{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:44:02Z","timestamp":1792424642290,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000738","name":"Department of Veterans Affairs","doi-asserted-by":"publisher","award":["BX003025"],"award-info":[{"award-number":["BX003025"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005625","name":"RSNA Research and Education Foundation","doi-asserted-by":"publisher","award":["075717-00002B"],"award-info":[{"award-number":["075717-00002B"]}],"id":[{"id":"10.13039\/100005625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.bone.2022.116340","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T03:44:28Z","timestamp":1642995868000},"page":"116340","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Cortical porosity development and progression is mitigated after etelcalcetide treatment in an animal model of chronic kidney disease"],"prefix":"10.1016","volume":"157","author":[{"given":"Elizabeth A.","family":"Swallow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne E.","family":"Metzger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Newman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal X.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon M.","family":"Moe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bone.2022.116340_bb0005","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1046\/j.1523-1755.2000.00178.x","article-title":"Increased risk of hip fracture among patients with end-stage renal disease","volume":"58","author":"Alem","year":"2000","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.bone.2022.116340_bb0010","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/ki.2013.279","article-title":"High rates of death and hospitalization follow bone fracture among hemodialysis patients","volume":"85","author":"Tentori","year":"2014","journal-title":"Kidney Int."},{"issue":"10","key":"10.1016\/j.bone.2022.116340_bb0015","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1002\/jbmr.2862","article-title":"Hip fracture in patients with non-dialysis-requiring chronic kidney disease","volume":"31","author":"Kim","year":"2016","journal-title":"J. Bone Miner. Res."},{"issue":"6","key":"10.1016\/j.bone.2022.116340_bb0020","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1053\/ajkd.2000.19812","article-title":"Increased incidence of hip fractures in dialysis patients with low serum parathyroid hormone","volume":"36","author":"Coco","year":"2000","journal-title":"Am. J. Kidney Dis."},{"issue":"7","key":"10.1016\/j.bone.2022.116340_bb0025","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2018.4412","article-title":"Changes in the US burden of chronic kidney disease from 2002 to 2016: an analysis of the global burden of disease study","volume":"1","author":"Bowe","year":"2018","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.bone.2022.116340_bb0030","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.2215\/CJN.09500916","article-title":"Fractures in patients with CKD: time for action","volume":"11","author":"Moe","year":"2016","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bone.2022.116340_bb0035","series-title":"Chronic Kidney Disease in the United States, 2021","year":"2021"},{"issue":"8","key":"10.1016\/j.bone.2022.116340_bb0040","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1002\/jbmr.1916","article-title":"Rapid cortical bone loss in patients with chronic kidney disease","volume":"28","author":"Nickolas","year":"2013","journal-title":"J. Bone Miner. Res."},{"issue":"8","key":"10.1016\/j.bone.2022.116340_bb0045","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1359\/jbmr.1998.13.8.1213","article-title":"A structural approach to renal bone disease","volume":"13","author":"Parfitt","year":"1998","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2022.116340_bb0050","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0021-9290(88)90186-8","article-title":"Stiffness of compact bone: effects of porosity and density","volume":"21","author":"Schaffler","year":"1988","journal-title":"J. Biomech."},{"key":"10.1016\/j.bone.2022.116340_bb0055","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s001980200000","article-title":"Biomechanics of bone: determinants of skeletal fragility and bone quality","volume":"13","author":"Turner","year":"2002","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2022.116340_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115632","article-title":"Reversing cortical porosity: Cortical pore infilling in preclinical models of chronic kidney disease","volume":"143","author":"Metzger","year":"2021","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.bone.2022.116340_bb0065","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/jbmr.2372","article-title":"Anti-sclerostin antibody treatment in a rat model of progressive renal osteodystrophy","volume":"30","author":"Moe","year":"2015","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.bone.2022.116340_bb0070","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1002\/jbmr.2089","article-title":"A comparison of calcium to zoledronic acid for improvement of cortical bone in an animal model of CKD","volume":"29","author":"Moe","year":"2014","journal-title":"J. Bone Miner. Res."},{"issue":"6","key":"10.1016\/j.bone.2022.116340_bb0075","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s00223-017-0319-7","article-title":"Etelcalcetide, a novel calcimimetic, prevents vascular calcification in a rat model of renal insufficiency with secondary hyperparathyroidism","volume":"101","author":"Yu","year":"2017","journal-title":"Calcif. Tissue Int."},{"issue":"2","key":"10.1016\/j.bone.2022.116340_bb0080","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1001\/jama.2016.19468","article-title":"Effect of etelcalcetide vs cinacalcet on serum parathyroid hormone in patients receiving hemodialysis with secondary hyperparathyroidism: a randomized clinical trial","volume":"317","author":"Block","year":"2017","journal-title":"JAMA - J. Am. Med. Assoc."},{"issue":"2","key":"10.1016\/j.bone.2022.116340_bb0085","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1001\/jama.2016.19456","article-title":"Effect of etelcalcetide vs placebo on serum parathyroid hormone in patients receiving hemodialysis with secondary hyperparathyroidism: two randomized clinical trials","volume":"317","author":"Block","year":"2017","journal-title":"JAMA - J. Am. Med. Assoc."},{"issue":"April","key":"10.1016\/j.bone.2022.116340_bb0090","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.bone.2019.05.002","article-title":"Time course of rapid bone loss and cortical porosity formation observed by longitudinal \u03bc CT in a rat model of CKD","volume":"125","author":"Mcnerny","year":"2019","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.bone.2022.116340_bb0095","first-page":"176","article-title":"A rat model of chronic kidney disease-mineral bone disorder (CKD-MBD) and the effect of dietary protein source","volume":"75","author":"Moe","year":"2009","journal-title":"Vascular"},{"issue":"2","key":"10.1016\/j.bone.2022.116340_bb0100","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/ki.2008.456","article-title":"A rat model of chronic kidney disease-mineral bone disorder (CKD-MBD) and the effect of dietary protein source","volume":"75","author":"Moe","year":"2009","journal-title":"Kidney Int."},{"issue":"7","key":"10.1016\/j.bone.2022.116340_bb0105","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro-computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.bone.2022.116340_bb0110","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/8756-3282(93)90081-K","article-title":"Basic biomechanical measurements of bone: a tutorial","volume":"14","author":"Turner","year":"1993","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.bone.2022.116340_bb0115","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1159\/000489671","article-title":"Deterioration of cortical bone microarchitecture: critical component of renal osteodystrophy evaluation","volume":"47","author":"Sharma","year":"2018","journal-title":"Am. J. Nephrol."},{"issue":"4 April","key":"10.1016\/j.bone.2022.116340_bb0120","first-page":"1","article-title":"Adenine-induced chronic kidney disease induces a similar skeletal phenotype in male and female C57BL\/6 mice with more severe deficits in cortical bone properties of male mice","volume":"16","author":"Metzger","year":"2021","journal-title":"PLoS One"},{"issue":"April","key":"10.1016\/j.bone.2022.116340_bb0125","article-title":"Strain-specific alterations in the skeletal response to adenine-induced chronic kidney disease are associated with differences in parathyroid hormone levels","volume":"148","author":"Metzger","year":"2021","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.bone.2022.116340_bb0130","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1124\/jpet.103.057273","article-title":"Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl","volume":"308","author":"Nemeth","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"4","key":"10.1016\/j.bone.2022.116340_bb0135","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1210\/jc.2012-4003","article-title":"Pharmacodynamics of cinacalcet over 48 hours in patients with controlled secondary hyperparathyroidism: useful data in clinical practice","volume":"98","author":"Arenas","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.bone.2022.116340_bb0140","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.kint.2017.04.006","article-title":"Executive summary of the 2017 KDIGO chronic kidney disease-mineral and bone disorder (CKD-MBD) guideline update: what\u2019s changed and why it matters","volume":"92","author":"Ketteler","year":"2017","journal-title":"Kidney Int."},{"issue":"5","key":"10.1016\/j.bone.2022.116340_bb0145","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s11914-016-0319-y","article-title":"Cortical bone porosity: what is it, why is it important, and how can we detect It?","volume":"14","author":"Cooper","year":"2016","journal-title":"Curr. Osteoporos. Rep."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328222000163?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328222000163?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:59:21Z","timestamp":1757613561000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328222000163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":29,"alternative-id":["S8756328222000163"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2022.116340","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cortical porosity development and progression is mitigated after etelcalcetide treatment in an animal model of chronic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2022.116340","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116340"}}