{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T10:22:30Z","timestamp":1784802150161,"version":"3.55.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T00:00:00Z","timestamp":1664928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["949"],"award-info":[{"award-number":["949"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82,172,503"],"award-info":[{"award-number":["82,172,503"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81,601,949"],"award-info":[{"award-number":["81,601,949"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.bone.2022.116566","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T14:40:19Z","timestamp":1663771219000},"page":"116566","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["MiR-1 is a critical regulator of chondrocyte proliferation and hypertrophy by inhibiting Indian hedgehog pathway during postnatal endochondral ossification in miR-1 overexpression transgenic mice"],"prefix":"10.1016","volume":"165","author":[{"given":"Linlin","family":"Cong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinpin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaige","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianda","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunfang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penghua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.bone.2022.116566_bb0005","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1172\/JCI24397","article-title":"Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP","volume":"115","author":"Kobayashi","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.bone.2022.116566_bb0010","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.devcel.2008.02.003","article-title":"Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression","volume":"14","author":"Mak","year":"2008","journal-title":"Dev. Cell"},{"issue":"15","key":"10.1016\/j.bone.2022.116566_bb0015","doi-asserted-by":"crossref","first-page":"6382","DOI":"10.1073\/pnas.0608449104","article-title":"Indian hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone","volume":"104","author":"Maeda","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6937","key":"10.1016\/j.bone.2022.116566_bb0020","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/nature01657","article-title":"Developmental regulation of the growth plate","volume":"423","author":"Kronenberg","year":"2003","journal-title":"Nature"},{"issue":"5275","key":"10.1016\/j.bone.2022.116566_bb0025","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1126\/science.273.5275.613","article-title":"Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein","volume":"273","author":"Vortkamp","year":"1996","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.bone.2022.116566_bb0030","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1002\/jbmr.1696","article-title":"The postnatal role of Sox9 in cartilage","volume":"27","author":"Henry","year":"2012","journal-title":"J. Bone Miner. Res."},{"issue":"1\u20132","key":"10.1016\/j.bone.2022.116566_bb0035","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1089\/ten.tea.2014.0096","article-title":"In vitro osteogenic potential of human mesenchymal stem cells is predicted by Runx2\/Sox9 ratio","volume":"21","author":"Loebel","year":"2015","journal-title":"Tissue Eng.A"},{"issue":"50","key":"10.1016\/j.bone.2022.116566_bb0040","doi-asserted-by":"crossref","first-page":"19004","DOI":"10.1073\/pnas.0605170103","article-title":"Dominance of SOX9 function over RUNX2 during skeletogenesis","volume":"103","author":"Zhou","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.bone.2022.116566_bb0045","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1002\/jbmr.3379","article-title":"Inhibition of CaMKK2enhances fracture healing by stimulating Indian hedgehog signaling and accelerating endochondral ossification","volume":"33","author":"Williams","year":"2018","journal-title":"J. Bone Miner. Res."},{"issue":"7","key":"10.1016\/j.bone.2022.116566_bb0050","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1172\/JCI24397","article-title":"Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP","volume":"115","author":"Kobayashi","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.bone.2022.116566_bb0055","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1515\/JPEM.1996.9.1.31","article-title":"Skeletal dysplasias: response to growth hormone therapy","volume":"9","author":"Burren","year":"1996","journal-title":"J. Pediatr. Endocrinol. Metab."},{"issue":"21","key":"10.1016\/j.bone.2022.116566_bb0060","doi-asserted-by":"crossref","first-page":"4645","DOI":"10.1242\/dev.02070","article-title":"microPrimer: the biogenesis and function of microRNA","volume":"132","author":"Du","year":"2005","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.bone.2022.116566_bb0065","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.molcel.2014.08.028","article-title":"mRNA destabilization is the dominant effect of mammalian microRNAs by the time substantial repression ensues","volume":"2;56","author":"Eichhorn","year":"2014","journal-title":"Mol. Cell"},{"issue":"13\u201314","key":"10.1016\/j.bone.2022.116566_bb0070","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1089\/ten.tea.2018.0189","article-title":"SOX-6, 9-transfected adipose stem cells to treat surgically-induced osteoarthritis in goats","volume":"25","author":"Ko","year":"2019","journal-title":"Tissue Eng.A"},{"issue":"2","key":"10.1016\/j.bone.2022.116566_bb0075","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.bbrc.2012.12.133","article-title":"MicroRNA-181b regulates articular chondrocytes differentiation and cartilage integrity","volume":"8;431","author":"Song","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"12","key":"10.1016\/j.bone.2022.116566_bb0080","doi-asserted-by":"crossref","first-page":"4457","DOI":"10.1096\/fj.11-185132","article-title":"MiR-365: a mechanosensitive microRNA stimulates chondrocyte differentiation through targeting histone deacetylase 4","volume":"25","author":"Guan","year":"2011","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.bone.2022.116566_bb0085","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1074\/jbc.M111.302430","article-title":"Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145)","volume":"287","author":"Martinez-Sanchez","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.bone.2022.116566_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021679","article-title":"MicroRNA-145 regulates chondrogenic differentiation of mesenchymal stem cells by targeting Sox9","volume":"6","author":"Yang","year":"2011","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.bone.2022.116566_bb0095","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.3892\/mmr.2020.11296","article-title":"MicroRNA-1 promotes cartilage matrix synthesis and regulates chondrocyte differentiation via post-transcriptional suppression of Ihh expression","volume":"22","author":"Chen","year":"2020","journal-title":"Mol. Med. Rep."},{"issue":"15","key":"10.1016\/j.bone.2022.116566_bb0100","doi-asserted-by":"crossref","first-page":"6382","DOI":"10.1073\/pnas.0608449104","article-title":"Indian hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone","volume":"104","author":"Maeda","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.bone.2022.116566_bb0105","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ydbio.2007.05.011","article-title":"Tamoxifen-inducible gene deletion reveals a distinct cell type associated with trabecular bone, and direct regulation of PTHrP expression and chondrocyte morphology by ihh in growth region cartilage","volume":"308","author":"Hilton","year":"2007","journal-title":"Dev. Biol."},{"issue":"11","key":"10.1016\/j.bone.2022.116566_bb0110","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/s41580-020-00279-w","article-title":"Mechanisms of bone development and repair","volume":"21","author":"Salhotra","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"7209","key":"10.1016\/j.bone.2022.116566_bb0115","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nature07228","article-title":"Widespread changes in protein synthesis induced by microRNAs","volume":"455","author":"Selbach","year":"2008","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.bone.2022.116566_bb0120","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/ng1725","article-title":"The role of microRNA-1 and micro-RNA-133 in skeletal muscle proliferation and differentiation","volume":"38","author":"Chen","year":"2006","journal-title":"J. Nat. Genet."},{"issue":"9","key":"10.1016\/j.bone.2022.116566_bb0125","doi-asserted-by":"crossref","first-page":"3930","DOI":"10.1096\/fj.13-249318","article-title":"MicroRNA-1 regulates chondrocyte phenotype by repressing histone deacetylase 4 during growth plate development","volume":"28","author":"Li","year":"2014","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.bone.2022.116566_bb0130","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.joca.2015.07.025","article-title":"Col2-cre and tamoxifen-inducible Col2-CreER target different cell populations in the knee joint","volume":"24","author":"Nagao","year":"2016","journal-title":"Osteoarthr. Cartil."},{"issue":"1","key":"10.1016\/j.bone.2022.116566_bb0135","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ydbio.2007.05.011","article-title":"Tamoxifen-inducible gene deletion reveals a distinct cell type associated with trabecular bone, and direct regulation of PTHrP expression and chondrocyte morphology by Ihh in growth region cartilage","volume":"308","author":"Hilton","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bone.2022.116566_bb0140","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.55212","article-title":"Secondary ossification center induces and protects growth plate structure","volume":"9","author":"Xie","year":"2020","journal-title":"elife"},{"issue":"9","key":"10.1016\/j.bone.2022.116566_bb0155","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nrrheum.2015.84","article-title":"The role of hedgehog signalling in skeletal health and disease","volume":"11","author":"Alman","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"issue":"18","key":"10.1016\/j.bone.2022.116566_bb0160","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21186665","article-title":"Hedgehog signaling in skeletal development: roles of Indian hedgehog and the mode of its action","volume":"21","author":"Ohba","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"15","key":"10.1016\/j.bone.2022.116566_bb0165","doi-asserted-by":"crossref","first-page":"6382","DOI":"10.1073\/pnas.0608449104","article-title":"Indian hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone","volume":"104","author":"Maeda","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.bone.2022.116566_bb0170","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ajhg.2010.07.011","article-title":"Haploinsufficiency of HDAC4 causes brachydactyly mental retardation syndrome, with brachydactyly type E, developmental delays, and behavioral problems","volume":"13;87","author":"Williams","year":"2010","journal-title":"Am. J. Hum. Genet."},{"issue":"23","key":"10.1016\/j.bone.2022.116566_bb0175","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1101\/gad.938601","article-title":"Hedgehog signaling in animal development: paradigms and principles","volume":"15","author":"Ingham","year":"2001","journal-title":"Genes Dev."},{"issue":"2","key":"10.1016\/j.bone.2022.116566_bb0180","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3390\/jdb4020020","article-title":"Hedgehog signaling in endochondral ossification","volume":"4","author":"Ohba","year":"2016","journal-title":"J. Dev. Biol."},{"issue":"4","key":"10.1016\/j.bone.2022.116566_bb0185","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cell.2004.10.024","article-title":"Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis","volume":"119","author":"Vega","year":"2004","journal-title":"Cell"},{"issue":"13","key":"10.1016\/j.bone.2022.116566_bb0190","doi-asserted-by":"crossref","first-page":"9616","DOI":"10.1074\/jbc.M109.094862","article-title":"HDAC4 represses matrix metalloproteinase-13 transcription in osteoblastic cells, and parathyroid hormone controls this repression","volume":"285","author":"Shimizu","year":"2010","journal-title":"J. Biol. Chem."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328222002435?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328222002435?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T14:15:26Z","timestamp":1778940926000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328222002435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":36,"alternative-id":["S8756328222002435"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2022.116566","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MiR-1 is a critical regulator of chondrocyte proliferation and hypertrophy by inhibiting Indian hedgehog pathway during postnatal endochondral ossification in miR-1 overexpression transgenic mice","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2022.116566","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116566"}}