{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:41:01Z","timestamp":1792125661571,"version":"4.4.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"am","delay-in-days":296,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01 AR065564"],"award-info":[{"award-number":["R01 AR065564"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.bone.2021.116171","type":"journal-article","created":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T19:05:34Z","timestamp":1630782334000},"page":"116171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Mechanical loading and parathyroid hormone effects and synergism in bone vary by site and modeling\/remodeling regime"],"prefix":"10.1016","volume":"153","author":[{"given":"Samuel T.","family":"Robinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter T.","family":"Shyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. Edward","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2021.116171_bb0005","doi-asserted-by":"crossref","DOI":"10.1002\/jbm4.10192","article-title":"Healthcare policy changes in osteoporosis can improve outcomes and reduce costs in the United States","volume":"3","author":"Lewiecki","year":"2019","journal-title":"JBMR Plus"},{"key":"10.1016\/j.bone.2021.116171_bb0010","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.bone.2014.05.006","article-title":"Aging diminishes lamellar and woven bone formation induced by tibial compression in adult C57BL\/6","volume":"65","author":"Holguin","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116171_bb0015","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1210\/er.2004-0006","article-title":"Parathyroid hormone and teriparatide for the treatment of osteoporosis: a review of the evidence and suggested guidelines for its use","volume":"26","author":"Hodsman","year":"2005","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.bone.2021.116171_bb0020","first-page":"499","article-title":"Teriparatide in the management of osteoporosis","volume":"2","author":"Bodenner","year":"2007","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.bone.2021.116171_bb0025","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1359\/JBMR.051109","article-title":"A novel tetracycline labeling schedule for longitudinal evaluation of the short-term effects of anabolic therapy with a single iliac crest bone biopsy: early actions of teriparatide","volume":"21","author":"Lindsay","year":"2006","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2021.116171_bb0030","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1359\/jbmr.060314","article-title":"Teriparatide increases bone formation in modeling and remodeling osteons and enhances IGF-II immunoreactivity in postmenopausal women with osteoporosis","volume":"21","author":"Ma","year":"2006","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2021.116171_bb0035","doi-asserted-by":"crossref","first-page":"5127","DOI":"10.1210\/endo.136.11.7588250","article-title":"Intermittent parathyroid hormone treatment increases osteoblast number, steady state messenger ribonucleic acid levels for osteocalcin, and bone formation in tibial metaphysis of hypophysectomized female rats","volume":"136","author":"Schmidt","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2021.116171_bb0040","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.bone.2007.03.017","article-title":"Molecular and cellular mechanisms of the anabolic effect of intermittent PTH","volume":"40","author":"Jilka","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116171_bb0045","doi-asserted-by":"crossref","first-page":"50259","DOI":"10.1074\/jbc.M307444200","article-title":"Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism","volume":"278","author":"Bellido","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2021.116171_bb0050","first-page":"801","article-title":"Catabolic and anabolic actions of parathyroid hormone on the skeleton","volume":"34","author":"Silva","year":"2011","journal-title":"J. Endocrinol. Investig."},{"key":"10.1016\/j.bone.2021.116171_bb0055","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.coph.2005.07.004","article-title":"Parathyroid hormone - a bone anabolic and catabolic agent","volume":"5","author":"Poole","year":"2005","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.bone.2021.116171_bb0060","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1210\/endo-110-2-506","article-title":"Parathyroid hormone stimulates the bone apposition rate independently of its resorptive action: differential effects of intermittent and continuous administration","volume":"110","author":"Tam","year":"1982","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2021.116171_bb0065","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/jbmr.5650070110","article-title":"Effects of continuous and intermittent administration and inhibition of resorption on the anabolic response of bone to parathyroid hormone","volume":"7","author":"Hock","year":"1992","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2021.116171_bb0070","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1172\/JCI6610","article-title":"Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone","volume":"104","author":"Jilka","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bone.2021.116171_bb0075","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1002\/jbmr.1665","article-title":"Intermittent parathyroid hormone administration converts quiescent lining cells to active osteoblasts","volume":"27","author":"Kim","year":"2012","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2021.116171_bb0080","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.bone.2008.04.012","article-title":"Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1-34) on trabecular and cortical bone in mice","volume":"43","author":"Sugiyama","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116171_bb0085","series-title":"The Law of Bone Remodelling","author":"Wolff","year":"1986"},{"key":"10.1016\/j.bone.2021.116171_bb0090","doi-asserted-by":"crossref","first-page":"204","DOI":"10.2106\/00004623-197759020-00012","article-title":"Humeral hypertrophy in response to exercise","volume":"59","author":"Jones","year":"1977","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.bone.2021.116171_bb0095","doi-asserted-by":"crossref","first-page":"5337","DOI":"10.1073\/pnas.1321605111","article-title":"Physical activity when young provides lifelong benefits to cortical bone size and strength in men","volume":"111","author":"Warden","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bone.2021.116171_bb0100","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1359\/jbmr.2002.17.3.493","article-title":"Noninvasive loading of the murine tibia: an in vivo model for the study of mechanotransduction","volume":"17","author":"Gross","year":"2002","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2021.116171_bb0105","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.bone.2005.02.013","article-title":"Loading induces site-specific increases in mineral content assessed by microcomputed tomography of the mouse tibia","volume":"36","author":"Fritton","year":"2005","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116171_bb0110","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.bone.2005.07.022","article-title":"Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: a new model to study cortical and cancellous compartments in a single loaded element","volume":"37","author":"De Souza","year":"2005","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116171_bb0115","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13630-015-0016-y","article-title":"The primary cilium functions as a mechanical and calcium signaling nexus","volume":"4","author":"Lee","year":"2015","journal-title":"Cilia"},{"key":"10.1016\/j.bone.2021.116171_bb0120","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41467-019-14146-6","article-title":"Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk","volume":"11","author":"Wang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bone.2021.116171_bb0125","first-page":"8","article-title":"Stimulation of Piezo1 by mechanical signals promotes bone anabolism","author":"Li","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.bone.2021.116171_bb0130","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1615\/CritRevEukarGeneExpr.v19.i3.40","article-title":"Bone modeling and remodeling","volume":"19","author":"Seeman","year":"2009","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"10.1016\/j.bone.2021.116171_bb0135","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1615\/CritRevEukarGeneExpr.v19.i4.50","article-title":"Mechanical signaling for bone modeling and remodeling","volume":"19","author":"Robling","year":"2009","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"10.1016\/j.bone.2021.116171_bb0140","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nm.1979","article-title":"TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation","volume":"15","author":"Tang","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.bone.2021.116171_bb0145","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.tem.2004.01.006","article-title":"Parathyroid hormone: a double-edged sword for bone metabolism","volume":"15","author":"Qin","year":"2004","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.bone.2021.116171_bb0150","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1177\/1759720X16670154","article-title":"Bone modeling and remodeling: potential as therapeutic targets for the treatment of osteoporosis","volume":"8","author":"Langdahl","year":"2016","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"10.1016\/j.bone.2021.116171_bb0155","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1002\/jbmr.2480","article-title":"Sustained modeling-based bone formation during adulthood in Cynomolgus monkeys may contribute to continuous BMD gains with denosumab","volume":"30","author":"Ominsky","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2021.116171_bb0160","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bone.2014.12.061","article-title":"\u03bcCT-based, in vivo dynamic bone histomorphometry allows 3D evaluation of the early responses of bone resorption and formation to PTH and alendronate combination therapy","volume":"73","author":"de Bakker","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116171_bb0165","doi-asserted-by":"crossref","first-page":"4855","DOI":"10.1038\/ncomms5855","article-title":"Bone remodelling in humans is load-driven but not lazy","volume":"5","author":"Christen","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bone.2021.116171_bb0170","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1359\/jbmr.071009","article-title":"Complete volumetric decomposition of individual trabecular plates and rods and its morphological correlations with anisotropic elastic moduli in human trabecular bone","volume":"23","author":"Liu","year":"2008","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2021.116171_bb0175","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jbiomech.2013.10.052","article-title":"Experimental and finite element analysis of strains induced by axial tibial compression in young-adult and old female C57Bl\/6 mice","volume":"47","author":"Patel","year":"2014","journal-title":"J. Biomech."},{"key":"10.1016\/j.bone.2021.116171_bb0180","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bone.2014.05.019","article-title":"Characterization of cancellous and cortical bone strain in the in vivo mouse tibial loading model using microCT-based finite element analysis","volume":"66","author":"Yang","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116171_bb0185","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1007\/s00198-011-1656-4","article-title":"Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered","volume":"23","author":"Moustafa","year":"2012","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2021.116171_bb0190","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1359\/jbmr.070507","article-title":"Age-related changes in trabecular architecture differ in female and male C57BL\/6J mice","volume":"22","author":"Glatt","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2021.116171_bb0195","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bone.2014.05.013","article-title":"Mineralizing surface is the main target of mechanical stimulation independent of age: 3D dynamic in vivo morphometry","volume":"66","author":"Birkhold","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116171_bb0200","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.bone.2011.08.035","article-title":"Mouse tail vertebrae adapt to cyclic mechanical loading by increasing bone formation rate and decreasing bone resorption rate as shown by time-lapsed in vivo imaging of dynamic bone morphometry","volume":"49","author":"Lambers","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116171_bb0205","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bone.2013.05.005","article-title":"Mineralization kinetics in murine trabecular bone quantified by time-lapsed in vivo micro-computed tomography","volume":"56","author":"Lukas","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116171_bb0210","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.bone.2015.07.037","article-title":"Quantification of skeletal growth, modeling, and remodeling by in vivo micro computed tomography","volume":"81","author":"Altman","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116171_bb0215","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/nm.3668","article-title":"PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis","volume":"20","author":"Xie","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.bone.2021.116171_bb0220","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/164_2020_354","article-title":"Reduced bone modeling and unbalanced bone remodeling: targets for Antiresorptive and anabolic therapy","volume":"262","author":"Ramchand","year":"2020","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.bone.2021.116171_bb0225","first-page":"781","article-title":"Differential effects on bone and mesenchymal stem cells caused by intermittent and continuous PTH administration","volume":"98","author":"Zhang","year":"2018","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"10.1016\/j.bone.2021.116171_bb0230","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1385\/ENDO:17:1:29","article-title":"Differential effects of intermittent and continuous administration of parathyroid hormone on bone histomorphometry and gene expression","volume":"17","author":"Lotinun","year":"2002","journal-title":"Endocrine"},{"key":"10.1016\/j.bone.2021.116171_bb0235","first-page":"E146","article-title":"Role for parathyroid hormone in mechanical responsiveness of rat bone","volume":"274","author":"Chow","year":"1998","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.bone.2021.116171_bb0240","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1359\/jbmr.2003.18.12.2116","article-title":"Trabecular bone response to mechanical and parathyroid hormone stimulation: the role of mechanical microenvironment","volume":"18","author":"Kim","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2021.116171_bb0245","doi-asserted-by":"crossref","first-page":"4466","DOI":"10.1210\/en.2007-0229","article-title":"The effects of combination of alendronate and human parathyroid hormone(1-34) on bone strength are synergistic in the lumbar vertebra and additive in the femur of C57BL\/6J mice","volume":"148","author":"Johnston","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2021.116171_bb0250","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.bone.2008.05.010","article-title":"The anabolic action of intermittent PTH in combination with cathepsin K inhibitor or alendronate differs depending on the remodeling status in bone in ovariectomized mice","volume":"44","author":"Yamane","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116171_bb0255","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.bone.2009.04.201","article-title":"Contributions of trabecular rods of various orientations in determining the elastic properties of human vertebral trabecular bone","volume":"45","author":"Liu","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116171_bb0260","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.bone.2010.02.005","article-title":"Effects of trabecular type and orientation on microdamage susceptibility in trabecular bone","volume":"46","author":"Shi","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116171_bb0265","doi-asserted-by":"crossref","first-page":"5866","DOI":"10.1074\/jbc.M705092200","article-title":"Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost\/sclerostin","volume":"283","author":"Robling","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2021.116171_bb0270","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11914-013-0142-7","article-title":"Clinical imaging of bone microarchitecture with HR-pQCT","volume":"11","author":"Nishiyama","year":"2013","journal-title":"Curr Osteoporos Rep"},{"key":"10.1016\/j.bone.2021.116171_bb0275","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/jbmr.562","article-title":"Individual trabecula segmentation (ITS)-based morphological analyses and microfinite element analysis of HR-pQCT images discriminate postmenopausal fragility fractures independent of DXA measurements","volume":"27","author":"Liu","year":"2012","journal-title":"J. Bone Miner. Res."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328221003379?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328221003379?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T18:04:24Z","timestamp":1757613864000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328221003379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":55,"alternative-id":["S8756328221003379"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2021.116171","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanical loading and parathyroid hormone effects and synergism in bone vary by site and modeling\/remodeling regime","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2021.116171","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116171"}}