{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T19:22:38Z","timestamp":1774466558131,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T00:00:00Z","timestamp":1720224000000},"content-version":"am","delay-in-days":309,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["TANGPR11A0"],"award-info":[{"award-number":["TANGPR11A0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["WU21Q0"],"award-info":[{"award-number":["WU21Q0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["TL1TR002382"],"award-info":[{"award-number":["TL1TR002382"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR000454"],"award-info":[{"award-number":["UL1TR000454"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002378"],"award-info":[{"award-number":["UL1TR002378"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006939","name":"Emory University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006939","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008801","name":"Atlanta Clinical and Translational Science Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.bone.2023.116835","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T14:09:18Z","timestamp":1687961358000},"page":"116835","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Changes in bone turnover after high-dose vitamin D supplementation during acute pulmonary exacerbation in cystic fibrosis"],"prefix":"10.1016","volume":"174","author":[{"given":"Malinda","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anirudh","family":"Bhimavarapu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica A.","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R.","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vin","family":"Tangpricha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2023.116835_bb0005","series-title":"Cystic Fibrosis Foundation Patient Registry 2019 Annual Data Report","year":"2020"},{"issue":"4","key":"10.1016\/j.bone.2023.116835_bb0010","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s00198-015-3343-3","article-title":"Bone disease in cystic fibrosis: new pathogenic insights opening novel therapies","volume":"27","author":"Jacquot","year":"2016","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2023.116835_bb0015","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1016\/j.jcf.2019.08.018","article-title":"Cystic fibrosis bone disease: pathophysiology, assessment and prognostic implications","volume":"18","author":"Anabtawi","year":"2019","journal-title":"J. Cyst. Fibros."},{"issue":"3","key":"10.1016\/j.bone.2023.116835_bb0020","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1365-2265.2008.03216.x","article-title":"Vitamin D and bone health in adults with cystic fibrosis","volume":"69","author":"Wolfenden","year":"2008","journal-title":"Clin. Endocrinol."},{"issue":"3","key":"10.1016\/j.bone.2023.116835_bb0025","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1203\/00006450-199703000-00016","article-title":"Bone demineralization in cystic fibrosis: evidence of imbalance between bone formation and degradation","volume":"41","author":"Baroncelli","year":"1997","journal-title":"Pediatr. Res."},{"issue":"9","key":"10.1016\/j.bone.2023.116835_bb0030","doi-asserted-by":"crossref","first-page":"3399","DOI":"10.1210\/jc.2014-1982","article-title":"Compromised bone microarchitecture and estimated bone strength in young adults with cystic fibrosis","volume":"99","author":"Putman","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.bone.2023.116835_bb0035","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1210\/jc.2004-1629","article-title":"Guide to bone health and disease in cystic fibrosis","volume":"90","author":"Aris","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.bone.2023.116835_bb0040","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1378\/chest.130.2.539","article-title":"Prevalence of vertebral fractures in adults with cystic fibrosis and their relationship to bone mineral density","volume":"130","author":"Stephenson","year":"2006","journal-title":"Chest"},{"issue":"2","key":"10.1016\/j.bone.2023.116835_bb0045","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1136\/thorax.2003.006726","article-title":"Bone mineral density in Australian children, adolescents and adults with cystic fibrosis: a controlled cross sectional study","volume":"59","author":"Buntain","year":"2004","journal-title":"Thorax"},{"issue":"3 Pt 1","key":"10.1016\/j.bone.2023.116835_bb0050","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1164\/ajrccm.162.3.9910118","article-title":"Bone density, body composition, and inflammatory status in cystic fibrosis","volume":"162","author":"Ionescu","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"2","key":"10.1016\/j.bone.2023.116835_bb0055","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jcf.2009.11.007","article-title":"Osteoclast function, bone turnover and inflammatory cytokines during infective exacerbations of cystic fibrosis","volume":"9","author":"Shead","year":"2010","journal-title":"J. Cyst. Fibros."},{"issue":"3","key":"10.1016\/j.bone.2023.116835_bb0060","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1164\/rccm.200512-1943OC","article-title":"Osteoclastogenesis during infective exacerbations in patients with cystic fibrosis","volume":"174","author":"Shead","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"5","key":"10.1016\/j.bone.2023.116835_bb0065","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1164\/ajrccm.162.5.2002100","article-title":"Adverse alterations in bone metabolism are associated with lung infection in adults with cystic fibrosis","volume":"162","author":"Aris","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"Suppl. 2","key":"10.1016\/j.bone.2023.116835_bb0070","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1016\/S1569-1993(11)60004-0","article-title":"European cystic fibrosis bone mineralisation guidelines","volume":"10","author":"Sermet-Gaudelus","year":"2011","journal-title":"J. Cyst. Fibros."},{"key":"10.1016\/j.bone.2023.116835_bb0075","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1016\/j.jcf.2019.08.017","article-title":"Cystic fibrosis bone disease treatment: current knowledge and future directions","volume":"18","author":"Putman","year":"2019","journal-title":"J. Cyst. Fibros."},{"key":"10.1016\/j.bone.2023.116835_bb0080","doi-asserted-by":"crossref","first-page":"S66","DOI":"10.1016\/j.jcf.2019.08.022","article-title":"Vitamin D deficiency and its treatment in cystic fibrosis","volume":"18","author":"Daley","year":"2019","journal-title":"J. Cyst. Fibros."},{"issue":"2","key":"10.1016\/j.bone.2023.116835_bb0085","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4161\/derm.20332","article-title":"Pilot study of vitamin D supplementation in adults with cystic fibrosis pulmonary exacerbation: a randomized, controlled trial","volume":"4","author":"Grossmann","year":"2012","journal-title":"Dermato-endocrinology"},{"issue":"9","key":"10.1016\/j.bone.2023.116835_bb0090","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/ejcn.2012.82","article-title":"Impact of vitamin D supplementation on markers of inflammation in adults with cystic fibrosis hospitalized for a pulmonary exacerbation","volume":"66","author":"Grossmann","year":"2012","journal-title":"Eur. J. Clin. Nutr."},{"issue":"3","key":"10.1016\/j.bone.2023.116835_bb0095","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/cei.12984","article-title":"Vitamin D treatment modulates immune activation in cystic fibrosis","volume":"189","author":"Pincikova","year":"2017","journal-title":"Clin. Exp. Immunol."},{"issue":"2","key":"10.1016\/j.bone.2023.116835_bb0100","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/ejcn.2016.259","article-title":"Clinical impact of vitamin D treatment in cystic fibrosis: a pilot randomized, controlled trial","volume":"71","author":"Pincikova","year":"2017","journal-title":"Eur. J. Clin. Nutr."},{"issue":"1","key":"10.1016\/j.bone.2023.116835_bb0105","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13052-019-0634-x","article-title":"Vitamin D inhibits pro-inflammatory cytokines in the airways of cystic fibrosis patients infected by Pseudomonas aeruginosa- pilot study","volume":"45","author":"Olszowiec-Chlebna","year":"2019","journal-title":"Ital. J. Pediatr."},{"key":"10.1016\/j.bone.2023.116835_bb0110","series-title":"Current Osteoporosis Reports","first-page":"101","article-title":"Pathways for bone loss in inflammatory disease","volume":"10(2)","author":"Braun","year":"2012"},{"issue":"3","key":"10.1016\/j.bone.2023.116835_bb0115","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/ajcn\/nqy291","article-title":"Vitamin D for the immune system in cystic fibrosis (DISC): a double-blind, multicenter, randomized, placebo-controlled clinical trial","volume":"109","author":"Tangpricha","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bone.2023.116835_bb0120","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.conctc.2017.02.010","volume":"6","author":"Tangpricha","year":"2017","journal-title":"Contemp. Clin. Trials Commun."},{"issue":"1","key":"10.1016\/j.bone.2023.116835_bb0125","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jcf.2009.11.005","article-title":"Cystic fibrosis transmembrane conductance regulator (CFTR) regulates the production of osteoprotegerin (OPG) and prostaglandin (PG) E2 in human bone","volume":"9","author":"Le Heron","year":"2010","journal-title":"J. Cyst. Fibros."},{"issue":"5","key":"10.1016\/j.bone.2023.116835_bb0130","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1097\/QAI.0000000000001545","article-title":"Effects of vitamin D supplementation on bone mineral density and bone markers in HIV-infected youth","volume":"76","author":"Eckard","year":"2017","journal-title":"J. Acquir. Immune Defic. Syndr."},{"issue":"9","key":"10.1016\/j.bone.2023.116835_bb0135","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1093\/cid\/ciab547","article-title":"Impact of vitamin D and calcium supplementation on bone mineral density and bone metabolism among Thai adolescents with perinatally acquired human immunodeficiency virus (HIV) infection: a randomized clinical trial","volume":"73","author":"Sudjaritruk","year":"2021","journal-title":"Clin. Infect. Dis."},{"issue":"1","key":"10.1016\/j.bone.2023.116835_bb0140","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00198-011-1752-5","article-title":"The effect of high-dose vitamin D on bone mineral density and bone turnover markers in postmenopausal women with low bone mass--a randomized controlled 1-year trial","volume":"23","author":"Grimnes","year":"2012","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2023.116835_bb0145","series-title":"Dietary Reference Intakes for Calcium and Vitamin D","article-title":"The National Academies Collection: Reports funded by National Institutes of Health","author":"Institute of Medicine Committee to Review Dietary Reference Intakes for Vitamin D, Calcium","year":"2011"},{"issue":"6","key":"10.1016\/j.bone.2023.116835_bb0150","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00223-012-9637-y","article-title":"Dose-dependent short-term effects of single high doses of oral vitamin D(3) on bone turnover markers","volume":"91","author":"Rossini","year":"2012","journal-title":"Calcif. Tissue Int."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328223001680?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328223001680?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T18:05:19Z","timestamp":1757613919000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328223001680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":30,"alternative-id":["S8756328223001680"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2023.116835","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Changes in bone turnover after high-dose vitamin D supplementation during acute pulmonary exacerbation in cystic fibrosis","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2023.116835","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116835"}}