{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:04:43Z","timestamp":1790888683321,"version":"4.1.0"},"reference-count":149,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.bone.2021.116076","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T09:05:35Z","timestamp":1624525535000},"page":"116076","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"special_numbering":"C","title":["Cholesterol metabolism related genes in osteoarthritis"],"prefix":"10.1016","volume":"152","author":[{"given":"Ioanna","family":"Papathanasiou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Anastasopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aspasia","family":"Tsezou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2021.116076_bb0005","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"Spencer","year":"2018","journal-title":"Lancet."},{"key":"10.1016\/j.bone.2021.116076_bb0010","unstructured":"United States Bone and Joint Initiative. The Burden of Musculoskeletal Diseases in the United States (BMUS). https:\/\/www.boneandjointburden.org\/fourth-edition, 2018 (Accessed June 12 2019)."},{"key":"10.1016\/j.bone.2021.116076_bb0015","unstructured":"United Nations. World population to 2300. http:\/\/www.un.org\/esa\/population\/publications\/...\/WorldPop2300final.pdf."},{"key":"10.1016\/j.bone.2021.116076_bb0020","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.mad.2019.03.003","article-title":"Age and frailty as risk factors for the development of osteoarthritis","volume":"180","author":"O'Brien","year":"2019","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.bone.2021.116076_bb0025","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: a disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bone.2021.116076_bb0030","doi-asserted-by":"crossref","first-page":"16072","DOI":"10.1038\/nrdp.2016.72","article-title":"Osteoarthritis","volume":"2","author":"Martel-Pelletier","year":"2016","journal-title":"Nat. Rev. Dis. Primers."},{"key":"10.1016\/j.bone.2021.116076_bb0035","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1136\/ard.2006.058347","article-title":"Yet more evidence that osteoarthritis is not a cartilage disease","volume":"65","author":"Brandt","year":"2006","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bone.2021.116076_bb0040","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1001\/jama.2020.22171","article-title":"Diagnosis and treatment of hip and knee osteoarthritis: a review","volume":"325","author":"Katz","year":"2021","journal-title":"JAMA."},{"key":"10.1016\/j.bone.2021.116076_bb0045","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","article-title":"Osteoarthritis","volume":"386","author":"Glyn-Jones","year":"2015","journal-title":"Lancet."},{"key":"10.1016\/j.bone.2021.116076_bb0050","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.joca.2017.11.014","article-title":"Osteoarthritis year in review 2017: clinical","volume":"26","author":"Nelson","year":"2018","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2021.116076_bb0055","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.joca.2017.10.016","article-title":"Osteoarthritis biomarkers: year in review","volume":"26","author":"Watt","year":"2018","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2021.116076_bb0060","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","article-title":"Osteoarthritis","volume":"27","author":"Hunter","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.bone.2021.116076_bb0065","doi-asserted-by":"crossref","unstructured":"L.A. Deveza, R.F. Loeser RF, Is osteoarthritis one disease or a collection of many? Rheumatology (Oxford) 57 (2018) iv34\u201342. doi:10.1093\/rheumatology\/kex417.","DOI":"10.1093\/rheumatology\/kex417"},{"key":"10.1016\/j.bone.2021.116076_bb0070","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/S0140-6736(11)60243-2","article-title":"Osteoarthritis: an update with relevance for clinical practice","volume":"377","author":"Bijlsma","year":"2011","journal-title":"Lancet."},{"key":"10.1016\/j.bone.2021.116076_bb0075","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/rheumatology\/key011","article-title":"What is the evidence for a role for diet and nutrition in osteoarthritis?","volume":"57","author":"Thomas","year":"2018","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.bone.2021.116076_bb0080","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/jcb.25758","article-title":"Dietary fats and osteoarthritis: insights, evidences, and new horizons","volume":"118","author":"Sekar","year":"2017","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bone.2021.116076_bb0085","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13075-020-02170-7","article-title":"Transgenic conversion of \u03c9-6 to \u03c9-3 polyunsaturated fatty acids via fat-1 reduces the severity of post-traumatic osteoarthritis","volume":"22","author":"Kimmerling","year":"2020","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bone.2021.116076_bb0090","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/jor.24219","article-title":"Effects of dietary fatty acid content on humeral cartilage and bone structure in a mouse model of diet-induced obesity","volume":"37","author":"Votava","year":"2019","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2021.116076_bb0095","doi-asserted-by":"crossref","unstructured":"C.L. Wu, K.A. Kimmerling, D. Little, F. Guilak, Serum and synovial fluid lipidomic profiles predict obesity-associated osteoarthritis, synovitis, and wound repair, Sci. Rep. 20 (2017) 7:44315. doi:10.1038\/srep44315.","DOI":"10.1038\/srep44315"},{"key":"10.1016\/j.bone.2021.116076_bb0100","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1136\/annrheumdis-2014-205601","article-title":"Dietary fatty acid content regulates wound repair and the pathogenesis of osteoarthritis following joint injury","volume":"74","author":"Wu","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bone.2021.116076_bb0105","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.joca.2018.03.004","article-title":"Systemic and local adipose tissue in knee osteoarthritis","volume":"26","author":"Chang","year":"2018","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2021.116076_bb0110","doi-asserted-by":"crossref","unstructured":"K.H. Collins, K.L. Lenz, E.N. Pollitt, D. Ferguson, I. Hutson, L.E. Springer, A.K. Oestreich, R. Tang, Y.R. Choi, G.A. Meyer, S.L. Teitelbaum, C.T.N. Pham, C.A. Harris, F. Guilak. Adipose tissue is a critical regulator of osteoarthritis. Proc Natl Acad Sci U S A. 118 (2021)):e2021096118. doi:10.1073\/pnas.2021096118.","DOI":"10.1073\/pnas.2021096118"},{"key":"10.1016\/j.bone.2021.116076_bb0115","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.joca.2010.03.014","article-title":"The infrapatellar fat pad should be considered as an active osteoarthritic joint tissue: a narrative review","volume":"18","author":"Clockaerts","year":"2010","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2021.116076_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ecl.2013.09.009","article-title":"Metabolic syndrome","volume":"43","author":"Samson","year":"2014","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"10.1016\/j.bone.2021.116076_bb0125","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1186\/1753-6561-3-S7-S42","article-title":"Multivariate association analysis of the components of metabolic syndrome from the Framingham Heart Study","volume":"3","author":"Baker","year":"2009","journal-title":"BMC Proc."},{"key":"10.1016\/j.bone.2021.116076_bb0130","doi-asserted-by":"crossref","unstructured":"K.G. Alberti, P.Z. Zimmet, Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation, Diabet. Med. J. Br. Diabet. Assoc. 15 (1998) 539\u2013553. doi:10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S.","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S"},{"key":"10.1016\/j.bone.2021.116076_bb0135","doi-asserted-by":"crossref","first-page":"155043","DOI":"10.1016\/j.cyto.2020.155043","article-title":"An update on the association between metabolic syndrome and osteoarthritis and on the potential role of leptin in osteoarthritis","volume":"129","author":"Gao","year":"2020","journal-title":"Cytokine."},{"key":"10.1016\/j.bone.2021.116076_bb0140","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.biochi.2015.12.008","article-title":"Inter-relations between osteoarthritis and metabolic syndrome: a common link?","volume":"121","author":"Clanche","year":"2016","journal-title":"Biochimie."},{"key":"10.1016\/j.bone.2021.116076_bb0145","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3810\/pgm.2009.11.2073","article-title":"Increased prevalence of metabolic syndrome in individuals with osteoarthritis: an analysis of NHANES III data","volume":"121","author":"Puenpatom","year":"2009","journal-title":"Postgrad. Med."},{"key":"10.1016\/j.bone.2021.116076_bb0150","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2015-000077","article-title":"Association between diabetes mellitus and osteoarthritis: systematic literature review and meta-analysis","volume":"1","author":"Louati","year":"2015","journal-title":"RMD Open"},{"key":"10.1016\/j.bone.2021.116076_bb0155","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1136\/ard.2010.146399","article-title":"Diabetes-induced osteoarthritis: from a new paradigm to a new phenotype","volume":"70","author":"Berenbaum","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bone.2021.116076_bb0160","doi-asserted-by":"crossref","unstructured":"G. Engstrom, M. Gerhardsson de Verdier, J. Rollof, P.M. Nilsson, L.S. Lohmander, C reactive protein, metabolic syndrome and incidence of severe hip and knee osteoarthritis. A population-based cohort study, Osteoarthritis Cartilage. 17 (2009) 168\u2013173. doi:https:\/\/doi.org\/10.1016\/j.joca.2008.07.003.","DOI":"10.1016\/j.joca.2008.07.003"},{"key":"10.1016\/j.bone.2021.116076_bb0165","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1002\/art.39586","article-title":"Insulin resistance: releasing the brakes on synovial inflammation and osteoarthritis?","volume":"68","author":"Griffin","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.bone.2021.116076_bb0170","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1002\/art.39561","article-title":"Suppressive effects of insulin on tumor necrosisfactor\u2013dependent early osteoarthritic changes associated with obesity and type 2 diabetes mellitus","volume":"68","author":"Hamada","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.bone.2021.116076_bb0175","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.berh.2014.01.004","article-title":"The epidemiology of osteoarthritis","volume":"28","author":"Johnson","year":"2014","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.bone.2021.116076_bb0180","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/j.joca.2011.08.009","article-title":"The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review","volume":"19","author":"Pereira","year":"2011","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2021.116076_bb0185","first-page":"00634","article-title":"The prevalence of radiographic thumb base osteoarthritis: a meta-analysis","volume":"S1063-4584","author":"van der Oest","year":"2021","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2021.116076_bb0190","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/art.39929","article-title":"Cam deformity and acetabular dysplasia as risk factors for hip osteoarthritis","volume":"69","author":"Hosnijeh","year":"2017","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.bone.2021.116076_bb0195","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1136\/annrheumdis-2015-207602","article-title":"Longitudinal validation of periarticular bone area and 3D shape as biomarkers for knee OA progression? Data from the FNIH OA Biomarkers Consortium","volume":"75","author":"Hunter","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bone.2021.116076_bb0200","doi-asserted-by":"crossref","unstructured":"A.E. Nelson, Y.M. Golightly, S. Lateef, J.B. Renner, J.M. Jordan, R.M. Aspden, H. Hillstrom, J.S. Gregory, Cross-sectional associations between variations in ankle shape by statistical shape modeling, injury history, and race: the Johnston County Osteoarthritis Project, J. Foot Ankle Res. 26 (2017) 10:34. doi:10.1186\/s13047-017-0216-3.","DOI":"10.1186\/s13047-017-0216-3"},{"key":"10.1016\/j.bone.2021.116076_bb0205","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1038\/s41598-020-60587-1","article-title":"Level of obesity is directly associated with the clinical and functional consequences of knee osteoarthritis","volume":"10","author":"Raud","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bone.2021.116076_bb0210","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2014-007568","article-title":"Body mass index and risk of knee osteoarthritis: systematic review and meta-analysis of prospective studies","volume":"5","author":"Zheng","year":"2015","journal-title":"BMJ Open"},{"key":"10.1016\/j.bone.2021.116076_bb0215","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1186\/s12891-016-1179-4","article-title":"Factors associated with diagnostic stage of hip osteoarthritis due to acetabular dysplasia among Japanese female patients: a cross-sectional study","volume":"17","author":"Ohfuji","year":"2016","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.bone.2021.116076_bb0220","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1002\/art.39707","article-title":"Association between overweight and obesity and risk of clinically diagnosed knee, hip, and hand osteoarthritis: a population-based cohort study","volume":"68","author":"Reyes","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.bone.2021.116076_bb0225","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.plipres.2010.11.001","article-title":"Lipid metabolism and osteoarthritis: lessons from atherosclerosis","volume":"50","author":"Gkretsi","year":"2011","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.bone.2021.116076_bb0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/bmj.2.5243.1","article-title":"Osteoarthrosis in patients and populations","volume":"2","author":"Kellgren","year":"1961","journal-title":"Br. Med. J."},{"key":"10.1016\/j.bone.2021.116076_bb0235","first-page":"1118","article-title":"Association between metabolic factors and knee osteoarthritis in women: the Chingford Study","volume":"22","author":"Hart","year":"1995","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.bone.2021.116076_bb0240","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1038\/s41598-017-03317-4","article-title":"Serum lipid levels and risk of hand osteoarthritis: the Chingford prospective cohort study","volume":"7","author":"Garcia-Gil","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bone.2021.116076_bb0245","unstructured":"T. St\u00fcrmer, Y. Sun, S. Sauerland, I. Zeissig, K.P. G\u00fcnther, W. Puhl, H. Brenner, Serum cholesterol and osteoarthritis. The baseline examination of the Ulm Osteoarthritis study, J. Rheumatol. 25 (1998) 1827\u20131832."},{"key":"10.1016\/j.bone.2021.116076_bb0250","first-page":"745","article-title":"Radiographic osteoarthritis and serum cholesterol","volume":"23","author":"Al-Arfaj","year":"2003","journal-title":"Saudi Med. J."},{"key":"10.1016\/j.bone.2021.116076_bb0255","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.joca.2017.01.014","article-title":"Hyperlipidaemia and incident osteoarthritis of the hand: a population based case-control study","volume":"25","author":"Frey","year":"2017","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2021.116076_bb0260","first-page":"1218","article-title":"Factors associated with radiographic osteoarthritis: results from the population study 70-year-old people in G\u00f6teborg","volume":"18","author":"Bagge","year":"1991","journal-title":"Rheumatol."},{"key":"10.1016\/j.bone.2021.116076_bb0265","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1136\/ard.2005.045724","article-title":"Do metabolic factors add to the effect of overweight on hand osteoarthritis?","volume":"66","author":"Dahaghin","year":"2007","journal-title":"The Rotterdam Study. Ann. Rheum. Dis."},{"key":"10.1016\/j.bone.2021.116076_bb0270","article-title":"Is there an association of serum low density lipoprotein, high density lipoprotein or total cholesterol with development of knee osteoarthritis?","author":"Schwager","year":"2020","journal-title":"Arthritis Care Res. (Hoboken)."},{"key":"10.1016\/j.bone.2021.116076_bb0275","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13098-020-00547-x","article-title":"Bidirectional association between metabolic syndrome and osteoarthritis: a meta-analysis of observational studies","volume":"12","author":"Liu","year":"2020","journal-title":"Diabetol. Metab. Syndr."},{"key":"10.1016\/j.bone.2021.116076_bb0280","article-title":"Dyslipidemia might be associated with an increased risk of osteoarthritis","volume":"3105248","author":"Xiong","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.bone.2021.116076_bb0285","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1016\/j.clinthera.2004.11.016","volume":"26","author":"Bays","year":"2004","journal-title":"Clin. Ther."},{"key":"10.1016\/j.bone.2021.116076_bb0290","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S0140-6736(05)67394-1","article-title":"Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins","volume":"366","author":"Baigent","year":"2005","journal-title":"Lancet."},{"key":"10.1016\/j.bone.2021.116076_bb0295","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1161\/CIRCRESAHA.116.308537","article-title":"Pleiotropic effects of statins on the cardiovascular system","volume":"120","author":"Oesterle","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.bone.2021.116076_bb0300","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10799893.2018.1557206","article-title":"Protective effects of atorvastatin against high glucose-induced nuclear factor-\u03baB activation in cultured C28I2 chondrocytes","volume":"39","author":"Juybari","year":"2019","journal-title":"J. Recept. Signal Transduct. Res."},{"key":"10.1016\/j.bone.2021.116076_bb0305","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.abb.2019.01.038","article-title":"Simvastatin promotes restoration of chondrocyte morphology and phenotype","volume":"665","author":"Terabe","year":"2019","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bone.2021.116076_bb0310","doi-asserted-by":"crossref","first-page":"990","DOI":"10.18632\/aging.100213","article-title":"Statin prevents chondrocyte aging and degeneration of articular cartilage in osteoarthritis (OA)","volume":"2","author":"Yudoh","year":"2010","journal-title":"Aging"},{"key":"10.1016\/j.bone.2021.116076_bb0315","first-page":"696","article-title":"Simvastatin inhibits cytokine production and nuclear factor-kB activation in interleukin 1beta-stimulated synoviocytes from rheumatoid arthritis patients","volume":"25","author":"Lazzerini","year":"2007","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.bone.2021.116076_bb0320","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/jor.20953","article-title":"Protective effect of atorvastatin in cultured osteoarthritic chondrocytes","volume":"28","author":"Simopoulou","year":"2010","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2021.116076_bb0325","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/term.2804","article-title":"Attenuation of osteoarthritis progression in mice following intra-articular administration of simvastatin-conjugated gelatin hydrogel","volume":"13","author":"Tanaka","year":"2019","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"10.1016\/j.bone.2021.116076_bb0330","doi-asserted-by":"crossref","first-page":"182097","DOI":"10.5402\/2012\/182097","article-title":"An assessment of the chondroprotective effects of intra-articular application of statin and tetracycline on early-stage experimental osteoarthritis","volume":"2012","author":"Dinc","year":"2012","journal-title":"ISRN Orthop."},{"key":"10.1016\/j.bone.2021.116076_bb0335","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10195-011-0154-y","article-title":"Mechanically induced experimental knee osteoarthritis benefits from anti-inflammatory and immunomodulatory properties of simvastatin via inhibition of matrix metalloproteinase-3","volume":"12","author":"Aktas","year":"2011","journal-title":"J. Orthop. Traumatol."},{"key":"10.1016\/j.bone.2021.116076_bb0340","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.joca.2008.06.012","article-title":"Mevastatin reduces cartilage degradation in rabbit experimental osteoarthritis through inhibition of synovial inflammation","volume":"17","author":"Akasaki","year":"2009","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2021.116076_bb0345","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1136\/annrheumdis-2011-200092","article-title":"Statin use is associated with reduced incidence and progression of knee osteoarthritis in the Rotterdam study","volume":"71","author":"Clockaerts","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bone.2021.116076_bb0350","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1002\/acr.23735","article-title":"Statin use and knee osteoarthritis outcomes: a longitudinal cohort study","volume":"71","author":"Veronese","year":"2019","journal-title":"Arthritis Care Res. (Hoboken)"},{"key":"10.1016\/j.bone.2021.116076_bb0355","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1148\/radiol.2019190557","article-title":"Statin use and knee osteoarthritis outcome measures according to the presence of heberden nodes: results from the osteoarthritis initiative","volume":"293","author":"Haj-Mirzaian","year":"2019","journal-title":"Radiology"},{"key":"10.1016\/j.bone.2021.116076_bb0360","first-page":"106","article-title":"Association of statin use and development and progression of hip osteoarthritis in elderly women","volume":"32","author":"Beattie","year":"2005","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.bone.2021.116076_bb0365","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jbspin.2017.09.014","article-title":"Statin use and knee osteoarthritis progression: results from a post-hoc analysis of the SEKOIA trial","volume":"85","author":"Eymard","year":"2018","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.bone.2021.116076_bb0370","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1002\/acr.23616","article-title":"Risk of incident osteoarthritis of the hand in statin initiators: a sequential cohort study","volume":"70","author":"Burkard","year":"2018","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.bone.2021.116076_bb0375","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1016\/j.joca.2017.07.013","article-title":"Association between statin use and consultation or surgery for osteoarthritis of the hip or knee: a pooled analysis of four cohort studies","volume":"25","author":"Micha\u00eblsson","year":"2017","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2021.116076_bb0380","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/acr.22389","article-title":"Is statin use associated with new joint-related symptoms, physical function, and quality of life? Results from two population-based cohorts of women","volume":"67","author":"Peeters","year":"2015","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.bone.2021.116076_bb0385","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1136\/annrheumdis-2012-202159","article-title":"Associations between statin use and changes in pain, function and structural progression: a longitudinal study of persons with knee osteoarthritis","volume":"72","author":"Riddle","year":"2013","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bone.2021.116076_bb0390","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1136\/annrheumdis-2013-204382","article-title":"Use of statins is associated with a lower prevalence of generalised osteoarthritis","volume":"73","author":"Valdes","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bone.2021.116076_bb0395","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.joca.2020.04.007","article-title":"Association between statin use and incidence or progression of osteoarthritis: meta-analysis of observational studies","volume":"28","author":"Wang","year":"2020","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2021.116076_bb0400","doi-asserted-by":"crossref","unstructured":"P. Agarwal, E. Moshier, M. Ru, N. Ohri, R. Ennis, K. Rosenzweig, M. Mazumdar, Immortal time bias in observational studies of time-to-event outcomes: assessing effects of postmastectomy radiation therapy using the national cancer database, Cancer Control 25 (2018) 1073274818789355. doi:https:\/\/doi.org\/10.1177\/1073274818789355.","DOI":"10.1177\/1073274818789355"},{"key":"10.1016\/j.bone.2021.116076_bb0405","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.semarthrit.2020.11.010","article-title":"Statins and lower mortality in rheumatic diseases: an effect of immortal time bias?","volume":"51","author":"Abrahami","year":"2021","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.bone.2021.116076_bb0410","doi-asserted-by":"crossref","unstructured":"C. Buettner, R.B. Davis, S.G. Leveille, M.A. Mittleman, K.J Mukamal, Prevalence of musculoskeletal pain and statin use. J. Gen. Intern. 23 (2008) 1182\u20131186.","DOI":"10.1007\/s11606-008-0636-7"},{"key":"10.1016\/j.bone.2021.116076_bb0415","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1177\/2047487315610663","article-title":"Association between osteoarthritis and cardiovascular disease: systematic review and meta-analysis","volume":"23","author":"Hall","year":"2016","journal-title":"Eur. J. Prev. Cardiol."},{"key":"10.1016\/j.bone.2021.116076_bb0420","doi-asserted-by":"crossref","unstructured":"J.G. Robinson, M. Farnier, M. Krempf, J. Bergeron, G. Luc, M. Averna, E.S. Stroes, G. Langslet, F.J. Raal, M.E.l. Shahawy, M.J. Koren, N.E. Lepor, C. Lorenzato, R. Pordy, U. Chaudhari, J.J.P. Kastelein, Efficacy and safety of alirocumab in reducing lipids and cardiovascular events, N. Engl. J. Med. 372 (2015) 1489\u20131499. doi:10.1056\/NEJMoa1501031.","DOI":"10.1056\/NEJMoa1501031"},{"key":"10.1016\/j.bone.2021.116076_bb0425","doi-asserted-by":"crossref","unstructured":"F.E. Dewey, V. Gusarova, R.L. Dunbar, C. O'Dushlaine, C. Schurmann, O. Gottesman, S. McCarthy, et al., Genetic and pharmacologic inactivation of ANGPTL3 and cardiovascular disease, N. Engl, J. Med. 377 (2017) 211\u2013221. doi:10.1056\/NEJMoa1612790.","DOI":"10.1056\/NEJMoa1612790"},{"key":"10.1016\/j.bone.2021.116076_bb0430","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1056\/NEJMc1705994","article-title":"ANGPTL3 inhibition in homozygous familial hypercholesterolemia","volume":"377","author":"Gaudet","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bone.2021.116076_bb0435","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0168-9525(97)01377-2","article-title":"Cholesterol metabolism and embryogenesis","volume":"14","author":"Farese","year":"1998","journal-title":"Trends Genet."},{"key":"10.1016\/j.bone.2021.116076_bb0440","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.joca.2015.01.002","article-title":"A new prescription for growth? Statins, cholesterol and cartilage homeostasis","volume":"23","author":"Bush","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2021.116076_bb0445","doi-asserted-by":"crossref","first-page":"760","DOI":"10.3390\/nu10060760","article-title":"Molecular pathways underlying cholesterol homeostasis","volume":"10","author":"Afonso","year":"2018","journal-title":"Nutrients."},{"key":"10.1016\/j.bone.2021.116076_bb0450","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1126\/science.290.5497.1721","article-title":"How cells handle cholesterol","volume":"290","author":"Simons","year":"2000","journal-title":"Science."},{"key":"10.1016\/j.bone.2021.116076_bb0455","doi-asserted-by":"crossref","first-page":"52772","DOI":"10.1074\/jbc.M410302200","article-title":"Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs","volume":"279","author":"Adams","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2021.116076_bb0460","doi-asserted-by":"crossref","unstructured":"M.S. Brown, A. Radhakrishnan, J.L Goldstein, Retrospective on cholesterol homeostasis: the central role of scap, Annu. Rev. Biochem. 87 (2018) 783\u2013807. doi:https:\/\/doi.org\/10.1146\/annurev-biochem-062917-011852.","DOI":"10.1146\/annurev-biochem-062917-011852"},{"key":"10.1016\/j.bone.2021.116076_bb0465","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S1537-1891(02)00175-1","article-title":"LXRs; oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis","volume":"38","author":"Edwards","year":"2002","journal-title":"Vascul. Pharmacol."},{"key":"10.1016\/j.bone.2021.116076_bb0470","doi-asserted-by":"crossref","first-page":"11067","DOI":"10.1021\/bi901564g","article-title":"Small discoidal pre-\u03b21 HDL particles are efficient acceptors of cell cholesterol via ABCA1 and ABCG1","volume":"48","author":"Favari","year":"2009","journal-title":"Biochemistry."},{"key":"10.1016\/j.bone.2021.116076_bb0475","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1194\/jlr.M800362-JLR200","article-title":"Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux","volume":"50","author":"Sankaranarayanan","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bone.2021.116076_bb0480","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1161\/CIRCRESAHA.119.312617","article-title":"HDL and reverse cholesterol transport","volume":"124","author":"Ouimet","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.bone.2021.116076_bb0485","doi-asserted-by":"crossref","unstructured":"F.N. Ghadially, P.N. Mehta, W.H. Kirkaldy-Willis, W. Ultrastructure of articular cartilage in experimentally produced lipoarthrosis. J. Bone Joint Surg. Am. 52 (1970) 1147\u20131158.","DOI":"10.2106\/00004623-197052060-00007"},{"key":"10.1016\/j.bone.2021.116076_bb0490","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.abb.2006.09.014","article-title":"Fatty acid transport in articular cartilage","volume":"456","author":"Arkill","year":"2006","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bone.2021.116076_bb0495","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1101\/gad.13.16.2072","article-title":"Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation","volume":"13","author":"St-Jacques","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.bone.2021.116076_bb0500","doi-asserted-by":"crossref","first-page":"4642","DOI":"10.1074\/jbc.M305518200","article-title":"Role of cholesterol in the regulation of growth plate chondrogenesis and longitudinal bone growth","volume":"279","author":"Wu","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2021.116076_bb0505","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.matbio.2004.12.003","article-title":"Cholesterol secretion and homeostasis in chondrocytes: a liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein A1 expression","volume":"24","author":"Gentili","year":"2005","journal-title":"Matrix Biol."},{"key":"10.1016\/j.bone.2021.116076_bb0510","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.joca.2012.02.007","article-title":"High dietary fat and the development of osteoarthritis in a rabbit model","volume":"20","author":"Brunner","year":"2012","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2021.116076_bb0515","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/art.33332","article-title":"Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise","volume":"64","author":"Griffin","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bone.2021.116076_bb0520","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.joca.2015.03.014","article-title":"Relationship between inflammation, the gut microbiota, and metabolic osteoarthritis development: studies in a rat model","volume":"23","author":"Collins","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2021.116076_bb0525","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1002\/art.33443","article-title":"A-M Zuurmond, Metabolic stress-induced inflammation plays a major role in the development of osteoarthritis in mice","volume":"64","author":"Gierman","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bone.2021.116076_bb0530","doi-asserted-by":"crossref","unstructured":"L.M. Gierman, S. K\u00fchnast, A. Koudijs, E.J. Pieterman, M. Kloppenburg, G.J.V.M. van Osch, V. Stojanovic-Susulic, T.W.J. Huizinga, H.M.G. Princen, A-M Zuurmond, Osteoarthritis development is induced by increased dietary cholesterol and can be inhibited by atorvastatin in APOE*3Leiden.CETP mice\u2014a translational model for atherosclerosis, Ann. Rheum. Dis. 73 (2014) 921\u2013927. doi:10.1016\/ doi:10.1016\/10.1136\/annrheumdis-2013-203248.","DOI":"10.1136\/annrheumdis-2013-203248"},{"key":"10.1016\/j.bone.2021.116076_bb0535","series-title":"Novel High-Intensive Cholesterol-lowering Therapies Do Not Ameliorate Knee OA Development in Humanized Dyslipidemic Mice, Osteoarthritis Cartilage","author":"van Gemert","year":"2021"},{"key":"10.1016\/j.bone.2021.116076_bb0540","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.joca.2012.11.003","article-title":"Perturbations in the HDL metabolic pathway predispose to the development of osteoarthritis in mice following long-term exposure to western-type diet","volume":"21","author":"Triantaphyllidou","year":"2013","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2021.116076_bb0545","doi-asserted-by":"crossref","first-page":"R178","DOI":"10.1186\/ar4367","article-title":"Cholesterol accumulation caused by low density lipoprotein receptor deficiency or a cholesterol-rich diet results in ectopic bone formation during experimental osteoarthritis","volume":"15","author":"de Munter","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bone.2021.116076_bb0550","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.joca.2015.11.016","article-title":"High LDL levels lead to increased synovial inflammation and accelerated ectopic bone formation during experimental osteoarthritis","volume":"24","author":"de Munter","year":"2016","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2021.116076_bb0555","first-page":"566250","volume":"7","author":"Villalvilla","year":"2020","journal-title":"Modulation of the inflammatory process by hypercholesterolemia in osteoarthritis. Front Med. (Lausanne)."},{"key":"10.1016\/j.bone.2021.116076_bb0560","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s13075-017-1473-z","article-title":"Increased synovial lipodystrophy induced by high fat diet aggravates synovitis in experimental osteoarthritis","volume":"19","author":"Larra\u00f1aga-Vera","year":"2017","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bone.2021.116076_bb0565","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.pharmthera.2014.09.009","article-title":"Rabbit models for the study of human atherosclerosis: from pathophysiological mechanisms to translational medicine","volume":"146","author":"Fan","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bone.2021.116076_bb0570","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3390\/ani9070463","article-title":"Diet-induced rabbit models for the study of metabolic syndrome","volume":"9","author":"Lozano","year":"2019","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.bone.2021.116076_bb0575","doi-asserted-by":"crossref","first-page":"686","DOI":"10.3390\/nu10060686","article-title":"Effect of fucoidan on anterior cruciate ligament transection and medial meniscectomy induced osteoarthritis in high-fat diet-induced obese rats","volume":"10","author":"Sudirman","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.bone.2021.116076_bb0580","doi-asserted-by":"crossref","unstructured":"H.M. de Visser, S.C. Mastbergen, A.E. Kozijn, K. Coeleveld, B. Pouran, M.H. van Rijen, F.P.J.G Lafeber, H. Weinans, Metabolic dysregulation accelerates injury-induced joint degeneration, driven by local inflammation; an in vivo rat study, J. Orthop. Res. 36 (2018) 881\u2013890. doi:10.1002\/jor.23712.","DOI":"10.1002\/jor.23712"},{"key":"10.1016\/j.bone.2021.116076_bb0585","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.joca.2020.03.008","article-title":"High-fat feeding primes the mouse knee joint to develop osteoarthritis and pathologic infrapatellar fat pad changes after surgically induced injury","volume":"28","author":"Warmink","year":"2020","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2021.116076_bb0590","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.joca.2017.10.010","article-title":"Variable cartilage degradation in mice with diet-induced metabolic dysfunction: food for thought","volume":"26","author":"Kozijn","year":"2018","journal-title":"Osteoarthr. Cartil."},{"issue":"2017","key":"10.1016\/j.bone.2021.116076_bb0595","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1096\/fj.201600600r","article-title":"Protective effects of mitochondria-targeted antioxidants and statins on cholesterol-induced osteoarthritis","volume":"31","author":"Farnaghi","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.bone.2021.116076_bb0600","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/art.39337","article-title":"Regulation of cholesterol homeostasis by Hedgehog signaling in osteoarthritic cartilage","volume":"68","author":"Ali","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.bone.2021.116076_bb0605","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s41586-019-0920-1","article-title":"The CH25H-CYP7B1-ROR\u03b1 axis of cholesterol metabolism regulates osteoarthritis","volume":"566","author":"Choi","year":"2019","journal-title":"Nature."},{"key":"10.1016\/j.bone.2021.116076_bb0610","doi-asserted-by":"crossref","unstructured":"J.W. Watters, C. Cheng, M. Pickarski, G.A. Wesolowski, Y. Zhuo, T. Hayami, W. Wang, J. Szumiloski, R.L. Phillips, L.T. Duong, Inverse relationship between matrix remodeling and lipid metabolism during osteoarthritis progression in the STR\/Ort mouse Arthritis Rheum. 56 (2007) 2999\u20133009. doi:10.1002\/art.22836.","DOI":"10.1002\/art.22836"},{"key":"10.1016\/j.bone.2021.116076_bb0615","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/s13075-020-02289-7","article-title":"Widespread regulation of gene expression by glucocorticoids in chondrocytes from patients with osteoarthritis as determined by RNA-Seq","volume":"22","author":"Pemmari","year":"2020","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bone.2021.116076_bb0620","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.joca.2007.12.012","article-title":"Gene expression profiling of chondrocytes from a porcine impact injury model","volume":"16","author":"Ashwell","year":"2008","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2021.116076_bb0625","doi-asserted-by":"crossref","unstructured":"T. Wei, N.H. Kulkarni, Q.Q. Zeng, L.M. Helvering, X. Lin, F. Lawrence, L. Hale, M.G. Chambers, C. Lin, A. Harvey, Y. L. Ma, R.L. Cain, J. Oskins, M.A. Carozza, D.D. Edmondson, T. Hu, R.R. Miles, T.P. Ryan, J.E. Onyia, P.G, Mitchell Analysis of early changes in the articular cartilage transcriptisome in the rat meniscal tear model of osteoarthritis: pathway comparisons with the rat anterior cruciate transection model and with human osteoarthritic cartilage, Osteoarthritis Cartilage. 18 (2010) 992\u20131000. doi:10.1016\/j.joca.2010.04.012.","DOI":"10.1016\/j.joca.2010.04.012"},{"key":"10.1016\/j.bone.2021.116076_bb0630","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1002\/art.22876","article-title":"Comparative proteomic characterization of articular cartilage tissue from normal donors and patients with osteoarthritis","volume":"56","author":"Wu","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bone.2021.116076_bb0635","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003740","article-title":"Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks","volume":"3","author":"Iliopoulos","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2021.116076_bb0640","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12014-015-9085-6","article-title":"Comparative proteomic analysis of hypertrophic chondrocytes in osteoarthritis","volume":"12","author":"Tsolis","year":"2015","journal-title":"Clin. Proteomics"},{"key":"10.1016\/j.bone.2021.116076_bb0645","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1021\/acs.jproteome.6b00980","article-title":"Screening and validation of novel biomarkers in osteoarticular pathologies by comprehensive combination of protein array technologies","volume":"16","author":"Sierra-S\u00e1nchez","year":"2017","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bone.2021.116076_bb0650","doi-asserted-by":"crossref","first-page":"R180","DOI":"10.1186\/ar4369","article-title":"Proteomic profiling and functional characterization of early and late shoulder osteoarthritis","volume":"15","author":"Wanner","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bone.2021.116076_bb0655","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.joca.2008.12.011","article-title":"Global analysis of nuclear receptor expression and dysregulation in human osteoarthritic articular cartilage: reduced LXR signaling contributes to catabolic metabolism typical of osteoarthritis","volume":"17","author":"Collins-Racie","year":"2009","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2021.116076_bb0660","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00109-016-1501-5","article-title":"Nuclear receptors regulate lipid metabolism and oxidative stress markers in chondrocytes","volume":"95","author":"Ratneswaran","year":"2017","journal-title":"J. Mol. Med. (Berl)"},{"key":"10.1016\/j.bone.2021.116076_bb0665","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1101\/gad.850400","article-title":"Role of LXRs in control of lipogenesis","volume":"14","author":"Schultz","year":"2020","journal-title":"Genes Dev."},{"key":"10.1016\/j.bone.2021.116076_bb0670","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1039\/C9BM00426B","article-title":"Tauroursodeoxycholic acid (TUDCA) counters osteoarthritis by regulating intracellular cholesterol levels and membrane fluidity of degenerated chondrocytes","volume":"7","author":"Arai","year":"2019","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bone.2021.116076_bb0675","first-page":"605","article-title":"Lectin-like oxidized low density lipoprotein receptor 1 (LOX-1) expression in human articular chondrocytes","volume":"25","author":"Simopoulou","year":"2007","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.bone.2021.116076_bb0680","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/rheumatology\/kev270","article-title":"High systemic levels of low-density lipoprotein cholesterol: fuel to the flames in inflammatory osteoarthritis? Rheumatology (Oxford)","volume":"55","author":"de Munter","year":"2016","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.bone.2021.116076_bb0685","doi-asserted-by":"crossref","unstructured":"K. Hashimoto, M. Akagi, 2020. The role of oxidation of low-density lipids in pathogenesis of osteoarthritis: a narrative review. J. Int. Med. Res. 48, 300060520931609. doi:https:\/\/doi.org\/10.1177\/0300060520931609.","DOI":"10.1177\/0300060520931609"},{"key":"10.1016\/j.bone.2021.116076_bb0690","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1002\/jor.21084","article-title":"Impaired expression of genes regulating cholesterol efflux in human osteoarthritic chondrocytes","volume":"28","author":"Tsezou","year":"2010","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2021.116076_bb0695","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035753","article-title":"Central role of SREBP-2 in the pathogenesis of osteoarthritis","volume":"7","author":"Kostopoulou","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2021.116076_bb0700","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nrg.2016.59","article-title":"The molecular hallmarks of epigenetic control","volume":"17","author":"Allis","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bone.2021.116076_bb0705","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41576-018-0089-8","article-title":"Chromatin accessibility and the regulatory epigenome","volume":"20","author":"Klemm","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bone.2021.116076_bb0710","doi-asserted-by":"crossref","unstructured":"L.N. Reynard, M.J Barter, Osteoarthritis year in review 2019: Genetics, genomics and epigenetics, Osteoarthr. Cartil. 28 (2020) 275\u2013284. doi:https:\/\/doi.org\/10.1016\/j.joca.2019.11.010.","DOI":"10.1016\/j.joca.2019.11.010"},{"key":"10.1016\/j.bone.2021.116076_bb0715","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41584-020-0407-3","article-title":"Interplay between genetics and epigenetics in osteoarthritis","volume":"16","author":"Rice","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bone.2021.116076_bb0720","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.mad.2018.02.006","article-title":"Studying microRNAs in osteoarthritis: critical overview of different analytical approaches","volume":"171","author":"Trachana","year":"2018","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.bone.2021.116076_bb0725","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.121630","article-title":"The complex landscape of microRNAs in articular cartilage: biology, pathology, and therapeutic targets","volume":"3","author":"Endisha","year":"2018","journal-title":"JCI Insight."},{"key":"10.1016\/j.bone.2021.116076_bb0730","doi-asserted-by":"crossref","unstructured":"F. Kostopoulou, K.N Malizos, I. Papathanasiou, A. Tsezou, 2015. MicroRNA-33a regulates cholesterol synthesis and cholesterol efflux-related genes in osteoarthritic chondrocytes. Arthritis Res. Ther. 17, 42. doi:https:\/\/doi.org\/10.1186\/s13075-015-0556-y.","DOI":"10.1186\/s13075-015-0556-y"},{"key":"10.1016\/j.bone.2021.116076_bb0735","doi-asserted-by":"crossref","first-page":"119096","DOI":"10.1016\/j.lfs.2021.119096","article-title":"Vaspin regulated cartilage cholesterol metabolism through miR155\/LXR\u03b1 and participated in the occurrence of osteoarthritis in rats","volume":"269","author":"He","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.bone.2021.116076_bb0740","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s13148-017-0428-1","article-title":"Serum microRNA array analysis identifies miR-140-3p, miR-33b-3p and miR-671-3p as potential osteoarthritis biomarkers involved in metabolic processes","volume":"9","author":"Ntoumou","year":"2017","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.bone.2021.116076_bb0745","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/cbf.3356","article-title":"Suppression of ABCD2 dysregulates lipid metabolism via dysregulation of miR-141:ACSL4 in human osteoarthritis","volume":"36","author":"Park","year":"2018","journal-title":"Cell Biochem. Funct."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328221002386?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328221002386?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:57:37Z","timestamp":1757613457000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328221002386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":149,"alternative-id":["S8756328221002386"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2021.116076","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cholesterol metabolism related genes in osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2021.116076","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116076"}}