{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:52:47Z","timestamp":1793386367710,"version":"4.5.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["IC160100026"],"award-info":[{"award-number":["IC160100026"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["IC180100008"],"award-info":[{"award-number":["IC180100008"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001793","name":"Queensland University of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003112","name":"Mensa Education and Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003112","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["HE 7074\/1-1"],"award-info":[{"award-number":["HE 7074\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BE 4492\/1-2"],"award-info":[{"award-number":["BE 4492\/1-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.bone.2021.116163","type":"journal-article","created":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T16:45:02Z","timestamp":1630169102000},"page":"116163","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"special_numbering":"C","title":["Scaffold-guided bone regeneration in large volume tibial segmental defects"],"prefix":"10.1016","volume":"153","author":[{"given":"Jan","family":"Henkel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Medeiros Savi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Berner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Fountain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siamak","family":"Saifzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Steck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devakar R.","family":"Epari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Woodruff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Knackstedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Schuetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar W.","family":"Hutmacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2021.116163_bb0005","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2474-14-42","article-title":"Tibia shaft fractures: costly burden of nonunions","volume":"14","author":"Antonova","year":"2013","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.bone.2021.116163_bb0010","series-title":"The Global Burden of Disease: 2004 Update","first-page":"146","author":"World Health Organization","year":"2008"},{"key":"10.1016\/j.bone.2021.116163_bb0015","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.bone.2014.07.033","article-title":"Bone fracture healing: cell therapy in delayed unions and nonunions","volume":"70","author":"G\u00f3mez-Barrena","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116163_bb0020","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.bone.2010.02.011","article-title":"Repair of a segmental long bone defect in human by implantation of a novel multiple disc graft","volume":"46","author":"Hesse","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116163_bb0025","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2106\/00004623-200703000-00026","article-title":"Bone grafts and bone graft substitutes in orthopaedic trauma surgery. A critical analysis","volume":"89","author":"De Long","year":"2007","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.bone.2021.116163_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1749-799X-8-33","article-title":"Outcomes and complication rates of different bone grafting modalities in long bone fracture nonunions: a retrospective cohort study in 182 patients","volume":"8","author":"Flierl","year":"2013","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.bone.2021.116163_bb0035","doi-asserted-by":"crossref","first-page":"115602","DOI":"10.1016\/j.bone.2020.115602","article-title":"Biology of bone morphogenetic protein in bone repair and regeneration: a role for autologous blood coagulum as carrier","volume":"141","author":"Sampath","year":"2020","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116163_bb0040","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.2106\/JBJS.J.01513","article-title":"Autogenous bone graft: donor sites and techniques","volume":"93","author":"Myeroff","year":"2011","journal-title":"J. Bone Joint Surg. A"},{"key":"10.1016\/j.bone.2021.116163_bb0045","doi-asserted-by":"crossref","first-page":"216","DOI":"10.4248\/BR201303002","article-title":"Bone regeneration based on tissue engineering conceptions \u2014 a 21st century perspective","volume":"1","author":"Henkel","year":"2013","journal-title":"Bone Res."},{"key":"10.1016\/j.bone.2021.116163_bb0050","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bone.2014.09.017","article-title":"Bringing new life to damaged bone: the importance of angiogenesis in bone repair and regeneration","volume":"70","author":"Stegen","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116163_bb0055","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5082\/1\/1\/012001","article-title":"Scaffold engineering: a bridge to where?","volume":"1","author":"Hollister","year":"2009","journal-title":"Biofabrication"},{"key":"10.1016\/j.bone.2021.116163_bb0060","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.bone.2014.08.011","article-title":"Stem cells and bone: a historical perspective","volume":"70","author":"Bianco","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116163_bb0065","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1111\/j.1445-2197.2007.04175.x","article-title":"Bone morphogenetic proteins in clinical applications","volume":"77","author":"Gautschi","year":"2007","journal-title":"ANZ J. Surg."},{"key":"10.1016\/j.bone.2021.116163_bb0070","doi-asserted-by":"crossref","first-page":"115542","DOI":"10.1016\/j.bone.2020.115542","article-title":"The role of bone morphogenetic protein signaling in vascular calcification","volume":"141","author":"Yang","year":"2020","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116163_bb0075","doi-asserted-by":"crossref","first-page":"5241","DOI":"10.1016\/j.biomaterials.2011.03.063","article-title":"Effects of protein dose and delivery system on BMP-mediated bone regeneration","volume":"32","author":"Boerckel","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.bone.2021.116163_bb0080","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/term.74","article-title":"Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery)","volume":"2","author":"Bessa","year":"2008","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"10.1016\/j.bone.2021.116163_bb0085","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ocl.2017.03.004","article-title":"Bone morphogenetic protein: is there still a role in orthopedic trauma in 2017?","volume":"48","author":"Barcak","year":"2017","journal-title":"Orthop. Clin. North Am."},{"key":"10.1016\/j.bone.2021.116163_bb0090","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/ten.teb.2015.0357","article-title":"A review of the clinical side effects of bone morphogenetic protein-2","volume":"22","author":"James","year":"2016","journal-title":"Tissue Eng. Part B Rev."},{"key":"10.1016\/j.bone.2021.116163_bb0095","doi-asserted-by":"crossref","first-page":"115548","DOI":"10.1016\/j.bone.2020.115548","article-title":"Discovery of bone morphogenetic proteins \u2013 a historical perspective","volume":"140","author":"Sampath","year":"2020","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116163_bb0100","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1211\/0022357023312","article-title":"Delivery systems for bone growth factors \u2014 the new players in skeletal regeneration","volume":"56","author":"Rose","year":"2010","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.bone.2021.116163_bb0105","article-title":"Clinical effectiveness and cost-effectiveness of bone morphogenetic proteins in the non-healing of fractures and spinal fusion: a systematic review","volume":"11","author":"Garrison","year":"2007","journal-title":"Health Technol. Assess. (Rockv)"},{"key":"10.1016\/j.bone.2021.116163_bb0110","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1023\/B:ABME.0000007798.78548.b8","article-title":"Genetic modification of stem cells to enhance bone repair","volume":"32","author":"Gamradt","year":"2004","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.bone.2021.116163_bb0115","doi-asserted-by":"crossref","first-page":"6113","DOI":"10.1016\/j.biomaterials.2012.05.030","article-title":"Hyaluronic acid-based hydrogels functionalized with heparin that support controlled release of bioactive BMP-2","volume":"33","author":"Bhakta","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.bone.2021.116163_bb0120","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1002\/term.2104","article-title":"Scaffold-cell bone engineering in a validated preclinical animal model: precursors vs differentiated cell source","volume":"11","author":"Berner","year":"2017","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"10.1016\/j.bone.2021.116163_bb0125","doi-asserted-by":"crossref","first-page":"503","DOI":"10.5966\/sctm.2014-0244","article-title":"Delayed minimally invasive injection of allogenic bone marrow stromal cell sheets regenerates large bone defects in an ovine preclinical animal model","volume":"4","author":"Berner","year":"2015","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.bone.2021.116163_bb0130","doi-asserted-by":"crossref","first-page":"7874","DOI":"10.1016\/j.actbio.2013.04.035","article-title":"Autologous vs. allogenic mesenchymal progenitor cells for the reconstruction of critical sized segmental tibial bone defects in aged sheep","volume":"9","author":"Berner","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bone.2021.116163_bb0135","doi-asserted-by":"crossref","first-page":"9960","DOI":"10.1016\/j.biomaterials.2013.09.011","article-title":"Polycaprolactone scaffold and reduced rhBMP-7 dose for the regeneration of critical-sized defects in sheep tibiae","volume":"34","author":"Cipitria","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.bone.2021.116163_bb0140","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.actbio.2015.05.015","article-title":"BMP delivery complements the guiding effect of scaffold architecture without altering bone microstructure in critical-sized long bone defects: a multiscale analysis","volume":"23","author":"Cipitria","year":"2015","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bone.2021.116163_bb0145","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003720","article-title":"A tissue engineering solution for segmental defect regeneration in load-bearing long bones","volume":"4","author":"Reichert","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bone.2021.116163_bb0150","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s00132-011-1855-x","article-title":"Bone tissue engineering. Reconstruction of critical sized segmental bone defects in the ovine tibia","volume":"41","author":"Reichert","year":"2012","journal-title":"Orthop\u00e4de"},{"key":"10.1016\/j.bone.2021.116163_bb0155","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1089\/ten.teb.2009.0455","article-title":"Establishment of a preclinical ovine model for tibial segmental bone defect repair by applying bone tissue engineering strategies","volume":"16","author":"Reichert","year":"2010","journal-title":"Tissue Eng. Part B Rev."},{"key":"10.1016\/j.bone.2021.116163_bb0160","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1016\/j.biomaterials.2008.12.050","article-title":"The challenge of establishing preclinical models for segmental bone defect research","volume":"30","author":"Reichert","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.bone.2021.116163_bb0165","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1007\/s00264-010-1146-x","article-title":"Custom-made composite scaffolds for segmental defect repair in long bones","volume":"35","author":"Reichert","year":"2011","journal-title":"Int. Orthop."},{"key":"10.1016\/j.bone.2021.116163_bb0170","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1002\/jbmr.1589","article-title":"Porous scaffold architecture guides tissue formation","volume":"27","author":"Cipitria","year":"2012","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2021.116163_bb0175","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/s41596-019-0271-2","article-title":"A preclinical large-animal model for the assessment of critical-size load-bearing bone defect reconstruction","volume":"15","author":"Sparks","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bone.2021.116163_bb0180","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3390\/ma9040259","article-title":"Microparticles for sustained growth factor delivery in the regeneration of critically-sized segmental tibial bone defects","volume":"9","author":"Kirby","year":"2016","journal-title":"Materials (Basel)"},{"key":"10.1016\/j.bone.2021.116163_bb0185","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1089\/ten.teb.2011.0143","article-title":"Skeletal tissue regeneration: current approaches, challenges, and novel reconstructive strategies for an aging population","volume":"17","author":"Smith","year":"2011","journal-title":"Tissue Eng. Part B Rev."},{"key":"10.1016\/j.bone.2021.116163_bb0190","series-title":"Monitoring Healing Progression and Characterising the Mechanical Environment in a Preclinical Bone Defect Model","author":"Fountain","year":"2016"},{"key":"10.1016\/j.bone.2021.116163_bb0195","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1016\/j.jbiomech.2015.09.013","article-title":"Mechanical testing of internal fixation devices: a theoretical and practical examination of current methods","volume":"48","author":"Grant CA","year":"2015","journal-title":"J. Biomech."},{"key":"10.1016\/j.bone.2021.116163_bb0200","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1089\/ten.teb.2015.0123","article-title":"Monitoring healing progression and characterizing the mechanical environment in preclinical models for bone tissue engineering","volume":"22","author":"Fountain","year":"2016","journal-title":"Tissue Eng. Part B Rev."},{"key":"10.1016\/j.bone.2021.116163_bb0205","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1160\/TH03-07-0440","article-title":"Autologous platelets as a source of proteins for healing and tissue regeneration","volume":"91","author":"Anitua","year":"2004","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.bone.2021.116163_bb0210","first-page":"693","article-title":"Correlation of platelet concentration in platelet-rich plasma to the extraction method, age, sex, and platelet count of the donor","volume":"16","author":"Weibrich","year":"2001","journal-title":"Int. J. Oral Maxillofac. Implants"},{"key":"10.1016\/j.bone.2021.116163_bb0215","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.1016\/j.biomaterials.2008.06.018","article-title":"3D imaging of tissue integration with porous biomaterials","volume":"29","author":"Guldberg","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.bone.2021.116163_bb0220","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1089\/ten.tec.2019.0179","article-title":"Histomorphometric evaluation of critical-sized bone defects using Osteomeasure and Aperio image analysis systems","volume":"25","author":"Savi","year":"2019","journal-title":"Tissue Eng. Part C Methods"},{"key":"10.1016\/j.bone.2021.116163_bb0225","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1108\/13552541211193502","article-title":"Effect of process parameters on the morphological and mechanical properties of 3D bioextruded poly(1-caprolactone) scaffolds","volume":"18","author":"Domingos","year":"2012","journal-title":"Rapid Prototyp. J."},{"key":"10.1016\/j.bone.2021.116163_bb0230","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/1097-4636(200105)55:2<203::AID-JBM1007>3.0.CO;2-7","article-title":"Mechanical properties and cell cultural response of polycaprolactone scaffolds designed and fabricated via fused deposition modeling","volume":"55","author":"Hutmacher","year":"2001","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.bone.2021.116163_bb0235","doi-asserted-by":"crossref","first-page":"8013","DOI":"10.1039\/c1sm05793f","article-title":"High performance additive manufactured scaffolds for bone tissue engineering application","volume":"7","author":"Tarik Arafat","year":"2011","journal-title":"Soft Matter"},{"key":"10.1016\/j.bone.2021.116163_bb0240","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S0142-9612(01)00232-0","article-title":"Fused deposition modeling of novel scaffold architectures for tissue engineering applications","volume":"23","author":"Zein","year":"2002","journal-title":"Biomaterials"},{"key":"10.1016\/j.bone.2021.116163_bb0245","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s00198-004-1728-9","article-title":"Mechanics and mechano-biology of fracture healing in normal and osteoporotic bone","volume":"16","author":"Augat","year":"2005","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2021.116163_bb0250","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s00113-016-0280-3","article-title":"Mechanobiology of fracture healing part 1: principles","volume":"120","author":"Claes","year":"2017","journal-title":"Unfallchirurg"},{"key":"10.1016\/j.bone.2021.116163_bb0255","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1243\/09544119JEIM808","article-title":"Mechanobiology of bone healing and regeneration: in vivo models","volume":"224","author":"Epari","year":"2010","journal-title":"Proc. Inst. Mech. Eng. H J. Eng. Med."},{"key":"10.1016\/j.bone.2021.116163_bb0260","series-title":"BIODEVICES 2014 - 7th Int. Conference on Biomedical Electronics and Devices, Proceedings; Part of 7th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2014","first-page":"243","article-title":"A biofeedback system for continuous monitoring of bone healing","author":"Windolf","year":"2014"},{"key":"10.1016\/j.bone.2021.116163_bb0265","series-title":"Biomater Silver Jubil Compend","first-page":"175","article-title":"Scaffolds in tissue engineering bone and cartilage","volume":"21","author":"Hutmacher","year":"2000"},{"key":"10.1016\/j.bone.2021.116163_bb0270","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00264-013-2201-1","article-title":"The clinical use of bone morphogenetic proteins revisited: a novel biocompatible carrier device OSTEOGROW for bone healing","volume":"38","author":"Vukicevic","year":"2014","journal-title":"Int. Orthop."},{"issue":"Suppl. 3","key":"10.1016\/j.bone.2021.116163_bb0275","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.injury.2005.07.033","article-title":"Critical analysis and efficacy of BMPs in long bones non-union","volume":"36","author":"Obert","year":"2005","journal-title":"Injury"},{"key":"10.1016\/j.bone.2021.116163_bb0280","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1002\/jor.20411","article-title":"Bone formation following OP-1 implantation is improved by addition of autogenous bone marrow cells in a canine femur defect model","volume":"25","author":"Takigami","year":"2007","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2021.116163_bb0285","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S8756-3282(98)00056-8","article-title":"Distinct and overlapping patterns of localization of bone morphogenetic protein (BMP) family members and a BMP type II receptor during fracture healing in rats","volume":"22","author":"Onishi","year":"1998","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116163_bb0290","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1007\/s00784-016-1719-1","article-title":"Comparative release of growth factors from PRP, PRF, and advanced-PRF","volume":"20","author":"Kobayashi","year":"2016","journal-title":"Clin. Oral Investig."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632822100329X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632822100329X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T14:14:45Z","timestamp":1778940885000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S875632822100329X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":58,"alternative-id":["S875632822100329X"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2021.116163","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Scaffold-guided bone regeneration in large volume tibial segmental defects","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2021.116163","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2021 Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116163"}}