{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:13:46Z","timestamp":1790511226045,"version":"4.1.0"},"reference-count":250,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T00:00:00Z","timestamp":1666483200000},"content-version":"am","delay-in-days":295,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100016592","name":"Universit\u00e9 du Littoral C\u00f4te d&apos;Opale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010095","name":"R\u00e9gion Hauts-de-France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.bone.2021.116232","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T06:16:28Z","timestamp":1634883388000},"page":"116232","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Sirtuin function and metabolism: Role in pancreas, liver, and adipose tissue and their crosstalk impacting bone homeostasis"],"prefix":"10.1016","volume":"154","author":[{"given":"Viktorija","family":"Avilkina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Chauveau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olfa","family":"Ghali Mhenni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb0005","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cbpa.2008.01.019","article-title":"The sirtuin family: therapeutic targets to treat diseases of aging","volume":"12","author":"Milne","year":"2008","journal-title":"Curr. Opin. Chem. Biol."},{"issue":"10","key":"10.1016\/j.bone.2021.116232_bb0010","first-page":"726","article-title":"Inhibitors to understand molecular mechanisms of NAD+-dependent deacetylases (sirtuins)","volume":"1799","author":"Lawson","year":"2010"},{"key":"10.1016\/j.bone.2021.116232_bb0015","unstructured":"H Lin Chapter 4 - the enzymatic activities of sirtuins L Guarente R Mostoslavsky A Kazantsev Introductory Review on Sirtuins in Biology, Aging, and Disease Academic Press 4562."},{"issue":"6771","key":"10.1016\/j.bone.2021.116232_bb0020","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/35001622","article-title":"Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase","volume":"403","author":"Imai","year":"2000","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.bone.2021.116232_bb0025","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1186\/1479-7364-5-5-485","article-title":"The human sirtuin family: evolutionary divergences and functions","volume":"5","author":"Vassilopoulos","year":"2011","journal-title":"Hum. Genomics"},{"key":"10.1016\/j.bone.2021.116232_bb0030","first-page":"61130","article-title":"Mitochondrial sirtuins: emerging roles in metabolic regulations, energy homeostasis and diseases","author":"Parihar","year":"2015","journal-title":"Exp. Gerontol."},{"issue":"2\u20133","key":"10.1016\/j.bone.2021.116232_bb0035","first-page":"303","article-title":"The conserved role of sirtuins in chromatin regulation","volume":"53","author":"Vaquero","year":"2009"},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb0040","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev.biochem.73.011303.073651","article-title":"The Sir2 family of protein deacetylases","volume":"73","author":"Blander","year":"2004","journal-title":"Annu. Rev. Biochem."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb0045","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1021\/bi052014t","article-title":"Sir2 protein deacetylases: evidence for chemical intermediates and functions of a conserved histidine","volume":"45","author":"Smith","year":"2006","journal-title":"Biochemistry"},{"issue":"12","key":"10.1016\/j.bone.2021.116232_bb0050","doi-asserted-by":"crossref","first-page":"6658","DOI":"10.1073\/pnas.97.12.6658","article-title":"A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family","volume":"97","author":"Smith","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"26","key":"10.1016\/j.bone.2021.116232_bb0055","doi-asserted-by":"crossref","first-page":"14178","DOI":"10.1073\/pnas.250422697","article-title":"Silent information regulator 2 family of NADdependent histone\/protein deacetylases generates a unique product, 1-O-acetyl-ADPribose","volume":"97","author":"Tanner","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.bone.2021.116232_bb0060","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.cell.2005.03.035","article-title":"Assembly of the SIR complex and its regulation by O-acetyl-ADP-ribose, a product of NAD-dependent histone deacetylation","volume":"121","author":"Liou","year":"2005","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb0065","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.molcel.2004.08.031","article-title":"Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin","volume":"16","author":"Vaquero","year":"2004","journal-title":"Mol. Cell"},{"issue":"10","key":"10.1016\/j.bone.2021.116232_bb0070","doi-asserted-by":"crossref","first-page":"4623","DOI":"10.1091\/mbc.e05-01-0033","article-title":"Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins","volume":"16","author":"Michishita","year":"2005","journal-title":"Mol. Biol. Cell"},{"issue":"46","key":"10.1016\/j.bone.2021.116232_bb0075","doi-asserted-by":"crossref","first-page":"33583","DOI":"10.1074\/jbc.M705488200","article-title":"Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase","volume":"282","author":"Ahuja","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"22","key":"10.1016\/j.bone.2021.116232_bb0080","doi-asserted-by":"crossref","first-page":"21313","DOI":"10.1074\/jbc.M413296200","article-title":"Mouse Sir2 homolog SIRT6 is a nuclear ADPribosyltransferase","volume":"280","author":"Liszt","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2021.116232_bb0085","first-page":"861","article-title":"Sirtuin functions and modulation: from chemistry to the clinic","author":"Carafa","year":"2016","journal-title":"Clin. Epigenetics"},{"issue":"23","key":"10.1016\/j.bone.2021.116232_bb0090","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1056\/NEJMra1100831","article-title":"Sirtuins, aging, and medicine","volume":"364","author":"Guarente","year":"2011","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20070140","article-title":"Sirtuins in mammals: insights into their biological function","volume":"404","author":"Michan","year":"2007","journal-title":"Biochem. J."},{"issue":"5","key":"10.1016\/j.bone.2021.116232_bb0100","article-title":"Five days periodic fasting elevates levels of longevity related christensenella and sirtuin expression in humans","volume":"22","author":"Lilja","year":"2021"},{"key":"10.1016\/j.bone.2021.116232_bb0105","first-page":"56133","article-title":"Seven sirtuins for seven deadly diseases of aging","author":"Morris","year":"2013","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.bone.2021.116232_bb0110","article-title":"Sirtuins as important factors in pathological states and the role of their molecular activity modulators","volume":"22","author":"Kratz","year":"2021"},{"key":"10.1016\/j.bone.2021.116232_bb0115","first-page":"75669","article-title":"Metabolic and neuropsychiatric effects of calorie restriction and sirtuins","author":"Libert","year":"2013","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.bone.2021.116232_bb0120","first-page":"100","article-title":"Role of sirtuins in obesity","volume":"17","author":"Nijhawan","year":"2020","journal-title":"Obes. Med."},{"issue":"4","key":"10.1016\/j.bone.2021.116232_bb0125","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nrm1616","article-title":"Calorie restriction, SIRT1 and metabolism: understanding longevity","volume":"6","author":"Bordone","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.bone.2021.116232_bb0130","first-page":"350","article-title":"SIRT1 and caloric restriction: an insight into possible trade-offs between robustness and frailty","volume":"12","author":"Imai","year":"2009","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"issue":"7","key":"10.1016\/j.bone.2021.116232_bb0135","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.tem.2009.03.008","article-title":"Caloric restriction, SIRT1 and longevity","volume":"20","author":"Cant\u00f3","year":"2009","journal-title":"Trends Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb0140","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1038\/s41467-020-16348-9","article-title":"SIRT1 accelerates the progression of activity-based anorexia","volume":"11","author":"Robinette","year":"2020","journal-title":"Nat. Commun."},{"issue":"13","key":"10.1016\/j.bone.2021.116232_bb0145","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1101\/gad.1650608","article-title":"Tissue-specific regulation of SIRT1 by calorie restriction","volume":"22","author":"Chen","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.bone.2021.116232_bb0150","doi-asserted-by":"crossref","first-page":"115361","DOI":"10.1016\/j.bone.2020.115361","article-title":"Sirtuin 1 deficiency decreases bone mass and increases bone marrow adiposity in a mouse model of chronic energy deficiency","volume":"136","author":"Louvet","year":"2020","journal-title":"Bone"},{"issue":"5","key":"10.1016\/j.bone.2021.116232_bb0155","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/MOG.0b013e32832e9c41","article-title":"Neural and hormonal regulation of pancreatic secretion","volume":"25","author":"Chandra","year":"2009","journal-title":"Curr. Opin. Gastroenterol."},{"issue":"14","key":"10.1016\/j.bone.2021.116232_bb0160","doi-asserted-by":"crossref","first-page":"7882","DOI":"10.1074\/jbc.270.14.7882","article-title":"Glucose, other secretagogues, and nerve growth factor stimulate mitogen-activated protein kinase in the insulin-secreting \u03b2-cell line, INS-1","volume":"270","author":"Fr\u00f6din","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.bone.2021.116232_bb0165","doi-asserted-by":"crossref","first-page":"E949","DOI":"10.1152\/ajpendo.00416.2015","article-title":"Mechanisms for greater insulin-stimulated glucose uptake in normal and insulin-resistant skeletal muscle after acute exercise","volume":"309","author":"Cartee","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.bone.2021.116232_bb0170","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF03401634","article-title":"Insulin-stimulated glucose uptake involves the transition of glucose transporters to a caveolae-rich fraction within the plasma membrane: implications for type II diabetes","volume":"2","author":"Gustavsson","year":"1996","journal-title":"Mol. Med."},{"issue":"12","key":"10.1016\/j.bone.2021.116232_bb0175","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.2337\/db09-0328","article-title":"Effects of insulin on the metabolic control of hepatic gluconeogenesis in vivo","volume":"58","author":"Edgerton","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.bone.2021.116232_bb0180","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-1-4939-2895-8_5","article-title":"Regulation of glucose homeostasis by glucocorticoids","volume":"872","author":"Kuo","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bone.2021.116232_bb0185","article-title":"Pro-inflammatory cytokines: the link between obesity and osteoarthritis","volume":"4438\u201350","author":"Wang","year":"2018","journal-title":"Cytokine Growth Factor Rev."},{"issue":"10","key":"10.1016\/j.bone.2021.116232_bb0190","doi-asserted-by":"crossref","first-page":"4001","DOI":"10.1172\/JCI129188","article-title":"\u03b2 cell dysfunction during progression of metabolic syndrome to type 2 diabetes","volume":"129","author":"Hudish","year":"2019","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.bone.2021.116232_bb0195","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1620\/tjem.227.245","article-title":"Calorie restriction from a young age preserves the functions of pancreatic \u03b2 cells in aging rats","volume":"227","author":"He","year":"2012","journal-title":"Tohoku J. Exp. Med."},{"issue":"4","key":"10.1016\/j.bone.2021.116232_bb0200","first-page":"E709","article-title":"Caloric restriction recovers impaired \u03b2-cell-\u03b2-cell gap junction coupling, calcium oscillation coordination, and insulin secretion in prediabetic mice","volume":"319","author":"Corezola do Amaral","year":"2020"},{"issue":"5","key":"10.1016\/j.bone.2021.116232_bb0205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0094151","article-title":"Calorie restriction decreases murine and human pancreatic tumor cell growth, nuclear factor-\u03baB activation, and inflammation-related gene expression in an insulin-like growth Factor-1-Dependent manner","volume":"9","author":"Harvey","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bone.2021.116232_bb0210","doi-asserted-by":"crossref","first-page":"8167273","DOI":"10.1155\/2016\/8167273","article-title":"Sirtuins link inflammation and metabolism","volume":"2016","author":"Vachharajani","year":"2016","journal-title":"J. Immunol. Res."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb0215","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41467-017-02586-x","article-title":"SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-\u03baB pathway","volume":"9","author":"Santos-Barriopedro","year":"2018","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.bone.2021.116232_bb0220","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1038\/sj.emboj.7600244","article-title":"Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase","volume":"23","author":"Yeung","year":"2004","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb0225","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s40618-015-0328-1","article-title":"Artesunate protects pancreatic beta cells against cytokine-induced damage via SIRT1 inhibiting NF-\u03baB activation","volume":"39","author":"Yu","year":"2016","journal-title":"J. Endocrinol. Investig."},{"issue":"2","key":"10.1016\/j.bone.2021.116232_bb0230","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0092-8674(01)00524-4","article-title":"Negative control of p53 by Sir2\u03b1 promotes cell survival under stress","volume":"107","author":"Luo","year":"2001","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.bone.2021.116232_bb0235","first-page":"401","article-title":"Nitric oxide and cell death","volume":"1411","author":"Murphy","year":"1999"},{"issue":"2","key":"10.1016\/j.bone.2021.116232_bb0240","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/cr.2016.4","article-title":"SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2","volume":"26","author":"Pan","year":"2016","journal-title":"Cell Res."},{"issue":"6","key":"10.1016\/j.bone.2021.116232_bb0245","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/embor.2011.65","article-title":"Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS","volume":"12","author":"Chen","year":"2011","journal-title":"EMBO Rep."},{"issue":"47","key":"10.1016\/j.bone.2021.116232_bb0250","doi-asserted-by":"crossref","first-page":"49064","DOI":"10.1074\/jbc.M407715200","article-title":"Complex III releases superoxide to both sides of the inner mitochondrial membrane","volume":"279","author":"Muller","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb0255","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.celrep.2018.05.088","article-title":"Remodeling of the acetylproteome by SIRT3 manipulation fails to affect insulin secretion or \u03b2 cell metabolism in the absence of overnutrition","volume":"24","author":"Peterson","year":"2018","journal-title":"Cell Rep."},{"issue":"6","key":"10.1016\/j.bone.2021.116232_bb0260","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.cmet.2010.11.015","article-title":"Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation","volume":"12","author":"Qiu","year":"2010","journal-title":"Cell Metab."},{"issue":"6","key":"10.1016\/j.bone.2021.116232_bb0265","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.molcel.2010.12.013","article-title":"Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress","volume":"40","author":"Tao","year":"2010","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb0270","doi-asserted-by":"crossref","first-page":"17547","DOI":"10.1038\/s41598-018-35890-7","article-title":"SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain","volume":"8","author":"Tyagi","year":"2018","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.bone.2021.116232_bb0275","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.ccr.2013.02.024","article-title":"SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism","volume":"23","author":"Jeong","year":"2013","journal-title":"Cancer Cell"},{"issue":"3","key":"10.1016\/j.bone.2021.116232_bb0280","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1159\/000354469","article-title":"SIRT4 prevents hypoxia-induced apoptosis in H9c2 cardiomyoblast cells","volume":"32","author":"Liu","year":"2013","journal-title":"Cell. Physiol. Biochem."},{"issue":"2","key":"10.1016\/j.bone.2021.116232_bb0285","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cmet.2005.07.001","article-title":"Increased dosage of mammalian Sir2 in pancreatic \u03b2 cells enhances glucose-stimulated insulin secretion in mice","volume":"2","author":"Moynihan","year":"2005","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb0290","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41387-019-0075-z","article-title":"Pharmacologic or genetic activation of SIRT1 attenuates the fat-induced decrease in beta-cell function in vivo","volume":"9","author":"Desai","year":"2019","journal-title":"Nutr. Diabetes"},{"issue":"11","key":"10.1016\/j.bone.2021.116232_bb0295","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.2337\/db11-0132","article-title":"Beta-cell uncoupling protein 2 regulates reactive oxygen species production, which influences both insulin and glucagon secretion","volume":"60","author":"Robson-Doucette","year":"2011","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.bone.2021.116232_bb0300","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1371\/journal.pbio.0040031","article-title":"Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells","volume":"4","author":"Bordone","year":"2006","journal-title":"PLoS Biol."},{"issue":"3","key":"10.1016\/j.bone.2021.116232_bb0305","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2005.08.004","article-title":"FoxO1 protects against pancreatic \u03b2 cell failure through NeuroD and MafA induction","volume":"2","author":"Kitamura","year":"2005","journal-title":"Cell Metab."},{"issue":"8","key":"10.1016\/j.bone.2021.116232_bb0310","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.1074\/jbc.M110.176842","article-title":"Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism","volume":"286","author":"Vetterli","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.bone.2021.116232_bb0315","doi-asserted-by":"crossref","first-page":"934","DOI":"10.7150\/ijbs.7529","article-title":"SIRT1 deacetylates FOXA2 and is critical for Pdx1 transcription and \u03b2-cell formation","volume":"9","author":"Wang","year":"2013","journal-title":"Int. J. Biol. Sci."},{"issue":"2","key":"10.1016\/j.bone.2021.116232_bb0320","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1474-9726.2009.00544.x","article-title":"SIRT6 protects against pathological damage caused by diet-induced obesity","volume":"9","author":"Kanfi","year":"2010","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb0325","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00125-015-3778-2","article-title":"Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells","volume":"59","author":"Xiong","year":"2016","journal-title":"Diabetologia"},{"issue":"3","key":"10.1016\/j.bone.2021.116232_bb0330","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1530\/JOE-17-0033","article-title":"Fabp4-cre-mediated Sirt6 deletion impairs adipose tissue function and metabolic homeostasis in mice","volume":"233","author":"Xiong","year":"2017","journal-title":"J. Endocrinol."},{"issue":"29","key":"10.1016\/j.bone.2021.116232_bb0335","doi-asserted-by":"crossref","first-page":"10684","DOI":"10.1073\/pnas.1411026111","article-title":"Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion","volume":"111","author":"Zhang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.bone.2021.116232_bb0340","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1101\/gad.12.12.1763","article-title":"Beta-cell-specific inactivation of the mouse Ipf1\/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes","volume":"12","author":"Ahlgren","year":"1998","journal-title":"Genes Dev."},{"issue":"2","key":"10.1016\/j.bone.2021.116232_bb0345","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/ng890","article-title":"Regulation of insulin action and pancreatic \u03b2-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1","volume":"32","author":"Nakae","year":"2002","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb0350","doi-asserted-by":"crossref","first-page":"30321","DOI":"10.1038\/srep30321","article-title":"Insulin secretion impairment in Sirt6 knockout pancreatic \u03b2 cells is mediated by suppression of the FoxO1-Pdx1-Glut2 pathway","volume":"6","author":"Song","year":"2016","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.bone.2021.116232_bb0355","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1080\/15384101.2016.1152427","article-title":"Calorie restriction-induced SIRT6 activation delays aging by suppressing NF-\u03baB signaling","volume":"15","author":"Zhang","year":"2016","journal-title":"Cell Cycle"},{"issue":"5","key":"10.1016\/j.bone.2021.116232_bb0360","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1007\/s00125-013-2851-y","article-title":"Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients","volume":"56","author":"Caton","year":"2013","journal-title":"Diabetologia"},{"issue":"2","key":"10.1016\/j.bone.2021.116232_bb0365","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/S0021-9258(18)48391-3","article-title":"Novel fatty acid beta-oxidation enzymes in rat liver mitochondria. II. Purification and properties of enoyl-coenzyme a (CoA) hydratase\/3- hydroxyacyl-CoA dehydrogenase\/3-ketoacyl-CoA thiolase trifunctional protein","volume":"267","author":"Uchida","year":"1992","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bone.2021.116232_bb0370","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/s41419-019-1349-z","article-title":"The pivotal role of protein acetylation in linking glucose and fatty acid metabolism to \u03b2-cell function","volume":"10","author":"Zhang","year":"2019","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.bone.2021.116232_bb0375","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.cell.2006.08.031","article-title":"Insulin secretion: SIRT4 gets in on the act","volume":"126","author":"Argmann","year":"2006","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.bone.2021.116232_bb0380","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.cell.2006.06.057","article-title":"SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic \u03b2 cells","volume":"126","author":"Haigis","year":"2006","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.bone.2021.116232_bb0385","first-page":"E805","article-title":"\u03b2-cell-specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice","volume":"319","author":"Huynh","year":"2020"},{"issue":"3","key":"10.1016\/j.bone.2021.116232_bb0390","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.cmet.2018.01.016","article-title":"The mitochondrial acylome emerges: proteomics, regulation by sirtuins, and metabolic and disease implications","volume":"27","author":"Carrico","year":"2018","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.bone.2021.116232_bb0395","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.cell.2013.04.023","article-title":"The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4","volume":"153","author":"Csibi","year":"2013","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb0400","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s11064-017-2428-0","article-title":"Glutamate dehydrogenase, a complex enzyme at a crucial metabolic branch point","volume":"44","author":"Smith","year":"2019","journal-title":"Neurochem. Res."},{"issue":"6","key":"10.1016\/j.bone.2021.116232_bb0405","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0198414","article-title":"3-Methylcrotonyl coenzyme A (CoA) carboxylase complex is involved in the Xanthomonas citri subsp. citri lifestyle during citrus infection","volume":"13","author":"Tomassetti","year":"2018","journal-title":"PLoS ONE"},{"issue":"4","key":"10.1016\/j.bone.2021.116232_bb0410","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.cmet.2017.03.003","article-title":"SIRT4 is a lysine deacylase that controls leucine metabolism and insulin secretion","volume":"25","author":"Anderson","year":"2017","journal-title":"Cell Metab."},{"issue":"7","key":"10.1016\/j.bone.2021.116232_bb0415","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/j.cell.2014.11.046","article-title":"Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity","volume":"159","author":"Mathias","year":"2014","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.bone.2021.116232_bb0420","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.molcel.2013.05.012","article-title":"SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase","volume":"50","author":"Laurent","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bone.2021.116232_bb0425","first-page":"8895","article-title":"The impact of current and novel anti-diabetic therapies on cardiovascular risk","author":"Ussher","year":"2012","journal-title":"Futur. Cardiol."},{"key":"10.1016\/j.bone.2021.116232_bb0430","first-page":"111312","article-title":"Insulin receptor expression in bone","author":"Thomas","year":"2009","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"issue":"5","key":"10.1016\/j.bone.2021.116232_bb0435","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.diff.2012.02.002","article-title":"Insulin receptor isoforms are differently expressed during human osteoblastogenesis","volume":"83","author":"Avnet","year":"2012","journal-title":"Differentiation"},{"issue":"2","key":"10.1016\/j.bone.2021.116232_bb0440","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.cell.2010.06.002","article-title":"Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition","volume":"142","author":"Fulzele","year":"2010","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.bone.2021.116232_bb0445","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s11154-014-9307-7","article-title":"An overview of the metabolic functions of osteocalcin","volume":"16","author":"Wei","year":"2015","journal-title":"Rev. Endocr. Metab. Disord."},{"issue":"2","key":"10.1016\/j.bone.2021.116232_bb0450","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.cell.2010.06.003","article-title":"Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism","volume":"142","author":"Ferron","year":"2010","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.bone.2021.116232_bb0455","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1530\/EC-15-0022","article-title":"The effects of acute hyperinsulinemia on bone metabolism","volume":"4","author":"Ivaska","year":"2015","journal-title":"Endocr. Connect."},{"key":"10.1016\/j.bone.2021.116232_bb0460","unstructured":"Maimoun L, Paris F, Coste O, et al. [Intensive training and menstrual disorders in young female: Impact on bone mass]."},{"issue":"9","key":"10.1016\/j.bone.2021.116232_bb0465","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/0026-0495(93)90275-S","article-title":"Insulin sensitivity, insulin secretion, and glucose effectiveness in anorexia nervosa: a minimal model analysis","volume":"42","author":"Fukushima","year":"1993","journal-title":"Metabolism"},{"issue":"21","key":"10.1016\/j.bone.2021.116232_bb0470","doi-asserted-by":"crossref","first-page":"R1147","DOI":"10.1016\/j.cub.2017.09.019","article-title":"The liver","volume":"27","author":"Trefts","year":"2017","journal-title":"Curr. Biol."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb0475","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/j.2040-4603.2014.tb00548.x","article-title":"Energy metabolism in the liver","volume":"4","author":"Rui","year":"2014","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.bone.2021.116232_bb0480","doi-asserted-by":"crossref","first-page":"e21594","DOI":"10.1371\/journal.pone.0021594","article-title":"Insulin promotes glycogen storage and cell proliferation in primary human astrocytes","volume":"6","author":"Heni","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2021.116232_bb0485","first-page":"67078","article-title":"Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo","author":"Titchenell","year":"2015","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.bone.2021.116232_bb0490","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1172\/JCI46243","article-title":"Hepatic Sirt1 deficiency in mice impairs mTorc2\/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance","volume":"121","author":"Wang","year":"2011","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.bone.2021.116232_bb0495","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.cmet.2008.08.014","article-title":"SirT1 gain of function increases energy efficiency and prevents diabetes in mice","volume":"8","author":"Banks","year":"2008","journal-title":"Cell Metab."},{"issue":"7117","key":"10.1016\/j.bone.2021.116232_bb0500","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature05354","article-title":"Resveratrol improves health and survival of mice on a high-calorie diet","volume":"444","author":"Baur","year":"2006","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.bone.2021.116232_bb0505","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.cmet.2008.08.017","article-title":"Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation","volume":"8","author":"Feige","year":"2008","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.bone.2021.116232_bb0510","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1096\/fj.10-173492","article-title":"Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver","volume":"25","author":"Li","year":"2011","journal-title":"FASEB J."},{"issue":"7170","key":"10.1016\/j.bone.2021.116232_bb0515","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/nature06261","article-title":"Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes","volume":"450","author":"Milne","year":"2007","journal-title":"Nature"},{"issue":"21","key":"10.1016\/j.bone.2021.116232_bb0520","doi-asserted-by":"crossref","first-page":"20589","DOI":"10.1074\/jbc.M412357200","article-title":"Nuclear trapping of the forkhead transcription factor FoxO1 via sirt-dependent deacetylation promotes expression of glucogenetic genes","volume":"280","author":"Frescas","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"6939","key":"10.1016\/j.bone.2021.116232_bb0525","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nature01667","article-title":"Insulin-regulated hepatic gluconeogenesis through FOXO1\u2013PGC-1\u03b1 interaction","volume":"423","author":"Puigserver","year":"2003","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.bone.2021.116232_bb0530","doi-asserted-by":"crossref","first-page":"e74340","DOI":"10.1371\/journal.pone.0074340","article-title":"Deletion of hepatic FoxO1\/3\/4 genes in mice significantly impacts on glucose metabolism through downregulation of gluconeogenesis and upregulation of glycolysis","volume":"8","author":"Xiong","year":"2013","journal-title":"PLoS One"},{"issue":"15","key":"10.1016\/j.bone.2021.116232_bb0535","doi-asserted-by":"crossref","first-page":"10105","DOI":"10.1074\/jbc.M600272200","article-title":"FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression","volume":"281","author":"Zhang","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb0540","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.molcel.2011.04.028","article-title":"Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase","volume":"43","author":"Jiang","year":"2011","journal-title":"Mol. Cell"},{"issue":"7219","key":"10.1016\/j.bone.2021.116232_bb0545","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nature07349","article-title":"A fasting inducible switch modulates gluconeogenesis via activator\/coactivator exchange","volume":"456","author":"Liu","year":"2008","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.bone.2021.116232_bb0550","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.molcel.2012.09.030","article-title":"The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis","volume":"48","author":"Dominy","year":"2012","journal-title":"Mol. Cell"},{"issue":"3","key":"10.1016\/j.bone.2021.116232_bb0555","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.cmet.2010.06.009","article-title":"Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis","volume":"12","author":"Kim","year":"2010","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.bone.2021.116232_bb0560","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.cmet.2014.03.006","article-title":"SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway","volume":"19","author":"Yoshizawa","year":"2014","journal-title":"Cell Metab."},{"issue":"11","key":"10.1016\/j.bone.2021.116232_bb0565","first-page":"2280","article-title":"PGK1-mediated cancer progression and drug resistance","volume":"9","author":"He","year":"2019","journal-title":"Am. J. Cancer Res."},{"issue":"2","key":"10.1016\/j.bone.2021.116232_bb0570","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/hep.28887","article-title":"Acetylation of PGK1 promotes liver cancer cell proliferation and tumorigenesis","volume":"65","author":"Hu","year":"2017","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.bone.2021.116232_bb0575","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.cmet.2009.02.006","article-title":"Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation","volume":"9","author":"Purushotham","year":"2009","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb0580","first-page":"13","article-title":"Role of sirtuin 1 in the pathogenesis of ocular disease (Review)","volume":"42","author":"Zhou","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bone.2021.116232_bb0585","first-page":"871434","article-title":"Effects of calorie restriction on SIRT1 expression in liver of nonalcoholic fatty liver disease: experiment with rats","author":"Chen","year":"2007","journal-title":"Zhonghua Yi Xue Za Zhi"},{"issue":"3","key":"10.1016\/j.bone.2021.116232_bb0590","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jhep.2014.10.039","article-title":"Molecular mechanism of PPAR\u03b1 action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease","volume":"62","author":"Pawlak","year":"2015","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.bone.2021.116232_bb0595","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.celrep.2013.08.006","article-title":"Multiple regulatory layers of SREBP1\/2 by SIRT6","volume":"4","author":"Elhanati","year":"2013","journal-title":"Cell Rep."},{"issue":"7285","key":"10.1016\/j.bone.2021.116232_bb0600","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nature08778","article-title":"SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation","volume":"464","author":"Hirschey","year":"2010","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bone.2021.116232_bb0605","doi-asserted-by":"crossref","DOI":"10.3390\/ani10040560","article-title":"Low expression\u00a0of Sirtuin 1 in the dairy cows with mild fatty liver alters hepatic lipid metabolism","volume":"10","author":"Li","year":"2020","journal-title":"Animals"},{"issue":"13","key":"10.1016\/j.bone.2021.116232_bb0610","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1101\/gad.1901210","article-title":"Conserved role of SIRT1 orthologs in fastingdependent inhibition of the lipid\/cholesterol regulator SREBP","volume":"24","author":"Walker","year":"2010","journal-title":"Genes Dev."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb0615","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.molcel.2007.07.032","article-title":"SIRT1 deacetylates and positively regulates the nuclear receptor LXR","volume":"28","author":"Li","year":"2007","journal-title":"Mol. Cell"},{"issue":"9","key":"10.1016\/j.bone.2021.116232_bb0620","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1161\/CIRCULATIONAHA.117.032636","article-title":"Cholesterol efflux pathways suppress inflammasome activation, NETosis, and atherogenesis","volume":"138","author":"Westerterp","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.bone.2021.116232_bb0625","series-title":"Cellular and Molecular Gastroenterology and Hepatology. Epub ahead of print April 17","article-title":"SIRT6 protects against liver fibrosis by deacetylation and suppression of SMAD3 in hepatic stellate cells","author":"Zhong","year":"2020"},{"issue":"3","key":"10.1016\/j.bone.2021.116232_bb0630","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.celrep.2013.10.007","article-title":"SIRT7 represses myc activity to suppress ER stress and prevent fatty liver disease","volume":"5","author":"Shin","year":"2013","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb0635","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2337\/db10-0628","article-title":"Nuclear orphan receptor TAK1\/TR4-deficient mice are protected against obesity-linked inflammation, hepatic steatosis, and insulin resistance","volume":"60","author":"Kang","year":"2011","journal-title":"Diabetes"},{"issue":"6","key":"10.1016\/j.bone.2021.116232_bb0640","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1172\/JCI0215463","article-title":"Circulating levels of IGF-1 directly regulate bone growth and density","volume":"110","author":"Yakar","year":"2002","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb0645","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s13287-019-1223-z","article-title":"IGF-1 overexpression improves mesenchymal stem cell survival and promotes neurological recovery after spinal cord injury","volume":"10","author":"Allahdadi","year":"2019","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.bone.2021.116232_bb0650","first-page":"1591","article-title":"IGF-1 enhances cell proliferation and survival during early differentiation of mesenchymal stem cells to neural progenitor-like cells","author":"Huat","year":"2014","journal-title":"BMC Neurosci."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb0655","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/aps.2008.8","article-title":"Insulin-like growth factor-1 promotes cell cycle progression via upregulation of cyclin D1 expression through the phosphatidylinositol 3-kinase\/nuclear factor-\u03baB signaling pathway in FRTL thyroid cells","volume":"30","author":"Ren","year":"2009","journal-title":"Acta Pharmacol. Sin."},{"issue":"3","key":"10.1016\/j.bone.2021.116232_bb0660","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1161\/01.ATV.0000105902.89459.09","article-title":"Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels","volume":"24","author":"Patrice","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"5","key":"10.1016\/j.bone.2021.116232_bb0665","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1007\/s11357-012-9469-8","article-title":"Low levels of plasma IGF-1 inhibit intracortical bone remodeling during aging","volume":"35","author":"Courtland","year":"2013","journal-title":"Age (Dordr.)"},{"key":"10.1016\/j.bone.2021.116232_bb0670","doi-asserted-by":"crossref","first-page":"235060","DOI":"10.1155\/2014\/235060","article-title":"Effect of GH\/IGF-1 on bone metabolism and osteoporsosis","volume":"2014","author":"Locatelli","year":"2014","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.bone.2021.116232_bb0675","first-page":"439","article-title":"The regulation of IGF-1 gene transcription and splicing during development and aging","author":"Oberbauer","year":"2013","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.bone.2021.116232_bb0680","article-title":"Bone status in a patient with insulin-like growth Factor-1 receptor deletion syndrome: bone quality and structure evaluation using dual-energy X-ray absorptiometry, peripheral quantitative computed tomography, and quantitative ultrasonography","volume":"8227","author":"Pelosi","year":"2017","journal-title":"Front. Endocrinol."},{"issue":"5","key":"10.1016\/j.bone.2021.116232_bb0685","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1210\/er.2007-0036","article-title":"Growth hormone, insulin-like growth factors, and the skeleton","volume":"29","author":"Giustina","year":"2008","journal-title":"Endocr. Rev."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb0690","doi-asserted-by":"crossref","DOI":"10.1530\/JME-17-0292","article-title":"40 YEARS OF IGF1: the emerging connections between IGF1, the intestinal microbiome, lactobacillus strains and bone growth","volume":"61","author":"Poinsot","year":"2018","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.bone.2021.116232_bb0695","first-page":"2826","article-title":"Regulation of skeletal growth and mineral acquisition by the GH\/IGF-1 axis: lessons from mouse models","author":"Yakar","year":"2016","journal-title":"Growth Hormon. IGF Res."},{"issue":"4","key":"10.1016\/j.bone.2021.116232_bb0700","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/jbmr.281","article-title":"Older men with low serum IGF-1 have an increased risk of incident fractures: the MrOS Sweden study","volume":"26","author":"Ohlsson","year":"2011","journal-title":"J. Bone Miner. Res."},{"issue":"8","key":"10.1016\/j.bone.2021.116232_bb0705","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1359\/jbmr.1997.12.8.1272","article-title":"Serum levels of insulin-like growth factor (IGF) I, IGF-binding protein (IGFBP)-2, and IGFBP-3 in osteoporotic patients with and without spinal fractures","volume":"12","author":"Nishiyama","year":"1997","journal-title":"J. Bone Miner. Res."},{"issue":"36","key":"10.1016\/j.bone.2021.116232_bb0710","doi-asserted-by":"crossref","first-page":"E5337","DOI":"10.1073\/pnas.1611494113","article-title":"Vibrio cholerae biofilm growth program and architecture revealed by single-cell live imaging","volume":"113","author":"Yan","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bone.2021.116232_bb0715","unstructured":"SZ Bathaie N Faridi A Nasimian et al Chapter one - how phytochemicals prevent chemical carcinogens and\/or suppress tumor growth? SZ Bathaie F Tamanoi The Enzymes Academic Press 142."},{"issue":"8 Suppl","key":"10.1016\/j.bone.2021.116232_bb0720","first-page":"3","article-title":"Signals that determine the fate of osteoblastic cells","volume":"28","author":"Canalis","year":"2005","journal-title":"J. Endocrinol. Investig."},{"issue":"5","key":"10.1016\/j.bone.2021.116232_bb0725","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1172\/JCI28551","article-title":"Regulation of bone mass by wnt signaling","volume":"116","author":"Krishnan","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bone.2021.116232_bb0730","first-page":"9605","article-title":"The essential role of SIRT1 in hypothalamic-pituitary","author":"Yamamoto","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"37","key":"10.1016\/j.bone.2021.116232_bb0735","doi-asserted-by":"crossref","first-page":"14948","DOI":"10.1073\/pnas.1220606110","article-title":"SIRT1 regulates adaptive response of the growth hormone\u2013insulin-like growth factor-I axis under fasting conditions in liver","volume":"110","author":"Yamamoto","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.bone.2021.116232_bb0740","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1242\/jcs.104992","article-title":"A comparative perspective on lipid storage in animals","volume":"126","author":"Birsoy","year":"2013","journal-title":"J. Cell Sci."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb0745","first-page":"25","article-title":"Adipose tissue: an endocrine organ playing role in metabolic regulation","volume":"26","author":"Booth","year":"2016","journal-title":"Horm. Mol. Biol. Clin. Invest."},{"issue":"2","key":"10.1016\/j.bone.2021.116232_bb0750","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.mce.2009.08.018","article-title":"Adipose tissue as an endocrine organ","volume":"316","author":"Galic","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"issue":"7","key":"10.1016\/j.bone.2021.116232_bb0755","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.2337\/db16-0251","article-title":"De novo lipogenesis products and endogenous lipokines","volume":"65","author":"Yilmaz","year":"2016","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.bone.2021.116232_bb0760","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.cell.2012.09.010","article-title":"Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria","volume":"151","author":"Fedorenko","year":"2012","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb0765","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1038\/s41467-020-15055-9","article-title":"FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis","volume":"11","author":"Shamsi","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb0770","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/nrendo.2016.136","article-title":"Brown adipose tissue as a secretory organ","volume":"13","author":"Villarroya","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bone.2021.116232_bb0775","unstructured":"A Carri\u00e8re L Casteilla Chapter 7 - role of mitochondria in adipose tissues metabolism and plasticity B Morio L P\u00e9nicaud M Rigoulet Mitochondria in Obesity and Type 2 Diabetes Academic Press 173194."},{"issue":"4","key":"10.1016\/j.bone.2021.116232_bb0780","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1242\/jcs.103.4.931","article-title":"Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization","volume":"103","author":"Cousin","year":"1992","journal-title":"J. Cell Sci."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb0785","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0014-5793(84)80822-4","article-title":"Brown adipose tissue in the parametrial fat pad of the mouse","volume":"167","author":"Young","year":"1984","journal-title":"FEBS Lett."},{"issue":"2","key":"10.1016\/j.bone.2021.116232_bb0790","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1242\/jcs.102.2.341","article-title":"Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures","volume":"102","author":"Beresford","year":"1992","journal-title":"J. Cell Sci."},{"issue":"6","key":"10.1016\/j.bone.2021.116232_bb0795","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/j.jhep.2013.07.027","article-title":"Adipose tissue and liver expression of SIRT1, 3, and 6 increase after extensive weight loss in morbid obesity","volume":"59","author":"Moschen","year":"2013","journal-title":"J. Hepatol."},{"issue":"8","key":"10.1016\/j.bone.2021.116232_bb0800","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1038\/ijo.2008.78","article-title":"Low Sirt1 expression, which is upregulated by fasting, in human adipose tissue from obese women","volume":"32","author":"Pedersen","year":"2008","journal-title":"Int. J. Obes."},{"issue":"4","key":"10.1016\/j.bone.2021.116232_bb0805","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1474-9726.2007.00304.x","article-title":"SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction","volume":"6","author":"Wang","year":"2007","journal-title":"Aging Cell"},{"issue":"5","key":"10.1016\/j.bone.2021.116232_bb0810","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.molmet.2015.02.007","article-title":"Adipocyte SIRT1 knockout promotes PPAR\u03b3 activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity","volume":"4","author":"Mayoral","year":"2015","journal-title":"Mol Metab"},{"issue":"6993","key":"10.1016\/j.bone.2021.116232_bb0815","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nature02583","article-title":"Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-\u03b3","volume":"429","author":"Picard","year":"2004","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.bone.2021.116232_bb0820","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.cell.2012.06.027","article-title":"Brown remodeling of white adipose tissue by SirT1 dependent deacetylation of Ppar\u03b3","volume":"150","author":"Qiang","year":"2012","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.bone.2021.116232_bb0825","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0048874","article-title":"Cross regulation of sirtuin 1, AMPK, and PPAR\u03b3 in conjugated linoleic acid treated adipocytes","volume":"7","author":"Jiang","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bone.2021.116232_bb0830","first-page":"9449","article-title":"Inverse association of circulating SIRT1 and adiposity: a study on underweight, normal weight, and obese patients","author":"Mariani","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"2","key":"10.1016\/j.bone.2021.116232_bb0835","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cmet.2007.07.003","article-title":"SIRT2 regulates adipocyte differentiation through FoxO1 acetylation\/deacetylation","volume":"6","author":"Jing","year":"2007","journal-title":"Cell Metab."},{"issue":"3","key":"10.1016\/j.bone.2021.116232_bb0840","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1091\/mbc.e08-06-0647","article-title":"SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1\u2019s repressive interaction with PPARgamma","volume":"20","author":"Wang","year":"2009","journal-title":"Mol. Biol. Cell"},{"issue":"31","key":"10.1016\/j.bone.2021.116232_bb0845","doi-asserted-by":"crossref","first-page":"11805","DOI":"10.1074\/jbc.RA119.008708","article-title":"Enhanced acetylation of ATP-citrate lyase promotes the progression of nonalcoholic fatty liver disease","volume":"294","author":"Guo","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bone.2021.116232_bb0850","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.molcel.2013.07.002","article-title":"Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth","volume":"51","author":"Lin","year":"2013","journal-title":"Mol. Cell"},{"issue":"3","key":"10.1016\/j.bone.2021.116232_bb0855","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1101\/gad.180406.111","article-title":"Dietary obesity-associated Hif1\u03b1 activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system","volume":"26","author":"Krishnan","year":"2012","journal-title":"Genes Dev."},{"issue":"40","key":"10.1016\/j.bone.2021.116232_bb0860","doi-asserted-by":"crossref","first-page":"E8352","DOI":"10.1073\/pnas.1706945114","article-title":"Sirt7 promotes adipogenesis in the mouse by inhibiting autocatalytic activation of Sirt1","volume":"114","author":"Fang","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.bone.2021.116232_bb0865","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1172\/JCI63967","article-title":"Malonyl-CoA: the regulator of fatty acid synthesis and oxidation","volume":"122","author":"Foster","year":"2012","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.bone.2021.116232_bb0870","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.bbrc.2009.09.045","article-title":"Structure\u2013function analysis of human protein Ero1-L\u03b1","volume":"389","author":"Chu","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"13","key":"10.1016\/j.bone.2021.116232_bb0875","doi-asserted-by":"crossref","first-page":"4698","DOI":"10.1128\/MCB.02279-06","article-title":"Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-L\u03b1","volume":"27","author":"Qiang","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bone.2021.116232_bb0880","first-page":"28139915","article-title":"SIRT1 regulates adiponectin gene expression through Foxo1-C\/enhancer-binding protein transcriptional complex","author":"Qiao","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bone.2021.116232_bb0885","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2337\/db19-0526","article-title":"Inhibition of mitochondrial calcium overload by SIRT3 prevents obesity- or age-related whitening of Brown adipose tissue","volume":"69","author":"Gao","year":"2020","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.bone.2021.116232_bb0890","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1152\/physrev.00022.2011","article-title":"Sirtuin 1 and sirtuin 3: physiological modulators of metabolism","volume":"92","author":"Nogueiras","year":"2012","journal-title":"Physiol. Rev."},{"issue":"6","key":"10.1016\/j.bone.2021.116232_bb0895","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2006.11.013","article-title":"Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1\u03b1","volume":"127","author":"Lagouge","year":"2006","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.bone.2021.116232_bb0900","doi-asserted-by":"crossref","DOI":"10.3390\/antiox10030338","article-title":"Sirt1 and Sirt3 activation improved cardiac function of diabetic rats via modulation of mitochondrial function","volume":"10","author":"Paramesha","year":"2021","journal-title":"Antioxidants"},{"issue":"14","key":"10.1016\/j.bone.2021.116232_bb0905","doi-asserted-by":"crossref","first-page":"13560","DOI":"10.1074\/jbc.M414670200","article-title":"SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes","volume":"280","author":"Shi","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.bone.2021.116232_bb0910","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.2337\/db18-1103","article-title":"SIRT5 regulates brown adipocyte differentiation and browning of subcutaneous white adipose tissue","volume":"68","author":"Shuai","year":"2019","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.bone.2021.116232_bb0915","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.celrep.2017.06.069","article-title":"Cold-inducible SIRT6 regulates thermogenesis of brown and beige fat","volume":"20","author":"Yao","year":"2017","journal-title":"Cell Rep."},{"issue":"4","key":"10.1016\/j.bone.2021.116232_bb0920","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.cmet.2014.03.006","article-title":"SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway","volume":"19","author":"Yoshizawa","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.bone.2021.116232_bb0925","article-title":"Sirt1 promotes a thermogenic gene program in bone marrow adipocytes: from mice to (wo)men","volume":"10126","author":"Artsi","year":"2019","journal-title":"Front. Endocrinol."},{"issue":"12","key":"10.1016\/j.bone.2021.116232_bb0930","doi-asserted-by":"crossref","first-page":"4514","DOI":"10.1210\/en.2011-1128","article-title":"Sirt1 is a regulator of bone mass and a repressor of sost encoding for sclerostin, a bone formation inhibitor","volume":"152","author":"Cohen-Kfir","year":"2011","journal-title":"Endocrinology"},{"issue":"9","key":"10.1016\/j.bone.2021.116232_bb0935","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.1210\/en.2014-1334","article-title":"The Sirtuin1 activator SRT3025 Down-regulates sclerostin and rescues ovariectomy-induced bone loss and biomechanical deterioration in female mice","volume":"155","author":"Artsi","year":"2014","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.bone.2021.116232_bb0940","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1002\/jbmr.1824","article-title":"Silent information regulator (Sir)T1 inhibits NF-\u03baB signaling to maintain normal skeletal remodeling","volume":"28","author":"Edwards","year":"2013","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.bone.2021.116232_bb0945","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nrrheum.2011.23","article-title":"Advances in osteoclast biology: old findings and new insights from mouse models","volume":"7","author":"Edwards","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb0950","doi-asserted-by":"crossref","first-page":"434","DOI":"10.4049\/jimmunol.163.1.434","article-title":"Osteoclast differentiation factor acts as a multifunctional regulator in murine osteoclast differentiation and function","volume":"163","author":"Jimi","year":"1999","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.bone.2021.116232_bb0955","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1002\/jbmr.3677","article-title":"Sirt1 promotes osteogenic differentiation and increases alveolar bone mass via Bmi1 activation in mice","volume":"34","author":"Wang","year":"2019","journal-title":"J. Bone Miner. Res."},{"issue":"7","key":"10.1016\/j.bone.2021.116232_bb0960","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1359\/jbmr.060415","article-title":"Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells","volume":"21","author":"B\u00e4ckesj\u00f6","year":"2006","journal-title":"J. Bone Miner. Res."},{"issue":"5","key":"10.1016\/j.bone.2021.116232_bb0965","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037162","article-title":"Resveratrol exerts dosage and duration dependent effect on human mesenchymal stem cell development","volume":"7","author":"Peltz","year":"2012","journal-title":"PLoS ONE"},{"issue":"3","key":"10.1016\/j.bone.2021.116232_bb0970","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/emmm.201201606","article-title":"SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating \u03b2-catenin","volume":"5","author":"Simic","year":"2013","journal-title":"EMBO Mol. Med."},{"issue":"9","key":"10.1016\/j.bone.2021.116232_bb0975","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1210\/en.2016-1739","article-title":"Sirtuin-3 promotes adipogenesis, osteoclastogenesis, and bone loss in aging male mice","volume":"158","author":"Ho","year":"2017","journal-title":"Endocrinology"},{"issue":"6","key":"10.1016\/j.bone.2021.116232_bb0980","doi-asserted-by":"crossref","first-page":"e00670","DOI":"10.1002\/prp2.670","article-title":"Sirt3 regulates adipogenesis and adipokine secretion via its enzymatic activity","volume":"8","author":"Ma","year":"2020","journal-title":"Pharmacol. Res. Perspect."},{"key":"10.1016\/j.bone.2021.116232_bb0985","doi-asserted-by":"crossref","first-page":"8412","DOI":"10.12659\/MSM.917118","article-title":"Inhibitory effect of Sirtuin6 (SIRT6) on osteogenic differentiation of bone marrow mesenchymal stem cells","volume":"25","author":"Xiao","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.bone.2021.116232_bb0990","article-title":"MiR-33a inhibits the adipogenic differentiation of ovine adipose\u2013derived stromal vascular fraction cells by targeting SIRT6","volume":"74106513","author":"Wang","year":"2021","journal-title":"Domest. Anim. Endocrinol."},{"issue":"2","key":"10.1016\/j.bone.2021.116232_bb0995","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.cmet.2014.06.003","article-title":"Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction","volume":"20","author":"Cawthorn","year":"2014","journal-title":"Cell Metab."},{"issue":"3","key":"10.1016\/j.bone.2021.116232_bb1000","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1080\/21623945.2016.1149269","article-title":"Inside out: bone marrow adipose tissue as a source of circulating adiponectin","volume":"5","author":"Scheller","year":"2016","journal-title":"Adipocyte"},{"key":"10.1016\/j.bone.2021.116232_bb1005","doi-asserted-by":"crossref","first-page":"975178","DOI":"10.1155\/2014\/975178","article-title":"Adiponectin as a biomarker of osteoporosis in postmenopausal women: controversies","volume":"2014","author":"Lubkowska","year":"2014","journal-title":"Dis. Markers"},{"issue":"2","key":"10.1016\/j.bone.2021.116232_bb1010","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1530\/EJE-08-0569","article-title":"Adiponectin is associated with low bone mineral density in elderly men","volume":"160","author":"Basurto","year":"2009","journal-title":"Eur. J. Endocrinol."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb1015","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jbspin.2018.03.014","article-title":"Adipokines and bone status in a cohort of anorexic patients","volume":"86","author":"Legroux-G\u00e9rot","year":"2019","journal-title":"Joint Bone Spine"},{"issue":"4","key":"10.1016\/j.bone.2021.116232_bb1020","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.bone.2004.06.008","article-title":"Adiponectin and its receptors are expressed in bone-forming cells","volume":"35","author":"Berner","year":"2004","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb1025","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.yexcr.2005.05.021","article-title":"Adiponectin stimulates human osteoblasts proliferation and differentiation via the MAPK signaling pathway","volume":"309","author":"Luo","year":"2005","journal-title":"Exp. Cell Res."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb1030","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/jcb.20890","article-title":"Regulation of bone formation by adiponectin through autocrine\/paracrine and endocrine pathways","volume":"99","author":"Shinoda","year":"2006","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb1035","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1471-2121-8-51","article-title":"Adiponectin and AMP kinase activator stimulate proliferation, differentiation, and mineralization of osteoblastic MC3T3-E1 cells","volume":"8","author":"Kanazawa","year":"2007","journal-title":"BMC Cell Biol."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb1040","doi-asserted-by":"crossref","first-page":"3652","DOI":"10.1038\/s41598-017-03899-z","article-title":"Adiponectin regulates BMSC osteogenic differentiation and osteogenesis through the Wnt\/\u03b2-catenin pathway","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.bone.2021.116232_bb1045","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.bbrc.2015.03.168","article-title":"Adiponectin enhances osteogenic differentiation in human adipose-derived stem cells by activating the APPL1-AMPK signaling pathway","volume":"461","author":"Chen","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.bone.2021.116232_bb1050","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.bbrc.2005.03.210","article-title":"Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast","volume":"331","author":"Oshima","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb1055","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-2474-12-18","article-title":"Hyperadiponectinemia enhances bone formation in mice","volume":"12","author":"Mitsui","year":"2011","journal-title":"BMC Musculoskelet. Disord."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb1060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41413-020-00122-0","article-title":"Adiponectin signalling in bone homeostasis, with age and in disease","volume":"9","author":"Lewis","year":"2021","journal-title":"Bone Res."},{"key":"10.1016\/j.bone.2021.116232_bb1065","first-page":"10815","article-title":"Adiponectin deficiency triggers bone loss by up- regulation of osteoclastogenesis and down-regulation of osteoblastogenesis","author":"Yang","year":"2019","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"8","key":"10.1016\/j.bone.2021.116232_bb1070","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.jnutbio.2011.04.011","article-title":"Caloric restriction increases adiponectin expression by adipose tissue and prevents the inhibitory effect of insulin on circulating adiponectin in rats","volume":"23","author":"Ding","year":"2012","journal-title":"J. Nutr. Biochem."},{"issue":"8","key":"10.1016\/j.bone.2021.116232_bb1075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0103775","article-title":"Long-term physiological alterations and recovery in a mouse model of separation associated with time-restricted feeding: a tool to study anorexia nervosa related consequences","volume":"9","author":"Zgheib","year":"2014","journal-title":"PLoS ONE"},{"issue":"4","key":"10.1016\/j.bone.2021.116232_bb1080","first-page":"1833","article-title":"Adiponectin in anorexia nervosa and bulimia nervosa","volume":"89","author":"Tagami","year":"2004"},{"issue":"9","key":"10.1016\/j.bone.2021.116232_bb1085","first-page":"2703","article-title":"Influence of adipokines and ghrelin on bone mineral density and fracture risk: a systematic review and meta-analysis","volume":"96","author":"Biver","year":"2011"},{"issue":"2","key":"10.1016\/j.bone.2021.116232_bb1090","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1365-2265.2004.02081.x","article-title":"Lack of independent relationship between plasma adiponectin, leptin levels and bone density in nondiabetic female adolescents","volume":"61","author":"Huang","year":"2004","journal-title":"Clin. Endocrinol."},{"issue":"5","key":"10.1016\/j.bone.2021.116232_bb1095","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00223-004-1128-3","article-title":"Umbilical cord leptin predicts neonatal bone mass","volume":"76","author":"Javaid","year":"2005","journal-title":"Calcif. Tissue Int."},{"issue":"8","key":"10.1016\/j.bone.2021.116232_bb1100","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.3346\/jkms.2010.25.8.1187","article-title":"Effects of body composition, leptin, and adiponectin on bone mineral density in prepubertal girls","volume":"25","author":"Rhie","year":"2010","journal-title":"J. Korean Med. Sci."},{"issue":"10","key":"10.1016\/j.bone.2021.116232_bb1105","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1359\/jbmr.2002.17.10.1896","article-title":"Relationship of serum leptin concentration with bone mineral density in the United States population","volume":"17","author":"Ruhl","year":"2002","journal-title":"J. Bone Miner. Res."},{"issue":"3","key":"10.1016\/j.bone.2021.116232_bb1110","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1046\/j.1365-2265.2001.01361.x","article-title":"Plasma leptin concentrations are associated with bone mineral density and the presence of vertebral fractures in postmenopausal women","volume":"55","author":"Yamauchi","year":"2001","journal-title":"Clin. Endocrinol."},{"issue":"3","key":"10.1016\/j.bone.2021.116232_bb1115","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.bone.2003.11.020","article-title":"Leptin deficiency produces contrasting phenotypes in bones of the limb and spine","volume":"34","author":"Hamrick","year":"2004","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb1120","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0167-0115(00)00152-X","article-title":"Leptin is a potent stimulator of bone growth in ob\/ob mice","volume":"92","author":"Steppan","year":"2000","journal-title":"Regul. Pept."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb1125","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/jbmr.1734","article-title":"Peripheral leptin regulates bone formation","volume":"28","author":"Turner","year":"2013","journal-title":"J. Bone Miner. Res."},{"issue":"7032","key":"10.1016\/j.bone.2021.116232_bb1130","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/nature03398","article-title":"Leptin regulation of bone resorption by the sympathetic nervous system and CART","volume":"434","author":"Elefteriou","year":"2005","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.bone.2021.116232_bb1135","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1210\/er.2017-00226","article-title":"Effects of leptin on the skeleton","volume":"39","author":"Reid","year":"2018","journal-title":"Endocr. Rev."},{"issue":"8","key":"10.1016\/j.bone.2021.116232_bb1140","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1359\/jbmr.2001.16.8.1426","article-title":"Leptin is expressed in and secreted from primary cultures of human osteoblasts and promotes bone mineralization","volume":"16","author":"Reseland","year":"2001","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.bone.2021.116232_bb1145","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1210\/endo.140.4.6637","article-title":"Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes","volume":"140","author":"Thomas","year":"1999","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb1150","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/sj.mp.4001909","article-title":"The role of leptin in anorexia nervosa: clinical implications","volume":"12","author":"Hebebrand","year":"2007","journal-title":"Mol. Psychiatry"},{"issue":"8","key":"10.1016\/j.bone.2021.116232_bb1155","first-page":"2693","article-title":"Brown adipose tissue and its relationship to bone structure in pediatric patients","volume":"97","author":"Ponrartana","year":"2012"},{"issue":"8","key":"10.1016\/j.bone.2021.116232_bb1160","first-page":"2687","article-title":"Inducible brown adipose tissue, or beige fat,is anabolic for the skeleton","volume":"154","author":"Rahman","year":"2013"},{"issue":"10","key":"10.1016\/j.bone.2021.116232_bb1165","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/nm.2448","article-title":"Matrix-embedded cells control osteoclast formation","volume":"17","author":"Xiong","year":"2011","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb1170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2011.10.044","article-title":"Update on wnt signaling in bone cell biology and bone disease","volume":"492","author":"Monroe","year":"2012","journal-title":"Gene"},{"issue":"4","key":"10.1016\/j.bone.2021.116232_bb1175","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1097\/MOP.0000000000000508","article-title":"Eating disorders and bone metabolism in women","volume":"29","author":"Robinson","year":"2017","journal-title":"Curr. Opin. Pediatr."},{"issue":"4","key":"10.1016\/j.bone.2021.116232_bb1180","doi-asserted-by":"crossref","first-page":"E584","DOI":"10.1210\/jc.2011-2246","article-title":"Young women with cold-activated brown adipose tissue have higher bone mineral density and lower Pref-1 than women without brown adipose tissue: a study in women with anorexia nervosa, women recovered from anorexia nervosa, and normal-weight women","volume":"97","author":"Bredella","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.bone.2021.116232_bb1185","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1210\/en.2015-1477","article-title":"Expansion of bone marrow adipose tissue during caloric restriction is associated with increased circulating glucocorticoids and not with hypoleptinemia","volume":"157","author":"Cawthorn","year":"2016","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.bone.2021.116232_bb1190","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nrendo.2009.249","article-title":"Adiposity and bone accrual\u2014still an established paradigm?","volume":"6","author":"Kawai","year":"2010","journal-title":"Nat. Rev. Endocrinol."},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb1195","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1038\/s41467-020-16878-2","article-title":"Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis","volume":"11","author":"Suchacki","year":"2020","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.bone.2021.116232_bb1200","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1023\/A:1011513223894","article-title":"Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis","volume":"2","author":"Justesen","year":"2001","journal-title":"Biogerontology"},{"issue":"3","key":"10.1016\/j.bone.2021.116232_bb1205","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/8756-3282(87)90015-9","article-title":"Changes in trabecular bone, hematopoiesis and bone marrow vessels in aplastic anemia, primary osteoporosis, and old age: a comparative histomorphometric study","volume":"8","author":"Burkhardt","year":"1987","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.bone.2021.116232_bb1210","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.crad.2013.10.005","article-title":"Quantitative evaluation of vertebral marrow adipose tissue in postmenopausal female using MRI chemical shift-based water\u2013fat separation","volume":"69","author":"Li","year":"2014","journal-title":"Clin. Radiol."},{"issue":"4","key":"10.1016\/j.bone.2021.116232_bb1215","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1111\/j.1582-4934.2009.00751.x","article-title":"Inhibition of fatty acid biosynthesis prevents adipocyte lipotoxicity on human osteoblasts in vitro","volume":"14","author":"Elbaz","year":"2010","journal-title":"J. Cell. Mol. Med."},{"issue":"5","key":"10.1016\/j.bone.2021.116232_bb1220","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S8756-3282(00)00252-0","article-title":"Influence of mature adipocytes on osteoblast proliferation in human primary cocultures","volume":"26","author":"Maurin","year":"2000","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.bone.2021.116232_bb1225","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.diff.2010.04.004","article-title":"Human osteoblasts derived from mesenchymal stem cells express adipogenic markers upon coculture with bone marrow adipocytes","volume":"80","author":"Clabaut","year":"2010","journal-title":"Differentiation"},{"issue":"4","key":"10.1016\/j.bone.2021.116232_bb1230","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1210\/endo.139.4.5915","article-title":"Murine bone marrow stromally derived BMS2 adipocytes support differentiation and function of osteoclast-like cells in Vitro*","volume":"139","author":"Kelly","year":"1998","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.bone.2021.116232_bb1235","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.abb.2008.03.018","article-title":"Functions of RANKL\/RANK\/OPG in bone modeling and remodeling","volume":"473","author":"Boyce","year":"2008","journal-title":"Arch. Biochem. Biophys."},{"issue":"24","key":"10.1016\/j.bone.2021.116232_bb1240","doi-asserted-by":"crossref","first-page":"16699","DOI":"10.1074\/jbc.M114.547919","article-title":"Age-related marrow adipogenesis is linked to increased expression of RANKL","volume":"289","author":"Takeshita","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2021.116232_bb1245","article-title":"Sirtuins and type 2 diabetes: role in inflammation, oxidative stress, and mitochondrial function","volume":"10187","author":"Kitada","year":"2019","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bone.2021.116232_bb1250","doi-asserted-by":"crossref","first-page":"104485","DOI":"10.1016\/j.psyneuen.2019.104485","article-title":"Adipokines in anorexia nervosa: a systematic review and meta-analysis","volume":"112","author":"Karageorgiou","year":"2020","journal-title":"Psychoneuroendocrinology"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328221003987?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328221003987?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T18:01:38Z","timestamp":1757613698000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328221003987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":250,"alternative-id":["S8756328221003987"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2021.116232","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sirtuin function and metabolism: Role in pancreas, liver, and adipose tissue and their crosstalk impacting bone homeostasis","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2021.116232","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116232"}}