{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:08:01Z","timestamp":1778944081869,"version":"3.51.4"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000862","name":"Doris Duke Charitable Foundation","doi-asserted-by":"publisher","award":["2014099"],"award-info":[{"award-number":["2014099"]}],"id":[{"id":"10.13039\/100000862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["P30AR070155"],"award-info":[{"award-number":["P30AR070155"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR066735"],"award-info":[{"award-number":["R01AR066735"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000912","name":"March of Dimes Foundation","doi-asserted-by":"publisher","award":["1-FY14-211"],"award-info":[{"award-number":["1-FY14-211"]}],"id":[{"id":"10.13039\/100000912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005332","name":"Alpha Omega Alpha Honor Medical Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005332","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005865","name":"Mochida Memorial Foundation for Medical and Pharmaceutical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008069","name":"University of California, San Francisco","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AR075055"],"award-info":[{"award-number":["AR075055"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AR073015"],"award-info":[{"award-number":["AR073015"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["DK17035"],"award-info":[{"award-number":["DK17035"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.bone.2021.116129","type":"journal-article","created":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T05:53:19Z","timestamp":1627105999000},"page":"116129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages"],"prefix":"10.1016","volume":"153","author":[{"given":"Koji","family":"Matsuo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abigail","family":"Lepinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert D.","family":"Chavez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilie","family":"Barruet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania A.","family":"Moody","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy N.","family":"Ton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditi","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Hellman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiichiro","family":"Tomoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary C.","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward C.","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2021.116129_bb0005","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1126\/science.aam7928","article-title":"Inflammation and metabolism in tissue repair and regeneration","volume":"356","author":"Eming","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.bone.2021.116129_bb0010","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/intimm\/dxy054","article-title":"Macrophages in inflammation, repair and regeneration","volume":"30","author":"Oishi","year":"2018","journal-title":"Int. Immunol."},{"key":"10.1016\/j.bone.2021.116129_bb0015","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1002\/eji.201141783","article-title":"Inflammatory signaling in macrophages: transitions from acute to tolerant and alternative activation states","volume":"41","author":"Ivashkiv","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.bone.2021.116129_bb0020","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1055\/s-0030-1255354","article-title":"Macrophages: master regulators of inflammation and fibrosis","volume":"30","author":"Wynn","year":"2010","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.bone.2021.116129_bb0025","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Macrophages in tissue repair, regeneration, and fibrosis","volume":"44","author":"Wynn","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.bone.2021.116129_bb0030","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.2337\/db06-1650","article-title":"Increased number of islet-associated macrophages in type 2 diabetes","volume":"56","author":"Ehses","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.bone.2021.116129_bb0035","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1007\/s00125-009-1410-z","article-title":"Islet-associated macrophages in type 2 diabetes","volume":"52","author":"Richardson","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.bone.2021.116129_bb0040","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrd4275","article-title":"Targeting inflammation in the treatment of type 2 diabetes: time to start","volume":"13","author":"Donath","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bone.2021.116129_bb0045","doi-asserted-by":"crossref","DOI":"10.1126\/science.abc8511","article-title":"Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications","volume":"369","author":"Mathew","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.bone.2021.116129_bb0050","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41577-020-0331-4","article-title":"Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages","volume":"20","author":"Merad","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bone.2021.116129_bb0055","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.cell.2020.08.001","article-title":"Severe COVID-19 is marked by a dysregulated myeloid cell compartment","volume":"182","author":"Schulte-Schrepping","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.bone.2021.116129_bb0060","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s11914-019-00541-x","article-title":"Inflammation in fibrodysplasia ossificans progressiva and other forms of heterotopic ossification","volume":"17","author":"Matsuo","year":"2019","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bone.2021.116129_bb0065","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.it.2013.10.002","article-title":"Regulation of hematopoietic stem cells by bone marrow stromal cells","volume":"35","author":"Anthony","year":"2014","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bone.2021.116129_bb0070","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00774-003-0439-1","article-title":"The mechanism of osteoclast differentiation from macrophages: possible roles of T lymphocytes in osteoclastogenesis","volume":"21","author":"Udagawa","year":"2003","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.bone.2021.116129_bb0075","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1002\/jbmr.2422","article-title":"Macrophages promote osteoblastic differentiation in-vivo: implications in fracture repair and bone homeostasis","volume":"30","author":"Vi","year":"2015","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"key":"10.1016\/j.bone.2021.116129_bb0080","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1242\/dmm.010280","article-title":"Fibrodysplasia ossificans progressiva: mechanisms and models of skeletal metamorphosis","volume":"5","author":"Kaplan","year":"2012","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.bone.2021.116129_bb0085","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s00256-005-0958-z","article-title":"Heterotopic ossification: a review","volume":"34","author":"McCarthy","year":"2005","journal-title":"Skelet. Radiol."},{"key":"10.1016\/j.bone.2021.116129_bb0090","first-page":"459","article-title":"Risk factors for heterotopic ossification in children and adolescents with severe traumatic brain injury","volume":"73","author":"Hurvitz","year":"1992","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.1016\/j.bone.2021.116129_bb0095","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3928\/01477447-20091124-13","article-title":"Clinical significance of the heterotopic ossification after total hip arthroplasty","volume":"33","author":"Kocic","year":"2010","journal-title":"Orthopedics"},{"key":"10.1016\/j.bone.2021.116129_bb0100","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1227\/01.NEU.0000175856.31210.58","article-title":"Clinical significance of heterotopic ossification in cervical disc replacement: a prospective multicenter clinical trial","volume":"57","author":"Leung","year":"2005","journal-title":"Neurosurgery"},{"key":"10.1016\/j.bone.2021.116129_bb0105","doi-asserted-by":"crossref","first-page":"476","DOI":"10.2106\/JBJS.F.00412","article-title":"Heterotopic ossification following traumatic and combat-related amputations. Prevalence, risk factors, and preliminary results of excision","volume":"89","author":"Potter","year":"2007","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.bone.2021.116129_bb0110","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/jbmr.3304","article-title":"Depletion of mast cells and macrophages impairs heterotopic ossification in an Acvr1(R206H) mouse model of fibrodysplasia ossificans progressiva","volume":"33","author":"Convente","year":"2018","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2021.116129_bb0115","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1002\/stem.33","article-title":"Characterization of dendritic cells and macrophages generated by directed differentiation from mouse induced pluripotent stem cells","volume":"27","author":"Senju","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.bone.2021.116129_bb0120","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.immuni.2017.06.017","article-title":"Induced-pluripotent-stem-cell-derived primitive macrophages provide a platform for modeling tissue-resident macrophage differentiation and function","volume":"47","author":"Takata","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.bone.2021.116129_bb0125","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.stemcr.2015.01.005","article-title":"Large-scale hematopoietic differentiation of human induced pluripotent stem cells provides granulocytes or macrophages for cell replacement therapies","volume":"4","author":"Lachmann","year":"2015","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.bone.2021.116129_bb0130","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1038\/nm.4189","article-title":"Efficient derivation of microglia-like cells from human pluripotent stem cells","volume":"22","author":"Muffat","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.bone.2021.116129_bb0135","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.3389\/fimmu.2020.01016","article-title":"Macrophages derived from human induced pluripotent stem cells are low-activated \u201cnaive-like\u201d cells capable of restricting mycobacteria growth","volume":"11","author":"Nenasheva","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bone.2021.116129_bb0140","article-title":"Efficient, long term production of monocyte-derived macrophages from human pluripotent stem cells under partly-defined and fully-defined conditions","volume":"8","author":"van Wilgenburg","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2021.116129_bb0145","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.stemcr.2019.05.003","article-title":"Differentiation and functional comparison of monocytes and macrophages from hiPSCs with peripheral blood derivatives","volume":"12","author":"Cao","year":"2019","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.bone.2021.116129_bb0150","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.bone.2017.07.003","article-title":"Application of human induced pluripotent stem cells to model fibrodysplasia ossificans progressiva","volume":"109","author":"Barruet","year":"2018","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116129_bb0155","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1002\/jbmr.1637","article-title":"An Acvr1 R206H knock-in mouse has fibrodysplasia ossificans progressiva","volume":"27","author":"Chakkalakal","year":"2012","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2021.116129_bb0160","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/s41467-018-02988-5","article-title":"Inhibition of overactive TGF-beta attenuates progression of heterotopic ossification in mice","volume":"9","author":"Wang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bone.2021.116129_bb0165","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/1750-1172-8-190","article-title":"Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation","volume":"8","author":"Matsumoto","year":"2013","journal-title":"Orphanet. J. Rare Dis."},{"key":"10.1016\/j.bone.2021.116129_bb0170","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nmeth.2840","article-title":"Isolation of single-base genome-edited human iPS cells without antibiotic selection","volume":"11","author":"Miyaoka","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bone.2021.116129_bb0175","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/0092-8674(90)90385-R","article-title":"The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain","volume":"62","author":"McMahon","year":"1990","journal-title":"Cell"},{"issue":"22","key":"10.1016\/j.bone.2021.116129_bb0180","doi-asserted-by":"crossref","first-page":"e122958","DOI":"10.1172\/jci.insight.122958","article-title":"NF-kappaB\/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification","volume":"3","author":"Barruet","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.bone.2021.116129_bb0185","doi-asserted-by":"crossref","first-page":"3425","DOI":"10.1182\/blood-2011-11-395418","article-title":"Activated Gs signaling in osteoblastic cells alters the hematopoietic stem cell niche in mice","volume":"120","author":"Schepers","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.bone.2021.116129_bb0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0059243","article-title":"Robust and highly-efficient differentiation of functional monocytic cells from human pluripotent stem cells under serum- and feeder cell-free conditions","volume":"8","author":"Yanagimachi","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2021.116129_bb0195","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1161\/CIRCRESAHA.117.305860","article-title":"Functional analysis and transcriptomic profiling of iPSC-derived macrophages and their application in modeling Mendelian disease","volume":"117","author":"Zhang","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.bone.2021.116129_bb0200","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13287-018-0800-x","article-title":"Human-induced pluripotent stem cell-derived macrophages and their immunological function in response to tuberculosis infection","volume":"9","author":"Hong","year":"2018","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.bone.2021.116129_bb0205","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/ni.2956","article-title":"Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages","volume":"15","author":"Huang","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bone.2021.116129_bb0210","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1471-4906(02)02302-5","article-title":"Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes","volume":"23","author":"Mantovani","year":"2002","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bone.2021.116129_bb0215","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nri2356","article-title":"Colony-stimulating factors in inflammation and autoimmunity","volume":"8","author":"Hamilton","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bone.2021.116129_bb0220","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cellimm.2013.01.010","article-title":"Polarization profiles of human M-CSF-generated macrophages and comparison of M1-markers in classically activated macrophages from GM-CSF and M-CSF origin","volume":"281","author":"Jaguin","year":"2013","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.bone.2021.116129_bb0225","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.imbio.2010.05.020","article-title":"Heme oxygenase-1 expression in M-CSF-polarized M2 macrophages contributes to LPS-induced IL-10 release","volume":"215","author":"Sierra-Filardi","year":"2010","journal-title":"Immunobiology"},{"key":"10.1016\/j.bone.2021.116129_bb0230","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1186\/s12885-015-1546-9","article-title":"M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide","volume":"15","author":"Genin","year":"2015","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bone.2021.116129_bb0235","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1111\/bph.14796","article-title":"Histamine up-regulates oncostatin M expression in human M1 macrophages","volume":"177","author":"Mommert","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bone.2021.116129_bb0240","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/8570818","article-title":"Iron reduces M1 macrophage polarization in RAW264.7 macrophages associated with inhibition of STAT1","volume":"2017","author":"Gan","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.bone.2021.116129_bb0245","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.it.2004.09.015","article-title":"The chemokine system in diverse forms of macrophage activation and polarization","volume":"25","author":"Mantovani","year":"2004","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bone.2021.116129_bb0250","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.bone.2021.116129_bb0255","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1074\/jbc.M406968200","article-title":"Distinct roles for the alpha and beta subunits in the functions of integrin alphaMbeta2","volume":"280","author":"Solovjov","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2021.116129_bb0260","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006049","article-title":"Signaling in innate immunity and inflammation","volume":"4","author":"Newton","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bone.2021.116129_bb0265","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1600-065X.2012.01146.x","article-title":"PAMPs and DAMPs: signal 0s that spur autophagy and immunity","volume":"249","author":"Tang","year":"2012","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bone.2021.116129_bb0270","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1128\/CMR.00046-08","article-title":"Pathogen recognition and inflammatory signaling in innate immune defenses","volume":"22","author":"Mogensen","year":"2009","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.bone.2021.116129_bb0275","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.128474","article-title":"Inhibition of EZH2 methyltransferase decreases immunoediting of mesothelioma cells by autologous macrophages through a PD-1-dependent mechanism","volume":"4","author":"Hamaidia","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.bone.2021.116129_bb0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1189\/jlb.0306164","article-title":"DAMPs, PAMPs and alarmins: all we need to know about danger","volume":"81","author":"Bianchi","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bone.2021.116129_bb0285","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1158\/0008-5472.CAN-11-3481","article-title":"Cancer cell secretion of the DAMP protein HMGB1 supports progression in malignant mesothelioma","volume":"72","author":"Jube","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.bone.2021.116129_bb0290","doi-asserted-by":"crossref","first-page":"35237","DOI":"10.1074\/jbc.R114.619304","article-title":"Complexity of danger: the diverse nature of damage-associated molecular patterns","volume":"289","author":"Schaefer","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2021.116129_bb0295","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s13023-017-0674-5","article-title":"Prevalence of fibrodysplasia ossificans progressiva (FOP) in France: an estimate based on a record linkage of two national databases","volume":"12","author":"Baujat","year":"2017","journal-title":"Orphanet. J. Rare Dis."},{"key":"10.1016\/j.bone.2021.116129_bb0300","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1172\/JCI93521","article-title":"Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva","volume":"127","author":"Hino","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bone.2021.116129_bb0305","doi-asserted-by":"crossref","first-page":"15438","DOI":"10.1073\/pnas.1510540112","article-title":"Neofunction of ACVR1 in fibrodysplasia ossificans progressiva","volume":"112","author":"Hino","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bone.2021.116129_bb0310","doi-asserted-by":"crossref","first-page":"5092","DOI":"10.1182\/blood-2010-09-306993","article-title":"Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers","volume":"117","author":"Sierra-Filardi","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bone.2021.116129_bb0315","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1073\/pnas.0915000107","article-title":"Two physically, functionally, and developmentally distinct peritoneal macrophage subsets","volume":"107","author":"Ghosn","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bone.2021.116129_bb0320","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/imr.12215","article-title":"Origin, development, and homeostasis of tissue-resident macrophages","volume":"262","author":"Haldar","year":"2014","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bone.2021.116129_bb0325","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/imm.12451","article-title":"Tissue-resident macrophages: then and now","volume":"144","author":"Davies","year":"2015","journal-title":"Immunology"},{"key":"10.1016\/j.bone.2021.116129_bb0330","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/s41577-018-0054-y","article-title":"Studying tissue macrophages in vitro: are iPSC-derived cells the answer?","volume":"18","author":"Lee","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bone.2021.116129_bb0335","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/bonekey.2013.107","article-title":"Unraveling macrophage contributions to bone repair","volume":"2","author":"Wu","year":"2013","journal-title":"Bonekey Rep."},{"key":"10.1016\/j.bone.2021.116129_bb0340","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.scr.2010.04.007","article-title":"Multiparameter comparisons of embryoid body differentiation toward human stem cell applications","volume":"5","author":"Hong","year":"2010","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.bone.2021.116129_bb0345","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.jbiosc.2016.03.018","article-title":"Differentiation of mouse iPS cells is dependent on embryoid body size in microwell chip culture","volume":"122","author":"Miyamoto","year":"2016","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.bone.2021.116129_bb0350","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022261","article-title":"A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors","volume":"6","author":"Niwa","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2021.116129_bb0355","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bone.2021.116129_bb0360","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s00011-006-6112-0","article-title":"HMGB1 modulates inflammatory responses in LPS-activated macrophages","volume":"56","author":"El Gazzar","year":"2007","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.bone.2021.116129_bb0365","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.immuni.2008.03.003","article-title":"Contextual regulation of inflammation: a duet by transforming growth factor-beta and interleukin-10","volume":"28","author":"Li","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.bone.2021.116129_bb0370","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.cell.2008.07.025","article-title":"TGF-beta: a master of all T cell trades","volume":"134","author":"Li","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.bone.2021.116129_bb0375","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.coph.2009.04.008","article-title":"Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity","volume":"9","author":"Sanjabi","year":"2009","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.bone.2021.116129_bb0380","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/ng1783","article-title":"A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva","volume":"38","author":"Shore","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bone.2021.116129_bb0385","doi-asserted-by":"crossref","first-page":"10792","DOI":"10.1074\/jbc.M115.713487","article-title":"Transforming growth factor-beta family ligands can function as antagonists by competing for type II receptor binding","volume":"291","author":"Aykul","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2021.116129_bb0390","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aac4358","article-title":"ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A","volume":"7","author":"Hatsell","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bone.2021.116129_bb0395","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12964-015-0104-z","article-title":"Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B","volume":"13","author":"Olsen","year":"2015","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.bone.2021.116129_bb0400","doi-asserted-by":"crossref","first-page":"115473","DOI":"10.1016\/j.bone.2020.115473","article-title":"Activin A does not drive post-traumatic heterotopic ossification","volume":"138","author":"Hwang","year":"2020","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116129_bb0405","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s41467-018-02872-2","article-title":"Activin-dependent signaling in fibro\/adipogenic progenitors causes fibrodysplasia ossificans progressiva","volume":"9","author":"Lees-Shepard","year":"2018","journal-title":"Nat. Commun."}],"updated-by":[{"DOI":"10.1016\/j.bone.2022.116325","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000}}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328221002945?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328221002945?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T14:15:14Z","timestamp":1778940914000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328221002945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":81,"alternative-id":["S8756328221002945"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2021.116129","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2021.116129","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116129"}}