{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:14:39Z","timestamp":1792293279804,"version":"4.4.0"},"reference-count":156,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"am","delay-in-days":280,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["1R01AR074473-01"],"award-info":[{"award-number":["1R01AR074473-01"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RR190108"],"award-info":[{"award-number":["RR190108"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["BC150678P1"],"award-info":[{"award-number":["BC150678P1"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.bone.2021.115998","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T03:17:20Z","timestamp":1620443840000},"page":"115998","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Suppression of cancer-associated bone loss through dynamic mechanical loading"],"prefix":"10.1016","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0888-5117","authenticated-orcid":false,"given":"G.M.","family":"Pagnotti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.R.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.A.","family":"Guise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.T.","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bone.2021.115998_bb0005","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s11914-013-0154-3","article-title":"Osteoporosis and cancer","volume":"11","author":"Drake","year":"2013","journal-title":"Curr. Osteoporos. Rep."},{"issue":"3","key":"10.1016\/j.bone.2021.115998_bb0010","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1056\/NEJMcp1513724","article-title":"Postmenopausal osteoporosis","volume":"374","author":"Black","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"8","key":"10.1016\/j.bone.2021.115998_bb0015","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1002\/(SICI)1097-0142(19971015)80:8+<1588::AID-CNCR9>3.0.CO;2-G","article-title":"Skeletal complications of malignancy","volume":"80","author":"Coleman","year":"1997","journal-title":"Cancer"},{"issue":"8","key":"10.1016\/j.bone.2021.115998_bb0020","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1002\/cncr.22991","article-title":"Pathologic fractures correlate with reduced survival in patients with malignant bone disease","volume":"110","author":"Saad","year":"2007","journal-title":"Cancer"},{"issue":"10","key":"10.1016\/j.bone.2021.115998_bb0025","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1634\/theoncologist.11-10-1121","article-title":"Bone loss and fracture risk associated with cancer therapy","volume":"11","author":"Guise","year":"2006","journal-title":"Oncologist"},{"key":"10.1016\/j.bone.2021.115998_bb0030","doi-asserted-by":"crossref","unstructured":"Coleman, R.E., Clinical features of metastatic bone disease and risk of skeletal morbidity. Clin. Cancer Res., 2006. 12(20): p. 6243s\u20136249s.","DOI":"10.1158\/1078-0432.CCR-06-0931"},{"issue":"4","key":"10.1016\/j.bone.2021.115998_bb0035","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1093\/annonc\/mdi122","article-title":"The significance of skeletal-related events for the health-related quality of life of patients with metastatic prostate cancer","volume":"16","author":"Weinfurt","year":"2005","journal-title":"Ann. Oncol."},{"issue":"2","key":"10.1016\/j.bone.2021.115998_bb0040","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/pcan.2011.7","article-title":"Mortality following bone metastasis and skeletal-related events among men with prostate cancer: a population-based analysis of US Medicare beneficiaries, 1999-2006","volume":"14","author":"Sathiakumar","year":"2011","journal-title":"Prostate Cancer Prostatic Dis."},{"issue":"4","key":"10.1016\/j.bone.2021.115998_bb0045","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3816\/CLC.2009.n.030","article-title":"Skeletal disease contributes substantially to morbidity and mortality in patients with lung cancer","volume":"10","author":"Hirsh","year":"2009","journal-title":"Clin. Lung Cancer"},{"issue":"4","key":"10.1016\/j.bone.2021.115998_bb0050","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s11914-007-0013-1","article-title":"Bone loss in patients with breast or prostate cancer","volume":"5","author":"Hu","year":"2007","journal-title":"Curr. Osteoporos. Rep."},{"issue":"3","key":"10.1016\/j.bone.2021.115998_bb0055","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/leu.2008.336","article-title":"Pathogenesis of myeloma bone disease","volume":"23","author":"Roodman","year":"2009","journal-title":"Leukemia"},{"issue":"1","key":"10.1016\/j.bone.2021.115998_bb0060","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/bjc.1987.13","article-title":"The clinical course of bone metastases from breast cancer","volume":"55","author":"Coleman","year":"1987","journal-title":"Br. J. Cancer"},{"issue":"6","key":"10.1016\/j.bone.2021.115998_bb0065","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nrc3055","article-title":"Cancer to bone: a fatal attraction","volume":"11","author":"Weilbaecher","year":"2011","journal-title":"Nat. Rev. Cancer"},{"issue":"4","key":"10.1016\/j.bone.2021.115998_bb0070","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3816\/CLC.2009.n.030","article-title":"Skeletal disease contributes substantially to morbidity and mortality in patients with lung cancer","volume":"10","author":"Hirsh","year":"2009","journal-title":"Clin. Lung Cancer"},{"issue":"4","key":"10.1016\/j.bone.2021.115998_bb0075","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1359\/jbmr.2000.15.4.710","article-title":"Risk factors for longitudinal bone loss in elderly men and women: the Framingham osteoporosis study","volume":"15","author":"Hannan","year":"2000","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.bone.2021.115998_bb0080","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.bone.2006.12.002","article-title":"Exercise-induced changes in the cortical bone of growing mice are bone- and gender-specific","volume":"40","author":"Wallace","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.115998_bb0085","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.69","article-title":"Postmenopausal osteoporosis","volume":"2","author":"Eastell","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.bone.2021.115998_bb0090","unstructured":"Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults. WMJ, 1998. 97(9): p. 20\u20131, 24\u20135, 27\u201337."},{"issue":"6","key":"10.1016\/j.bone.2021.115998_bb0095","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s00198-007-0540-8","article-title":"Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy","volume":"19","author":"Russell","year":"2008","journal-title":"Osteoporos. Int."},{"issue":"9041","key":"10.1016\/j.bone.2021.115998_bb0100","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/S0140-6736(96)07088-2","article-title":"Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures","volume":"348","author":"Black","year":"1996","journal-title":"Lancet"},{"issue":"18","key":"10.1016\/j.bone.2021.115998_bb0105","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1056\/NEJMoa067312","article-title":"Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis","volume":"356","author":"Black","year":"2007","journal-title":"N. Engl. J. Med."},{"issue":"7","key":"10.1016\/j.bone.2021.115998_bb0110","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S1470-2045(11)70122-X","article-title":"Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 62-month follow-up from the ABCSG-12 randomised trial","volume":"12","author":"Gnant","year":"2011","journal-title":"Lancet Oncol."},{"issue":"2","key":"10.1016\/j.bone.2021.115998_bb0115","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1093\/annonc\/mds277","article-title":"Zoledronic acid (zoledronate) for postmenopausal women with early breast cancer receiving adjuvant letrozole (ZO-FAST study): final 60-month results","volume":"24","author":"Coleman","year":"2013","journal-title":"Ann. Oncol."},{"issue":"6","key":"10.1016\/j.bone.2021.115998_bb0120","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S1470-2045(06)70726-4","article-title":"Bisphosphonate-associated osteonecrosis: a long-term complication of bisphosphonate treatment","volume":"7","author":"Migliorati","year":"2006","journal-title":"Lancet Oncol."},{"issue":"1","key":"10.1016\/j.bone.2021.115998_bb0125","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jocd.2016.09.005","article-title":"Case-based review of osteonecrosis of the jaw (ONJ) and application of the international recommendations for management from the international task force on ONJ","volume":"20","author":"Khan","year":"2017","journal-title":"J. Clin. Densitom."},{"key":"10.1016\/j.bone.2021.115998_bb0130","first-page":"S399","article-title":"Pharmacokinetics (PK), pharmacodynamics (PD), and safety of AMG 162, a fully human monoclonal antibody to RANKL, following a single subcutaneous dose to healthy men aged 50 years and older","volume":"36","author":"Peterson","year":"2005","journal-title":"Bone"},{"issue":"10","key":"10.1016\/j.bone.2021.115998_bb0135","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1002\/jbmr.149","article-title":"Effects of denosumab on bone histomorphometry: the FREEDOM and STAND studies","volume":"25","author":"Reid","year":"2010","journal-title":"J. Bone Miner. Res."},{"issue":"8","key":"10.1016\/j.bone.2021.115998_bb0140","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1056\/NEJMoa044459","article-title":"Denosumab in postmenopausal women with low bone mineral density","volume":"354","author":"McClung","year":"2006","journal-title":"N. Engl. J. Med."},{"issue":"19","key":"10.1016\/j.bone.2021.115998_bb0145","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1056\/NEJMx090058","article-title":"Denosumab for prevention of fractures in postmenopausal women with osteoporosis. (vol 361, pg 756, 2009)","volume":"361","author":"Cummings","year":"2009","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.bone.2021.115998_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ar.1092190104","article-title":"Bone \u201cmass\u201d and the \u201cmechanostat\u201d: a proposal","volume":"219","author":"Frost","year":"1987","journal-title":"Anat. Rec."},{"issue":"2","key":"10.1016\/j.bone.2021.115998_bb0155","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/jor.1100050217","article-title":"Osteoregulatory nature of mechanical stimuli - function as a determinant for adaptive remodeling in bone","volume":"5","author":"Rubin","year":"1987","journal-title":"J. Orthop. Res."},{"issue":"3","key":"10.1016\/j.bone.2021.115998_bb0160","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1249\/00005768-198406000-00005","article-title":"The effect of long-distance running upon appendicular bone-mineral content","volume":"16","author":"Williams","year":"1984","journal-title":"Med. Sci. Sports Exerc."},{"issue":"6","key":"10.1016\/j.bone.2021.115998_bb0165","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s002239900467","article-title":"Bone mineral content and density in professional tennis players","volume":"62","author":"Calbet","year":"1998","journal-title":"Calcif. Tissue Int."},{"issue":"10","key":"10.1016\/j.bone.2021.115998_bb0170","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1097\/00005768-200110000-00011","article-title":"High femoral bone mineral content and density in male football (soccer) players","volume":"33","author":"Calbet","year":"2001","journal-title":"Med. Sci. Sports Exerc."},{"issue":"3","key":"10.1016\/j.bone.2021.115998_bb0175","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S8756-3282(00)00331-8","article-title":"Exercise-induced bone gain is due to enlargement in bone size without a change in volumetric bone density: a peripheral quantitative computed tomography study of the upper arms of male tennis players","volume":"27","author":"Haapasalo","year":"2000","journal-title":"Bone"},{"issue":"12","key":"10.1016\/j.bone.2021.115998_bb0180","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/0021-9290(84)90003-4","article-title":"Static vs dynamic loads as an influence on bone remodeling","volume":"17","author":"Lanyon","year":"1984","journal-title":"J. Biomech."},{"key":"10.1016\/j.bone.2021.115998_bb0185","doi-asserted-by":"crossref","unstructured":"Rubin, C.T. and L.E. Lanyon, Regulation of bone-formation by applied dynamic loads. J. Bone Joint Surg. Am., 1984. 66a(3): p. 397\u2013402.","DOI":"10.2106\/00004623-198466030-00012"},{"issue":"6","key":"10.1016\/j.bone.2021.115998_bb0190","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.bone.2005.03.001","article-title":"Bone geometry and density in the skeleton of pre-pubertal gymnasts and school children","volume":"36","author":"Ward","year":"2005","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.bone.2021.115998_bb0195","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1359\/jbmr.2003.18.2.352","article-title":"Effect of long-term impact-loading on mass, size, and estimated strength of humerus and radius of female racquet-sports players: a peripheral quantitative computed tomography study between young and old starters and controls","volume":"18","author":"Kontulainen","year":"2003","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2021.115998_bb0200","doi-asserted-by":"crossref","first-page":"26","DOI":"10.12965\/jer.1836564.282","article-title":"The effect of long-distance running on bone strength and bone biochemical markers","volume":"15","author":"Lee","year":"2019","journal-title":"J. Exerc. Rehabil."},{"issue":"1","key":"10.1016\/j.bone.2021.115998_bb0205","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.bone.2009.03.660","article-title":"Bone mass and geometry of the tibia and the radius of master sprinters, middle and long distance runners, race-walkers and sedentary control participants: a pQCT study","volume":"45","author":"Wilks","year":"2009","journal-title":"Bone"},{"issue":"4","key":"10.1016\/j.bone.2021.115998_bb0210","first-page":"236","article-title":"Age-dependency in bone mass and geometry: a pQCT study on male and female master sprinters, middle and long distance runners, race-walkers and sedentary people","volume":"9","author":"Wilks","year":"2009","journal-title":"J. Musculoskelet. Neuronal Interact."},{"issue":"4","key":"10.1016\/j.bone.2021.115998_bb0215","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/BF02553711","article-title":"Regulation of bone mass by mechanical strain magnitude","volume":"37","author":"Rubin","year":"1985","journal-title":"Calcif. Tissue Int."},{"issue":"1","key":"10.1016\/j.bone.2021.115998_bb0220","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1152\/japplphysiol.00741.2003","article-title":"Resistance exercise as a countermeasure to disuse-induced bone loss","volume":"97","author":"Shackelford","year":"2004","journal-title":"J. Appl. Physiol."},{"issue":"8","key":"10.1016\/j.bone.2021.115998_bb0225","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1002\/jbmr.3159","article-title":"Exercise decreases marrow adipose tissue through beta-oxidation in obese running mice","volume":"32","author":"Styner","year":"2017","journal-title":"J. Bone Miner. Res."},{"issue":"8","key":"10.1016\/j.bone.2021.115998_bb0230","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1210\/en.2015-1213","article-title":"Exercise regulation of marrow fat in the setting of PPARgamma agonist treatment in female C57BL\/6 mice","volume":"156","author":"Styner","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2021.115998_bb0235","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3389\/fendo.2016.00094","article-title":"Exercise regulation of marrow adipose tissue","volume":"7","author":"Pagnotti","year":"2016","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bone.2021.115998_bb0240","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bone.2014.03.044","article-title":"Bone marrow fat accumulation accelerated by high fat diet is suppressed by exercise","volume":"64","author":"Styner","year":"2014","journal-title":"Bone"},{"issue":"8","key":"10.1016\/j.bone.2021.115998_bb0245","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1002\/jbmr.3159","article-title":"Exercise decreases marrow adipose tissue through ss-oxidation in obese running mice","volume":"32","author":"Styner","year":"2017","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.bone.2021.115998_bb0250","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/00005768-199702000-00006","article-title":"Changes in musculoskeletal structure and function with prolonged bed rest","volume":"29","author":"Bloomfield","year":"1997","journal-title":"Med. Sci. Sports Exerc."},{"issue":"6","key":"10.1016\/j.bone.2021.115998_bb0255","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/BF02555744","article-title":"Bone remodeling during the development of osteoporosis in paraplegia","volume":"38","author":"Chantraine","year":"1986","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2021.115998_bb0260","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41526-020-0103-2","article-title":"A systematic review and meta-analysis of bone loss in space travelers","volume":"6","author":"Stavnichuk","year":"2020","journal-title":"NPJ Microgravity"},{"issue":"6","key":"10.1016\/j.bone.2021.115998_bb0265","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1359\/JBMR.040307","article-title":"Cortical and trabecular bone mineral loss from the spine and hip in long-duration spaceflight","volume":"19","author":"Lang","year":"2004","journal-title":"J. Bone Miner. Res."},{"issue":"10","key":"10.1016\/j.bone.2021.115998_bb0270","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1001\/jama.1982.03330100041028","article-title":"Disuse and aging","volume":"248","author":"Bortz","year":"1982","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.bone.2021.115998_bb0275","doi-asserted-by":"crossref","first-page":"R159","DOI":"10.1152\/ajpregu.00499.2011","article-title":"Multiple exposures to unloading decrease bone's responsivity but compound skeletal losses in C57BL\/6 mice","volume":"303","author":"Gupta","year":"2012","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"7","key":"10.1016\/j.bone.2021.115998_bb0280","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1002\/jbmr.2807","article-title":"Osteocyte apoptosis caused by hindlimb unloading is required to trigger osteocyte RANKL production and subsequent resorption of cortical and trabecular bone in mice femurs","volume":"31","author":"Cabahug-Zuckerman","year":"2016","journal-title":"J. Bone Miner. Res."},{"issue":"6","key":"10.1016\/j.bone.2021.115998_bb0285","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41574-019-0170-1","article-title":"Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity","volume":"15","author":"Pagnotti","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"issue":"6","key":"10.1016\/j.bone.2021.115998_bb0290","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.jsams.2013.01.004","article-title":"Safety and severity of accelerations delivered from whole body vibration exercise devices to standing adults","volume":"16","author":"Muir","year":"2013","journal-title":"J. Sci. Med. Sport"},{"key":"10.1016\/j.bone.2021.115998_bb0295","first-page":"S294","article-title":"Safety of whole body vibration, considered for the prevention and\/or treatment of osteoporosis, relative to standards set by the international safety organization","volume":"21","author":"Muir","year":"2006","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2021.115998_bb0300","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s11914-012-0132-1","article-title":"The potential benefits and inherent risks of vibration as a non-drug therapy for the prevention and treatment of osteoporosis","volume":"11","author":"Chan","year":"2013","journal-title":"Curr. Osteopor. Rep."},{"issue":"6847","key":"10.1016\/j.bone.2021.115998_bb0305","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/35088122","article-title":"Anabolism. Low mechanical signals strengthen long bones","volume":"412","author":"Rubin","year":"2001","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.bone.2021.115998_bb0310","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1097\/MED.0000000000000111","article-title":"Vibration therapy: clinical applications in bone","volume":"21","author":"Thompson","year":"2014","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"issue":"3","key":"10.1016\/j.bone.2021.115998_bb0315","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1359\/JBMR.0301251","article-title":"Prevention of postmenopausal bone loss by a low-magnitude, high-frequency mechanical stimuli: a clinical trial assessing compliance, efficacy, and safety","volume":"19","author":"Rubin","year":"2004","journal-title":"J. Bone Miner. Res."},{"issue":"5","key":"10.1016\/j.bone.2021.115998_bb0320","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3109\/15412555.2015.1008693","article-title":"Effects of whole body vibration in patients with COPD","volume":"12","author":"Salhi","year":"2015","journal-title":"COPD"},{"issue":"9","key":"10.1016\/j.bone.2021.115998_bb0325","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1359\/jbmr.060612","article-title":"Low-level, high-frequency mechanical signals enhance musculoskeletal development of young women with low BMD","volume":"21","author":"Gilsanz","year":"2006","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2021.115998_bb0330","doi-asserted-by":"crossref","unstructured":"Holguin, N., et al., Mechanical vibrations reduce the intervertebral disc swelling and muscle atrophy from bed rest. 2007 IEEE 33rd Annual Northeast Bioengineering Conference, 2007: p. 25\u2212+.","DOI":"10.1109\/NEBC.2007.4413262"},{"issue":"6","key":"10.1016\/j.bone.2021.115998_bb0335","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/jor.20354","article-title":"Low-level accelerations applied in the absence of weight bearing can enhance trabecular bone formation","volume":"25","author":"Garman","year":"2007","journal-title":"J. Orthop. Res."},{"issue":"12","key":"10.1016\/j.bone.2021.115998_bb0340","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1096\/fj.01-0166com","article-title":"The anabolic activity of bone tissue, suppressed by disuse, is normalized by brief exposure to extremely low-magnitude mechanical stimuli","volume":"15","author":"Rubin","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.bone.2021.115998_bb0345","doi-asserted-by":"crossref","unstructured":"Ozcivici, E., et al., Low-level vibrations retain bone marrow's osteogenic potential and augment recovery of trabecular bone during reambulation. PLoS One, 2010. 5(6).","DOI":"10.1371\/journal.pone.0011178"},{"issue":"7","key":"10.1016\/j.bone.2021.115998_bb0350","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1002\/jor.20824","article-title":"Low-magnitude high-frequency mechanical signals accelerate and augment endochondral bone repair: preliminary evidence of efficacy","volume":"27","author":"Goodship","year":"2009","journal-title":"J. Orthop. Res."},{"issue":"5","key":"10.1016\/j.bone.2021.115998_bb0355","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.bone.2006.05.012","article-title":"Low-level mechanical vibrations can influence bone resorption and bone formation in the growing skeleton","volume":"39","author":"Xie","year":"2006","journal-title":"Bone"},{"issue":"9","key":"10.1016\/j.bone.2021.115998_bb0360","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1359\/jbmr.2002.17.9.1613","article-title":"Low-magnitude mechanical loading becomes osteogenic when rest is inserted between each load cycle","volume":"17","author":"Srinivasan","year":"2002","journal-title":"J. Bone Miner. Res."},{"issue":"10","key":"10.1016\/j.bone.2021.115998_bb0365","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1002\/oby.21958","article-title":"Incorporating refractory period in mechanical stimulation mitigates obesity-induced adipose tissue dysfunction in adult mice","volume":"25","author":"Patel","year":"2017","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.bone.2021.115998_bb0370","series-title":"Basic and Applied Bone Biology","first-page":"75","article-title":"Bone modeling and remodeling","author":"Allen","year":"2014"},{"key":"10.1016\/j.bone.2021.115998_bb0375","first-page":"S375","article-title":"Fluid flow shear stress and prostaglandin E2 activates beta-catenin signaling in MLO-Y4 osteocytic and 2T3 osteoblastic cells","volume":"22","author":"Kamel","year":"2007","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.bone.2021.115998_bb0380","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/jbmr.320","article-title":"The amazing osteocyte","volume":"26","author":"Bonewald","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2021.115998_bb0385","doi-asserted-by":"crossref","unstructured":"Guise, T.A. and J.M. Chirgwin, Transforming growth factor-beta in osteolytic breast cancer bone metastases. Clin. Orthop. Relat. Res., 2003(415 Suppl): p. S32\u20138.","DOI":"10.1097\/01.blo.0000093055.96273.69"},{"issue":"8","key":"10.1016\/j.bone.2021.115998_bb0390","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1182\/blood-2011-11-393348","article-title":"Annexin II interactions with the annexin II receptor enhance multiple myeloma cell adhesion and growth in the bone marrow microenvironment","volume":"119","author":"D'Souza","year":"2012","journal-title":"Blood"},{"issue":"13","key":"10.1016\/j.bone.2021.115998_bb0395","doi-asserted-by":"crossref","first-page":"3992","DOI":"10.1182\/blood-2006-05-026112","article-title":"Multiple myeloma bone disease: pathophysiology of osteoblast inhibition","volume":"108","author":"Giuliani","year":"2006","journal-title":"Blood"},{"issue":"27","key":"10.1016\/j.bone.2021.115998_bb0400","doi-asserted-by":"crossref","first-page":"24571","DOI":"10.1074\/jbc.M202561200","article-title":"Transforming growth factor-beta stimulates parathyroid hormone-related protein and osteolytic metastases via Smad and mitogen-activated protein kinase signaling pathways","volume":"277","author":"Kakonen","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.bone.2021.115998_bb0405","first-page":"570","article-title":"The vicious cycle of bone metastases","volume":"2","author":"Guise","year":"2002","journal-title":"J. Musculoskelet. Neuronal Interact."},{"issue":"10","key":"10.1016\/j.bone.2021.115998_bb0410","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1158\/1535-7163.MCT-07-0234","article-title":"Molecular biology of bone metastasis","volume":"6","author":"Kingsley","year":"2007","journal-title":"Mol. Cancer Ther."},{"issue":"17","key":"10.1016\/j.bone.2021.115998_bb0415","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.1158\/0008-5472.CAN-11-1194","article-title":"TGF-beta\/SMAD\/GLI2 signaling axis in cancer progression and metastasis","volume":"71","author":"Javelaud","year":"2011","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.bone.2021.115998_bb0420","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bone.2010.06.007","article-title":"Matrix metalloproteinases as master regulators of the vicious cycle of bone metastasis","volume":"48","author":"Lynch","year":"2011","journal-title":"Bone"},{"issue":"16","key":"10.1016\/j.bone.2021.115998_bb0425","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1056\/NEJMra030831","article-title":"Mechanisms of bone metastasis","volume":"350","author":"Roodman","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.bone.2021.115998_bb0430","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.bone.2012.09.017","article-title":"For whom the bell tolls: Distress signals from long-lived osteocytes and the pathogenesis of metabolic bone diseases","volume":"54","author":"Manolagas","year":"2013","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.bone.2021.115998_bb0435","doi-asserted-by":"crossref","DOI":"10.1002\/jbm4.10186","article-title":"The emerging role of osteocytes in cancer in bone","volume":"3","author":"Atkinson","year":"2019","journal-title":"JBMR Plus"},{"issue":"5","key":"10.1016\/j.bone.2021.115998_bb0440","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1158\/0008-5472.CAN-15-1703","article-title":"Bidirectional Notch signaling and osteocyte-derived factors in the bone marrow microenvironment promote tumor cell proliferation and bone destruction in multiple myeloma","volume":"76","author":"Delgado-Calle","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.bone.2021.115998_bb0445","doi-asserted-by":"crossref","unstructured":"Mulcrone, P.L., et al., Osteocyte Vegf-a contributes to myeloma-associated angiogenesis and is regulated by Fgf23. Sci. Rep., 2020. 10(1).","DOI":"10.1038\/s41598-020-74352-x"},{"issue":"10","key":"10.1016\/j.bone.2021.115998_bb0450","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/S0021-9290(03)00127-1","article-title":"Fluid pressure gradients, arising from oscillations in intramedullary pressure, is correlated with the formation of bone and inhibition of intracortical porosity","volume":"36","author":"Qin","year":"2003","journal-title":"J. Biomech."},{"issue":"1","key":"10.1016\/j.bone.2021.115998_bb0455","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ar.1092190104","article-title":"Bone mass and the mechanostat - a proposal","volume":"219","author":"Frost","year":"1987","journal-title":"Anat. Rec."},{"key":"10.1016\/j.bone.2021.115998_bb0460","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.ijbiomac.2017.03.021","article-title":"Role of Runx2 in breast cancer-mediated bone metastasis","volume":"99","author":"Vishal","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"10.1016\/j.bone.2021.115998_bb0465","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s10555-006-9032-0","article-title":"Regulatory roles of Runx2 in metastatic tumor and cancer cell interactions with bone","volume":"25","author":"Pratap","year":"2006","journal-title":"Cancer Metastasis Rev."},{"issue":"6","key":"10.1016\/j.bone.2021.115998_bb0470","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/onc.2009.389","article-title":"Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions","volume":"29","author":"Akech","year":"2010","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.bone.2021.115998_bb0475","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.ygyno.2013.09.034","article-title":"The Wnt\/beta-catenin pathway in ovarian cancer: a review","volume":"131","author":"Arend","year":"2013","journal-title":"Gynecol. Oncol."},{"issue":"1","key":"10.1016\/j.bone.2021.115998_bb0480","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nrrheum.2009.239","article-title":"Mechanical signals as anabolic agents in bone","volume":"6","author":"Ozcivici","year":"2010","journal-title":"Nat. Rev. Rheumatol."},{"issue":"11","key":"10.1016\/j.bone.2021.115998_bb0485","first-page":"5575","article-title":"Spontaneous malignant granulosa-cell tumors in ovaries of young Swr mice","volume":"45","author":"Beamer","year":"1985","journal-title":"Cancer Res."},{"issue":"18","key":"10.1016\/j.bone.2021.115998_bb0490","first-page":"5092","article-title":"Gene for ovarian granulosa-cell tumor susceptibility, Gct, in Swxj recombinant inbred strains of mice revealed by dehydroepiandrosterone","volume":"48","author":"Beamer","year":"1988","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.bone.2021.115998_bb0495","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1158\/0008-5472.CAN-04-2992","article-title":"Distal chr 4 harbors a genetic locus (Gct1) fundamental for spontaneous ovarian granulosa cell tumorigenesis in a mouse model","volume":"65","author":"Dorward","year":"2005","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.bone.2021.115998_bb0500","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.bone.2012.05.004","article-title":"Low magnitude mechanical signals mitigate osteopenia without compromising longevity in an aged murine model of spontaneous granulosa cell ovarian cancer","volume":"51","author":"Pagnotti","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.115998_bb0505","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bone.2016.05.014","article-title":"Low intensity vibration mitigates tumor progression and protects bone quantity and quality in a murine model of myeloma","volume":"90","author":"Pagnotti","year":"2016","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.115998_bb0510","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.30314","article-title":"Mechanical loading attenuates breast cancer-associated bone metastasis in obese mice by regulating the bone marrow microenvironment","author":"Huang","year":"2021","journal-title":"J. Cell. Physiol."},{"issue":"11","key":"10.1016\/j.bone.2021.115998_bb0515","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1002\/jbmr.1966","article-title":"In vivo tibial compression decreases osteolysis and tumor formation in a human metastatic breast cancer model","volume":"28","author":"Lynch","year":"2013","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.bone.2021.115998_bb0520","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.gene.2012.04.076","article-title":"Mechanical regulation of signaling pathways in bone","volume":"503","author":"Thompson","year":"2012","journal-title":"Gene"},{"issue":"1","key":"10.1016\/j.bone.2021.115998_bb0525","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0955-0674(96)80051-2","article-title":"Assembly of focal adhesions: progress, paradigms, and portents","volume":"8","author":"Craig","year":"1996","journal-title":"Curr. Opin. Cell Biol."},{"issue":"11","key":"10.1016\/j.bone.2021.115998_bb0530","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1002\/stem.732","article-title":"Mechanically induced focal adhesion assembly amplifies anti-adipogenic pathways in mesenchymal stem cells","volume":"29","author":"Sen","year":"2011","journal-title":"Stem Cells"},{"key":"10.1016\/j.bone.2021.115998_bb0535","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2005.10.028","article-title":"Molecular pathways mediating mechanical signaling in bone","volume":"367","author":"Rubin","year":"2006","journal-title":"Gene"},{"issue":"1","key":"10.1016\/j.bone.2021.115998_bb0540","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1359\/jbmr.080817","article-title":"Mechanical stimulation of mesenchymal stem cell proliferation and differentiation promotes osteogenesis while preventing dietary-induced obesity","volume":"24","author":"Luu","year":"2009","journal-title":"J. Bone Miner. Res."},{"issue":"12","key":"10.1016\/j.bone.2021.115998_bb0545","doi-asserted-by":"crossref","first-page":"6065","DOI":"10.1210\/en.2008-0687","article-title":"Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable beta-catenin signal","volume":"149","author":"Sen","year":"2008","journal-title":"Endocrinology"},{"issue":"43","key":"10.1016\/j.bone.2021.115998_bb0550","doi-asserted-by":"crossref","first-page":"29196","DOI":"10.1074\/jbc.M801907200","article-title":"Beta-catenin levels influence rapid mechanical responses in osteoblasts","volume":"283","author":"Case","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.bone.2021.115998_bb0555","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/jor.1100170504","article-title":"Osteoclastogenesis is repressed by mechanical strain in an in vitro model","volume":"17","author":"Rubin","year":"1999","journal-title":"J. Orthop. Res."},{"issue":"50","key":"10.1016\/j.bone.2021.115998_bb0560","doi-asserted-by":"crossref","first-page":"34607","DOI":"10.1074\/jbc.M109.039453","article-title":"Mechanical loading regulates NFATc1 and beta-catenin signaling through a GSK3 beta control node","volume":"284","author":"Sen","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"8\u20139","key":"10.1016\/j.bone.2021.115998_bb0565","first-page":"1059","article-title":"Changes in the numbers of osteoclasts in newts under conditions of microgravity","volume":"21","author":"Berezovska","year":"1998","journal-title":"Life Sci. Microgravity Res."},{"key":"10.1016\/j.bone.2021.115998_bb0570","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.actaastro.2018.08.044","article-title":"Osteoclast-derived exosomes inhibit osteogenic differentiation through Wnt\/beta-catenin signaling pathway in simulated microgravity model","volume":"154","author":"Ting","year":"2019","journal-title":"Acta Astronaut."},{"issue":"13","key":"10.1016\/j.bone.2021.115998_bb0575","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1016\/j.jbiomech.2013.06.008","article-title":"Vibration induced osteogenic commitment of mesenchymal stem cells is enhanced by cytoskeletal remodeling but not fluid shear","volume":"46","author":"Uzer","year":"2013","journal-title":"J. Biomech."},{"issue":"1","key":"10.1016\/j.bone.2021.115998_bb0580","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/(SICI)1097-4652(199701)170:1<81::AID-JCP9>3.0.CO;2-H","article-title":"Pressure regulates osteoclast formation and MCSF expression in marrow culture","volume":"170","author":"Rubin","year":"1997","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bone.2021.115998_bb0585","doi-asserted-by":"crossref","first-page":"110012","DOI":"10.1016\/j.jbiomech.2020.110012","article-title":"Isolated nuclei stiffen in response to low intensity vibration","volume":"111","author":"Newberg","year":"2020","journal-title":"J. Biomech."},{"key":"10.1016\/j.bone.2021.115998_bb0590","article-title":"Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation","volume":"24","author":"Swift","year":"2013","journal-title":"Mol. Biol. Cell"},{"issue":"1","key":"10.1016\/j.bone.2021.115998_bb0595","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s40610-016-0032-8","article-title":"Cell mechanosensitivity is enabled by the LINC nuclear complex","volume":"2","author":"Uzer","year":"2016","journal-title":"Curr. Mol. Biol. Rep."},{"issue":"6","key":"10.1016\/j.bone.2021.115998_bb0600","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1002\/stem.2004","article-title":"Cell mechanosensitivity to extremely low-magnitude signals is enabled by a LINCed nucleus","volume":"33","author":"Uzer","year":"2015","journal-title":"Stem Cells"},{"key":"10.1016\/j.bone.2021.115998_bb0605","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jbiomech.2018.04.013","article-title":"Sun-mediated mechanical LINC between nucleus and cytoskeleton regulates beta catenin nuclear access","volume":"74","author":"Uzer","year":"2018","journal-title":"J. Biomech."},{"key":"10.1016\/j.bone.2021.115998_bb0610","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13036-019-0197-9","article-title":"The LINC complex, mechanotransduction, and mesenchymal stem cell function and fate","volume":"13","author":"Bouzid","year":"2019","journal-title":"J. Biol. Eng."},{"key":"10.1016\/j.bone.2021.115998_bb0615","doi-asserted-by":"crossref","unstructured":"Menon, S. and K.A. Beningo, Cancer cell invasion is enhanced by applied mechanical stimulation. PLoS One, 2011. 6(2).","DOI":"10.1371\/journal.pone.0017277"},{"key":"10.1016\/j.bone.2021.115998_bb0620","doi-asserted-by":"crossref","DOI":"10.1186\/s12935-014-0102-z","article-title":"Daily application of low magnitude mechanical stimulus inhibits the growth of MDA-MB-231 breast cancer cells in vitro","volume":"14","author":"Olcum","year":"2014","journal-title":"Cancer Cell Int."},{"issue":"1","key":"10.1016\/j.bone.2021.115998_bb0625","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41413-020-00111-3","article-title":"Mechanical suppression of breast cancer cell invasion and paracrine signaling to osteoclasts requires nucleo-cytoskeletal connectivity","volume":"8","author":"Yi","year":"2020","journal-title":"Bone Res."},{"issue":"10","key":"10.1016\/j.bone.2021.115998_bb0630","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1002\/cam4.495","article-title":"Global loss of a nuclear lamina component, lamin A\/C, and LINC complex components SUN1, SUN2, and nesprin-2 in breast cancer","volume":"4","author":"Matsumoto","year":"2015","journal-title":"Cancer Med."},{"key":"10.1016\/j.bone.2021.115998_bb0635","doi-asserted-by":"crossref","first-page":"5961","DOI":"10.12659\/MSM.915986","article-title":"Fluid shear stress increases osteocyte and inhibits osteoclasts via downregulating receptor-activator of nuclear factor kappaB (RANK)\/osteoprotegerin expression in myeloma microenvironment","volume":"25","author":"Wang","year":"2019","journal-title":"Med. Sci. Monit."},{"issue":"4","key":"10.1016\/j.bone.2021.115998_bb0640","first-page":"132","article-title":"Mechanical signals as a non-invasive means to influence mesenchymal stem cell fate, promoting bone and suppressing the fat phenotype","volume":"6","author":"Luu","year":"2009","journal-title":"Bonekey Osteovision"},{"key":"10.1016\/j.bone.2021.115998_bb0645","doi-asserted-by":"crossref","unstructured":"Shen, B., et al., A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis. Nature, 2021. 591(7850): p. 438\u2212+.","DOI":"10.1038\/s41586-021-03298-5"},{"issue":"4","key":"10.1016\/j.bone.2021.115998_bb0650","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1002\/jbmr.1505","article-title":"Devastation of adult stem cell pools by irradiation precedes collapse of trabecular bone quality and quantity","volume":"27","author":"Green","year":"2012","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2021.115998_bb0655","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1148\/114.1.155","article-title":"The effects of radiation therapy on bone growth","volume":"114","author":"Probert","year":"1975","journal-title":"Radiology"},{"issue":"1","key":"10.1016\/j.bone.2021.115998_bb0660","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.bone.2003.09.003","article-title":"Ionizing radiation sensitizes bone cells to apoptosis","volume":"34","author":"Szymczyk","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.115998_bb0665","article-title":"Bisphosphonate therapy for children and adolescents with secondary osteoporosis","volume":"4","author":"Ward","year":"2007","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.bone.2021.115998_bb0670","doi-asserted-by":"crossref","DOI":"10.1186\/s40200-014-0109-y","article-title":"Bisphosphonate therapy in pediatric patients","volume":"13","author":"Eghbali-Fatourechi","year":"2014","journal-title":"J. Diabetes Metab. Disord."},{"issue":"7","key":"10.1016\/j.bone.2021.115998_bb0675","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1002\/jbmr.1603","article-title":"Denosumab treatment for fibrous dysplasia","volume":"27","author":"Boyce","year":"2012","journal-title":"J. Bone Miner. Res."},{"issue":"12","key":"10.1016\/j.bone.2021.115998_bb0680","doi-asserted-by":"crossref","first-page":"E200","DOI":"10.1200\/JCO.2012.46.4255","article-title":"Denosumab treatment of metastatic giant-cell tumor of bone in a 10-year-old girl","volume":"31","author":"Karras","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bone.2021.115998_bb0685","doi-asserted-by":"crossref","first-page":"115918","DOI":"10.1016\/j.bone.2021.115918","article-title":"Sclerostin antibody increases trabecular bone and bone mechanical properties by increasing osteoblast activity damaged by whole-body irradiation in mice","volume":"147","author":"Costa","year":"2021","journal-title":"Bone"},{"issue":"18","key":"10.1016\/j.bone.2021.115998_bb0690","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1093\/jnci\/86.18.1403","article-title":"Physical exercise and reduced risk of breast-cancer in young-women","volume":"86","author":"Bernstein","year":"1994","journal-title":"J. Natl. Cancer Inst."},{"issue":"11","key":"10.1016\/j.bone.2021.115998_bb0695","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1249\/MSS.0000000000002116","article-title":"Exercise guidelines for cancer survivors: consensus statement from international multidisciplinary roundtable","volume":"51","author":"Campbell","year":"2019","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.bone.2021.115998_bb0700","doi-asserted-by":"crossref","unstructured":"Fuller, J.T., et al., Therapeutic effects of aerobic and resistance exercises for cancer survivors: a systematic review of meta-analyses of clinical trials. Br. J. Sports Med., 2018. 52(20): p. 1311\u2212+.","DOI":"10.1136\/bjsports-2017-098285"},{"issue":"8","key":"10.1016\/j.bone.2021.115998_bb0705","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1001\/jamaoncol.2020.2045","article-title":"Association of sedentary behavior with cancer mortality in middle-aged and older US adults","volume":"6","author":"Gilchrist","year":"2020","journal-title":"JAMA Oncol."},{"issue":"13","key":"10.1016\/j.bone.2021.115998_bb0710","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1200\/JCO.2006.09.5083","article-title":"Randomized trial of exercise therapy in women treated for breast cancer","volume":"25","author":"Daley","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bone.2021.115998_bb0715","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.breast.2019.02.001","article-title":"Physical activity in breast cancer survivors: a systematic review and meta-analysis on overall and breast cancer survival","volume":"44","author":"Spei","year":"2019","journal-title":"Breast"},{"issue":"11","key":"10.1016\/j.bone.2021.115998_bb0720","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1249\/MSS.0000000000002117","article-title":"American College of Sports Medicine roundtable report on physical activity, sedentary behavior, and cancer prevention and control","volume":"51","author":"Patel","year":"2019","journal-title":"Med. Sci. Sports Exerc."},{"issue":"4","key":"10.1016\/j.bone.2021.115998_bb0725","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1440-1754.2009.01653.x","article-title":"Physical activity in survivors of childhood acute lymphoblastic leukaemia","volume":"46","author":"Heath","year":"2010","journal-title":"J. Paediatr. Child Health"},{"issue":"1","key":"10.1016\/j.bone.2021.115998_bb0730","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/pbc.21942","article-title":"A randomized trial investigating an exercise program to prevent reduction of bone mineral density and impairment of motor performance during treatment for childhood acute lymphoblastic leukemia","volume":"53","author":"Hartman","year":"2009","journal-title":"Pediatr. Blood Cancer"},{"issue":"1","key":"10.1016\/j.bone.2021.115998_bb0735","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cmet.2017.09.015","article-title":"Molecular mechanisms linking exercise to cancer prevention and treatment","volume":"27","author":"Hojman","year":"2018","journal-title":"Cell Metab."},{"issue":"11","key":"10.1016\/j.bone.2021.115998_bb0740","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1249\/01.MSS.0000093622.41587.B6","article-title":"Exercise in cancer survivors: an overview of research","volume":"35","author":"Courneya","year":"2003","journal-title":"Med. Sci. Sports Exerc."},{"issue":"1\u20132","key":"10.1016\/j.bone.2021.115998_bb0745","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1365-2702.2012.04322.x","article-title":"Predicting exercise adherence in cancer patients and survivors: a systematic review and meta-analysis of motivational and behavioural factors","volume":"22","author":"Husebo","year":"2013","journal-title":"J. Clin. Nurs."},{"issue":"7","key":"10.1016\/j.bone.2021.115998_bb0750","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1002\/cncr.11227","article-title":"Physical activity levels before and after a diagnosis of breast carcinoma - the health, eating, activity, and lifestyle (HEAL) study","volume":"97","author":"Irwin","year":"2003","journal-title":"Cancer"},{"issue":"2","key":"10.1016\/j.bone.2021.115998_bb0755","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/pcan.2015.6","article-title":"Safety and efficacy of resistance exercise in prostate cancer patients with bone metastases (vol 16, pg 328, 2013)","volume":"18","author":"Cormie","year":"2015","journal-title":"Prostate Cancer Prostatic Dis."},{"issue":"3","key":"10.1016\/j.bone.2021.115998_bb0760","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1359\/JBMR.040129","article-title":"Low magnitude mechanical loading is osteogenic in children with disabling conditions","volume":"19","author":"Ward","year":"2004","journal-title":"J. Bone Miner. Res."},{"issue":"5","key":"10.1016\/j.bone.2021.115998_bb0765","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1007\/s00198-012-2144-1","article-title":"Effect of whole body vibration (WBV) therapy on bone density and bone quality in osteopenic girls with adolescent idiopathic scoliosis: a randomized, controlled trial","volume":"24","author":"Lam","year":"2013","journal-title":"Osteoporos. Int."},{"issue":"7","key":"10.1016\/j.bone.2021.115998_bb0770","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1001\/jamaoncol.2015.6557","article-title":"Effect of low-magnitude, high-frequency mechanical stimulation on BMD among young childhood cancer survivors: a randomized clinical trial","volume":"2","author":"Mogil","year":"2016","journal-title":"JAMA Oncol."},{"issue":"1","key":"10.1016\/j.bone.2021.115998_bb0775","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1359\/jbmr.0301212","article-title":"Fracture risk in monoclonal gammopathy of undetermined significance","volume":"19","author":"Melton","year":"2004","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2021.115998_bb0780","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbo.2020.100323","article-title":"Impact of whole-body vibration exercise on physical performance and bone turnover in patients with monoclonal gammopathy of undetermined significance","volume":"25","author":"Seefried","year":"2020","journal-title":"J. Bone Oncol."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328221001605?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328221001605?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:43:30Z","timestamp":1762659810000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328221001605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":156,"alternative-id":["S8756328221001605"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2021.115998","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Suppression of cancer-associated bone loss through dynamic mechanical loading","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2021.115998","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115998"}}