{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T04:45:41Z","timestamp":1792903541955,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31600757"],"award-info":[{"award-number":["31600757"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570956"],"award-info":[{"award-number":["81570956"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870744"],"award-info":[{"award-number":["81870744"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.bone.2021.116231","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T17:51:05Z","timestamp":1634147465000},"page":"116231","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["PTX3 promotes osteogenic differentiation by triggering HA\/CD44\/FAK\/AKT positive feedback loop in an inflammatory environment"],"prefix":"10.1016","volume":"154","author":[{"given":"Wei","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.bone.2021.116231_bb0005","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41577-019-0178-8","article-title":"Osteoimmunology: evolving concepts in bone-immune interactions in health and disease","volume":"19","author":"Tsukasaki","year":"2019","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.bone.2021.116231_bb0010","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/nrd3669","article-title":"Inflammatory bone loss: pathogenesis and therapeutic intervention","volume":"11","author":"Redlich","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.bone.2021.116231_bb0015","doi-asserted-by":"crossref","DOI":"10.4110\/in.2018.18.e8","article-title":"Regulation of osteoclast differentiation by cytokine networks","volume":"18","author":"Amarasekara","year":"2018","journal-title":"Immune Netw."},{"issue":"9","key":"10.1016\/j.bone.2021.116231_bb0020","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1359\/jbmr.090320","article-title":"Osteoblast function is compromised at sites of focal bone erosion in inflammatory arthritis","volume":"24","author":"Walsh","year":"2009","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.bone.2021.116231_bb0025","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1152\/physrev.00016.2017","article-title":"PTX3, a humoral pattern recognition molecule, in innate immunity, tissue repair, and cancer","volume":"98","author":"Garlanda","year":"2018","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.bone.2021.116231_bb0030","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.imlet.2014.04.012","article-title":"The yin-yang of long pentraxin PTX3 in inflammation and immunity","volume":"161","author":"Daigo","year":"2014","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.bone.2021.116231_bb0035","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.3389\/fimmu.2019.02628","article-title":"The long pentraxin PTX3 in bone homeostasis and pathology","volume":"10","author":"Parente","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bone.2021.116231_bb0040","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3389\/fimmu.2018.00417","article-title":"The long pentraxin 3 plays a role in bone turnover and repair","volume":"9","author":"Gr\u010devi\u0107","year":"2018","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.bone.2021.116231_bb0045","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.514","article-title":"Impairment of PTX3 expression in osteoblasts: a key element for osteoporosis","volume":"8","author":"Scimeca","year":"2017","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.bone.2021.116231_bb0050","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20201165","article-title":"Pentraxin 3 promotes the osteoblastic differentiation of MC3T3-E1 cells through the PI3K\/Akt signaling pathway","volume":"40","author":"Liu","year":"2020","journal-title":"Biosci. Rep."},{"issue":"2","key":"10.1016\/j.bone.2021.116231_bb0055","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1902\/jop.2013.120718","article-title":"Estimation of pentraxin-3 levels in the gingival tissues of chronic and aggressive periodontitis participants: an in vivo study","volume":"85","author":"Lakshmanan","year":"2014","journal-title":"J. Periodontol."},{"issue":"1","key":"10.1016\/j.bone.2021.116231_bb0060","doi-asserted-by":"crossref","first-page":"81","DOI":"10.5114\/aoms.2017.69726","article-title":"Is pentraxin 3 level an effective biomarker in disease activity in patients with rheumatoid arthritis?","volume":"16","author":"Balbaloglu","year":"2020","journal-title":"Arch. Med. Sci."},{"issue":"3","key":"10.1016\/j.bone.2021.116231_bb0065","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1155\/2013\/259273","article-title":"Pentraxins as key disease markers for periodontal diagnosis","volume":"34","author":"Kathariya","year":"2013","journal-title":"Dis. Markers"},{"key":"10.1016\/j.bone.2021.116231_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110628","article-title":"Pentraxin 3 inhibits fibroblast growth factor 2 induced osteoclastogenesis in rheumatoid arthritis","volume":"131","author":"Zhao","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"19","key":"10.1016\/j.bone.2021.116231_bb0075","doi-asserted-by":"crossref","first-page":"13531","DOI":"10.1074\/jbc.M113.525287","article-title":"Constitutive expression of pentraxin 3 (PTX3) protein by human amniotic membrane cells leads to formation of the heavy chain (HC)-hyaluronan (HA)-PTX3 complex","volume":"289","author":"Zhang","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"5\u20136","key":"10.1016\/j.bone.2021.116231_bb0080","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.matbio.2011.05.002","article-title":"Implication of the oligomeric state of the N-terminal PTX3 domain in cumulus matrix assembly","volume":"30","author":"Ievoli","year":"2011","journal-title":"Matrix Biol."},{"issue":"44","key":"10.1016\/j.bone.2021.116231_bb0085","doi-asserted-by":"crossref","first-page":"30481","DOI":"10.1074\/jbc.M114.568154","article-title":"Incorporation of pentraxin 3 into hyaluronan matrices is tightly regulated and promotes matrix cross-linking","volume":"289","author":"Baranova","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.bone.2021.116231_bb0090","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1242\/dev.01056","article-title":"PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization","volume":"131","author":"Salustri","year":"2004","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.bone.2021.116231_bb0095","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/stem.3323","article-title":"HC-HA\/PTX3 from amniotic membrane reverts senescent limbal niche cells to Pax6+ neural crest progenitors to support limbal epithelial progenitors","volume":"39","author":"Chen","year":"2021","journal-title":"Stem Cells"},{"issue":"5","key":"10.1016\/j.bone.2021.116231_bb0100","doi-asserted-by":"crossref","DOI":"10.1167\/iovs.15-17637","article-title":"HC-HA\/PTX3 purified from amniotic membrane as novel regenerative matrix: insight into relationship between inflammation and regeneration","volume":"57","author":"Tseng","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.bone.2021.116231_bb0105","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1167\/iovs.61.5.62","article-title":"HC-HA\/PTX3 purified from human amniotic membrane reverts human corneal fibroblasts and myofibroblasts to keratocytes by activating BMP signaling","volume":"61","author":"Zhu","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"38","key":"10.1016\/j.bone.2021.116231_bb0110","doi-asserted-by":"crossref","first-page":"19939","DOI":"10.1074\/jbc.M115.710673","article-title":"Tumor necrosis factor-stimulated Gene-6 (TSG-6) is constitutively expressed in adult central nervous system (CNS) and associated with astrocyte-mediated glial scar formation following spinal cord injury","volume":"291","author":"Coulson-Thomas","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.bone.2021.116231_bb0115","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/s41419-019-1957-7","article-title":"Human induced pluripotent stem cell-derived mesenchymal stem cells promote healing via TNF-\u03b1-stimulated gene-6 in inflammatory bowel disease models","volume":"10","author":"Yang","year":"2019","journal-title":"Cell Death Dis."},{"issue":"10","key":"10.1016\/j.bone.2021.116231_bb0120","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1359\/jbmr.090410","article-title":"LPS-induced inhibition of osteogenesis is TNF-alpha dependent in a murine tooth extraction model","volume":"24","author":"Tomomatsu","year":"2009","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2021.116231_bb0125","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201899529","article-title":"Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and \u03b21-integrin","volume":"38","author":"Fossati","year":"2018","journal-title":"EMBO J."},{"issue":"13","key":"10.1016\/j.bone.2021.116231_bb0130","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.addr.2007.08.008","article-title":"Hyaluronan-dependent pericellular matrix","volume":"59","author":"Evanko","year":"2007","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bone.2021.116231_bb0135","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.biocel.2013.12.016","article-title":"Extensive CD44-dependent hyaluronan coats on human bone marrow-derived mesenchymal stem cells produced by hyaluronan synthases HAS1, HAS2 and HAS3","volume":"48","author":"Qu","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"1\u20133","key":"10.1016\/j.bone.2021.116231_bb0140","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0014-5793(02)03262-3","article-title":"CD44 signaling through focal adhesion kinase and its anti-apoptotic effect","volume":"528","author":"Fujita","year":"2002","journal-title":"FEBS Lett."},{"issue":"16","key":"10.1016\/j.bone.2021.116231_bb0145","doi-asserted-by":"crossref","first-page":"3656","DOI":"10.1111\/febs.12887","article-title":"Akt enhances Runx2 protein stability by regulating Smurf2 function during osteoblast differentiation","volume":"281","author":"Choi","year":"2014","journal-title":"FEBS J."},{"issue":"1","key":"10.1016\/j.bone.2021.116231_bb0150","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1083\/jcb.200401138","article-title":"Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-akt signaling","volume":"166","author":"Fujita","year":"2004","journal-title":"J. Cell Biol."},{"issue":"4","key":"10.1016\/j.bone.2021.116231_bb0155","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1177\/1753425919887236","article-title":"MMP9 protects against LPS-induced inflammation in osteoblasts","volume":"26","author":"Zhang","year":"2020","journal-title":"Innate Immun."},{"issue":"5","key":"10.1016\/j.bone.2021.116231_bb0160","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.joen.2014.01.003","article-title":"MMP9 deficiency increased the size of experimentally induced apical periodontitis","volume":"40","author":"Wan","year":"2014","journal-title":"J. Endod."},{"issue":"6","key":"10.1016\/j.bone.2021.116231_bb0165","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.molmed.2016.04.007","article-title":"The dual complexity of PTX3 in health and disease: a balancing act?","volume":"22","author":"Magrini","year":"2016","journal-title":"Trends Mol. Med."},{"issue":"11","key":"10.1016\/j.bone.2021.116231_bb0170","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1002\/jcp.24626","article-title":"PTX3 stimulates osteoclastogenesis by increasing osteoblast RANKL production","volume":"229","author":"Lee","year":"2014","journal-title":"J. Cell. Physiol."},{"issue":"2","key":"10.1016\/j.bone.2021.116231_bb0175","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.molmed.2004.12.004","article-title":"Osteoclast-derived activity in the coupling of bone formation to resorption","volume":"11","author":"Martin","year":"2005","journal-title":"Trends Mol. Med."},{"issue":"2","key":"10.1016\/j.bone.2021.116231_bb0180","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.bone.2010.05.021","article-title":"Disruption of the Fgf2 gene activates the adipogenic and suppresses the osteogenic program in mesenchymal marrow stromal stem cells","volume":"47","author":"Xiao","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.bone.2021.116231_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.matbio.2019.02.002","article-title":"Hyaluronan biology: a complex balancing act of structure, function, location and context","volume":"78\u201379","author":"Garantziotis","year":"2019","journal-title":"Matrix Biol."},{"issue":"12","key":"10.1016\/j.bone.2021.116231_bb0190","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.it.2005.09.009","article-title":"Hyaluronan cross-linking: a protective mechanism in inflammation?","volume":"26","author":"Day","year":"2005","journal-title":"Trends Immunol."},{"issue":"1","key":"10.1016\/j.bone.2021.116231_bb0195","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bone.2007.01.024","article-title":"Reconciling the roles of FAK in osteoblast differentiation, osteoclast remodeling, and bone regeneration","volume":"41","author":"Kim","year":"2007","journal-title":"Bone"},{"issue":"8","key":"10.1016\/j.bone.2021.116231_bb0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042709","article-title":"Visualization of src and FAK activity during the differentiation process from HMSCs to osteoblasts","volume":"7","author":"Liao","year":"2012","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.bone.2021.116231_bb0205","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/odi.12202","article-title":"TNF\u03b1 contributes for attenuating both Y397FAK and Y416Src phosphorylations in osteoblasts","volume":"20","author":"Cavagis","year":"2014","journal-title":"Oral Dis."},{"issue":"2","key":"10.1016\/j.bone.2021.116231_bb0210","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/sj.emboj.7600960","article-title":"Dynamic study of the transition from hyaluronan- to integrin-mediated adhesion in chondrocytes","volume":"25","author":"Cohen","year":"2006","journal-title":"EMBO J."},{"issue":"14","key":"10.1016\/j.bone.2021.116231_bb0215","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.1158\/0008-5472.CAN-16-2545","article-title":"Akt signaling is sustained by a CD44 splice isoform-mediated positive feedback loop","volume":"77","author":"Liu","year":"2017","journal-title":"Cancer Res."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328221003975?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328221003975?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T18:00:40Z","timestamp":1757613640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328221003975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":43,"alternative-id":["S8756328221003975"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2021.116231","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PTX3 promotes osteogenic differentiation by triggering HA\/CD44\/FAK\/AKT positive feedback loop in an inflammatory environment","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2021.116231","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116231"}}