{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T04:06:16Z","timestamp":1789617976626,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013348","name":"Swiss Commission for Technology and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.bone.2021.115903","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T18:32:09Z","timestamp":1614450729000},"page":"115903","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Quantitative measures of bone shape, cartilage morphometry and joint alignment are associated with disease in an ACLT and MMx rat model of osteoarthritis"],"prefix":"10.1016","volume":"146","author":[{"given":"Bryce A.","family":"Besler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jemima E.","family":"Schadow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pholpat","family":"Durongbhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"Steiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J.","family":"Choo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin A.","family":"Zulliger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Wilke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailash","family":"Atal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Firminger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelie","family":"Quintin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Koller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dobrila","family":"Nesic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn S.","family":"Stok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2021.115903_bb0005","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1749-6632.2009.05240.x","article-title":"Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis","volume":"1192","author":"Goldring","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"1","key":"10.1016\/j.bone.2021.115903_bb0010","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s13075-018-1636-6","article-title":"Glycation marker glucosepane increases with the progression of osteoarthritis and correlates with morphological and functional changes of cartilage in vivo","volume":"20","author":"Legrand","year":"2018","journal-title":"Arthritis research & therapy"},{"key":"10.1016\/j.bone.2021.115903_bb0015","doi-asserted-by":"crossref","unstructured":"Latourte, A., et al., Systemic inhibition of IL-6\/Stat3 signalling protects against experimental osteoarthritis. 2017. 76(4): p. 748\u2013755.","DOI":"10.1136\/annrheumdis-2016-209757"},{"issue":"2","key":"10.1016\/j.bone.2021.115903_bb0020","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.joca.2018.10.007","article-title":"Regional gene expression analysis of multiple tissues in an experimental animal model of post-traumatic osteoarthritis","volume":"27","author":"Salazar-Noratto","year":"2019","journal-title":"Osteoarthritis & cartilage"},{"issue":"5","key":"10.1016\/j.bone.2021.115903_bb0025","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.jbspin.2016.09.006","article-title":"Long noncoding RNAs in osteoarthritis","volume":"84","author":"Lu","year":"2017","journal-title":"Joint Bone Spine"},{"issue":"12","key":"10.1016\/j.bone.2021.115903_bb0030","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1016\/j.joca.2017.08.005","article-title":"Predictive and concurrent validity of cartilage thickness change as a marker of knee osteoarthritis progression: data from the osteoarthritis initiative","volume":"25","author":"Wirth","year":"2017","journal-title":"Osteoarthritis & cartilage"},{"key":"10.1016\/j.bone.2021.115903_bb0035","doi-asserted-by":"crossref","first-page":"A1","DOI":"10.1016\/j.joca.2006.11.009","article-title":"Atlas of individual radiographic features in osteoarthritis, revised","volume":"15","author":"Altman","year":"2007","journal-title":"Osteoarthritis & cartilage"},{"key":"10.1016\/j.bone.2021.115903_bb0040","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.joca.2015.04.009","article-title":"Quantitative morphometric patterns in cartilage and bone from the humeral heads of end-stage osteoarthritis patients","volume":"23","author":"Pawson","year":"2015","journal-title":"Osteoarthr. Cartil."},{"issue":"12","key":"10.1016\/j.bone.2021.115903_bb0045","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.2106\/00004623-200312000-00015","article-title":"Osteoporosis and vitamin-D deficiency among postmenopausal women with osteoarthritis undergoing total hip arthroplasty","volume":"85-A","author":"Glowacki","year":"2003","journal-title":"J. Bone Joint Surg. Am."},{"issue":"1","key":"10.1016\/j.bone.2021.115903_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0147564","article-title":"Three-dimensional quantitative morphometric analysis (QMA) for in situ joint and tissue assessment of osteoarthritis in a preclinical rabbit disease model","volume":"11","author":"Stok","year":"2016","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.bone.2021.115903_bb0055","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1007\/s10439-013-0871-x","article-title":"Quantitative in vivo HR-pQCT imaging of 3D wrist and metacarpophalangeal joint space width in rheumatoid arthritis","volume":"41","author":"Burghardt","year":"2013","journal-title":"Ann. Biomed. Eng."},{"issue":"6","key":"10.1016\/j.bone.2021.115903_bb0060","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.bone.2005.11.026","article-title":"Cancellous bone adaptation to in vivo loading in a rabbit model","volume":"38","author":"van der Meulen","year":"2006","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.bone.2021.115903_bb0065","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/BF02347054","article-title":"3D micro-computed tomography of trabecular and cortical bone architecture with application to a rat model of immobilisation osteoporosis","volume":"38","author":"Laib","year":"2000","journal-title":"Med Biol Eng Comput"},{"issue":"5","key":"10.1016\/j.bone.2021.115903_bb0070","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00223-005-0039-2","article-title":"Compartmental bone morphometry in the mouse femur: reproducibility and resolution dependence of microtomographic measurements","volume":"77","author":"Kohler","year":"2005","journal-title":"Calcif. Tissue Int."},{"issue":"4","key":"10.1016\/j.bone.2021.115903_bb0075","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1089\/ten.teb.2010.0572","article-title":"Mechanical properties of natural cartilage and tissue-engineered constructs","volume":"17","author":"Little","year":"2011","journal-title":"Tissue Eng Part B Rev"},{"issue":"3","key":"10.1016\/j.bone.2021.115903_bb0080","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/jor.20995","article-title":"Low-intensity pulsed ultrasound (LIPUS) increases the articular cartilage type II collagen in a rat osteoarthritis model","volume":"28","author":"Naito","year":"2010","journal-title":"J. Orthop. Res."},{"issue":"Suppl. 3","key":"10.1016\/j.bone.2021.115903_bb0085","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1016\/j.joca.2010.05.030","article-title":"The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the rat","volume":"18","author":"Gerwin","year":"2010","journal-title":"Osteoarthr. Cartil."},{"issue":"11","key":"10.1016\/j.bone.2021.115903_bb0090","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1093\/bioinformatics\/btp184","article-title":"Globally optimal stitching of tiled 3D microscopic image acquisitions","volume":"25","author":"Preibisch","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bone.2021.115903_bb0095","doi-asserted-by":"crossref","first-page":"S108","DOI":"10.1016\/S0021-9290(12)70109-4","article-title":"3D spatial mapping of osteocytes in an in vivo model for bone adaption","volume":"45","author":"Tr\u00fcssel","year":"2012","journal-title":"J. Biomech."},{"issue":"7","key":"10.1016\/j.bone.2021.115903_bb0100","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1359\/jbmr.1999.14.7.1167","article-title":"Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus","volume":"14","author":"Hildebrand","year":"1999","journal-title":"J. Bone Miner. Res."},{"issue":"9","key":"10.1016\/j.bone.2021.115903_bb0105","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/jemt.20713","article-title":"Morphometric characterization of murine articular cartilage--novel application of confocal laser scanning microscopy","volume":"72","author":"Stok","year":"2009","journal-title":"Microsc. Res. Tech."},{"issue":"3","key":"10.1016\/j.bone.2021.115903_bb0110","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.bone.2009.05.017","article-title":"Revealing the interplay of bone and cartilage in osteoarthritis through multimodal imaging of murine joints","volume":"45","author":"Stok","year":"2009","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.bone.2021.115903_bb0115","doi-asserted-by":"crossref","first-page":"314","DOI":"10.21037\/qims.2019.12.11","article-title":"Consensus approach for 3D joint space width of metacarpophalangeal joints of rheumatoid arthritis patients using high-resolution peripheral quantitative computed tomography","volume":"10","author":"Stok","year":"2020","journal-title":"Quantitative Imaging in Medicine Surgery"},{"issue":"2","key":"10.1016\/j.bone.2021.115903_bb0120","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1037\/0033-2909.86.2.420","article-title":"Intraclass correlations: uses in assessing rater reliability","volume":"86","author":"Shrout","year":"1979","journal-title":"Psychol. Bull."},{"issue":"23\u201324","key":"10.1016\/j.bone.2021.115903_bb0125","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1002\/sim.4780132310","article-title":"A critical discussion of intraclass correlation coefficients","volume":"13","author":"M\u00fcller","year":"1994","journal-title":"Stat. Med."},{"issue":"4","key":"10.1016\/j.bone.2021.115903_bb0130","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/BF01774016","article-title":"Accurate assessment of precision errors: how to measure the reproducibility of bone densitometry techniques","volume":"5","author":"Gluer","year":"1995","journal-title":"Osteoporos. Int."},{"issue":"1","key":"10.1016\/j.bone.2021.115903_bb0135","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.bone.2009.09.023","article-title":"Reproducibility of bone micro-architecture measurements in rodents by in vivo micro-computed tomography is maximized with three-dimensional image registration","volume":"46","author":"Nishiyama","year":"2010","journal-title":"Bone"},{"issue":"5","key":"10.1016\/j.bone.2021.115903_bb0140","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1080\/10255842.2012.699526","article-title":"Image interpolation allows accurate quantitative bone morphometry in registered micro-computed tomography scans","volume":"17","author":"Schulte","year":"2014","journal-title":"Comput Methods Biomech Biomed Engin"},{"issue":"2","key":"10.1016\/j.bone.2021.115903_bb0145","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.bone.2008.10.045","article-title":"Non-invasive bone competence analysis by high-resolution pQCT: an in vitro reproducibility study on structural and mechanical properties at the human radius","volume":"44","author":"Mueller","year":"2009","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.bone.2021.115903_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-25186-1","article-title":"Progression of post-traumatic osteoarthritis in rat meniscectomy models: comprehensive monitoring using MRI","volume":"8","author":"Ali","year":"2018","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.bone.2021.115903_bb0155","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/jor.24470","article-title":"Characterization of post-traumatic osteoarthritis in rats following anterior cruciate ligament rupture by non-Invasive Knee Injury (NIKI)","volume":"38","author":"Brown","year":"2019","journal-title":"Journal of Orthopaedic Research\u00ae"},{"issue":"5","key":"10.1016\/j.bone.2021.115903_bb0160","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1053\/joca.2001.0413","article-title":"High-resolution MRI detects cartilage swelling at the early stages of experimental osteoarthritis","volume":"9","author":"Calvo","year":"2001","journal-title":"Osteoarthritis & Cartilage"},{"issue":"11","key":"10.1016\/j.bone.2021.115903_bb0165","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.joca.2004.07.007","article-title":"Histopathological correlation of cartilage swelling detected by magnetic resonance imaging in early experimental osteoarthritis","volume":"12","author":"Calvo","year":"2004","journal-title":"Osteoarthritis & cartilage"},{"issue":"2","key":"10.1016\/j.bone.2021.115903_bb0170","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.bone.2005.08.007","article-title":"Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis","volume":"38","author":"Hayami","year":"2006","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.bone.2021.115903_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4172\/2167-7921.1000193","article-title":"A less invasive approach of medial meniscectomy in rat: a model to target early or less severe human osteoarthritis","volume":"5","author":"Juneja","year":"2016","journal-title":"Journal of Arthritis"},{"issue":"12","key":"10.1016\/j.bone.2021.115903_bb0180","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.joca.2004.08.010","article-title":"Ex vivo characterization of articular cartilage and bone lesions in a rabbit ACL transection model of osteoarthritis using MRI and micro-CT","volume":"12","author":"Batiste","year":"2004","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2021.115903_bb0185","first-page":"12(3)","article-title":"Automated assessment of bone changes in cross-sectional micro-CT studies of murine experimental osteoarthritis","author":"Borges","year":"2017","journal-title":"PLoS One"},{"issue":"14","key":"10.1016\/j.bone.2021.115903_bb0190","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1016\/j.jbiomech.2016.08.024","article-title":"Comparison of micro-CT post-processing methods for evaluating the trabecular bone volume fraction in a rat ACL-transection model","volume":"49","author":"Chin","year":"2016","journal-title":"J. Biomech."},{"issue":"12","key":"10.1016\/j.bone.2021.115903_bb0195","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1002\/jor.22975","article-title":"Assessment of cortical and trabecular bone changes in two models of post-traumatic osteoarthritis","volume":"33","author":"Pauly","year":"2015","journal-title":"J. Orthop. Res."},{"issue":"3","key":"10.1016\/j.bone.2021.115903_bb0200","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.joca.2004.11.004","article-title":"Long-term periarticular bone adaptation in a feline knee injury model for post-traumatic experimental osteoarthritis","volume":"13","author":"Boyd","year":"2005","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2021.115903_bb0205","doi-asserted-by":"crossref","unstructured":"Maerz, T., et al., Subchondral and epiphyseal bone remodeling following surgical transection and noninvasive rupture of the anterior cruciate ligament as models of post-traumatic osteoarthritis. 2016. 24(4): p. 698\u2013708.","DOI":"10.1016\/j.joca.2015.11.005"},{"issue":"4","key":"10.1016\/j.bone.2021.115903_bb0210","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2106\/JBJS.16.00199","article-title":"Rotational knee instability in ACL-deficient knees: role of the anterolateral ligament and iliotibial band as defined by tibiofemoral compartment translations and rotations","volume":"99","author":"Noyes","year":"2017","journal-title":"JBJS"},{"issue":"8","key":"10.1016\/j.bone.2021.115903_bb0215","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1177\/0363546506287299","article-title":"The 6 degrees of freedom kinematics of the knee after anterior cruciate ligament deficiency: an in vivo imaging analysis","volume":"34","author":"DeFrate","year":"2006","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.bone.2021.115903_bb0220","first-page":"1","article-title":"Increased femoral anteversion related to infratrochanteric femoral torsion is associated with ACL rupture","author":"Alpay","year":"2020","journal-title":"Knee Surgery, Sports Traumatology, Arthroscopy"},{"issue":"2","key":"10.1016\/j.bone.2021.115903_bb0225","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jbiomech.2004.02.012","article-title":"Comparison of kinematics in the healthy and ACL injured knee using MRI","volume":"38","author":"Scarvell","year":"2005","journal-title":"J. Biomech."},{"key":"10.1016\/j.bone.2021.115903_bb0230","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00003086-199003000-00004","article-title":"Material properties and structure-function relationships in the menisci","volume":"252","author":"Fithian","year":"1990","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"10","key":"10.1016\/j.bone.2021.115903_bb0235","first-page":"S840","article-title":"Importance of hand positioning in 3D joint space morphology assessment","volume":"65","author":"Boutroy","year":"2013","journal-title":"Arthr Rheum"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632822100065X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632822100065X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:55:40Z","timestamp":1757613340000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S875632822100065X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":47,"alternative-id":["S875632822100065X"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2021.115903","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitative measures of bone shape, cartilage morphometry and joint alignment are associated with disease in an ACLT and MMx rat model of osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2021.115903","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115903"}}