{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:21:40Z","timestamp":1792790500718,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.bone.2021.116230","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T19:31:10Z","timestamp":1633635070000},"page":"116230","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["The effect of different training frequency on bone mineral density in older adults. A comparative systematic review and meta-analysis"],"prefix":"10.1016","volume":"154","author":[{"given":"Anna-Lena","family":"Zitzmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdieh","family":"Shojaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Kast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Kohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"von Stengel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Borucki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Gosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Jakob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Kerschan-Schindl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Kladny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Middeldorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Schoene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornel","family":"Sieber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"Thomasius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Uder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Kemmler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2021.116230_bb0005","unstructured":"National_Steering_Group Best Practice Guidelines to Prevent and Manage Osteoporosis and Fractures, Department_of_Health_and_Children. Strategy to Prevent Falls and Fractures in Ireland\u2019s Ageing Population Report of the National Steering Group on the Prevention of Falls in Older People and the Prevention and Management of Osteoporosis throughout Life. (2008)."},{"key":"10.1016\/j.bone.2021.116230_bb0010","unstructured":"RACGP Osteoporosis prevention, diagnosis and management in postmenopausal women and men over 50 years of age, The Royal Australian College of General Practitioners and Osteoporosis Australia, (2017)."},{"key":"10.1016\/j.bone.2021.116230_bb0015","unstructured":"SIGN Management of osteoporosis and the prevention of fragility fractures. A national clinical guideline, Scottish_Intercollegiate_Guidelines_Network. (2020)."},{"issue":"1","key":"10.1016\/j.bone.2021.116230_bb0020","article-title":"Exercise for preventing falls in older people living in the community","volume":"31","author":"Sherrington","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.bone.2021.116230_bb0025","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD000333.pub2","article-title":"Exercise for preventing and treating osteoporosis in postmenopausal women","author":"Howe","year":"2011","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.bone.2021.116230_bb0030","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1007\/s11357-011-9311-8","article-title":"Exercise effects on bone mineral density in older adults: a meta-analysis of randomized controlled trials","volume":"34","author":"Marques","year":"2011","journal-title":"Age"},{"key":"10.1016\/j.bone.2021.116230_bb0035","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.3389\/fphys.2020.00652","article-title":"Effect of exercise training on bone mineral density in postmenopausal women: a systematic review and meta-analysis of intervention studies","volume":"11","author":"Shojaa","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bone.2021.116230_bb0040","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1007\/s00198-012-2248-7","article-title":"Effects of exercise on fracture reduction in older adults: a systematic review and meta-analysis","volume":"24","author":"Kemmler","year":"2013","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2021.116230_bb0045","unstructured":"Weineck J Optimales Training, Spitta-Verlag, Erlangen (2019)."},{"key":"10.1016\/j.bone.2021.116230_bb0050","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.amepre.2010.06.006","article-title":"Loustalot F trend and prevalence estimates based on the 2008 Physical Activity Guidelines for Americans","volume":"39","author":"Carlson","year":"2010","journal-title":"Am. J. Prev. Med."},{"key":"10.1016\/j.bone.2021.116230_bb0055","unstructured":"Statistisches-Bundesamt Gesundheit in Deutschland [Health in Germany], Gesundheitsberichterstattung des Bundes. (2016)."},{"key":"10.1016\/j.bone.2021.116230_bb0060","unstructured":"R\u00fctten A, Abu-Omar K, Lampert T, Ziese T K\u00f6rperliche Aktivit\u00e4t [Physical Activity]. Report, Robert-Koch-Institut. Gesundheitsberichterstattung des Bundes. (2005)."},{"key":"10.1016\/j.bone.2021.116230_bb0065","unstructured":"DESTATIS Gesundheit - Ausgaben 2014, Wiesbaden (2016)."},{"key":"10.1016\/j.bone.2021.116230_bb0070","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00198-012-2000-3","article-title":"Does frequency of resistance training affect tibial cortical bone density in older women? A randomized controlled trial","volume":"24","author":"Ashe","year":"2013","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2021.116230_bb0075","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.bone.2009.12.001","article-title":"Optimum frequency of exercise for bone health: randomised controlled trial of a high-impact unilateral intervention","volume":"46","author":"Bailey","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116230_bb0080","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00198-010-1182-9","article-title":"Dose-response effect of 40\u00a0weeks of resistance training on bone mineral density in older adults","volume":"22","author":"Bemben","year":"2011","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2021.116230_bb0085","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1007\/s00198-005-2014-1","article-title":"Exercise frequency and calcium intake predict 4-year bone changes in postmenopausal women","volume":"16","author":"Cussler","year":"2005","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2021.116230_bb0090","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1016\/j.apmr.2013.05.013","article-title":"Exercise frequency, health risk factors, and diseases of the elderly","volume":"94","author":"Kemmler","year":"2013","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.1016\/j.bone.2021.116230_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bone.2016.04.019","article-title":"Exercise frequency and bone mineral density development in exercising postmenopausal osteopenic women. Is there a critical dose of exercise for affecting bone? Results of the Erlangen Fitness and Osteoporosis Prevention Study","volume":"89","author":"Kemmler","year":"2016","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116230_bb0100","doi-asserted-by":"crossref","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement, Ann. Intern. Med. 151 (2009) 264\u2013269, W264.","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"10.1016\/j.bone.2021.116230_bb0105","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1054\/math.2000.0372","article-title":"A database of randomized trials and systematic reviews in physiotherapy","volume":"5","author":"Sherrington","year":"2000","journal-title":"Man. Ther."},{"key":"10.1016\/j.bone.2021.116230_bb0110","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/XEB.0000000000000020","article-title":"Validation of a new tool for the assessment of study quality and reporting in exercise training studies: TESTEX","volume":"13","author":"Smart","year":"2015","journal-title":"Int. J. Evid. Based Healthc."},{"key":"10.1016\/j.bone.2021.116230_bb0115","series-title":"A Language and Environment for Statistical Computing","author":"R_Development_Core_Team R","year":"2020"},{"key":"10.1016\/j.bone.2021.116230_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v036.i03","article-title":"Conducting meta-analyses in R with the metafor package","volume":"36","author":"Viechtbauer","year":"2010","journal-title":"J. Stat. Softw."},{"key":"10.1016\/j.bone.2021.116230_bb0125","first-page":"89","article-title":"A nonparametric \u201ctrim and fill\u201d method of accounting for publication bias in meta-analysis","volume":"95","author":"Duval","year":"2000","journal-title":"JASA"},{"key":"10.1016\/j.bone.2021.116230_bb0130","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.archger.2016.02.010","article-title":"Resistance training programs on bone related variables and functional independence of postmenopausal women in pharmacological treatment: a randomized controlled trial","volume":"65","author":"Borba-Pinheiro","year":"2016","journal-title":"Arch. Gerontol. Geriatr."},{"key":"10.1016\/j.bone.2021.116230_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2021.115944","article-title":"Effects of exercise frequency and training volume on bone changes following a multi-component exercise intervention in middle aged and older men: secondary analysis of an 18-month randomized controlled trial","volume":"148","author":"Daly","year":"2021","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116230_bb0140","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/sms.12024","article-title":"Dose-response effect of exercise frequency on bone mineral density in post-menopausal, osteopenic women","volume":"24","author":"Kemmler","year":"2014","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"10.1016\/j.bone.2021.116230_bb0145","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1210\/jc.2010-2284","article-title":"Independent and combined effects of calcium-vitamin D3 and exercise on bone structure and strength in older men: an 18-month factorial design randomized controlled trial","volume":"96","author":"Kukuljan","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2021.116230_bb0150","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1001\/archinternmed.2009.499","article-title":"Exercise effects on bone mineral density, falls, coronary risk factors, and health care costs in older women: the randomized controlled senior fitness and prevention (SEFIP) study","volume":"170","author":"Kemmler","year":"2010","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.bone.2021.116230_bb0155","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1007\/s00198-011-1663-5","article-title":"Exercise and fractures in postmenopausal women: 12-year results of the Erlangen fitness and osteoporosis prevention study (EFOPS)","volume":"23","author":"Kemmler","year":"2012","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2021.116230_bb0160","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1359\/jbmr.1998.13.2.303","article-title":"The long-term effect of menopause on postmenopausal bone loss in Japanese women: results from a prospective study","volume":"13","author":"Okano","year":"1998","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2021.116230_bb0165","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/s001980050166","article-title":"Vertebral bone mineral density, content and area in 8789 normal women aged 33\u201373\u00a0years who have never had hormone replacement therapy","volume":"9","author":"Shipman","year":"1999","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2021.116230_bb0170","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1210\/jc.2011-2081","article-title":"Low-dose zoledronate in osteopenic postmenopausal women: a randomized controlled trial","volume":"97","author":"Grey","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2021.116230_bb0175","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00223-020-00744-w","article-title":"Effects of different types of exercise on bone mineral density in postmenopausal women: a systematic review and meta-analysis","volume":"107","author":"Kemmler","year":"2020","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2021.116230_bb0180","series-title":"The Role of Exercise on Fracture Reduction and Bone Strengthening","author":"Kemmler","year":"2019"},{"issue":"1","key":"10.1016\/j.bone.2021.116230_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00223-021-00829-0","article-title":"Detraining effects on musculoskeletal parameters in early postmenopausal osteopenic women: 3-month follow-up of the randomized controlled ACTLIFE study","volume":"109","author":"Kemmler","year":"2021","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2021.116230_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115772","article-title":"Detraining effects after 18\u00a0months of high intensity resistance training on osteosarcopenia in older men-six-month follow-up of the randomized controlled Franconian Osteopenia and Sarcopenia Trial (FrOST)","volume":"142","author":"Kemmler","year":"2021","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116230_bb0195","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s11154-010-9153-1","article-title":"Cellular mechanisms of bone remodeling","volume":"11","author":"Eriksen","year":"2010","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.bone.2021.116230_bb0200","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fendo.2015.00082","article-title":"Hypothesis: coupling between resorption and formation in cancellous bone remodeling is a mechanically controlled event","volume":"6","author":"Erben","year":"2015","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.bone.2021.116230_bb0205","first-page":"27","article-title":"Gesundheitsf\u00f6rdernde k\u00f6rperliche Aktivit\u00e4t in der Freizeit bei Erwachsenen in Deutschland","volume":"2","author":"Finger","year":"2017","journal-title":"J. Health Monitoring"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328221003963?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328221003963?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:46:14Z","timestamp":1762659974000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328221003963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":41,"alternative-id":["S8756328221003963"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2021.116230","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of different training frequency on bone mineral density in older adults. A comparative systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2021.116230","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116230"}}