{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T23:10:33Z","timestamp":1780441833327,"version":"3.54.1"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.bone.2021.115942","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T11:51:50Z","timestamp":1617709910000},"page":"115942","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Alendronate\/dexamethasone combination therapy worsens soft and hard tissue wound healing around implants in rat maxillae"],"prefix":"10.1016","volume":"148","author":[{"given":"Maaya","family":"Inoue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihaya","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Kuroshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Sawase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2021.115942_bb0005","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0300-9785(81)80077-4","article-title":"A 15-year study of osseointegrated implants in the treatment of the edentulous jaw","volume":"10","author":"Adell","year":"1981","journal-title":"Int. J. Oral Surg."},{"key":"10.1016\/j.bone.2021.115942_bb0010","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1177\/0022034518792567","article-title":"Trends in dental implant use in the U.S., 1999-2016, and projections to 2026","volume":"97","author":"Elani","year":"2018","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.bone.2021.115942_bb0015","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/joor.12866","article-title":"Survival and complications: a 9- to 15-year retrospective follow-up of dental implant therapy","volume":"47","author":"Adler","year":"2020","journal-title":"J. Oral Rehabil."},{"key":"10.1016\/j.bone.2021.115942_bb0020","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4103\/ejd.ejd_340_16","article-title":"Complications in implant dentistry","volume":"11","author":"Hanif","year":"2017","journal-title":"Eur. J. Dent."},{"key":"10.1016\/j.bone.2021.115942_bb0025","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1111\/j.1600-0501.2010.01912.x","article-title":"Long-term implant survival and success: a 10-16-year follow-up of non-submerged dental implants","volume":"21","author":"Simonis","year":"2010","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.bone.2021.115942_bb0030","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/clr.13288","article-title":"Effect of advanced age and\/or systemic medical conditions on dental implant survival: a systematic review and meta-analysis","volume":"29","author":"Schimmel","year":"2018","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.bone.2021.115942_bb0035","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.joms.2005.07.010","article-title":"Bisphosphonate-induced exposed bone (osteonecrosis\/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment","volume":"63","author":"Marx","year":"2005","journal-title":"J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.bone.2021.115942_bb0040","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.joms.2014.04.031","article-title":"American Association of Oral and Maxillofacial Surgeons, American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw\u20142014 update","volume":"72","author":"Ruggiero","year":"2014","journal-title":"J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.bone.2021.115942_bb0045","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.ijom.2015.01.026","article-title":"Treatment strategies and outcomes of bisphosphonate-related osteonecrosis of the jaw (BRONJ) with characterization of patients: a systematic review","volume":"44","author":"Fliefel","year":"2015","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.bone.2021.115942_bb0050","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/clr.13282","article-title":"The effect of antiresorptive drugs on implant therapy: systematic review and meta-analysis","volume":"29","author":"Stavropoulos","year":"2018","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.bone.2021.115942_bb0055","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/clr.13342","article-title":"The influence of implant length and design and medications on clinical and patient-reported outcomes","volume":"29","author":"Jung","year":"2018","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.bone.2021.115942_bb0060","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1177\/0022034512472335","article-title":"Effect of local vs. systemic bisphosphonate delivery on dental implant fixation in a model of osteonecrosis of the jaw","volume":"92","author":"Abtahi","year":"2013","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.bone.2021.115942_bb0065","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/jbmr.2405","article-title":"International task force on osteonecrosis of the jaw, diagnosis and management of osteonecrosis of the jaw: A systematic review and international consensus","volume":"30","author":"Khan","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2021.115942_bb0070","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1200\/JCO.19.01186","article-title":"Medication-related osteonecrosis of the jaw: MASCC\/ISOO\/ASCO clinical practice guideline","volume":"37","author":"Yarom","year":"2019","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bone.2021.115942_bb0075","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bone.2013.05.013","article-title":"Chemotherapeutic and antiresorptive combination therapy suppressed lymphangiogenesis and induced osteonecrosis of the jaw-like lesions in mice","volume":"56","author":"Kuroshima","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.115942_bb0080","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00774-017-0872-1","article-title":"Effect of anti-angiogenesis induced by chemotherapeutic monotherapy, chemotherapeutic\/bisphosphonate combination therapy and anti-VEGFA mAb therapy on tooth extraction socket healing in mice","volume":"36","author":"Akita","year":"2018","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.bone.2021.115942_bb0085","doi-asserted-by":"crossref","first-page":"115308","DOI":"10.1016\/j.bone.2020.115308","article-title":"Distinct immunopathology in the early stages between different antiresorptives-related osteonecrosis of the jaw-like lesions in mice","author":"Hayano","year":"2020","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.115942_bb0090","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.bone.2018.05.001","article-title":"Prevalence of bisphosphonate-related osteonecrosis of the jaw-like lesions is increased in a chemotherapeutic dose-dependent manner in mice","volume":"112","author":"Kuroshima","year":"2018","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.115942_bb0095","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1002\/jbmr.37","article-title":"Cell-based immunotherapy with mesenchymal stem cells cures bisphosphonate-related osteonecrosis of the jaw-like disease in mice","volume":"25","author":"Kikuiri","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2021.115942_bb0100","doi-asserted-by":"crossref","first-page":"280","DOI":"10.2353\/ajpath.2010.090592","article-title":"Bisphosphonates cause osteonecrosis of the jaw-like disease in mice","volume":"177","author":"Bi","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bone.2021.115942_bb0105","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1158\/1078-0432.CCR-13-0042","article-title":"IL-17-mediated M1\/M2 macrophage alteration contributes to pathogenesis of bisphosphonate-related osteonecrosis of the jaws","volume":"19","author":"Zhang","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bone.2021.115942_bb0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0189893","article-title":"Effects of mechanical repetitive load on bone quality around implants in rat maxillae","volume":"12","author":"Uto","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2021.115942_bb0115","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1365-2818.2011.03541.x","article-title":"Limitations of using micro-computed tomography to predict bone-implant contact and mechanical fixation","volume":"245","author":"Liu","year":"2012","journal-title":"J. Microsc."},{"key":"10.1016\/j.bone.2021.115942_bb0120","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro-computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2021.115942_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0145342","article-title":"Novel markers to delineate murine M1 and M2 macrophages","volume":"10","author":"Jablonski","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2021.115942_bb0130","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.atherosclerosis.2012.09.013","article-title":"Distribution of macrophage polarization markers in human atherosclerosis","volume":"225","author":"St\u00f6ger","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bone.2021.115942_bb0135","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/1742-2094-11-82","article-title":"Macrophagic and microglial responses after focal traumatic brain injury in the female rat","volume":"11","author":"Turtzo","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bone.2021.115942_bb0140","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1902\/jop.2016.160392","article-title":"Decrease of pericytes is associated with liver disease caused by ligature-induced periodontitis in rats","volume":"88","author":"Vasconcelos","year":"2017","journal-title":"J. Periodontol."},{"key":"10.1016\/j.bone.2021.115942_bb0145","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/glia.20332","article-title":"NG2 proteoglycan-expressing microglia as multipotent neural progenitors in normal and pathologic brains","volume":"53","author":"Yokoyama","year":"2006","journal-title":"Glia."},{"key":"10.1016\/j.bone.2021.115942_bb0150","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1006\/mvre.1996.0049","article-title":"CNS microvascular pericytes express macrophage-like function, cell surface integrin alpha M, and macrophage marker ED-2","volume":"52","author":"Balabanov","year":"1996","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.bone.2021.115942_bb0155","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/(SICI)1098-1136(199909)27:3<259::AID-GLIA7>3.0.CO;2-8","article-title":"Expression of a homologue of rat NG2 on human microglia","volume":"27","author":"Pouly","year":"1999","journal-title":"Glia."},{"key":"10.1016\/j.bone.2021.115942_bb0160","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1177\/0022034513487558","article-title":"Intra-oral PTH administration promotes tooth extraction socket healing","volume":"92","author":"Kuroshima","year":"2013","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.bone.2021.115942_bb0165","doi-asserted-by":"crossref","first-page":"e0128021","DOI":"10.1371\/journal.pone.0128021","article-title":"Intramembranous bone healing process subsequent to tooth extraction in mice: micro-computed tomography, histomorphometric and molecular characterization","volume":"10","author":"Vieira","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2021.115942_bb0170","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1007\/s00198-013-2570-8","article-title":"Early effects of parathyroid hormone on bisphosphonate\/steroid-associated compromised osseous wound healing","volume":"25","author":"Kuroshima","year":"2014","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2021.115942_bb0175","first-page":"22","article-title":"Histology of the oral mucosa in patients with BRONJ at III stage: a microscopic study proves the unsuitability of local mucosal flaps","volume":"5","author":"Lorenzo","year":"2013","journal-title":"J. Clin. Med. Res."},{"key":"10.1016\/j.bone.2021.115942_bb0180","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1746-1596-7-78","article-title":"Bisphosphonate-related osteonecrosis of jaw (BRONJ): an anti-angiogenic side-effect?","volume":"7","author":"Petcu","year":"2012","journal-title":"Diagn. Pathol."},{"key":"10.1016\/j.bone.2021.115942_bb0185","doi-asserted-by":"crossref","first-page":"452737","DOI":"10.1155\/2014\/452737","article-title":"Is bisphosphonate-related osteonecrosis of the jaw an infection? A histological and microbiological ten-year summary","volume":"2014","author":"Hinson","year":"2014","journal-title":"Int. J. Dent."},{"key":"10.1016\/j.bone.2021.115942_bb0190","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ijom.2018.07.002","article-title":"Comparison of the histopathological characteristics of osteomyelitis, medication-related osteonecrosis of the jaw, and osteoradionecrosis","volume":"48","author":"Shuster","year":"2019","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.bone.2021.115942_bb0195","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.bone.2009.05.008","article-title":"Histologic and histomorphometric features of bisphosphonate-related osteonecrosis of the jaws: an analysis of 31 cases with confocal laser scanning microscopy","volume":"45","author":"Favia","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.115942_bb0200","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1034\/j.1600-0501.1991.020302.x","article-title":"Structure of the bone-titanium interface in retrieved clinical oral implants","volume":"2","author":"Sennerby","year":"1991","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.bone.2021.115942_bb0205","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/(SICI)1097-4636(199604)30:4<523::AID-JBM11>3.0.CO;2-I","article-title":"Light and electron microscopic studies of bone-titanium interface in the tibiae of young and mature rats","volume":"30","author":"Murai","year":"1996","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.bone.2021.115942_bb0210","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mce.2010.04.005","article-title":"The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights","volume":"335","author":"Coutinho","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.bone.2021.115942_bb0215","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jormas.2019.04.012","article-title":"Medication-related osteonecrosis of the jaw. Implant presence-triggered osteonecrosis: case series and literature review","volume":"121","author":"Escobedo","year":"2020","journal-title":"J. Stomatol. Oral Maxillofac. Surg."},{"key":"10.1016\/j.bone.2021.115942_bb0220","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic","volume":"61","author":"Marx","year":"2003","journal-title":"J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.bone.2021.115942_bb0225","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1124\/jpet.102.035295","article-title":"Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid","volume":"302","author":"Wood","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bone.2021.115942_bb0230","article-title":"Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB","volume":"12","author":"Gao","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2021.115942_bb0235","first-page":"2893","article-title":"Zoledronic acid induces significant and long-lasting modifications of circulating angiogenic factors in cancer patients","volume":"9","author":"Santini","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bone.2021.115942_bb0240","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1177\/0022034515592867","article-title":"Effect of alendronate on bone formation during tooth extraction wound healing","volume":"94","author":"Tanoue","year":"2015","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.bone.2021.115942_bb0245","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1365-2591.2010.01703.x","article-title":"Effect of alendronate on alveolar bone resorption and angiogenesis in rats with experimental periapical lesions","volume":"43","author":"Xiong","year":"2010","journal-title":"Int. Endod. J."},{"key":"10.1016\/j.bone.2021.115942_bb0250","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1471-2407-8-81","article-title":"Alendronate decreases orthotopic PC-3 prostate tumor growth and metastasis to prostate-draining lymph nodes in nude mice","volume":"8","author":"Tuomela","year":"2008","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bone.2021.115942_bb0255","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.bbrc.2007.01.014","article-title":"Alendronate suppresses tumor angiogenesis by inhibiting Rho activation of endothelial cells","volume":"354","author":"Hashimoto","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bone.2021.115942_bb0260","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1146\/annurev.immunol.23.021704.115816","article-title":"Macrophage receptors and immune recognition","volume":"23","author":"Taylor","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bone.2021.115942_bb0265","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1902\/jop.2013.130094","article-title":"Distinctive tooth-extraction socket healing: bisphosphonate versus parathyroid hormone therapy","volume":"85","author":"Kuroshima","year":"2014","journal-title":"J. Periodontol."},{"key":"10.1016\/j.bone.2021.115942_bb0270","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/cid.12578","article-title":"Osseointegration and foreign body reaction: titanium implants activate the immune system and suppress bone resorption during the first 4 weeks after implantation","volume":"20","author":"Trindade","year":"2018","journal-title":"Clin. Implant. Dent. Relat. Res."},{"key":"10.1016\/j.bone.2021.115942_bb0275","doi-asserted-by":"crossref","first-page":"526","DOI":"10.3390\/jcm7120526","article-title":"Bone immune response to materials, part I: titanium, PEEK and copper in comparison to sham at 10 days in rabbit tibia","volume":"7","author":"Trindade","year":"2018","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.bone.2021.115942_bb0280","doi-asserted-by":"crossref","first-page":"814","DOI":"10.3390\/jcm8060814","article-title":"Bone immune response to materials, part II: copper and polyetheretherketone (PEEK) compared to titanium at 10 and 28 days in rabbit tibia","volume":"8","author":"Trindade","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.bone.2021.115942_bb0285","doi-asserted-by":"crossref","first-page":"495","DOI":"10.11607\/jomi.8218","article-title":"An imbalance of the immune system instead of a disease behind marginal bone loss around oral implants: position paper","volume":"35","author":"Albrektsson","year":"2020","journal-title":"Int. J. Oral Maxillofac. Implants"},{"key":"10.1016\/j.bone.2021.115942_bb0290","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1177\/0022034514551754","article-title":"Composition of human peri-implantitis and periodontitis lesions","volume":"93","author":"Carcuac","year":"2014","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.bone.2021.115942_bb0295","article-title":"The M1 and M2 paradigm of macrophage activation: time for reassessment","volume":"613","author":"Martinez","year":"2014","journal-title":"F1000Prime Rep"},{"issue":"6","key":"10.1016\/j.bone.2021.115942_bb0300","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.3390\/ijms19061801","article-title":"Role of human macrophage polarization in inflammation during infectious diseases","volume":"19","author":"Atri","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bone.2021.115942_bb0305","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trsl.2017.09.002","article-title":"Macrophage polarization and allergic asthma","volume":"191","author":"Saradna","year":"2018","journal-title":"Transl. Res."},{"key":"10.1016\/j.bone.2021.115942_bb0310","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1002\/jbmr.3117","article-title":"Targeting notch-activated M1 macrophages attenuates joint tissue damage in a mouse model of inflammatory arthritis","volume":"32","author":"Sun","year":"2017","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2021.115942_bb0315","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1183\/09031936.00059814","article-title":"Ageing and the epidemiology of multimorbidity","volume":"44","author":"Divo","year":"2014","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bone.2021.115942_bb0320","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1001\/archinte.162.20.2269","article-title":"Prevalence, expenditures, and complications of multiple chronic conditions in the elderly","volume":"162","author":"Wolff","year":"2002","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.bone.2021.115942_bb0325","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0140-6736(12)60240-2","article-title":"Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study","volume":"380","author":"Barnett","year":"2012","journal-title":"Lancet."},{"key":"10.1016\/j.bone.2021.115942_bb0330","first-page":"1392","article-title":"Older age and steroid use are associated with increasing polypharmacy and potential medication interactions among patients with inflammatory bowel disease","volume":"21","author":"Parian","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.bone.2021.115942_bb0335","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-015905","article-title":"Prevalence and prescription patterns of oral glucocorticoids in adults: a retrospective cross-sectional and cohort analysis in France","volume":"7","author":"B\u00e9nard-Laribi\u00e8re","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.bone.2021.115942_bb0340","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1093\/rheumatology\/ker017","article-title":"Prevalence of long-term oral glucocorticoid prescriptions in the UK over the past 20 years","volume":"50","author":"Fardet","year":"2011","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.bone.2021.115942_bb0345","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/jbmr.5650060405","article-title":"The bisphosphonate alendronate (MK-217) inhibits bone loss due to ovariectomy in rats","volume":"6","author":"Seedor","year":"1991","journal-title":"J. Bone Miner. Res."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328221001046?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328221001046?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:52:45Z","timestamp":1757613165000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328221001046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":69,"alternative-id":["S8756328221001046"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2021.115942","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alendronate\/dexamethasone combination therapy worsens soft and hard tissue wound healing around implants in rat maxillae","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2021.115942","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115942"}}