{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:13:14Z","timestamp":1793643194324,"version":"4.5.1"},"reference-count":112,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.bone.2022.116467","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T14:10:30Z","timestamp":1654611030000},"page":"116467","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"special_numbering":"C","title":["Creatine supplementation for older adults: Focus on sarcopenia, osteoporosis, frailty and Cachexia"],"prefix":"10.1016","volume":"162","author":[{"given":"Darren G.","family":"Candow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip D.","family":"Chilibeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott C.","family":"Forbes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciaran M.","family":"Fairman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Gualano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamilton","family":"Roschel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2022.116467_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nu13030745","article-title":"Current evidence and possible future applications of creatine supplementation for older adults","volume":"13","author":"Candow","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.bone.2022.116467_bb0010","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1016\/S0140-6736(19)31138-9","article-title":"Sarcopenia","volume":"393","author":"Cruz-Jentoft","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.bone.2022.116467_bb0015","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1152\/physrev.00061.2017","article-title":"Sarcopenia: aging-related loss of muscle mass and function","volume":"99","author":"Larsson","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bone.2022.116467_bb0020","first-page":"192","article-title":"Prevalence of sarcopenia and its association with quality of life, postural stability, and past incidence of falls in postmenopausal women with osteoporosis: a cross-sectional study","volume":"10","author":"Okayama","year":"2022","journal-title":"Healthc. (Basel, Switzerland)"},{"key":"10.1016\/j.bone.2022.116467_bb0030","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3390\/jcm8040488","article-title":"Effectiveness of creatine supplementation on aging muscle and bone: focus on falls prevention and inflammation","volume":"8","author":"Candow","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.bone.2022.116467_bb0035","doi-asserted-by":"crossref","first-page":"226","DOI":"10.2147\/OAJSM.S123529","article-title":"Effect of creatine supplementation during resistance training on lean tissue mass and muscular strength in older adults: a meta-analysis","volume":"8","author":"Chilibeck","year":"2017","journal-title":"Open Access J. Sport. Med."},{"key":"10.1016\/j.bone.2022.116467_bb0040","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1249\/MSS.0000000000000220","article-title":"Creatine supplementation during resistance training in older adults-a meta-analysis","volume":"46","author":"Devries","year":"2014","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.bone.2022.116467_bb0045","series-title":"Meta-analysis Examining the Importance of Creatine Ingestion Strategies on Lean Tissue Mass and Strength in Older Adults","author":"Forbes","year":"2021"},{"key":"10.1016\/j.bone.2022.116467_bb0050","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.3390\/nu13113757","article-title":"Efficacy of creatine supplementation combined with resistance training on muscle strength and muscle mass in older females: a systematic review and meta-analysis","volume":"13","author":"Dos Santos","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.bone.2022.116467_bb0055","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1177\/0260106020975247","article-title":"Effect of 12 months of creatine supplementation and whole-body resistance training on measures of bone, muscle and strength in older males","volume":"27","author":"Candow","year":"2021","journal-title":"Nutr. Health"},{"key":"10.1016\/j.bone.2022.116467_bb0060","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1249\/MSS.0000000000002722","article-title":"Efficacy of creatine supplementation and resistance training on area and density of bone and muscle in older adults","volume":"53","author":"Candow","year":"2021","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.bone.2022.116467_bb0065","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1249\/MSS.0000000000000571","article-title":"Effects of creatine and resistance training on bone health in postmenopausal women","volume":"47","author":"Chilibeck","year":"2015","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.bone.2022.116467_bb0070","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1249\/MSS.0b013e318176b310","article-title":"Low-dose creatine combined with protein during resistance training in older men","volume":"40","author":"Candow","year":"2008","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.bone.2022.116467_bb0075","doi-asserted-by":"crossref","first-page":"846","DOI":"10.4103\/2230-8210.192914","article-title":"Bone turnover markers: emerging tool in the management of osteoporosis","volume":"20","author":"Shetty","year":"2016","journal-title":"Indian J. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2022.116467_bb0080","first-page":"1148","article-title":"International clinical practice guidelines for sarcopenia (ICFSR): screening, diagnosis and management","volume":"22","author":"Dent","year":"2018","journal-title":"J. Nutr. HealthAging"},{"key":"10.1016\/j.bone.2022.116467_bb0085","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s12020-013-0070-4","article-title":"Creatine supplementation and aging musculoskeletal health","volume":"45","author":"Candow","year":"2014","journal-title":"Endocrine"},{"key":"10.1016\/j.bone.2022.116467_bb0090","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1007\/s00726-016-2239-7","article-title":"Creatine supplementation in the aging population: effects on skeletal muscle, bone and brain","volume":"48","author":"Gualano","year":"2016","journal-title":"Amino Acids"},{"key":"10.1016\/j.bone.2022.116467_bb0095","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1519\/JSC.0000000000003230","article-title":"Resistance training for older adults: position statement from the National Strength and conditioning association","volume":"33","author":"Fragala","year":"2019","journal-title":"J. Strength Cond. Res."},{"key":"10.1016\/j.bone.2022.116467_bb0100","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1113\/jphysiol.2012.228833","article-title":"Supplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in men","volume":"590","author":"Churchward-Venne","year":"2012","journal-title":"J. Physiol."},{"key":"10.1016\/j.bone.2022.116467_bb0105","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s12603-009-0124-8","article-title":"The effects of supplementation with creatine and protein on muscle strength following a traditional resistance training program in middle-aged and older men","volume":"14","author":"Bemben","year":"2010","journal-title":"J. Nutr. Health Aging"},{"issue":"12","key":"10.1016\/j.bone.2022.116467_bb0110","first-page":"208","article-title":"The effects of creatine and whey protein supplementation on body composition in men aged 48 to 72 years during resistance training","volume":"123","author":"Eliot","year":"2008","journal-title":"J. Nutr. HealAging"},{"key":"10.1016\/j.bone.2022.116467_bb0115","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s00421-014-2821-1","article-title":"Periodized resistance training with and without supplementation improve body composition and performance in older men","volume":"114","author":"Villanueva","year":"2014","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.bone.2022.116467_bb0120","first-page":"126","article-title":"Resistance training and co-supplementation with creatine and protein in older subjects with frailty","volume":"5","author":"Collins","year":"2016","journal-title":"J. Frailty Aging."},{"key":"10.1016\/j.bone.2022.116467_bb0125","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1249\/01.mss.0000183860.42853.15","article-title":"The effects of conjugated linoleic acid supplementation during resistance training","volume":"38","author":"Pinkoski","year":"2006","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.bone.2022.116467_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0000991","article-title":"Creatine monohydrate and conjugated linoleic acid improve strength and body composition following resistance exercise in older adults","volume":"2","author":"Tarnopolsky","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2022.116467_bb0135","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00421-007-0580-y","article-title":"Creatine supplementation improves muscular performance in older women","volume":"102","author":"Gotshalk","year":"2007","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.bone.2022.116467_bb0140","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1097\/00005768-200203000-00023","article-title":"Creatine supplementation improves muscular performance in older men","volume":"34","author":"Gotshalk","year":"2002","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.bone.2022.116467_bb0145","first-page":"459","article-title":"Effects of creatine supplementation on the onset of neuromuscular fatigue threshold and muscle strength in elderly men and women (64 - 86 years)","volume":"11","author":"Stout","year":"2007","journal-title":"J. Nutr. Health Aging"},{"key":"10.1016\/j.bone.2022.116467_bb0150","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s004210050570","article-title":"Effects of 30 days of creatine ingestion in older men","volume":"80","author":"Rawson","year":"1999","journal-title":"Eur. J. Appl. Physiol. Occup. Physiol."},{"key":"10.1016\/j.bone.2022.116467_bb0155","first-page":"22","article-title":"Does creatine supplementation improve functional capacity in elderly women?","volume":"20","author":"Ca\u00f1ete","year":"2006","journal-title":"J. Strength Cond. Res."},{"key":"10.1016\/j.bone.2022.116467_bb0160","article-title":"Effects of creatine supplementation on properties of muscle, bone, and brain function in older adults: a narrative review","author":"Forbes","year":"2021","journal-title":"J. Diet. Suppl."},{"key":"10.1016\/j.bone.2022.116467_bb0165","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1042\/cs0830367","article-title":"Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation","volume":"83","author":"Harris","year":"1992","journal-title":"Clin. Sci."},{"key":"10.1016\/j.bone.2022.116467_bb0170","author":"Brose"},{"key":"10.1016\/j.bone.2022.116467_bb0175","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s12603-018-1148-8","article-title":"Effect of creatine supplementation dosing strategies on aging muscle performance","volume":"23","author":"Chami","year":"2019","journal-title":"J. Nutr. Health Aging"},{"key":"10.1016\/j.bone.2022.116467_bb0180","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.exger.2015.07.012","article-title":"Effects of long-term low-dose dietary creatine supplementation in older women","volume":"70","author":"Lobo","year":"2015","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.bone.2022.116467_bb0185","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1093\/gerona\/glz162","article-title":"Creatine supplementation (3 g\/d) and bone health in older women: a 2-year, randomized, placebo-controlled trial","volume":"75","author":"Sales","year":"2020","journal-title":"J. Gerontol. Ser. A"},{"key":"10.1016\/j.bone.2022.116467_bb0190","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1519\/JSC.0000000000001254","article-title":"Effect of preexercise creatine ingestion on muscle performance in healthy aging males","volume":"30","author":"Baker","year":"2016","journal-title":"J. Strength Cond. Res."},{"key":"10.1016\/j.bone.2022.116467_bb0195","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1111\/jgs.17043","article-title":"The prevention of osteoporosis and sarcopenia in older adults","volume":"69","author":"Coll","year":"2021","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.bone.2022.116467_bb0200","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/BF01267955","article-title":"Creatine kinase in non-muscle tissues and cells","volume":"133\u2013134","author":"Wallimann","year":"1994","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bone.2022.116467_bb0205","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1016\/S0021-9258(17)42172-7","article-title":"Transcriptional and posttranscriptional mechanisms modulate creatine kinase expression during differentiation of osteoblastic cells","volume":"269","author":"Ch\u2019ng","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2022.116467_bb0210","first-page":"129","article-title":"Enzyme histochemistry and its application in comparative studies of adenosinetriphosphatase (ATPase) and some oxidative enzymes in bone, cartilage and tooth germs","volume":"21","author":"Heyden","year":"1970","journal-title":"Odontol. Revy."},{"key":"10.1016\/j.bone.2022.116467_bb0215","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1677\/joe.0.1430251","article-title":"Stimulation by insulin-like growth factor-I of creatine kinase activity in skeletal-derived cells and tissues of male and female rats","volume":"143","author":"Somjen","year":"1994","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bone.2022.116467_bb0220","doi-asserted-by":"crossref","first-page":"8","DOI":"10.22203\/eCM.v010a02","article-title":"Stimulatory effects of creatine on metabolic activity, differentiation and mineralization of primary osteoblast-like cells in monolayer and micromass cell cultures","volume":"10","author":"Gerber","year":"2005","journal-title":"Eur. Cell. Mater."},{"key":"10.1016\/j.bone.2022.116467_bb0225","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s10103-011-0976-0","article-title":"Influence of creatine supplementation on bone quality in the ovariectomized rat model: an FT-Raman spectroscopy study","volume":"27","author":"De Souza","year":"2012","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.bone.2022.116467_bb0230","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1155\/2011\/212038","article-title":"Effect of different doses of creatine on the bone in thirty days of supplementation in mice: FT-Raman study","volume":"25","author":"Miranda","year":"2011","journal-title":"Spectroscopy"},{"key":"10.1016\/j.bone.2022.116467_bb0235","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1249\/mss.0b013e318031fac4","article-title":"Creatine monohydrate increases bone mineral density in young Sprague-dawley rats","volume":"39","author":"Antolic","year":"2007","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.bone.2022.116467_bb0240","first-page":"453","article-title":"Influence of creatine supplementation on bone mass of spontaneously hypertensive rats","volume":"52","author":"Alves","year":"2012","journal-title":"Rev. Bras. Reumatol."},{"key":"10.1016\/j.bone.2022.116467_bb0245","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1007\/s00198-014-3017-6","article-title":"Exercise training, creatine supplementation, and bone health in ovariectomized rats","volume":"26","author":"Murai","year":"2015","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2022.116467_bb0250","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/BF02553711","article-title":"Regulation of bone mass by mechanical strain magnitude","volume":"37","author":"Rubin","year":"1985","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2022.116467_bb0255","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1210\/endo.139.3.5837","article-title":"Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG\/OCIF inhibits osteoclastogenesis in vitro","volume":"139","author":"Yasuda","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2022.116467_bb0260","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/mus.10355","article-title":"Beneficial effects of creatine supplementation in dystrophic patients","volume":"27","author":"Louis","year":"2003","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.bone.2022.116467_bb0265","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1212\/01.WNL.0000125178.18862.9D","article-title":"Creatine monohydrate enhances strength and body composition in Duchenne muscular dystrophy","volume":"62","author":"Tarnopolsky","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.bone.2022.116467_bb0270","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1123\/ijsnem.19.1.79","article-title":"Conjugated linoleic acid combined with creatine monohydrate and whey protein supplementation during strength training","volume":"19","author":"Cornish","year":"2009","journal-title":"Int. J. Sport Nutr. Exerc. Metab."},{"key":"10.1016\/j.bone.2022.116467_bb0275","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.exger.2014.02.003","article-title":"Creatine supplementation and resistance training in vulnerable older women: a randomized double-blind placebo-controlled clinical trial","volume":"53","author":"Gualano","year":"2014","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.bone.2022.116467_bb0280","first-page":"352","article-title":"Creatine monohydrate and resistance training increase bone mineral content and density in older men","volume":"9","author":"Chilibeck","year":"2005","journal-title":"J. Nutr. Health Aging"},{"key":"10.1016\/j.bone.2022.116467_bb0285","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/jcsm.12094","article-title":"Impact of creatine supplementation in combination with resistance training on lean mass in the elderly","volume":"7","author":"Pinto","year":"2016","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.bone.2022.116467_bb0290","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2018.00027","article-title":"Creatine supplementation during resistance training does not lead to greater bone mineral density in older humans: a brief meta-analysis","volume":"5","author":"Forbes","year":"2018","journal-title":"Front. Nutr."},{"key":"10.1016\/j.bone.2022.116467_bb0295","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.exger.2019.01.025","article-title":"Effect of pre-exercise and post-exercise creatine supplementation on bone mineral content and density in healthy aging adults","volume":"119","author":"Candow","year":"2019","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.bone.2022.116467_bb0300","doi-asserted-by":"crossref","first-page":"4849","DOI":"10.1016\/j.clnu.2021.06.024","article-title":"Supplement-based nutritional strategies to tackle frailty: a multifactorial, double-blind, randomized placebo-controlled trial","volume":"40","author":"Roschel","year":"2021","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.bone.2022.116467_bb0305","article-title":"A high dose of creatine combined with resistance training appears to be required to augment indices of bone health in older adults","author":"Forbes","year":"2021","journal-title":"Ann. Nutr. Metab."},{"key":"10.1016\/j.bone.2022.116467_bb0310","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s00198-009-1056-1","article-title":"Hip structural geometry and incidence of hip fracture in postmenopausal women: what does it add to conventional bone mineral density?","volume":"21","author":"LaCroix","year":"2010","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2022.116467_bb0315","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1249\/MSS.0000000000002722","article-title":"Efficacy of creatine supplementation and resistance training on area and density of bone and muscle in older adults","volume":"53","author":"Candow","year":"2021","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.bone.2022.116467_bb0320","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.nutres.2008.01.001","article-title":"Long-term creatine supplementation is safe in aged patients with parkinson disease","volume":"28","author":"Bender","year":"2008","journal-title":"Nutr. Res."},{"key":"10.1016\/j.bone.2022.116467_bb0325","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1123\/japa.2016-0132","article-title":"Differences in function and fracture risk in postmenopausal women with and without a recent distal radius fracture","volume":"26","author":"Crockett","year":"2018","journal-title":"J. Aging Phys. Act."},{"key":"10.1016\/j.bone.2022.116467_bb0330","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2519\/jospt.1992.16.3.123","article-title":"Physical performance measures that predict faller status in community-dwelling older adults","volume":"16","author":"MacRae","year":"1992","journal-title":"J. Orthop. Sports Phys. Ther."},{"key":"10.1016\/j.bone.2022.116467_bb0335","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1007\/s00198-016-3514-x","article-title":"Lower leg muscle density is independently associated with fall status in community-dwelling older adults","volume":"27","author":"Frank-Wilson","year":"2016","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2022.116467_bb0340","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jgo.2016.06.003","article-title":"How should older adults with cancer be evaluated for frailty?","volume":"8","author":"Huisingh-Scheetz","year":"2017","journal-title":"J. Geriatr. Oncol."},{"key":"10.1016\/j.bone.2022.116467_bb0345","doi-asserted-by":"crossref","first-page":"9","DOI":"10.14283\/jfa.2019.33","article-title":"Clinically meaningful change for physical performance: perspectives of the ICFSR task force","volume":"9","author":"Guralnik","year":"2020","journal-title":"J. Frailty Aging"},{"key":"10.1016\/j.bone.2022.116467_bb0350","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s12603-012-0084-2","article-title":"A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged african americans","volume":"16","author":"Morley","year":"2012","journal-title":"J. Nutr. Health Aging"},{"key":"10.1016\/j.bone.2022.116467_bb0355","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.8398","article-title":"Global incidence of frailty and prefrailty among community-dwelling older adults: a systematic review and meta-analysis","volume":"2","author":"Ofori-Asenso","year":"2019","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.bone.2022.116467_bb0360","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-3-030-33330-0_3","article-title":"Epidemiology of frailty in older people","volume":"1216","author":"Rohrmann","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bone.2022.116467_bb0365","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cger.2010.08.001","article-title":"Exercise as an intervention for frailty","volume":"27","author":"Liu","year":"2011","journal-title":"Clin. Geriatr. Med."},{"key":"10.1016\/j.bone.2022.116467_bb0370","doi-asserted-by":"crossref","first-page":"93","DOI":"10.11124\/JBISRIR-2016-003081","article-title":"Effectiveness of exercise interventions on physical function in community-dwelling frail older people: an umbrella review protocol","volume":"14","author":"Jadczak","year":"2016","journal-title":"JBI Database Syst. Rev. Implement. Rep."},{"key":"10.1016\/j.bone.2022.116467_bb0375","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.exger.2018.04.013","article-title":"Effects of creatine supplementation on cognitive function of healthy individuals: a systematic review of randomized controlled trials","volume":"108","author":"Avgerinos","year":"2018","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.bone.2022.116467_bb0380","article-title":"Creatine supplementation on cognitive performance following creatine supplementation on cognitive performance following exercise in female muay thai athletes exercise in female muay thai athletes","volume":"1","author":"Pires","year":"2020","journal-title":"J. Soc. NeuroSports"},{"key":"10.1016\/j.bone.2022.116467_bb0385","doi-asserted-by":"crossref","first-page":"921","DOI":"10.3390\/nu14050921","article-title":"Effects of creatine supplementation on brain function and health","volume":"14","author":"Forbes","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.bone.2022.116467_bb0390","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/sj.bjp.0705316","article-title":"Anti-inflammatory activity of creatine supplementation in endothelial cells in vitro","volume":"139","author":"Nomura","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bone.2022.116467_bb0395","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.intimp.2015.12.034","article-title":"Beyond muscles: the untapped potential of creatine","volume":"37","author":"Riesberg","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bone.2022.116467_bb0400","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4251\/wjgo.v7.i4.17","article-title":"Cancer cachexia, mechanism and treatment","volume":"7","author":"Aoyagi","year":"2015","journal-title":"worldJ Gastrointest. Oncol."},{"key":"10.1016\/j.bone.2022.116467_bb0405","article-title":"Cancer-associated cachexia","volume":"4","author":"Baracos","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.bone.2022.116467_bb0410","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1177\/1758834017698643","article-title":"Cancer-induced muscle wasting: latest findings in prevention and treatment","volume":"9","author":"Aversa","year":"2017","journal-title":"Ther. Adv. Med. Oncol."},{"key":"10.1016\/j.bone.2022.116467_bb0415","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s13539-012-0087-1","article-title":"Cancer cachexia: impact, mechanisms and emerging treatments","volume":"4","author":"Vaughan","year":"2013","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.bone.2022.116467_bb0420","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1093\/ajcn\/83.4.735","article-title":"Cachexia: pathophysiology and clinical relevance","volume":"83","author":"Morley","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bone.2022.116467_bb0425","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/jcsm.12421","article-title":"Kidney cachexia or protein-energy wasting in chronic kidney disease: facts and numbers","volume":"10","author":"Koppe","year":"2019","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.bone.2022.116467_bb0430","first-page":"489","article-title":"Definition and classification of cancer cachexia: an international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"LancetOncologia"},{"key":"10.1016\/j.bone.2022.116467_bb0435","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1093\/annonc\/mdu086","article-title":"Validation of the consensus-definition for cancer cachexia and evaluation of a classification model--a study based on data from an international multicentre project (EPCRC-CSA)","volume":"25","author":"Blum","year":"2014","journal-title":"Ann. Oncol. Off. J. Eur. Soc. Med. Oncol."},{"key":"10.1016\/j.bone.2022.116467_bb0440","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/SPC.0000000000000301","article-title":"Research priorities in cancer cachexia: the University of Rochester Cancer Center NCI Community Oncology Research Program Research Base Symposium on cancer cachexia and sarcopenia","volume":"11","author":"Dunne","year":"2017","journal-title":"Curr. Opin. Support. Palliat. Care"},{"key":"10.1016\/j.bone.2022.116467_bb0445","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0083618","article-title":"Clinical classification of cancer cachexia: phenotypic correlates in human skeletal muscle","volume":"9","author":"Johns","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2022.116467_bb0450","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1093\/annonc\/mdx232","article-title":"A double-blind, placebo-controlled randomized trial of creatine for the cancer anorexia\/weight loss syndrome (N02C4): an alliance trial","volume":"28","author":"Jatoi","year":"2017","journal-title":"Ann. Oncol. Off. J. Eur. Soc. Med. Oncol."},{"key":"10.1016\/j.bone.2022.116467_bb0455","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.clnu.2006.01.014","article-title":"Effects of creatine supplementation on nutritional status, muscle function and quality of life in patients with colorectal cancer\u2013a double blind randomised controlled trial","volume":"25","author":"Norman","year":"2006","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.bone.2022.116467_bb0460","first-page":"183","article-title":"Creatine monohydrate attenuates body fat accumulation in children with acute lymphoblastic leukemia during maintenance chemotherapy","volume":"51","author":"Bourgeois","year":"2008","journal-title":"Pediatr. BloodCancer"},{"key":"10.1016\/j.bone.2022.116467_bb0465","doi-asserted-by":"crossref","DOI":"10.1186\/s12970-017-0173-z","article-title":"International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine","volume":"14","author":"Kreider","year":"2017","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"10.1016\/j.bone.2022.116467_bb0470","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.molmed.2018.06.002","article-title":"Exercise training as therapy for cancer-induced cardiac cachexia","volume":"24","author":"Antunes","year":"2018","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bone.2022.116467_bb0475","first-page":"447","article-title":"Nutritional support in multimodal therapy for cancer cachexia","volume":"16","author":"Bosaeus","year":"2008","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.bone.2022.116467_bb0480","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3109\/0284186X.2012.741325","article-title":"Feasibility and efficacy of progressive resistance training and dietary supplements in radiotherapy treated head and neck cancer patients\u2013the DAHANCA 25A study","volume":"52","author":"Lonbro","year":"2013","journal-title":"Acta Oncol."},{"key":"10.1016\/j.bone.2022.116467_bb0485","author":"Coletta"},{"key":"10.1016\/j.bone.2022.116467_bb0490","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-030080","article-title":"Examining the effects of creatine supplementation in augmenting adaptations to resistance training in patients with prostate cancer undergoing androgen deprivation therapy: a randomised, double-blind, placebo-controlled trial","volume":"9","author":"Fairman","year":"2019","journal-title":"BMJ Open"},{"key":"10.1016\/j.bone.2022.116467_bb0495","author":"Patel"},{"key":"10.1016\/j.bone.2022.116467_bb9005","author":"Alves"},{"key":"10.1016\/j.bone.2022.116467_bb9010","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s00421-012-2514-6","article-title":"Long-term creatine supplementation improves muscular performance during resistance training in older women","volume":"113","author":"Aguiar","year":"2013","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.bone.2022.116467_bb9015","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1097\/00005768-200112000-00021","article-title":"Creatine supplementation combined with resistance training in older men","volume":"33","author":"Chrusch","year":"2001","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.bone.2022.116467_bb9020","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1007\/s00421-014-2866-1","article-title":"Creatine supplementation post-exercise does not enhance training-induced adaptations in middle to older aged males","volume":"114","author":"Cooke","year":"2014","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.bone.2022.116467_bb9025","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1164\/rccm.200710-1508OC","article-title":"Randomized controlled trial of dietary creatine as an adjunct therapy to physical training in chronic obstructive pulmonary disease","volume":"178","author":"Deacon","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bone.2022.116467_bb9030","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1152\/japplphysiol.00891.2002","article-title":"Effects of creatine supplementation and exercise training on fitness in men 55\u201375\u202fyr old","volume":"95","author":"Eijnde","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.bone.2022.116467_bb9035","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1249\/MSS.0b013e3181fcee7d","article-title":"Lancha Jr, Creatine in type 2 diabetes: a randomized, double-blind, placebo-controlled trial","volume":"43","author":"Gualano","year":"2011","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.bone.2022.116467_bb9040","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1177\/1545968306293449","article-title":"Resistance training with creatine monohydrate improves upper-body strength in patients with Parkinson disease: a randomized trial","volume":"21","author":"Hass","year":"2007","journal-title":"Neurorehabil. Neural Repair"},{"key":"10.1016\/j.bone.2022.116467_bb9045","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.exger.2016.08.005","article-title":"Effect of creatine supplementation and drop-set resistance training in untrained aging adults","volume":"83","author":"Johannsmeyer","year":"2016","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.bone.2022.116467_bb9050","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1139\/h11-014","article-title":"Effect of creatine supplementation on measured glomerular filtration rate in postmenopausal women","volume":"36","author":"Neves","year":"2011","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"10.1016\/j.bone.2022.116467_bb9055","article-title":"Effect of 16 Weeks of Strength Training and Creatine Supplementation on Strength and Cognition in Older Adults: A Pilot Study","volume":"23","author":"Smolarek","year":"2020","journal-title":"J. Exerc. Physiol."},{"key":"10.1016\/j.bone.2022.116467_bb9070","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1046\/j.1365-201X.1998.00427.x","article-title":"Effects of creatine monohydrate ingestion in sedentary and weight-trained older adults","volume":"164","author":"Bermon","year":"1998","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.bone.2022.116467_bb9075","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1139\/apnm-2019-0066","article-title":"Effects of high-velocity resistance training and creatine supplementation in untrained healthy aging males","volume":"44","author":"Bernat","year":"2019","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"10.1016\/j.bone.2022.116467_bb9080","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1139\/apnm-2014-0498","article-title":"Strategic creatine supplementation and resistance training in healthy older adults","volume":"40","author":"Candow","year":"2015","journal-title":"Appl. Physiol. Nutr. Metab."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328222001442?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328222001442?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T18:01:19Z","timestamp":1757613679000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328222001442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":112,"alternative-id":["S8756328222001442"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2022.116467","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Creatine supplementation for older adults: Focus on sarcopenia, osteoporosis, frailty and Cachexia","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2022.116467","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116467"}}