{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T07:34:42Z","timestamp":1790494482529,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010125","name":"Jalmari ja Rauha Ahokkaan S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005609","name":"Turun Yliopisto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005609","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010129","name":"Maud Kuistilan Muistos\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019841","name":"Suomalais-Norjalainen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019841","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007083","name":"Orionin Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007083","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["139165"],"award-info":[{"award-number":["139165"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["268535"],"award-info":[{"award-number":["268535"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["298625"],"award-info":[{"award-number":["298625"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005424","name":"Southwest Finland Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005424","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.bone.2022.116497","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T12:46:48Z","timestamp":1658148408000},"page":"116497","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Mesenchymal cell-derived Wnt1 signaling regulates subchondral bone remodeling but has no effects on the development of growth plate or articular cartilage in mice"],"prefix":"10.1016","volume":"163","author":[{"given":"Fan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petri","family":"Rummukainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matias","family":"Pehkonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Marja","family":"S\u00e4\u00e4m\u00e4nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terhi J.","family":"Heino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riku","family":"Kiviranta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2022.116497_bb0005","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a008334","article-title":"Development of the endochondral skeleton","volume":"5","author":"Long","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bone.2022.116497_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2015.04.035","article-title":"Bone development","volume":"80","author":"Berendsen","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.bone.2022.116497_bb0015","doi-asserted-by":"crossref","DOI":"10.1242\/dev.105536","article-title":"A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation","volume":"142","author":"Kozhemyakina","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.bone.2022.116497_bb0020","doi-asserted-by":"crossref","DOI":"10.1002\/jbmr.1639","article-title":"Cartilage-specific \u03b2-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development","volume":"27","author":"Dao","year":"2012","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2022.116497_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115368","article-title":"Wnt signaling in chondroprogenitors during long bone development and growth","volume":"137","author":"Oichi","year":"2020","journal-title":"Bone"},{"key":"10.1016\/j.bone.2022.116497_bb0030","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.21262","article-title":"Integration of signaling pathways regulating chondrocyte differentiation during endochondral bone formation","volume":"213","author":"Adams","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bone.2022.116497_bb0035","doi-asserted-by":"crossref","DOI":"10.1172\/JCI11706","article-title":"Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development","volume":"107","author":"Chung","year":"2001","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.bone.2022.116497_bb0040","doi-asserted-by":"crossref","DOI":"10.1159\/000088791","article-title":"Endocrine regulation of the growth plate","volume":"64","author":"Nilsson","year":"2005","journal-title":"Horm. Res. Paediatr."},{"key":"10.1016\/j.bone.2022.116497_bb0045","doi-asserted-by":"crossref","DOI":"10.1002\/bdrc.20048","article-title":"Transcriptional control of chondrocyte fate and differentiation","volume":"75","author":"Lefebvre","year":"2005","journal-title":"Birth Defects Res. C Embryo Today"},{"key":"10.1016\/j.bone.2022.116497_bb0050","doi-asserted-by":"crossref","DOI":"10.1038\/nm.3074","article-title":"WNT signaling in bone homeostasis and disease: from human mutations to treatments","volume":"19","author":"Baron","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.bone.2022.116497_bb0055","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21041340","article-title":"Role of signal transduction pathways and transcription factors in cartilage and joint diseases","volume":"21","author":"Nishimura","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bone.2022.116497_bb0060","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1242\/dev.127.14.3141","article-title":"Dual roles of wnt signaling during chondrogenesis in the chicken limb","author":"Hartmann","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.bone.2022.116497_bb0065","doi-asserted-by":"crossref","DOI":"10.1242\/dev.00324","article-title":"Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation","volume":"130","author":"Yang","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.bone.2022.116497_bb0070","doi-asserted-by":"crossref","DOI":"10.1006\/dbio.1997.8536","article-title":"Inhibition of chondrogenesis by wnt gene expression in vivo and in vitro","volume":"185","author":"Rudnicki","year":"1997","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bone.2022.116497_bb0075","doi-asserted-by":"crossref","DOI":"10.1136\/annrheumdis-2018-214200","article-title":"Wnt16 attenuates osteoarthritis progression through a PCP\/JNK-mTORC1-PTHrP cascade","author":"Tong","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bone.2022.116497_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/0092-8674(88)90220-6","article-title":"Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice","volume":"55","author":"Tsukamoto","year":"1988","journal-title":"Cell"},{"key":"10.1016\/j.bone.2022.116497_bb0085","doi-asserted-by":"crossref","DOI":"10.1002\/jbmr.3680","article-title":"Mesenchymal cell-derived juxtacrine Wnt1 signaling regulates osteoblast activity and osteoclast differentiation","author":"Wang","year":"2019","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2022.116497_bb0090","doi-asserted-by":"crossref","DOI":"10.1002\/jbmr.1805","article-title":"Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR histomorphometry nomenclature committee","volume":"28","author":"Dempster","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2022.116497_bb0095","doi-asserted-by":"crossref","DOI":"10.1242\/dev.018044","article-title":"Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy","volume":"135","author":"Mak","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.bone.2022.116497_bb0100","doi-asserted-by":"crossref","DOI":"10.1186\/s12964-019-0411-x","article-title":"Wnt signaling: a promising target for osteoarthritis therapy","volume":"17","author":"Wang","year":"2019","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.bone.2022.116497_bb0105","doi-asserted-by":"crossref","DOI":"10.1038\/labinvest.2015.142","article-title":"Wnt signaling in cartilage development and diseases: lessons from animal studies","volume":"96","author":"Usami","year":"2016","journal-title":"Lab. Investig."},{"key":"10.1016\/j.bone.2022.116497_bb0110","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.devcel.2005.03.016","article-title":"Wnt\/\u03b2-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis","volume":"8","author":"Day","year":"2005","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bone.2022.116497_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajpath.2018.07.003","article-title":"Lineage-specific wnt reporter elucidates mesenchymal wnt signaling during bone repair","volume":"188","author":"Chang","year":"2018","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bone.2022.116497_bb0120","doi-asserted-by":"crossref","DOI":"10.1359\/JBMR.050204","article-title":"Expression patterns of matrix metalloproteinases and vascular endothelial growth factor during epiphyseal ossification","volume":"20","author":"\u00c1lvarez","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2022.116497_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/S0092-8674(00)81169-1","article-title":"MMP-9\/Gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes","volume":"93","author":"Vu","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.bone.2022.116497_bb0130","doi-asserted-by":"crossref","DOI":"10.1242\/dev.01461","article-title":"Altered endochondral bone development in matrix metalloproteinase 13-deficient mice","volume":"131","author":"Stickens","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.bone.2022.116497_bb0135","article-title":"Wnt signaling in cartilage development and degeneration","author":"Chun","year":"2008","journal-title":"J. Biochem. Mol. Biol."},{"key":"10.1016\/j.bone.2022.116497_bb0140","doi-asserted-by":"crossref","DOI":"10.2353\/ajpath.2009.081173","article-title":"Transient activation of Wnt\/\u03b2-catenin signaling induces abnormal growth plate closure and articular cartilage thickening in postnatal mice","volume":"175","author":"Yuasa","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bone.2022.116497_bb0145","doi-asserted-by":"crossref","DOI":"10.1101\/gad.1230704","article-title":"Wnt\/-catenin signaling is sufficient and necessary for synovial joint formation","volume":"18","author":"Guo","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.bone.2022.116497_bb0150","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M414275200","article-title":"Developmental regulation of Wnt\/\u03b2-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification","volume":"280","author":"Tamamura","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2022.116497_bb0155","doi-asserted-by":"crossref","DOI":"10.1002\/art.24247","article-title":"Involvement of the wnt signaling pathway in experimental and human osteoarthritis: prominent role of wnt-induced signaling protein 1","volume":"60","author":"Blom","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bone.2022.116497_bb0160","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2474-11-257","article-title":"Dickkopf-1 (Dkk-1) in plasma and synovial fluid is inversely correlated with radiographic severity of knee osteoarthritis patients","volume":"11","author":"Honsawek","year":"2010","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.bone.2022.116497_bb0165","doi-asserted-by":"crossref","DOI":"10.1002\/jbmr.4043","article-title":"Mice carrying a ubiquitous R235W mutation of Wnt1 display a bone-specific phenotype","author":"Yorgan","year":"2020","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2022.116497_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.joca.2019.07.001","article-title":"Defective WNT signaling may protect from articular cartilage deterioration \u2013 a quantitative MRI study on subjects with a heterozygous WNT1 mutation","author":"Lehtovirta","year":"2019","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2022.116497_bb0175","doi-asserted-by":"crossref","DOI":"10.1007\/s00198-012-2161-0","article-title":"Why subchondral bone in osteoarthritis? The importance of the cartilage bone interface in osteoarthritis","author":"Mahjoub","year":"2012","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2022.116497_bb0180","first-page":"359","article-title":"Adaptation of subchondral bone in osteoarthritis","volume":"41","author":"Day","year":"2004","journal-title":"Biorheology"},{"key":"10.1016\/j.bone.2022.116497_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.joca.2012.11.016","article-title":"Direct assessment of articular cartilage and underlying subchondral bone reveals a progressive gene expression change in human osteoarthritic knees","author":"Chou","year":"2013","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bone.2022.116497_bb0190","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.201011051","article-title":"WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways","volume":"193","author":"Nalesso","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bone.2022.116497_bb0195","doi-asserted-by":"crossref","DOI":"10.1242\/bio.201411031","article-title":"Dual pathways to endochondral osteoblasts: a novel chondrocyte-derived osteoprogenitor cell identified in hypertrophic cartilage","volume":"4","author":"Park","year":"2015","journal-title":"Biol. Open"},{"key":"10.1016\/j.bone.2022.116497_bb0200","doi-asserted-by":"crossref","DOI":"10.1002\/bdrc.20048","article-title":"Transcriptional control of chondrocyte fate and differentiation","volume":"75","author":"Lefebvre","year":"2005","journal-title":"Birth Defects Res. C Embryo Today"},{"key":"10.1016\/j.bone.2022.116497_bb0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-4644(199607)62:1<1::AID-JCB1>3.0.CO;2-X","article-title":"Expression of bone-specific genes by hypertrophic chondrocytes: implication of the complex functions of the hypertrophic chondrocyte during endochondral bone development","volume":"62","author":"Gerstenfeld","year":"1996","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bone.2022.116497_bb0210","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.0407788101","article-title":"Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification","volume":"101","author":"Inada","year":"2004","journal-title":"Proc. Natl. Acad. Sci."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328222001740?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328222001740?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T18:00:55Z","timestamp":1757613655000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328222001740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":42,"alternative-id":["S8756328222001740"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2022.116497","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mesenchymal cell-derived Wnt1 signaling regulates subchondral bone remodeling but has no effects on the development of growth plate or articular cartilage in mice","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2022.116497","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116497"}}