bone.2020.115807_bb0665","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.yexcr.2012.12.004","article-title":"Apolipoprotein E inhibits osteoclast differentiation via regulation of C-Fos, NFATc1 and NF-\u039aB","volume":"319","author":"Kim","year":"2013","journal-title":"Exp. Cell Res."},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb0670","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1210\/jc.2011-2332","article-title":"Update on bone anabolics in osteoporosis treatment: rationale, current status, and perspectives","volume":"97","author":"Baron","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.bone.2020.115807_bb0675","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.ajpath.2012.05.034","article-title":"Hypercholesterolemia promotes an osteoporotic phenotype","volume":"181","author":"Pelton","year":"2012","journal-title":"Am. J. Pathol."},{"issue":"4","key":"10.1016\/j.bone.2020.115807_bb0680","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/ar4261","article-title":"Hypercholesterolemia boosts joint destruction in chronic arthritis. An experimental model aggravated by foam macrophage infiltration","volume":"15","author":"Prieto-Pot\u00edn","year":"2013","journal-title":"Arthritis Research & Therapy"},{"issue":"5446","key":"10.1016\/j.bone.2020.115807_bb0685","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1126\/science.286.5446.1946","article-title":"Stimulation of bone formation in vitro and in rodents by statins","volume":"286","author":"Mundy","year":"1999","journal-title":"Science"},{"issue":"6 Suppl","key":"10.1016\/j.bone.2020.115807_bb0690","first-page":"8","article-title":"Role of the cholesterol biosynthetic pathway in osteoblastic differentiation","volume":"30","author":"Viccica","year":"2007","journal-title":"J. Endocrinol. Investig."},{"issue":"7","key":"10.1016\/j.bone.2020.115807_bb0695","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1074\/jbc.M606706200","article-title":"Statin-induced Ras activation integrates the phosphatidylinositol 3-kinase signal to Akt and MAPK for bone morphogenetic protein-2 expression in osteoblast differentiation","volume":"282","author":"Ghosh-Choudhury","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.bone.2020.115807_bb0700","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/aps.2011.135","article-title":"High cholesterol diet increases osteoporosis risk via inhibiting bone formation in rats","volume":"32","author":"You","year":"2011","journal-title":"Acta Pharmacol. Sin."},{"issue":"11","key":"10.1016\/j.bone.2020.115807_bb0705","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/S0022-2275(20)41388-4","article-title":"Bisphosphonates used for the treatment of bone disorders inhibit squalene synthase and cholesterol biosynthesis","volume":"33","author":"Amin","year":"1992","journal-title":"J. Lipid Res."},{"issue":"6","key":"10.1016\/j.bone.2020.115807_bb0710","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1002\/jcb.20598","article-title":"Atorvastatin stimulates the production of osteoprotegerin by human osteoblasts","volume":"96","author":"Viereck","year":"2005","journal-title":"J. Cell. Biochem."},{"issue":"4","key":"10.1016\/j.bone.2020.115807_bb0715","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/jor.1100150410","article-title":"Characterization of human bone marrow stromal cells with respect to osteoblastic differentiation","volume":"15","author":"Majors","year":"1997","journal-title":"J. Orthop. Res."},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb0720","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1159\/000048929","article-title":"Age-related bone loss: old bone, new facts","volume":"48","author":"Chan","year":"2002","journal-title":"Gerontology"},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb0725","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S8756-3282(00)00317-3","article-title":"Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis?","volume":"27","author":"Nuttall","year":"2000","journal-title":"Bone"},{"key":"10.1016\/j.bone.2020.115807_bb0730","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/00003086-197110000-00021","article-title":"Osteoporosis and the replacement of cell populations of the marrow by adipose tissue: a quantitative study of 84 iliac bone biopsies","volume":"80","author":"Meunier","year":"1971","journal-title":"Clin. Orthop. Relat. Res. (1976\u20132007)"},{"issue":"3","key":"10.1016\/j.bone.2020.115807_bb0735","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/8756-3282(87)90015-9","article-title":"Changes in trabecular bone, hematopoiesis and bone marrow vessels in aplastic anemia, primary osteoporosis, and old age: a comparative histomorphometric study","volume":"8","author":"Burkhardt","year":"1987","journal-title":"Bone"},{"issue":"4","key":"10.1016\/j.bone.2020.115807_bb0740","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.steroids.2013.01.007","article-title":"Cholesterol loading affects osteoblastic differentiation in mouse mesenchymal stem cells","volume":"78","author":"Li","year":"2013","journal-title":"Steroids"},{"issue":"11","key":"10.1016\/j.bone.2020.115807_bb0745","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1002\/jor.20437","article-title":"Oxysterols enhance osteoblast differentiation in vitro and bone healing in vivo","volume":"25","author":"Aghaloo","year":"2007","journal-title":"J. Orthop. Res."},{"issue":"5","key":"10.1016\/j.bone.2020.115807_bb0750","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1359\/jbmr.040115","article-title":"Oxysterols regulate differentiation of mesenchymal stem cells: pro-bone and anti-fat","volume":"19","author":"Kha","year":"2004","journal-title":"J. Bone Miner. Res."},{"issue":"12","key":"10.1016\/j.bone.2020.115807_bb0755","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1210\/en.2011-1298","article-title":"The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors","volume":"152","author":"Nelson","year":"2011","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.bone.2020.115807_bb0760","doi-asserted-by":"crossref","first-page":"S108","DOI":"10.1038\/sj.cdd.4401399","article-title":"Osteoclast formation, survival and morphology are highly dependent on exogenous cholesterol\/lipoproteins","volume":"11","author":"Luegmayr","year":"2004","journal-title":"Cell Death & Differentiation"},{"issue":"12","key":"10.1016\/j.bone.2020.115807_bb0765","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1359\/jbmr.1999.14.12.2067","article-title":"Atherogenic diet and minimally oxidized low density lipoprotein inhibit osteogenic and promote adipogenic differentiation of marrow stromal cells","volume":"14","author":"Parhami","year":"1999","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.bone.2020.115807_bb0770","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1161\/01.ATV.17.4.680","article-title":"Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation: a possible explanation for the paradox of arterial calcification in osteoporotic patients","volume":"17","author":"Parhami","year":"1997","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"6","key":"10.1016\/j.bone.2020.115807_bb0775","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/omi.12103","article-title":"Liver X receptors contribute to periodontal pathogen-elicited inflammation and oral bone loss","volume":"30","author":"Huang","year":"2015","journal-title":"Mol Oral Microbiol"},{"issue":"4","key":"10.1016\/j.bone.2020.115807_bb0780","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035036","article-title":"Macrophage-associated mesenchymal stem cells assume an activated, migratory, pro-inflammatory phenotype with increased IL-6 and CXCL10 secretion","volume":"7","author":"Anton","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb0785","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nm820","article-title":"Reciprocal regulation of inflammation and lipid metabolism by liver X receptors","volume":"9","author":"Joseph","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.bone.2020.115807_bb0790","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.08009","article-title":"LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling","volume":"4","author":"Ito","year":"2015","journal-title":"Elife"},{"issue":"8","key":"10.1016\/j.bone.2020.115807_bb0795","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.2310\/JIM.0000000000000016","article-title":"Bone loss in surgically ovariectomized premenopausal women is associated with T lymphocyte activation and thymic hypertrophy","volume":"61","author":"Adeel","year":"2013","journal-title":"J. Investig. Med."},{"issue":"14","key":"10.1016\/j.bone.2020.115807_bb0800","doi-asserted-by":"crossref","first-page":"4799","DOI":"10.1158\/0008-5472.CAN-10-3922","article-title":"CD8+ T cells regulate bone tumor burden independent of osteoclast resorption","volume":"71","author":"Zhang","year":"2011","journal-title":"Cancer Res."},{"issue":"9","key":"10.1016\/j.bone.2020.115807_bb0805","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046615","article-title":"LXR-mediated inhibition of CD4+ T helper cells","volume":"7","author":"Solt","year":"2012","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.bone.2020.115807_bb0810","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1172\/JCI11066","article-title":"Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-\u03b1","volume":"106","author":"Cenci","year":"2000","journal-title":"J. Clin. Invest."},{"issue":"24","key":"10.1016\/j.bone.2020.115807_bb0815","doi-asserted-by":"crossref","first-page":"13960","DOI":"10.1073\/pnas.251534698","article-title":"Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo","volume":"98","author":"Roggia","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"12","key":"10.1016\/j.bone.2020.115807_bb0820","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1016\/j.intimp.2011.09.002","article-title":"Synthetic LXR agonist T0901317 attenuates lipopolysaccharide-induced acute lung injury in rats","volume":"11","author":"Wang","year":"2011","journal-title":"Int. Immunopharmacol."},{"issue":"6","key":"10.1016\/j.bone.2020.115807_bb0825","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.febslet.2010.02.006","article-title":"Oxysterol represses high-affinity IgE receptor-stimulated mast cell activation in liver X receptor-dependent and-independent manners","volume":"584","author":"Nunomura","year":"2010","journal-title":"FEBS Lett."},{"issue":"3","key":"10.1016\/j.bone.2020.115807_bb0830","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1210\/edrv.20.3.0370","article-title":"Estrogen receptor null mice: what have we learned and where will they lead us?","volume":"20","author":"Couse","year":"1999","journal-title":"Endocr. Rev."},{"issue":"5484","key":"10.1016\/j.bone.2020.115807_bb0835","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1126\/science.289.5484.1508","article-title":"Therapeutic approaches to bone diseases","volume":"289","author":"Rodan","year":"2000","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.bone.2020.115807_bb0840","doi-asserted-by":"crossref","first-page":"9","DOI":"10.7326\/0003-4819-122-1-199501010-00002","article-title":"Estrogen replacement therapy and fractures in older women","volume":"122","author":"Cauley","year":"1995","journal-title":"Ann. Intern. Med."},{"issue":"1","key":"10.1016\/j.bone.2020.115807_bb0845","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1210\/me.2007-0383","article-title":"27-Hydroxycholesterol is an endogenous selective estrogen receptor modulator","volume":"22","author":"DuSell","year":"2008","journal-title":"Mol. Endocrinol."},{"issue":"10","key":"10.1016\/j.bone.2020.115807_bb0850","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/nm1641","article-title":"27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen","volume":"13","author":"Umetani","year":"2007","journal-title":"Nat. Med."},{"issue":"6","key":"10.1016\/j.bone.2020.115807_bb0855","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1210\/mend.13.6.0299","article-title":"The actions and interactions of sex steroids and growth factors\/cytokines on the skeleton","volume":"13","author":"Spelsberg","year":"1999","journal-title":"Mol. Endocrinol."},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb0860","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/S8756-3282(01)00682-2","article-title":"Involvement of receptor activator of NF\u03baB ligand and tumor necrosis factor-\u03b1 in bone destruction in rheumatoid arthritis","volume":"30","author":"Romas","year":"2002","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.bone.2020.115807_bb0865","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/abbs\/gmw136","article-title":"Activation of liver X receptors promotes inflammatory cytokine MRNA degradation by upregulation of tristetraprolin","volume":"49","author":"Xiao","year":"2017","journal-title":"Acta Biochim. Biophys. Sin."},{"issue":"7","key":"10.1016\/j.bone.2020.115807_bb0870","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.1074\/jbc.M108807200","article-title":"Oxysterol activators of liver X receptor and 9-cis-retinoic acid promote sequential steps in the synthesis and secretion of tumor necrosis factor-\u03b1 from human monocytes","volume":"277","author":"Landis","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.bone.2020.115807_bb0875","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1210\/en.2010-0080","article-title":"The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis","volume":"151","author":"DuSell","year":"2010","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.bone.2020.115807_bb0880","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bone.2012.11.011","article-title":"The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: implications for the treatment and prevention of osteoporosis","volume":"53","author":"Nelson","year":"2013","journal-title":"Bone"},{"issue":"12","key":"10.1016\/j.bone.2020.115807_bb0885","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1038\/nm1672","article-title":"PPAR-\u03b3 regulates osteoclastogenesis in mice","volume":"13","author":"Wan","year":"2007","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.bone.2020.115807_bb0890","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.bone.2006.04.008","article-title":"Surface-specific effects of a PPAR\u03b3 agonist, darglitazone, on bone in mice","volume":"39","author":"Li","year":"2006","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.bone.2020.115807_bb0895","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1172\/JCI200419900","article-title":"PPAR \u03b3 insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors","volume":"113","author":"Akune","year":"2004","journal-title":"J. Clin. Invest."},{"issue":"26","key":"10.1016\/j.bone.2020.115807_bb0900","doi-asserted-by":"crossref","first-page":"23270","DOI":"10.1074\/jbc.M211610200","article-title":"Activation of peroxisome proliferator-activated receptor-\u03b3 inhibits the Runx2-mediated transcription of osteocalcin in osteoblasts","volume":"278","author":"Jeon","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bone.2020.115807_bb0905","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1042\/bj20030426","article-title":"Peroxisome-proliferator-activated receptor \u03b3 suppresses Wnt\/\u03b2-catenin signalling during adipogenesis","volume":"376","author":"Moldes","year":"2003","journal-title":"Biochem. J."},{"issue":"6","key":"10.1016\/j.bone.2020.115807_bb0910","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1021\/tx500433r","article-title":"Tributyltin engages multiple nuclear receptor pathways and suppresses osteogenesis in bone marrow multipotent stromal cells","volume":"28","author":"Baker","year":"2015","journal-title":"Chem. Res. Toxicol."},{"issue":"8","key":"10.1016\/j.bone.2020.115807_bb0915","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1182\/blood-2006-09-048249","article-title":"MafB negatively regulates RANKL-mediated osteoclast differentiation","volume":"109","author":"Kim","year":"2007","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.bone.2020.115807_bb0920","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1007\/s00018-017-2458-4","article-title":"The multi-faceted role of retinoid X receptor in bone remodeling","volume":"74","author":"Men\u00e9ndez-Guti\u00e9rrez","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"issue":"11","key":"10.1016\/j.bone.2020.115807_bb0925","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.biochi.2004.09.018","article-title":"SREBP transcription factors: master regulators of lipid homeostasis","volume":"86","author":"Eberl\u00e9","year":"2004","journal-title":"Biochimie"},{"issue":"11","key":"10.1016\/j.bone.2020.115807_bb0930","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1038\/nm.3314","article-title":"Activation of hedgehog signaling by loss of GNAS causes heterotopic ossification","volume":"19","author":"Regard","year":"2013","journal-title":"Nat. Med."},{"issue":"6","key":"10.1016\/j.bone.2020.115807_bb0935","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.tips.2009.03.007","article-title":"Mechanisms of hedgehog pathway activation in cancer and implications for therapy","volume":"30","author":"Scales","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"issue":"1","key":"10.1016\/j.bone.2020.115807_bb0940","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms7709","article-title":"Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms","volume":"6","author":"Cohen","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bone.2020.115807_bb0945","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1146\/annurev-cellbio-092910-154048","article-title":"Gli proteins in development and disease","volume":"27","author":"Hui","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"5","key":"10.1016\/j.bone.2020.115807_bb0950","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.devcel.2008.03.007","article-title":"Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity","volume":"14","author":"Ohba","year":"2008","journal-title":"Dev. Cell"},{"issue":"10","key":"10.1016\/j.bone.2020.115807_bb0955","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0109597","article-title":"Gli1 haploinsufficiency leads to decreased bone mass with an uncoupling of bone metabolism in adult mice","volume":"9","author":"Kitaura","year":"2014","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.bone.2020.115807_bb0960","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.devcel.2008.02.003","article-title":"Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression","volume":"14","author":"Mak","year":"2008","journal-title":"Dev. Cell"},{"issue":"Dec","key":"10.1016\/j.bone.2020.115807_bb0965","first-page":"1","article-title":"Key triggers of osteoclast-related diseases and available strategies for targeted therapies: a review","volume":"4","author":"Bi","year":"2017","journal-title":"Frontiers in Medicine"},{"issue":"16","key":"10.1016\/j.bone.2020.115807_bb0970","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20163981","article-title":"Regulation of hedgehog signaling offers a novel perspective for bone homeostasis disorder treatment","volume":"20","author":"Lv","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.bone.2020.115807_bb0975","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1042\/CBI20110284","article-title":"Sonic hedgehog enhances the proliferation and osteogenic differentiation of bone marrow-derived mesenchymal stem cells","volume":"36","author":"Cai","year":"2012","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.bone.2020.115807_bb0980","article-title":"Hedgehog signaling inhibition by smoothened antagonist BMS-833923 reduces osteoblast differentiation and ectopic bone formation of human skeletal (mesenchymal) stem cells","volume":"2019","author":"Almuraikhi","year":"2019","journal-title":"Stem Cells International"},{"issue":"10","key":"10.1016\/j.bone.2020.115807_bb0990","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1210\/me.2008-0453","article-title":"Negative regulation of hedgehog signaling by liver X receptors","volume":"23","author":"Kim","year":"2009","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.bone.2020.115807_bb0995","series-title":"Oxysterols That Activate Liver X Receptor Signaling and Inhibit Hedgehog Signaling","author":"Parhami","year":"2016"},{"issue":"12","key":"10.1016\/j.bone.2020.115807_bb1000","doi-asserted-by":"crossref","first-page":"8959","DOI":"10.1074\/jbc.M611741200","article-title":"Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells","volume":"282","author":"Dwyer","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.bone.2020.115807_bb1005","doi-asserted-by":"crossref","first-page":"6509","DOI":"10.1074\/jbc.M707000200","article-title":"NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells","volume":"283","author":"Bai","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb1010","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1210\/en.2012-1732","article-title":"Osteoblast lineage-specific effects of notch activation in the skeleton","volume":"154","author":"Canalis","year":"2013","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.bone.2020.115807_bb1015","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nm1712","article-title":"Dimorphic effects of notch signaling in bone homeostasis","volume":"14","author":"Engin","year":"2008","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.bone.2020.115807_bb1020","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nm1716","article-title":"Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation","volume":"14","author":"Hilton","year":"2008","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.bone.2020.115807_bb1025","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1210\/er.2016-1002","article-title":"Notch signaling and the skeleton","volume":"37","author":"Zanotti","year":"2016","journal-title":"Endocr. Rev."},{"issue":"3","key":"10.1016\/j.bone.2020.115807_bb1030","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/jcp.10208","article-title":"HES and HERP families: multiple effectors of the notch signaling pathway","volume":"194","author":"Iso","year":"2003","journal-title":"J. Cell. Physiol."},{"issue":"10","key":"10.1016\/j.bone.2020.115807_bb1035","doi-asserted-by":"crossref","first-page":"6203","DOI":"10.1074\/jbc.M508370200","article-title":"Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt\/\u03b2-catenin but not bone morphogenetic protein signaling","volume":"281","author":"Deregowski","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bone.2020.115807_bb1040","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1074\/jbc.275.1.530","article-title":"The mammalian basic helix loop helix protein HES-1 binds to and modulates the transactivating function of the runt-related factor Cbfa1","volume":"275","author":"McLarren","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bone.2020.115807_bb1045","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1074\/jbc.M806389200","article-title":"Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells","volume":"284","author":"Sharff","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bone.2020.115807_bb1050","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1359\/jbmr.091024","article-title":"Osteogenic oxysterol, 20(S)-hydroxycholesterol, induces notch target gene expression in bone marrow stromal cells","volume":"25","author":"Kim","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2020.115807_bb1055","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.atherosclerosis.2016.03.008","article-title":"Apolipoprotein A-1 binding protein promotes macrophage cholesterol efflux by facilitating apolipoprotein A-1 binding to ABCA1 and preventing ABCA1 degradation","volume":"248","author":"Zhang","year":"2016","journal-title":"Atherosclerosis"},{"issue":"11","key":"10.1016\/j.bone.2020.115807_bb1060","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1161\/CIRCRESAHA.116.309754","article-title":"AIBP limits angiogenesis through \u03b3-secretase-mediated upregulation of notch signaling","volume":"120","author":"Mao","year":"2017","journal-title":"Circ. Res."},{"issue":"20","key":"10.1016\/j.bone.2020.115807_bb1065","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1056\/NEJMoa013444","article-title":"High bone density due to a mutation in LDL-receptor\u2013related protein 5","volume":"346","author":"Boyden","year":"2002","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.bone.2020.115807_bb1070","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0092-8674(01)00571-2","article-title":"LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development","volume":"107","author":"Gong","year":"2001","journal-title":"Cell"},{"issue":"3 Suppl","key":"10.1016\/j.bone.2020.115807_bb1075","first-page":"1113","article-title":"The OPG\/RANKL system and zinc ions are promoters of bone remodeling by osteoblast proliferation in postmenopausal osteoporosis","volume":"52","author":"Gurban","year":"2011","journal-title":"Romanian J. Morphol. Embryol."},{"issue":"4","key":"10.1016\/j.bone.2020.115807_bb1080","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2741\/3673","article-title":"Regulatory mechanism of osteoclastogenesis by RANKL and Wnt signals","volume":"16","author":"Takahashi","year":"2011","journal-title":"Front. Biosci."},{"issue":"1","key":"10.1016\/j.bone.2020.115807_bb1085","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1359\/jbmr.2000.15.1.2","article-title":"The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption","volume":"15","author":"Hofbauer","year":"2000","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2020.115807_bb1090","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/534352","article-title":"Serum \u03b2-catenin levels associated with the ratio of RANKL\/OPG in patients with postmenopausal osteoporosis","volume":"2013","author":"Xu","year":"2013","journal-title":"International Journal of Endocrinology"},{"issue":"3","key":"10.1016\/j.bone.2020.115807_bb1095","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1089\/ars.2016.6711","article-title":"Paraquat induces peripheral myelin disruption and locomotor defects: crosstalk with LXR and Wnt pathways","volume":"27","author":"Hichor","year":"2017","journal-title":"Antioxid. Redox Signal."},{"issue":"26","key":"10.1016\/j.bone.2020.115807_bb1100","doi-asserted-by":"crossref","first-page":"9620","DOI":"10.1523\/JNEUROSCI.0761-11.2011","article-title":"Interplay between LXR and Wnt\/\u03b2-catenin signaling in the negative regulation of peripheral myelin genes by oxysterols","volume":"31","author":"Makoukji","year":"2011","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb1105","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bcp.2008.10.007","article-title":"Suppression of \u03b2-catenin signaling by liver X receptor ligands","volume":"77","author":"Uno","year":"2009","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb1110","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/labinvest.2015.141","article-title":"Nuclear hormone receptor LXR \u03b1 inhibits adipocyte differentiation of mesenchymal stem cells with Wnt\/beta-catenin signaling","volume":"96","author":"Matsushita","year":"2016","journal-title":"Lab. Investig."},{"key":"10.1016\/j.bone.2020.115807_bb1115","unstructured":"Turner, C H, T Wang, T Hirano, D B Burr, J M Hock, C E Hotchkiss, R Brommage, and C P Jerome. 1999. \u201cIn primates, treatment with PTH (1\u201334), LY333334, increases bone strength at trabecular bone sites without compromising the strength of cortical bone.\u201d In Journal of Bone and Mineral Research, 14:S414\u2013S414. AMER SOC BONE & MINERAL RES PO BOX 2759, DURHAM, NC 27715\u20132759 USA."},{"issue":"8","key":"10.1016\/j.bone.2020.115807_bb1120","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.1210\/endo.136.8.7628403","article-title":"Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells","volume":"136","author":"Dobnig","year":"1995","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb1125","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.tem.2004.01.006","article-title":"Parathyroid hormone: a double-edged sword for bone metabolism","volume":"15","author":"Qin","year":"2004","journal-title":"Trends in Endocrinology & Metabolism"},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb1130","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s11914-008-0013-9","article-title":"The cell biology of parathyroid hormone in osteoblasts","volume":"6","author":"Kousteni","year":"2008","journal-title":"Current Osteoporosis Reports"},{"issue":"3","key":"10.1016\/j.bone.2020.115807_bb1135","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1210\/me.2002-0225","article-title":"Parathyroid hormone bone anabolic action requires Cbfa1\/Runx2-dependent signaling","volume":"17","author":"Krishnan","year":"2003","journal-title":"Mol. Endocrinol."},{"issue":"10","key":"10.1016\/j.bone.2020.115807_bb1140","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1194\/jlr.M500116-JLR200","article-title":"Synthetic LXR agonists increase LDL in CETP species","volume":"46","author":"Groot","year":"2005","journal-title":"J. Lipid Res."},{"issue":"23","key":"10.1016\/j.bone.2020.115807_bb1145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules24234316","article-title":"Synthesis and in vitro evaluation of novel liver X receptor agonists based on naphthoquinone derivatives","volume":"24","author":"Nishioka","year":"2019","journal-title":"Molecules"},{"issue":"12","key":"10.1016\/j.bone.2020.115807_bb1150","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1021\/acsmedchemlett.6b00234","article-title":"Discovery of highly potent liver X receptor \u03b2 agonists","volume":"7","author":"Kick","year":"2016","journal-title":"ACS Med. Chem. Lett."},{"issue":"6","key":"10.1016\/j.bone.2020.115807_bb1155","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.anai.2018.03.013","article-title":"Effect of short-term liver X receptor activation on epidermal barrier features in mild to moderate atopic dermatitis: a randomized controlled trial","volume":"120","author":"Czarnowicki","year":"2018","journal-title":"Annals of Allergy, Asthma & Immunology"},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb1160","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.bmcl.2009.11.098","article-title":"3-(3-Aryloxyaryl) imidazo [1, 2-a] pyridine sulfones as liver X receptor agonists","volume":"20","author":"Singhaus","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"2","key":"10.1016\/j.bone.2020.115807_bb1165","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.bmcl.2009.11.099","article-title":"1-(3-Aryloxyaryl) benzimidazole sulfones are liver X receptor agonists","volume":"20","author":"Travins","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"11","key":"10.1016\/j.bone.2020.115807_bb1170","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1021\/acs.bioconjchem.5b00203","article-title":"Targeted delivery of LXR agonist using a site-specific antibody-drug conjugate","volume":"26","author":"Lim","year":"2015","journal-title":"Bioconjug. Chem."},{"issue":"3","key":"10.1016\/j.bone.2020.115807_bb1175","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.bmcl.2018.12.025","article-title":"Development of novel liver X receptor modulators based on a 1,2,4-triazole scaffold","volume":"29","author":"Goher","year":"2019","journal-title":"Bioorganic and Medicinal Chemistry Letters"},{"issue":"20","key":"10.1016\/j.bone.2020.115807_bb1180","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1002\/cmdc.201600305","article-title":"Development of tetrachlorophthalimides as liver X receptor \u03b2 (LXR\u03b2)-selective agonists","volume":"11","author":"Nomura","year":"2016","journal-title":"ChemMedChem"},{"issue":"1","key":"10.1016\/j.bone.2020.115807_bb1185","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-019-0675-0","article-title":"Structural analysis identifies an escape route from the adverse lipogenic effects of liver X receptor ligands","volume":"2","author":"Belorusova","year":"2019","journal-title":"Communications Biology"},{"key":"10.1016\/j.bone.2020.115807_bb1190","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.26495","article-title":"Tributyltin induces distinct effects on cortical and trabecular bone in female C57Bl\/6J mice","volume":"233","author":"Watt","year":"2018","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/j.bone.2020.115807_bb1195","doi-asserted-by":"crossref","first-page":"41","DOI":"10.21775\/cimb.022.041","article-title":"Liver X receptors and their agonists: targeting for cholesterol homeostasis and cardiovascular diseases","volume":"22","author":"Ma","year":"2017","journal-title":"Curr Issues Mol Biol"},{"key":"10.1016\/j.bone.2020.115807_bb2000","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nrd4280","article-title":"Liver X receptors in lipid metabolism: opportunities for drug discovery","volume":"13","year":"2014","journal-title":"Nat Rev Drug Discov"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328220305950?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328220305950?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:52:21Z","timestamp":1757613141000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328220305950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":239,"alternative-id":["S8756328220305950"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2020.115807","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liver X receptors and skeleton: Current state-of-knowledge","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2020.115807","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115807"}}