{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:24:09Z","timestamp":1790630649807,"version":"4.1.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"am","delay-in-days":292,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21-DE028076"],"award-info":[{"award-number":["R21-DE028076"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T35-OD010991"],"award-info":[{"award-number":["T35-OD010991"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013674","name":"College of Veterinary Medicine and Biomedical Sciences, Texas A and M University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013674","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.bone.2022.116471","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T12:57:03Z","timestamp":1655297823000},"page":"116471","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Low bone mass and impaired fracture healing in mouse models of Trisomy21 (Down syndrome)"],"prefix":"10.1016","volume":"162","author":[{"given":"Kirby M.","family":"Sherman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diarra K.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey A.","family":"Welsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis M.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Falck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Huggins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rihana S.","family":"Bokhari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Gaddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent D.","family":"McKelvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay A.","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry J.","family":"Suva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bone.2022.116471_bb0005","first-page":"327","article-title":"El-hajj fuleihan, endocrine and musculoskeletal abnormalities in patients with down syndrome","volume":"5","author":"Hawli","year":"2009","journal-title":"Nat. Rev."},{"key":"10.1016\/j.bone.2022.116471_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2019.115215","article-title":"Skeletal dynamics of down syndrome: a developing perspective","volume":"133","author":"LaCombe","year":"2020","journal-title":"Bone"},{"issue":"24","key":"10.1016\/j.bone.2022.116471_bb0015","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1056\/NEJMra1706537","article-title":"Down syndrome","volume":"382","author":"Bull","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.bone.2022.116471_bb0020","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1034\/j.1399-0004.2002.620506.x","article-title":"The changing survival profile of people with Down's syndrome: implications for genetic counselling","volume":"62","author":"Glasson","year":"2002","journal-title":"Clin. Genet."},{"issue":"12","key":"10.1016\/j.bone.2022.116471_bb0025","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1111\/j.1532-5415.2008.01999.x","article-title":"Survival in elderly persons with down syndrome","volume":"56","author":"Coppus","year":"2008","journal-title":"J. Am. Geriatr. Soc."},{"issue":"1","key":"10.1016\/j.bone.2022.116471_bb0030","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1745-7599.2003.tb00248.x","article-title":"Health maintenance throughout the life span for individuals with down syndrome","volume":"15","author":"Bosch","year":"2003","journal-title":"J. Am. Acad. Nurse Pract."},{"issue":"3","key":"10.1016\/j.bone.2022.116471_bb0035","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s11914-021-00674-y","article-title":"Current analysis of skeletal phenotypes in down syndrome","volume":"19","author":"Thomas","year":"2021","journal-title":"Curr. Osteoporos. Rep."},{"issue":"15","key":"10.1016\/j.bone.2022.116471_bb0040","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1001\/jama.2020.17024","article-title":"Global down Syndrome Foundation medical care guidelines for adults with down syndrome, medical care of adults with Down syndrome: a clinical guideline","volume":"324","author":"Tsou","year":"2020","journal-title":"JAMA"},{"issue":"9311","key":"10.1016\/j.bone.2022.116471_bb0045","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0140-6736(02)08092-3","article-title":"Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study","volume":"359","author":"Yang","year":"2002","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.bone.2022.116471_bb0050","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00198-021-06070-7","article-title":"Changes in bone mineral density in down syndrome individuals: a systematic review and meta-analysis","volume":"33","author":"Zhang","year":"2022","journal-title":"Osteoporos. Int."},{"issue":"4","key":"10.1016\/j.bone.2022.116471_bb0055","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1007\/s00198-012-2109-4","article-title":"Low bone turnover and low bone density in a cohort of adults with down syndrome","volume":"24","author":"McKelvey","year":"2013","journal-title":"Osteoporos. Int."},{"issue":"4","key":"10.1016\/j.bone.2022.116471_bb0060","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1469-8749.2004.tb00483.x","article-title":"Clinical, social, and ethical implications of changing life expectancy in down syndrome","volume":"46","author":"Bittles","year":"2004","journal-title":"Dev. Med. Child Neurol."},{"issue":"1","key":"10.1016\/j.bone.2022.116471_bb0065","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/ddrr.1128","article-title":"Atypical aging in down syndrome","volume":"18","author":"Zigman","year":"2013","journal-title":"Dev. Disabil. Res. Rev."},{"issue":"4","key":"10.1016\/j.bone.2022.116471_bb0070","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.jpeds.2013.06.013","article-title":"Current estimate of down syndrome population prevalence in the United States","volume":"163","author":"Presson","year":"2013","journal-title":"J. Pediatr."},{"issue":"4","key":"10.1016\/j.bone.2022.116471_bb0075","first-page":"203","article-title":"Fracture epidemiology and control in a developmental center","volume":"170","author":"Lohiya","year":"1999","journal-title":"West J. Med."},{"issue":"Pt 4","key":"10.1016\/j.bone.2022.116471_bb0080","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1365-2788.2006.00872.x","article-title":"Prevalence of fractures in women with intellectual disabilities: a chart review","volume":"51","author":"Schrager","year":"2007","journal-title":"J. Intellect. Disabil. Res."},{"issue":"3","key":"10.1016\/j.bone.2022.116471_bb0085","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s11914-014-0221-4","article-title":"Aneuploidy and skeletal health","volume":"12","author":"Kamalakar","year":"2014","journal-title":"Curr. Osteoporos. Rep."},{"issue":"1","key":"10.1016\/j.bone.2022.116471_bb0090","first-page":"5","article-title":"Genetic syndromes in man with potential relevance to the pathobiology of aging","volume":"14","author":"Martin","year":"1978","journal-title":"Birth Defects Orig. Artic Ser."},{"key":"10.1016\/j.bone.2022.116471_bb0095","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.ijcard.2015.11.041","article-title":"Left ventricle diastolic function and cognitive performance in adults with Down syndrome","volume":"203","author":"Vetrano","year":"2016","journal-title":"Int. J. Cardiol."},{"issue":"5696","key":"10.1016\/j.bone.2022.116471_bb0100","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1126\/science.1098992","article-title":"A chromosome 21 critical region does not cause specific Down syndrome phenotypes","volume":"306","author":"Olson","year":"2004","journal-title":"Science (New York, N.Y.)"},{"issue":"10","key":"10.1016\/j.bone.2022.116471_bb0105","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nrg1448","article-title":"Chromosome 21 and down syndrome: from genomics to pathophysiology","volume":"5","author":"Antonarakis","year":"2004","journal-title":"Nat. Rev. Genet."},{"issue":"5743","key":"10.1016\/j.bone.2022.116471_bb0110","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1126\/science.1114535","article-title":"An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes","volume":"309","author":"O'Doherty","year":"2005","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.bone.2022.116471_bb0115","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neuroscience.2018.02.009","article-title":"Sleep behavior and EEG oscillations in aged Dp(16)1Yey\/+ mice: a down syndrome model","volume":"376","author":"Levenga","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.bone.2022.116471_bb0120","first-page":"263","article-title":"Segmental trisomy of murine chromosome 16: a new model system for studying down syndrome","volume":"360","author":"Davisson","year":"1990","journal-title":"Prog. Clin. Biol. Res."},{"issue":"11","key":"10.1016\/j.bone.2022.116471_bb0125","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1093\/hmg\/ddm086","article-title":"Duplication of the entire 22.9 Mb human chromosome 21 syntenic region on mouse chromosome 16 causes cardiovascular and gastrointestinal abnormalities","volume":"16","author":"Li","year":"2007","journal-title":"Hum. Mol. Genet."},{"issue":"10","key":"10.1016\/j.bone.2022.116471_bb0130","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1523\/JNEUROSCI.2513-15.2016","article-title":"Absence of prenatal forebrain defects in the Dp(16)1Yey\/+ mouse model of down syndrome","volume":"36","author":"Goodliffe","year":"2016","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.bone.2022.116471_bb0135","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.bone.2010.09.028","article-title":"Disruption of bone development and homeostasis by trisomy in Ts65Dn down syndrome mice","volume":"48","author":"Blazek","year":"2011","journal-title":"Bone"},{"issue":"8","key":"10.1016\/j.bone.2022.116471_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042967","article-title":"Low bone turnover and low BMD in down syndrome: effect of intermittent PTH treatment","volume":"7","author":"Fowler","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bone.2022.116471_bb0145","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s11657-019-0645-7","article-title":"Analysis of volumetric BMD in people with down syndrome using DXA-based 3D modeling","volume":"14","author":"Garcia Hoyos","year":"2019","journal-title":"Arch. Osteoporos."},{"issue":"1","key":"10.1016\/j.bone.2022.116471_bb0150","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/jbm4.10025","article-title":"Sclerostin antibody treatment stimulates bone formation to normalize bone mass in male down syndrome mice","volume":"2","author":"Williams","year":"2018","journal-title":"JBMR Plus"},{"issue":"2","key":"10.1016\/j.bone.2022.116471_bb0155","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1542\/peds.2011-1605","article-title":"G. Committee on, Health supervision for children with Down syndrome","volume":"128","author":"Bull","year":"2011","journal-title":"Pediatrics"},{"issue":"5","key":"10.1016\/j.bone.2022.116471_bb0160","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s00198-014-2655-z","article-title":"The clinical diagnosis of osteoporosis: a position statement from the National Bone Health Alliance Working Group","volume":"25","author":"Siris","year":"2014","journal-title":"Osteoporos. Int."},{"issue":"7","key":"10.1016\/j.bone.2022.116471_bb0165","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1007\/s00198-010-1443-7","article-title":"Bone mass in male and female children and adolescents with Down syndrome","volume":"22","author":"Gonzalez-Aguero","year":"2011","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2022.116471_bb0170","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.56223","article-title":"A non-mosaic transchromosomic mouse model of down syndrome carrying the long arm of human chromosome 21","volume":"9","author":"Kazuki","year":"2020","journal-title":"elife"},{"issue":"4","key":"10.1016\/j.bone.2022.116471_bb0175","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1210\/en.2006-0848","article-title":"Inhibin a is an endocrine stimulator of bone mass and strength","volume":"148","author":"Perrien","year":"2007","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.bone.2022.116471_bb0180","doi-asserted-by":"crossref","first-page":"430","DOI":"10.2353\/ajpath.2008.070417","article-title":"Platelet dysfunction and a high bone mass phenotype in a murine model of platelet-type von willebrand disease","volume":"172","author":"Suva","year":"2008","journal-title":"Am. J. Pathol."},{"issue":"7","key":"10.1016\/j.bone.2022.116471_bb0185","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro-computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2022.116471_bb0190","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1210\/en.2003-0746","article-title":"Bone is a target for the antidiabetic compound rosiglitazone","volume":"145","author":"Rzonca","year":"2004","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.bone.2022.116471_bb0195","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jbmr.1805","article-title":"Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR histomorphometry nomenclature committee","volume":"28","author":"Dempster","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2022.116471_bb0200","article-title":"Adult mouse digit amputation and regeneration: a simple model to investigate mammalian blastema formation and intramembranous ossification","volume":"149","author":"Dawson","year":"2019","journal-title":"J. Vis. Exp."},{"issue":"1","key":"10.1016\/j.bone.2022.116471_bb0205","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1210\/endo.143.1.8580","article-title":"Inhibin suppresses and activin stimulates osteoblastogenesis and osteoclastogenesis in murine bone marrow cultures","volume":"143","author":"Gaddy-Kurten","year":"2002","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.bone.2022.116471_bb0210","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/wrr.12666","article-title":"Blastema formation and periosteal ossification in the regenerating adult mouse digit","volume":"26","author":"Dawson","year":"2018","journal-title":"Wound Repair Regen."},{"issue":"3","key":"10.1016\/j.bone.2022.116471_bb0215","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/sctm.17-0236","article-title":"Digit tip regeneration: merging regeneration biology with regenerative medicine","volume":"7","author":"Dolan","year":"2018","journal-title":"Stem Cells Transl. Med."},{"issue":"3","key":"10.1016\/j.bone.2022.116471_bb0220","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/reg2.36","article-title":"The mammalian blastema: regeneration at our fingertips","volume":"2","author":"Simkin","year":"2015","journal-title":"Regeneration (Oxf)"},{"issue":"1","key":"10.1016\/j.bone.2022.116471_bb0225","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/reg2.51","article-title":"Analogous cellular contribution and healing mechanisms following digit amputation and phalangeal fracture in mice","volume":"3","author":"Dawson","year":"2016","journal-title":"Regeneration (Oxf)"},{"issue":"7","key":"10.1016\/j.bone.2022.116471_bb0230","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1002\/hed.25128","article-title":"Treatment with anti-sclerostin antibody to stimulate mandibular bone formation","volume":"40","author":"Tamplen","year":"2018","journal-title":"Head Neck"},{"issue":"5","key":"10.1016\/j.bone.2022.116471_bb0235","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1439-0272.2010.01043.x","article-title":"Causes of infertility in men with down syndrome","volume":"43","author":"Stefanidis","year":"2011","journal-title":"Andrologia"},{"key":"10.1016\/j.bone.2022.116471_bb0240","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.mod.2014.12.004","article-title":"Abnormal mineralization of the Ts65Dn down syndrome mouse appendicular skeleton begins during embryonic development in a Dyrk1a-independent manner","volume":"136","author":"Blazek","year":"2015","journal-title":"Mech. Dev."},{"key":"10.1016\/j.bone.2022.116471_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115367","article-title":"Interaction of sexual dimorphism and gene dosage imbalance in skeletal deficits associated with down syndrome","volume":"136","author":"Thomas","year":"2020","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.bone.2022.116471_bb0250","first-page":"629","article-title":"Development of the radiographic union score for tibial fractures for the assessment of tibial fracture healing after intramedullary fixation","volume":"68","author":"Whelan","year":"2010","journal-title":"J. Trauma"},{"issue":"11","key":"10.1016\/j.bone.2022.116471_bb0255","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1002\/jor.25172","article-title":"Methodology, selection, and integration of fracture healing assessments in mice","volume":"39","author":"Knox","year":"2021","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2022.116471_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2019.115119","article-title":"Engineering bone phenotypes in domestic animals: unique resources for enhancing musculoskeletal research","volume":"130","author":"Suva","year":"2020","journal-title":"Bone"},{"issue":"20","key":"10.1016\/j.bone.2022.116471_bb0265","doi-asserted-by":"crossref","first-page":"5687","DOI":"10.1093\/hmg\/ddv284","article-title":"Rescue of the abnormal skeletal phenotype in Ts65Dn down syndrome mice using genetic and therapeutic modulation of trisomic Dyrk1a","volume":"24","author":"Blazek","year":"2015","journal-title":"Hum. Mol. Genet."},{"issue":"9","key":"10.1016\/j.bone.2022.116471_bb0270","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.046243","article-title":"Longitudinal neuroanatomical and behavioral analyses show phenotypic drift and variability in the Ts65Dn mouse model of down syndrome","volume":"13","author":"Shaw","year":"2020","journal-title":"Dis. Model. Mech."},{"issue":"2","key":"10.1016\/j.bone.2022.116471_bb0275","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1534\/genetics.111.132639","article-title":"The genome architecture of the Collaborative Cross mouse genetic reference population","volume":"190","year":"2012","journal-title":"Genetics"},{"issue":"6","key":"10.1016\/j.bone.2022.116471_bb0280","doi-asserted-by":"crossref","first-page":"4516","DOI":"10.1016\/j.ygeno.2020.08.004","article-title":"Phenotypic and gene expression features associated with variation in chronic ethanol consumption in heterogeneous stock collaborative cross mice","volume":"112","author":"Hitzemann","year":"2020","journal-title":"Genomics"},{"issue":"1","key":"10.1016\/j.bone.2022.116471_bb0285","doi-asserted-by":"crossref","first-page":"7918","DOI":"10.1038\/s41598-020-64862-z","article-title":"Antecedent presentation of neurological phenotypes in the collaborative cross reveals four classes with complex sex-dependencies","volume":"10","author":"Eldridge","year":"2020","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.bone.2022.116471_bb0290","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s002230010035","article-title":"Bone mineral density and muscle strength in young men with mental retardation (with and without down syndrome)","volume":"66","author":"Angelopoulou","year":"2000","journal-title":"Calcif. Tissue Int."},{"issue":"4","key":"10.1016\/j.bone.2022.116471_bb0295","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s00198-004-1687-1","article-title":"Bone mineral mass in males and females with and without down syndrome","volume":"16","author":"Baptista","year":"2005","journal-title":"Osteoporos. Int."},{"issue":"10","key":"10.1016\/j.bone.2022.116471_bb0300","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1007\/s00198-017-4133-x","article-title":"Bone mineral density in adults with down syndrome","volume":"28","author":"Carfi","year":"2017","journal-title":"Osteoporos. Int."},{"issue":"5","key":"10.1016\/j.bone.2022.116471_bb0305","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1352\/1934-9556-55.5.315","article-title":"Bone mass assessment in a cohort of adults with down syndrome: a cross-sectional study","volume":"55","author":"Costa","year":"2017","journal-title":"Intellect. Dev. Disabil."},{"issue":"4","key":"10.1016\/j.bone.2022.116471_bb0310","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.jocd.2018.03.001","article-title":"Bone mineral density distribution curves in spanish adults with down syndrome","volume":"21","author":"Costa","year":"2018","journal-title":"J. Clin. Densitom."},{"issue":"4","key":"10.1016\/j.bone.2022.116471_bb0315","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1534\/genetics.111.131391","article-title":"Trisomic and allelic differences influence phenotypic variability during development of down syndrome mice","volume":"189","author":"Deitz","year":"2011","journal-title":"Genetics"},{"issue":"7","key":"10.1016\/j.bone.2022.116471_bb0320","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.injury.2020.04.011","article-title":"A comprehensive review of mouse diaphyseal femur fracture models","volume":"51","author":"Gunderson","year":"2020","journal-title":"Injury"},{"issue":"9","key":"10.1016\/j.bone.2022.116471_bb0325","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1002\/jbmr.3755","article-title":"VEGFA from early osteoblast lineage cells (Osterix+) is required in mice for fracture healing","volume":"34","author":"Buettmann","year":"2019","journal-title":"J. Bone Miner. Res."},{"issue":"11","key":"10.1016\/j.bone.2022.116471_bb0330","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1097\/BOT.0000000000000390","article-title":"Determination of radiographic healing: an assessment of consistency using RUST and modified RUST in metadiaphyseal fractures","volume":"29","author":"Litrenta","year":"2015","journal-title":"J. Orthop. Trauma"},{"issue":"3","key":"10.1016\/j.bone.2022.116471_bb0335","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/jor.23710","article-title":"Correlation between RUST assessments of fracture healing to structural and biomechanical properties","volume":"36","author":"Cooke","year":"2018","journal-title":"J. Orthop. Res."},{"issue":"4","key":"10.1016\/j.bone.2022.116471_bb0340","first-page":"444","article-title":"Risk of fractures in an intermediate care facility for persons with mental retardation","volume":"93","author":"Tannenbaum","year":"1989","journal-title":"Am. J. Ment. Retard."},{"issue":"2","key":"10.1016\/j.bone.2022.116471_bb0345","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/(SICI)1096-8628(19990625)89:2<100::AID-AJMG8>3.0.CO;2-N","article-title":"Health care concerns and guidelines for adults with down syndrome","volume":"89","author":"van Allen","year":"1999","journal-title":"Am. J. Med. Genet."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632822200148X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632822200148X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T18:02:10Z","timestamp":1757613730000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S875632822200148X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":69,"alternative-id":["S875632822200148X"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2022.116471","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low bone mass and impaired fracture healing in mouse models of Trisomy21 (Down syndrome)","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2022.116471","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116471"}}