{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:47:01Z","timestamp":1790830021647,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T00:00:00Z","timestamp":1700265600000},"content-version":"am","delay-in-days":290,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK047348"],"award-info":[{"award-number":["DK047348"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AR075042"],"award-info":[{"award-number":["P30AR075042"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 DK007028"],"award-info":[{"award-number":["T32 DK007028"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.bone.2022.116608","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T02:35:21Z","timestamp":1667874921000},"page":"116608","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["The PYY\/Y2R-deficient male mouse is not protected from bone loss due to Roux-en-Y gastric bypass"],"prefix":"10.1016","volume":"167","author":[{"given":"Bita","family":"Zahedi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen J.","family":"Daley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bruce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Leigh","family":"Townsend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Rudolf","family":"Berthoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary L.","family":"Bouxsein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine W.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"21","key":"10.1016\/j.bone.2022.116608_bb0005","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1001\/jama.2016.6458","article-title":"Trends in obesity among adults in the United States, 2005 to 2014","volume":"315","author":"Flegal","year":"2016","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.bone.2022.116608_bb0010","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.soard.2016.05.007","article-title":"A nationwide safety analysis of bariatric surgery in nonseverely obese patients with type 2 diabetes","volume":"12","author":"Aminian","year":"2016","journal-title":"Surg. Obes. Relat. Dis."},{"issue":"9","key":"10.1016\/j.bone.2022.116608_bb0015","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1001\/jama.2020.12567","article-title":"Benefits and risks of bariatric surgery in adults: a review","volume":"324","author":"Arterburn","year":"2020","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.bone.2022.116608_bb0020","doi-asserted-by":"crossref","first-page":"R119","DOI":"10.1530\/EJE-20-0548","article-title":"MANAGEMENT OF ENDOCRINE DISEASE: bone complications of bariatric surgery: updates on sleeve gastrectomy, fractures, and interventions","volume":"183","author":"Beavers","year":"2020","journal-title":"Eur. J. Endocrinol."},{"issue":"5","key":"10.1016\/j.bone.2022.116608_bb0025","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1007\/s00223-020-00798-w","article-title":"Bariatric surgery and osteoporosis","volume":"110","author":"Paccou","year":"2022","journal-title":"Calcif. Tissue Int."},{"issue":"10","key":"10.1016\/j.bone.2022.116608_bb0030","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1038\/s41366-020-0626-3","article-title":"The curious fate of bone following bariatric surgery: bone effects of sleeve gastrectomy (SG) and roux-en-Y gastric bypass (RYGB) in mice","volume":"44","author":"Corbeels","year":"2020","journal-title":"Int. J. Obes."},{"issue":"2","key":"10.1016\/j.bone.2022.116608_bb0035","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1210\/jc.2015-3437","article-title":"Effects of gastric bypass and gastric banding on bone remodeling in obese patients with type 2 diabetes","volume":"101","author":"Yu","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"8","key":"10.1016\/j.bone.2022.116608_bb0040","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1056\/NEJMoa2003697","article-title":"Effects of diet versus gastric bypass on metabolic function in diabetes","volume":"383","author":"Yoshino","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bone.2022.116608_bb0045","article-title":"Regulation of body weight: lessons learned from bariatric surgery","author":"Albaugh","year":"2022","journal-title":"Mol. Metab."},{"issue":"3","key":"10.1016\/j.bone.2022.116608_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/nu11030585","article-title":"The PYY\/Y2R-deficient mouse responds normally to high-fat diet and gastric bypass surgery","volume":"11","author":"Boland","year":"2019","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.bone.2022.116608_bb0055","first-page":"R352","article-title":"GLP-1 receptor signaling is not required for reduced body weight after RYGB in rodents","volume":"306","author":"Ye","year":"2014","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.bone.2022.116608_bb0060","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.bone.2019.07.011","article-title":"PYY is a negative regulator of bone mass and strength","volume":"127","author":"Leitch","year":"2019","journal-title":"Bone"},{"key":"10.1016\/j.bone.2022.116608_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2019.115115","article-title":"Increases in PYY and uncoupling of bone turnover are associated with loss of bone mass after gastric bypass surgery","volume":"131","author":"Kim","year":"2020","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.bone.2022.116608_bb0070","doi-asserted-by":"crossref","first-page":"4768","DOI":"10.1038\/s41467-021-24914-y","article-title":"Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice","volume":"12","author":"Bozadjieva-Kramer","year":"2021","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.bone.2022.116608_bb0075","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.bone.2011.04.011","article-title":"Estrogen and peptide YY are associated with bone mineral density in premenopausal exercising women","volume":"49","author":"Scheid","year":"2011","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.bone.2022.116608_bb0080","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.bone.2008.03.007","article-title":"Peptide YY (PYY) levels and bone mineral density (BMD) in women with anorexia nervosa","volume":"43","author":"Utz","year":"2008","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.bone.2022.116608_bb0085","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1210\/jc.2005-1878","article-title":"Elevated peptide YY levels in adolescent girls with anorexia nervosa","volume":"91","author":"Misra","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.bone.2022.116608_bb0090","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.bone.2009.03.668","article-title":"Peptide YY in adolescent athletes with amenorrhea, eumenorrheic athletes and non-athletic controls","volume":"45","author":"Russell","year":"2009","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.bone.2022.116608_bb0095","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/oby.2006.25","article-title":"Peptide YY levels are elevated after gastric bypass surgery","volume":"14","author":"Chan","year":"2006","journal-title":"Obesity (Silver Spring)"},{"issue":"3","key":"10.1016\/j.bone.2022.116608_bb0100","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/SLA.0b013e318156f012","article-title":"Weight loss, appetite suppression, and changes in fasting and postprandial ghrelin and peptide-YY levels after roux-en-Y gastric bypass and sleeve gastrectomy: a prospective, double blind study","volume":"247","author":"Karamanakos","year":"2008","journal-title":"Ann. Surg."},{"issue":"2","key":"10.1016\/j.bone.2022.116608_bb0105","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1590\/S0004-27302010000200011","article-title":"Bariatric surgery and bone metabolism: a systematic review","volume":"54","author":"Viegas","year":"2010","journal-title":"Arq. Bras. Endocrinol. Metabol."},{"issue":"5","key":"10.1016\/j.bone.2022.116608_bb0110","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.soard.2014.01.021","article-title":"Gastric bypass in obese rats causes bone loss, vitamin D deficiency, metabolic acidosis, and elevated peptide YY","volume":"10","author":"Canales","year":"2014","journal-title":"Surg. Obes. Relat. Dis."},{"issue":"6","key":"10.1016\/j.bone.2022.116608_bb0115","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1038\/oby.2009.473","article-title":"Superior appetite hormone profile after equivalent weight loss by gastric bypass compared to gastric banding","volume":"18","author":"Bose","year":"2010","journal-title":"Obesity (Silver Spring)"},{"issue":"7","key":"10.1016\/j.bone.2022.116608_bb0120","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.metabol.2004.01.015","article-title":"Changes in bone mineral content after surgical treatment of morbid obesity","volume":"53","author":"von Mach","year":"2004","journal-title":"Metabolism"},{"issue":"1","key":"10.1016\/j.bone.2022.116608_bb0125","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s11695-007-9258-0","article-title":"Effects of weight loss on bone status after bariatric surgery: association between adipokines and bone markers","volume":"18","author":"Wucher","year":"2008","journal-title":"Obes. Surg."},{"issue":"7","key":"10.1016\/j.bone.2022.116608_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0040038","article-title":"Peptide YY regulates bone remodeling in mice: a link between gut and skeletal biology","volume":"7","author":"Wong","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.bone.2022.116608_bb0135","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.bmc.2017.12.014","article-title":"Antiobesity and emetic effects of a short-length peptide YY analog and its PEGylated and alkylated derivatives","volume":"26","author":"Niida","year":"2018","journal-title":"Bioorg. Med. Chem."},{"issue":"26","key":"10.1016\/j.bone.2022.116608_bb0140","doi-asserted-by":"crossref","first-page":"19082","DOI":"10.1074\/jbc.M609629200","article-title":"Greater bone formation of Y2 knockout mice is associated with increased osteoprogenitor numbers and altered Y1 receptor expression","volume":"282","author":"Lundberg","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.bone.2022.116608_bb0145","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1359\/jbmr.060705","article-title":"Hypothalamic regulation of cortical bone mass: opposing activity of Y2 receptor and leptin pathways","volume":"21","author":"Baldock","year":"2006","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2022.116608_bb0150","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.npep.2017.11.005","article-title":"Neuropeptide Y Y2 antagonist treated ovariectomized mice exhibit greater bone mineral density","volume":"67","author":"Seldeen","year":"2018","journal-title":"Neuropeptides"},{"issue":"7","key":"10.1016\/j.bone.2022.116608_bb0155","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro-computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J. Bone Miner. Res."},{"issue":"9","key":"10.1016\/j.bone.2022.116608_bb0160","doi-asserted-by":"crossref","DOI":"10.3390\/nu13093197","article-title":"Associations between postprandial gut hormones and markers of bone remodeling","volume":"13","author":"Jensen","year":"2021","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.bone.2022.116608_bb0165","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0031-6997(24)01352-8","article-title":"XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors","volume":"50","author":"Michel","year":"1998","journal-title":"Pharmacol. Rev."},{"issue":"3","key":"10.1016\/j.bone.2022.116608_bb0170","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/jcb.22294","article-title":"Neuropeptide Y is expressed by osteocytes and can inhibit osteoblastic activity","volume":"108","author":"Igwe","year":"2009","journal-title":"J. Cell. Biochem."},{"issue":"3","key":"10.1016\/j.bone.2022.116608_bb0175","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.bone.2010.10.174","article-title":"Osteoblast specific Y1 receptor deletion enhances bone mass","volume":"48","author":"Lee","year":"2011","journal-title":"Bone"},{"issue":"8","key":"10.1016\/j.bone.2022.116608_bb0180","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1002\/jbmr.61","article-title":"Critical role for Y1 receptors in mesenchymal progenitor cell differentiation and osteoblast activity","volume":"25","author":"Lee","year":"2010","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.bone.2022.116608_bb0185","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1677\/JME-10-0015","article-title":"Hypothalamic regulation of bone","volume":"45","author":"Driessler","year":"2010","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.bone.2022.116608_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115230","article-title":"Consumption of nutrients and insulin resistance suppress markers of bone turnover in subjects with abdominal obesity","volume":"133","author":"Fuglsang-Nielsen","year":"2020","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.bone.2022.116608_bb0195","doi-asserted-by":"crossref","DOI":"10.3390\/nu10020122","article-title":"Pre-meal effect of whey proteins on metabolic parameters in subjects with and without type 2 diabetes: a randomized, crossover trial","volume":"10","author":"Bjornshave","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.bone.2022.116608_bb0200","doi-asserted-by":"crossref","first-page":"880","DOI":"10.3389\/fendo.2019.00880","article-title":"A short-term ketogenic diet impairs markers of bone health in response to exercise","volume":"10","author":"Heikura","year":"2019","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"9","key":"10.1016\/j.bone.2022.116608_bb0205","first-page":"R999","article-title":"Roux-en-Y gastric bypass surgery reduces bone mineral density and induces metabolic acidosis in rats","volume":"305","author":"Abegg","year":"2013","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"issue":"6","key":"10.1016\/j.bone.2022.116608_bb0210","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1210\/en.2012-2130","article-title":"Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rats","volume":"154","author":"Stemmer","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2022.116608_bb0215","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.bone.2016.01.017","article-title":"Cortical and trabecular deterioration in mouse models of roux-en-Y gastric bypass","volume":"85","author":"Yu","year":"2016","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.bone.2022.116608_bb0220","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1530\/EJE-17-0014","article-title":"Bone structural changes after gastric bypass surgery evaluated by HR-pQCT: a two-year longitudinal study","volume":"176","author":"Shanbhogue","year":"2017","journal-title":"Eur. J. Endocrinol."},{"issue":"11","key":"10.1016\/j.bone.2022.116608_bb0225","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1002\/jbmr.4112","article-title":"Bone density and trabecular morphology at least 10 years after gastric bypass and gastric banding","volume":"35","author":"Lindeman","year":"2020","journal-title":"J. Bone Miner. Res."},{"issue":"6","key":"10.1016\/j.bone.2022.116608_bb0230","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1172\/JCI126173","article-title":"G-CSF partially mediates effects of sleeve gastrectomy on the bone marrow niche","volume":"129","author":"Li","year":"2019","journal-title":"J. Clin. Invest."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632822200285X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632822200285X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T18:02:38Z","timestamp":1757613758000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S875632822200285X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":46,"alternative-id":["S875632822200285X"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2022.116608","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The PYY\/Y2R-deficient male mouse is not protected from bone loss due to Roux-en-Y gastric bypass","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2022.116608","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116608"}}