{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T09:36:06Z","timestamp":1779183366002,"version":"3.51.4"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"am","delay-in-days":297,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK054481"],"award-info":[{"award-number":["R01DK054481"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P40OD010939"],"award-info":[{"award-number":["P40OD010939"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F32AR071298"],"award-info":[{"award-number":["F32AR071298"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR071975"],"award-info":[{"award-number":["R01AR071975"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AR069619"],"award-info":[{"award-number":["P30AR069619"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016787","name":"Penn Center for Musculoskeletal Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013927","name":"National MPS Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013927","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.bone.2021.116237","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T10:06:32Z","timestamp":1634897192000},"page":"116237","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Effects of lithium administration on vertebral bone disease in mucopolysaccharidosis I dogs"],"prefix":"10.1016","volume":"154","author":[{"given":"Yian Khai","family":"Lau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun H.","family":"Peck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toren","family":"Arginteanu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meilun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen M.","family":"Shore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter S.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margret L.","family":"Casal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lachlan J.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2021.116237_bb0005","series-title":"The Metabolic and Molecular Bases of Inherited Disease","first-page":"3421","article-title":"The Mucopolysaccharidoses","author":"Neufeld","year":"2001"},{"issue":"4","key":"10.1016\/j.bone.2021.116237_bb0010","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/humu.1380060403","article-title":"Molecular genetics of mucopolysaccharidosis type I: diagnostic, clinical, and biological implications","volume":"6","author":"Scott","year":"1995","journal-title":"Hum. Mutat."},{"issue":"Suppl 5","key":"10.1016\/j.bone.2021.116237_bb0015","doi-asserted-by":"crossref","first-page":"v4","DOI":"10.1093\/rheumatology\/ker394","article-title":"Overview of the mucopolysaccharidoses","volume":"50","author":"Muenzer","year":"2011","journal-title":"Rheumatology (Oxford)"},{"issue":"10","key":"10.1016\/j.bone.2021.116237_bb0020","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/gim.2014.25","article-title":"The natural history of MPS I: global perspectives from the MPS I registry","volume":"16","author":"Beck","year":"2014","journal-title":"Genet. Med."},{"issue":"2","key":"10.1016\/j.bone.2021.116237_bb0025","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s10545-010-9262-8","article-title":"Growth, final height and endocrine sequelae in a UK population of patients with hurler syndrome (MPS1H)","volume":"34","author":"Gardner","year":"2011","journal-title":"J. Inherit. Metab. Dis."},{"issue":"1","key":"10.1016\/j.bone.2021.116237_bb0030","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13023-019-0997-5","article-title":"Treatment of thoracolumbar kyphosis in patients with mucopolysaccharidosis type I: results of an international consensus procedure","volume":"14","author":"Kuiper","year":"2019","journal-title":"Orphanet J. Rare Dis."},{"issue":"4","key":"10.1016\/j.bone.2021.116237_bb0035","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ymgme.2016.06.002","article-title":"Pathogenesis and treatment of spine disease in the mucopolysaccharidoses","volume":"118","author":"Peck","year":"2016","journal-title":"Mol. Genet. Metab."},{"issue":"3","key":"10.1016\/j.bone.2021.116237_bb0040","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s10545-011-9304-x","article-title":"Orthopaedic management of Hurler's disease after hematopoietic stem cell transplantation: a systematic review","volume":"34","author":"van der Linden","year":"2011","journal-title":"J. Inherit. Metab. Dis."},{"issue":"6","key":"10.1016\/j.bone.2021.116237_bb0045","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1302\/0301-620X.78B6.0780938","article-title":"Spinal problems in mucopolysaccharidosis I (Hurler syndrome)","volume":"78","author":"Tandon","year":"1996","journal-title":"J. Bone Joint Surg. (Br.)"},{"issue":"1","key":"10.1016\/j.bone.2021.116237_bb0050","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jocd.2013.03.004","article-title":"Low bone mineral content and challenges in interpretation of dual-energy X-ray absorptiometry in children with mucopolysaccharidosis types I, II, and VI","volume":"17","author":"Polgreen","year":"2014","journal-title":"J. Clin. Densitom."},{"issue":"1","key":"10.1016\/j.bone.2021.116237_bb0055","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bone.2013.03.014","article-title":"Postnatal progression of bone disease in the cervical spines of mucopolysaccharidosis I dogs","volume":"55","author":"Chiaro","year":"2013","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.bone.2021.116237_bb0060","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/joa.13305","article-title":"Ultrastructural analysis of different skeletal cell types in mucopolysaccharidosis dogs at the onset of postnatal growth","volume":"238","author":"Jiang","year":"2021","journal-title":"J. Anat."},{"issue":"6","key":"10.1016\/j.bone.2021.116237_bb0065","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s11914-020-00626-y","article-title":"Failures of endochondral ossification in the mucopolysaccharidoses","volume":"18","author":"Jiang","year":"2020","journal-title":"Curr. Osteoporos. Rep."},{"issue":"8","key":"10.1016\/j.bone.2021.116237_bb0070","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1111\/j.1651-2227.2008.00811.x","article-title":"Outcome in six children with mucopolysaccharidosis type IH, hurler syndrome, after haematopoietic stem cell transplantation (HSCT)","volume":"97","author":"Malm","year":"2008","journal-title":"Acta Paediatr."},{"issue":"1","key":"10.1016\/j.bone.2021.116237_bb0075","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/01241398-200401000-00019","article-title":"Musculoskeletal manifestations of hurler syndrome: long-term follow-up after bone marrow transplantation","volume":"24","author":"Weisstein","year":"2004","journal-title":"J. Pediatr. Orthop."},{"issue":"5","key":"10.1016\/j.bone.2021.116237_bb0080","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/BRS.0000000000000157","article-title":"Thoracolumbar kyphosis in treated mucopolysaccharidosis 1 (Hurler syndrome)","volume":"39","author":"Yasin","year":"2014","journal-title":"Spine (Phila Pa 1976)"},{"issue":"12","key":"10.1016\/j.bone.2021.116237_bb0085","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/bmt.2008.20","article-title":"Growth and endocrine function in patients with hurler syndrome after hematopoietic stem cell transplantation","volume":"41","author":"Polgreen","year":"2008","journal-title":"Bone Marrow Transplant."},{"issue":"2","key":"10.1016\/j.bone.2021.116237_bb0090","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ymgme.2013.11.015","article-title":"Early initiation of enzyme replacement therapy for the mucopolysaccharidoses","volume":"111","author":"Muenzer","year":"2014","journal-title":"Mol. Genet. Metab."},{"issue":"12","key":"10.1016\/j.bone.2021.116237_bb0095","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1002\/jbmr.2290","article-title":"Effects of neonatal enzyme replacement therapy and simvastatin treatment on cervical spine disease in mucopolysaccharidosis I dogs","volume":"29","author":"Chiaro","year":"2014","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2021.116237_bb0100","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ymgme.2013.03.005","article-title":"Enzyme replacement therapy started at birth improves outcome in difficult-to-treat organs in mucopolysaccharidosis I mice","volume":"109","author":"Baldo","year":"2013","journal-title":"Mol. Genet. Metab."},{"issue":"3","key":"10.1016\/j.bone.2021.116237_bb0105","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ymgme.2020.05.001","article-title":"Neonatal combination therapy improves some of the clinical manifestations in the mucopolysaccharidosis type I murine model","volume":"130","author":"Santi","year":"2020","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.bone.2021.116237_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2019.115042","article-title":"Molecular profiling of failed endochondral ossification in mucopolysaccharidosis VII","volume":"128","author":"Peck","year":"2019","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.bone.2021.116237_bb0115","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0022-3476(73)80162-3","article-title":"Beta glucuronidase deficiency: report of clinical, radiologic, and biochemical features of a new mucopolysaccharidosis","volume":"82","author":"Sly","year":"1973","journal-title":"J. Pediatr."},{"key":"10.1016\/j.bone.2021.116237_bb0120","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.ymgme.2021.06.005","article-title":"Progression of vertebral bone disease in mucopolysaccharidosis VII dogs from birth to skeletal maturity","volume":"133","author":"Peck","year":"2021","journal-title":"Mol. Genet. Metab."},{"issue":"3","key":"10.1016\/j.bone.2021.116237_bb0125","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ymgme.2015.09.008","article-title":"Delayed hypertrophic differentiation of epiphyseal chondrocytes contributes to failed secondary ossification in mucopolysaccharidosis VII dogs","volume":"116","author":"Peck","year":"2015","journal-title":"Mol. Genet. Metab."},{"issue":"5","key":"10.1016\/j.bone.2021.116237_bb0130","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/jor.21030","article-title":"Altered lumbar spine structure, biochemistry, and biomechanical properties in a canine model of mucopolysaccharidosis type VII","volume":"28","author":"Smith","year":"2010","journal-title":"J. Orthop. Res."},{"issue":"2","key":"10.1016\/j.bone.2021.116237_bb0135","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.3074","article-title":"WNT signaling in bone homeostasis and disease: from human mutations to treatments","volume":"19","author":"Baron","year":"2013","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.bone.2021.116237_bb0140","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nrm1681","article-title":"Heparan sulphate proteoglycans: the sweet side of development","volume":"6","author":"Hacker","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.bone.2021.116237_bb0145","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1083\/jcb.200212083","article-title":"QSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote wnt signaling","volume":"162","author":"Ai","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bone.2021.116237_bb0150","series-title":"Lithium Prescribing Information","author":"U.S. Food and Drug Administration","year":"2018"},{"issue":"48","key":"10.1016\/j.bone.2021.116237_bb0155","doi-asserted-by":"crossref","first-page":"17406","DOI":"10.1073\/pnas.0505259102","article-title":"Lrp5-independent activation of wnt signaling by lithium chloride increases bone formation and bone mass in mice","volume":"102","author":"Clement-Lacroix","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.bone.2021.116237_bb0160","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1177\/0022034510389180","article-title":"Lithium delivery enhances bone growth during midpalatal expansion","volume":"90","author":"Tang","year":"2011","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.bone.2021.116237_bb0165","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jbiomech.2017.09.043","article-title":"Design of experiments confirms optimization of lithium administration parameters for enhanced fracture healing","volume":"66","author":"Vachhani","year":"2018","journal-title":"J. Biomech."},{"issue":"2","key":"10.1016\/j.bone.2021.116237_bb0170","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.bone.2008.10.001","article-title":"Lithium's effect on bone mineral density","volume":"44","author":"Zamani","year":"2009","journal-title":"Bone"},{"issue":"16","key":"10.1016\/j.bone.2021.116237_bb0175","doi-asserted-by":"crossref","first-page":"8455","DOI":"10.1073\/pnas.93.16.8455","article-title":"A molecular mechanism for the effect of lithium on development","volume":"93","author":"Klein","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.bone.2021.116237_bb0180","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0888-7543(05)80182-X","article-title":"Architecture of the canine IDUA gene and mutation underlying canine mucopolysaccharidosis I","volume":"14","author":"Menon","year":"1992","journal-title":"Genomics"},{"issue":"4","key":"10.1016\/j.bone.2021.116237_bb0185","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1111\/j.1471-4159.1985.tb05544.x","article-title":"Neurochemical characterization of canine alpha-L-iduronidase deficiency disease (model of human mucopolysaccharidosis I)","volume":"45","author":"Constantopoulos","year":"1985","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.bone.2021.116237_bb0190","first-page":"487","article-title":"Morphologic and biochemical studies of canine mucopolysaccharidosis I","volume":"114","author":"Shull","year":"1984","journal-title":"Am. J. Pathol."},{"issue":"2","key":"10.1016\/j.bone.2021.116237_bb0195","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/00004424-198802000-00008","article-title":"Radiographic findings in a canine model of mucopolysaccharidosis I. Changes associated with bone marrow transplantation","volume":"23","author":"Shull","year":"1988","journal-title":"Investig. Radiol."},{"issue":"19","key":"10.1016\/j.bone.2021.116237_bb0200","doi-asserted-by":"crossref","first-page":"6091","DOI":"10.1073\/pnas.80.19.6091","article-title":"A canine model of human alpha-L-iduronidase deficiency","volume":"80","author":"Spellacy","year":"1983","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.bone.2021.116237_bb0205","doi-asserted-by":"crossref","first-page":"814","DOI":"10.2460\/javma.1992.200.06.814","article-title":"Use of lithium for treatment of estrogen-induced bone marrow hypoplasia in a dog","volume":"200","author":"Hall","year":"1992","journal-title":"J. Am. Vet. Med. Assoc."},{"issue":"1","key":"10.1016\/j.bone.2021.116237_bb0210","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1365-2885.1986.tb00015.x","article-title":"Pharmacokinetics of lithium in the dog","volume":"9","author":"Rosenthal","year":"1986","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.bone.2021.116237_bb0215","first-page":"1","article-title":"Lithium effects on granulopoiesis and immune function","volume":"127","author":"Rossof","year":"1980","journal-title":"Adv. Exp. Med. Biol."},{"issue":"12 Suppl","key":"10.1016\/j.bone.2021.116237_bb0220","first-page":"1","article-title":"Practice guideline for the treatment of patients with bipolar disorder. American Psychiatric Association","volume":"151","author":"A.P. Association","year":"1994","journal-title":"Am. J. Psychiatry"},{"issue":"22","key":"10.1016\/j.bone.2021.116237_bb0225","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1056\/NEJM198911303212201","article-title":"Comparison of standard and low serum levels of lithium for maintenance treatment of bipolar disorder","volume":"321","author":"Gelenberg","year":"1989","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.bone.2021.116237_bb0230","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ymgme.2015.09.008","article-title":"Delayed hypertrophic differentiation of epiphyseal chondrocytes contributes to failed secondary ossification in mucopolysaccharidosis VII dogs","volume":"116","author":"Peck","year":"2015","journal-title":"Mol. Genet. Metab."},{"issue":"2","key":"10.1016\/j.bone.2021.116237_bb0235","doi-asserted-by":"crossref","DOI":"10.3390\/cells10020255","article-title":"Lithium and therapeutic targeting of GSK-3","volume":"10","author":"Snitow","year":"2021","journal-title":"Cells"},{"issue":"21","key":"10.1016\/j.bone.2021.116237_bb0240","doi-asserted-by":"crossref","first-page":"pp","DOI":"10.14814\/phy2.13010","article-title":"Inhibition of GSK-3beta increases trabecular bone volume but not cortical bone volume in adenine-induced uremic mice with severe hyperparathyroidism","volume":"4","author":"Tatsumoto","year":"2016","journal-title":"Physiol. Rep."},{"issue":"11","key":"10.1016\/j.bone.2021.116237_bb0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081399","article-title":"Inhibition of GSK-3beta rescues the impairments in bone formation and mechanical properties associated with fracture healing in osteoblast selective connexin 43 deficient mice","volume":"8","author":"Loiselle","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bone.2021.116237_bb0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00223-004-0258-y","article-title":"Reduced relative risk of fractures among users of lithium","volume":"77","author":"Vestergaard","year":"2005","journal-title":"Calcif. Tissue Int."},{"issue":"1","key":"10.1016\/j.bone.2021.116237_bb0255","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/jcp.20656","article-title":"Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor","volume":"208","author":"Dong","year":"2006","journal-title":"J. Cell. Physiol."},{"issue":"5","key":"10.1016\/j.bone.2021.116237_bb0260","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/iep.12033","article-title":"Characterization of joint disease in mucopolysaccharidosis type I mice","volume":"94","author":"de Oliveira","year":"2013","journal-title":"Int. J. Exp. Pathol."},{"issue":"1","key":"10.1016\/j.bone.2021.116237_bb0265","doi-asserted-by":"crossref","first-page":"112","DOI":"10.2353\/ajpath.2008.070564","article-title":"Mechanism of glycosaminoglycan-mediated bone and joint disease: implications for the mucopolysaccharidoses and other connective tissue diseases","volume":"172","author":"Simonaro","year":"2008","journal-title":"Am. J. Pathol."},{"issue":"3","key":"10.1016\/j.bone.2021.116237_bb0270","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ymgme.2021.05.009","article-title":"Ultrasound findings of finger, wrist and knee joints in mucopolysaccharidosis type I","volume":"133","author":"Roth","year":"2021","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.bone.2021.116237_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115729","article-title":"Hip disease in mucopolysaccharidoses and mucolipidoses: a review of mechanisms, interventions and future perspectives","volume":"143","author":"Oussoren","year":"2021","journal-title":"Bone"},{"issue":"11","key":"10.1016\/j.bone.2021.116237_bb0280","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1093\/rheumatology\/keq217","article-title":"Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway","volume":"49","author":"Hui","year":"2010","journal-title":"Rheumatology (Oxford)"},{"issue":"5","key":"10.1016\/j.bone.2021.116237_bb0285","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1002\/art.38373","article-title":"Lithium protects against cartilage degradation in osteoarthritis","volume":"66","author":"Minashima","year":"2014","journal-title":"Arthritis Rheumatol."},{"issue":"10","key":"10.1016\/j.bone.2021.116237_bb0290","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1002\/jor.22913","article-title":"Lithium chloride prevents interleukin-1beta induced cartilage degradation and loss of mechanical properties","volume":"33","author":"Thompson","year":"2015","journal-title":"J. Orthop. Res."},{"issue":"6","key":"10.1016\/j.bone.2021.116237_bb0295","first-page":"742","article-title":"The use of lithium carbonate in the treatment of mood disorders","volume":"108","author":"Brown","year":"1973","journal-title":"Can. Med. Assoc. J."},{"issue":"6","key":"10.1016\/j.bone.2021.116237_bb0300","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/00004714-198712000-00005","article-title":"Lithium carbonate in the treatment of two patients with infantile autism and atypical bipolar symptomatology","volume":"7","author":"Kerbeshian","year":"1987","journal-title":"J. Clin. Psychopharmacol."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328221004038?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328221004038?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T14:15:00Z","timestamp":1778940900000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328221004038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":60,"alternative-id":["S8756328221004038"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2021.116237","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of lithium administration on vertebral bone disease in mucopolysaccharidosis I dogs","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2021.116237","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116237"}}