{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T20:08:52Z","timestamp":1792958932053,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T00:00:00Z","timestamp":1631577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009980","name":"Medizinische Universit\u00e4t Innsbruck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009980","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006012","name":"Christian Doppler Forschungsgesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006012","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.bone.2021.116202","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T23:04:28Z","timestamp":1631660668000},"page":"116202","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":126,"special_numbering":"C","title":["Hypophosphatemia after intravenous iron therapy: Comprehensive review of clinical findings and recommendations for management"],"prefix":"10.1016","volume":"154","author":[{"given":"Benedikt","family":"Schaefer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Tobiasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Glodny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Tilg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myles","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Zoller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2021.116202_bb0005","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0140-6736(20)32594-0","article-title":"Iron deficiency","volume":"397","author":"Pasricha","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.bone.2021.116202_bb0010","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1056\/NEJMra1401038","article-title":"Iron-deficiency anemia","volume":"372","author":"Camaschella","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bone.2021.116202_bb0015","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.ejpb.2011.03.016","article-title":"A comparative study of the physicochemical properties of iron isomaltoside 1000 (Monofer), a new intravenous iron preparation and its clinical implications","volume":"78","author":"Jahn","year":"2011","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.bone.2021.116202_bb0020","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s10534-015-9845-9","article-title":"Physico-chemical properties of the new generation IV iron preparations ferumoxytol, iron isomaltoside 1000 and ferric carboxymaltose","volume":"28","author":"Neiser","year":"2015","journal-title":"Biometals"},{"key":"10.1016\/j.bone.2021.116202_bb0025","first-page":"1439","article-title":"Structure\/histotoxicity relationship of parenteral iron preparations","volume":"42","author":"Geisser","year":"1992","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.bone.2021.116202_bb0030","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/trf.12289","article-title":"A multicenter, randomized, active-controlled study to investigate the efficacy and safety of intravenous ferric carboxymaltose in patients with iron deficiency anemia","volume":"54","author":"Onken","year":"2014","journal-title":"Transfusion"},{"key":"10.1016\/j.bone.2021.116202_bb0035","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1080\/00365521.2018.1498914","article-title":"Safety and efficacy of intravenous iron isomaltoside for correction of anaemia in patients with inflammatory bowel disease in everyday clinical practice","volume":"53","author":"Stein","year":"2018","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.bone.2021.116202_bb0040","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/ajh.25060","article-title":"Comparative safety of intravenous ferumoxytol versus ferric carboxymaltose in iron deficiency anemia: a randomized trial","volume":"93","author":"Adkinson","year":"2018","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.bone.2021.116202_bb0045","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1001\/jama.2019.22450","article-title":"Effects of Iron isomaltoside vs ferric carboxymaltose on hypophosphatemia in iron-deficiency anemia: two randomized clinical trials","volume":"323","author":"Wolf","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.bone.2021.116202_bb0050","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.124486","article-title":"Randomized trial of intravenous iron-induced hypophosphatemia","volume":"3","author":"Wolf","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.bone.2021.116202_bb0055","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.124486","article-title":"Randomized trial of intravenous iron-induced hypophosphatemia","volume":"3","author":"Wolf","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.bone.2021.116202_bb0060","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.tmrv.2020.07.002","article-title":"Comparative risk of hypophosphatemia following the administration of intravenous iron formulations: a network meta-analysis","volume":"34","author":"Bellos","year":"2020","journal-title":"Transfus. Med. Rev."},{"key":"10.1016\/j.bone.2021.116202_bb0065","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2147\/TCRM.S243462","article-title":"Hypophosphatemia associated with intravenous iron therapies for iron deficiency anemia: a systematic literature review","volume":"16","author":"Glaspy","year":"2020","journal-title":"Ther. Clin. Risk Manag."},{"key":"10.1016\/j.bone.2021.116202_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9113587","article-title":"A pooled analysis of serum phosphate measurements and potential hypophosphataemia events in 45 interventional trials with ferric carboxymaltose","volume":"9","author":"Rosano","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.bone.2021.116202_bb0075","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1111\/bcp.14643","article-title":"Hypophosphataemia after treatment of iron deficiency with intravenous ferric carboxymaltose or iron isomaltoside-a systematic review and meta-analysis","volume":"87","author":"Schaefer","year":"2021","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.bone.2021.116202_bb0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167146","article-title":"Choice of high-dose intravenous iron preparation determines hypophosphatemia risk","volume":"11","author":"Schaefer","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2021.116202_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115559","article-title":"Effects of ferric carboxymaltose on markers of mineral and bone metabolism: a single-center prospective observational study of women with iron deficiency","volume":"141","author":"Frazier","year":"2020","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116202_bb0090","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/apt.15386","article-title":"Incidence of hypophosphatemia in patients with inflammatory bowel disease treated with ferric carboxymaltose or iron isomaltoside","volume":"50","author":"Detlie","year":"2019","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.bone.2021.116202_bb0095","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1002\/jbmr.1923","article-title":"Effects of iron deficiency anemia and its treatment on fibroblast growth factor 23 and phosphate homeostasis in women","volume":"28","author":"Wolf","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2021.116202_bb0100","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s12916-020-01643-5","article-title":"Hypophosphatemia after high-dose iron repletion with ferric carboxymaltose and ferric derisomaltose-the randomized controlled HOMe aFers study","volume":"18","author":"Emrich","year":"2020","journal-title":"BMC Med."},{"key":"10.1016\/j.bone.2021.116202_bb0105","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41581-019-0189-5","article-title":"FGF23 at the crossroads of phosphate, iron economy and erythropoiesis","volume":"16","author":"Edmonston","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"issue":"5","key":"10.1016\/j.bone.2021.116202_bb0110","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1111\/bcp.14643","article-title":"Hypophosphataemia after treatment of iron deficiency with intravenous ferric carboxymaltose or iron isomaltoside-a systematic review and meta-analysis","volume":"87","author":"Schaefer","year":"2020","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.bone.2021.116202_bb0115","doi-asserted-by":"crossref","first-page":"11418","DOI":"10.1073\/pnas.1815166116","article-title":"Activation of unliganded FGF receptor by extracellular phosphate potentiates proteolytic protection of FGF23 by its O-glycosylation","volume":"116","author":"Takashi","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bone.2021.116202_bb0120","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/ki.2015.290","article-title":"Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production","volume":"89","author":"David","year":"2016","journal-title":"Kidney Int."},{"key":"10.1016\/j.bone.2021.116202_bb0125","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.bone.2015.12.055","article-title":"Posttranslational processing of FGF23 in osteocytes during the osteoblast to osteocyte transition","volume":"84","author":"Yamamoto","year":"2016","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116202_bb0130","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/ng1358","article-title":"Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis","volume":"36","author":"Topaz","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bone.2021.116202_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2020.100862","article-title":"Intravenous iron supplementation therapy","volume":"75","author":"Schaefer","year":"2020","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.bone.2021.116202_bb0140","doi-asserted-by":"crossref","first-page":"17044","DOI":"10.1038\/nrdp.2017.44","article-title":"Tumour-induced osteomalacia","volume":"3","author":"Minisola","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.bone.2021.116202_bb0145","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/S0140-6736(13)61650-5","article-title":"Rickets","volume":"383","author":"Elder","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.bone.2021.116202_bb0150","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/MNH.0000000000000329","article-title":"Iron-induced hypophosphatemia: an emerging complication","volume":"26","author":"Zoller","year":"2017","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.bone.2021.116202_bb0155","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/apt.14231","article-title":"Letter: inconsistency in reporting of hypophosphatemia after intravenous iron","volume":"46","author":"Schaefer","year":"2017","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.bone.2021.116202_bb0160","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1136\/jcp.35.6.625","article-title":"Value of plasma calcium, phosphate, and alkaline phosphatase measurements in the diagnosis of histological osteomalacia","volume":"35","author":"Peach","year":"1982","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.bone.2021.116202_bb0165","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.bone.2012.02.003","article-title":"Reference intervals of bone turnover markers in healthy premenopausal women: results from a cross-sectional European study","volume":"50","author":"Eastell","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116202_bb0170","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0140-6736(75)92736-1","article-title":"Nomogram for derivation of renal threshold phosphate concentration","volume":"2","author":"Walton","year":"1975","journal-title":"Lancet"},{"key":"10.1016\/j.bone.2021.116202_bb0175","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1055\/s-0036-1592429","article-title":"Metabolic bone disease in patients with malabsorption","volume":"20","author":"Phan","year":"2016","journal-title":"Semin. Musculoskelet. Radiol."},{"key":"10.1016\/j.bone.2021.116202_bb0180","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/qjmed\/hct192","article-title":"Clinician approach to diagnosis of stress fractures including bisphosphonate-associated fractures","volume":"107","author":"McKenna","year":"2014","journal-title":"QJM"},{"key":"10.1016\/j.bone.2021.116202_bb0185","author":"European Medicines Agency"},{"key":"10.1016\/j.bone.2021.116202_bb0190","author":"American Regent Inc., Vifor (International) Inc"},{"issue":"8","key":"10.1016\/j.bone.2021.116202_bb0195","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1093\/rheumatology\/kez627","article-title":"Novel use of burosumab in refractory iron-induced FGF23-mediated hypophosphataemic osteomalacia","volume":"59","author":"Amarnani","year":"2020","journal-title":"Rheumatology"},{"key":"10.1016\/j.bone.2021.116202_bb0200","first-page":"72","article-title":"Resistant iron-induced hypophosphatemia following colorectal surgery","volume":"132","author":"Chen","year":"2019","journal-title":"N. Z. Med. J."},{"key":"10.1016\/j.bone.2021.116202_bb0205","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/jbmr.3369","article-title":"Iron supplementation-induced phosphaturic osteomalacia: FGF23 is the culprit","volume":"33","author":"Urbina","year":"2018","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2021.116202_bb0210","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2016-219160","article-title":"Severe hypophosphataemia after intravenous iron administration","volume":"2017","author":"Anand","year":"2017","journal-title":"BMJ Case Rep."},{"key":"10.1016\/j.bone.2021.116202_bb0215","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/jbmr.3319","article-title":"Hypophosphatemia, severe bone pain, gait disturbance, and fatigue fractures after iron substitution in inflammatory bowel disease: a case report","volume":"33","author":"Bartko","year":"2018","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2021.116202_bb0220","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1093\/rheumatology\/kez627","article-title":"Novel use of burosumab in refractory iron-induced FGF23-mediated hypophosphataemic osteomalacia","volume":"59","author":"Amarnani","year":"2020","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.bone.2021.116202_bb0225","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1359\/jbmr.070304","article-title":"Cinacalcet in the management of tumor-induced osteomalacia","volume":"22","author":"Geller","year":"2007","journal-title":"J. Bone Miner. Res."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328221003689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328221003689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:56:54Z","timestamp":1757613414000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328221003689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":45,"alternative-id":["S8756328221003689"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2021.116202","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypophosphatemia after intravenous iron therapy: Comprehensive review of clinical findings and recommendations for management","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2021.116202","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116202"}}