{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:42:54Z","timestamp":1790062974704,"version":"4.0.1"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"am","delay-in-days":308,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R56DK110145"],"award-info":[{"award-number":["R56DK110145"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006227","name":"Lawrence Livermore National Laboratory","doi-asserted-by":"publisher","award":["DE-AC52-07NA27344"],"award-info":[{"award-number":["DE-AC52-07NA27344"]}],"id":[{"id":"10.13039\/100006227","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.bone.2023.116976","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T19:01:01Z","timestamp":1701370861000},"page":"116976","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Mef2c regulates bone mass through Sost-dependent and -independent mechanisms"],"prefix":"10.1016","volume":"179","author":[{"given":"Cesar","family":"Morfin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimy","family":"Sebastian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen P.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beheshta","family":"Amiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa K.","family":"Murugesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas R.","family":"Hum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blaine A.","family":"Christiansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela G.","family":"Loots","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bone.2023.116976_bb0005","first-page":"9","article-title":"Primary osteoporosis in postmenopausal women","volume":"1","author":"Ji","year":"2015","journal-title":"Chronic Dis. Transl. Med."},{"issue":"12","key":"10.1016\/j.bone.2023.116976_bb0010","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1007\/s00198-006-0172-4","article-title":"An estimate of the worldwide prevalence and disability associated with osteoporotic fractures","volume":"17","author":"Johnell","year":"2006","journal-title":"Osteoporos. Int."},{"issue":"25","key":"10.1016\/j.bone.2023.116976_bb0015","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1056\/NEJMoa1808082","article-title":"Fracture prevention with zoledronate in older women with osteopenia","volume":"379","author":"Reid","year":"2018","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.bone.2023.116976_bb0020","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1210\/endo-110-2-506","article-title":"Parathyroid hormone stimulates the bone apposition rate independently of its resorptive action: differential effects of intermittent and continuous administration","volume":"110","author":"Tam","year":"1982","journal-title":"Endocrinology"},{"issue":"19","key":"10.1016\/j.bone.2023.116976_bb0025","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1056\/NEJM200105103441904","article-title":"Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis","volume":"344","author":"Neer","year":"2001","journal-title":"N. Engl. J. Med."},{"issue":"7","key":"10.1016\/j.bone.2023.116976_bb0030","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1001\/jama.2016.11136","article-title":"Effect of abaloparatide vs placebo on new vertebral fractures in postmenopausal women with osteoporosis: a randomized clinical trial","volume":"316","author":"Miller","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.bone.2023.116976_bb0035","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.yrtph.2017.04.001","article-title":"Comparing the incidence of bone tumors in rats chronically exposed to the selective PTH type 1 receptor agonist abaloparatide or PTH(1-34)","volume":"86","author":"Jolette","year":"2017","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"1","key":"10.1016\/j.bone.2023.116976_bb0040","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/jbmr.173","article-title":"Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody","volume":"26","author":"Padhi","year":"2011","journal-title":"J. Bone Miner. Res."},{"issue":"7","key":"10.1016\/j.bone.2023.116976_bb0045","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/0002-9378(67)90077-4","article-title":"Electrophoretic studies of human placental dehydrogenases","volume":"98","author":"Van Bogaert","year":"1967","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"9","key":"10.1016\/j.bone.2023.116976_bb0050","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1210\/jc.2017-02163","article-title":"A phase III randomized placebo-controlled trial to evaluate efficacy and safety of romosozumab in men with osteoporosis","volume":"103","author":"Lewiecki","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"Pt 20","key":"10.1016\/j.bone.2023.116976_bb0055","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1242\/jeb.01172","article-title":"Myoglobin: an essential hemoprotein in striated muscle","volume":"207","author":"Ordway","year":"2004","journal-title":"J. Exp. Biol."},{"issue":"1","key":"10.1016\/j.bone.2023.116976_bb0060","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1161\/ATVBAHA.107.155788","article-title":"MCAT elements and the TEF-1 family of transcription factors in muscle development and disease","volume":"28","author":"Yoshida","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"40","key":"10.1016\/j.bone.2023.116976_bb0065","doi-asserted-by":"crossref","first-page":"26218","DOI":"10.1074\/jbc.273.40.26218","article-title":"Synergistic activation of the N-methyl-D-aspartate receptor subunit 1 promoter by myocyte enhancer factor 2C and Sp1","volume":"273","author":"Krainc","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.bone.2023.116976_bb0070","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S1074-7613(00)80575-0","article-title":"Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes","volume":"8","author":"Sun","year":"1998","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.bone.2023.116976_bb0075","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1006\/bbrc.2001.5589","article-title":"SOX18 directly interacts with MEF2C in endothelial cells","volume":"287","author":"Hosking","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.bone.2023.116976_bb0080","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1182\/blood-2007-07-100412","article-title":"Sox18 and Sox7 play redundant roles in vascular development","volume":"111","author":"Cermenati","year":"2008","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.bone.2023.116976_bb0085","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.devcel.2007.02.004","article-title":"MEF2C transcription factor controls chondrocyte hypertrophy and bone development","volume":"12","author":"Arnold","year":"2007","journal-title":"Dev. Cell"},{"issue":"35","key":"10.1016\/j.bone.2023.116976_bb0090","doi-asserted-by":"crossref","first-page":"14092","DOI":"10.1073\/pnas.1207188109","article-title":"Targeted deletion of Sost distal enhancer increases bone formation and bone mass","volume":"109","author":"Collette","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.bone.2023.116976_bb0095","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41413-020-00120-2","article-title":"MEF2C regulates osteoclastogenesis and pathologic bone resorption via c-FOS","volume":"9","author":"Fujii","year":"2021","journal-title":"Bone Res."},{"issue":"1","key":"10.1016\/j.bone.2023.116976_bb0100","doi-asserted-by":"crossref","first-page":"13274","DOI":"10.1038\/s41598-019-49499-x","article-title":"Hypoxia activates the PTHrP -MEF2C pathway to attenuate hypertrophy in mesenchymal stem cell derived cartilage","volume":"9","author":"Browe","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bone.2023.116976_bb0105","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3389\/fcell.2020.00081","article-title":"Significance of MEF2C and RUNX3 regulation for endochondral differentiation of human mesenchymal progenitor cells","volume":"8","author":"Dreher","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"4","key":"10.1016\/j.bone.2023.116976_bb0110","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s00223-013-9824-5","article-title":"A ChIP-seq-defined genome-wide map of MEF2C binding reveals inflammatory pathways associated with its role in bone density determination","volume":"94","author":"Johnson","year":"2014","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2023.116976_bb0115","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1186\/1471-2474-15-400","article-title":"Analysis of association of MEF2C, SOST and JAG1 genes with bone mineral density in Mexican-Mestizo postmenopausal women","volume":"15","author":"Velazquez-Cruz","year":"2014","journal-title":"BMC Musculoskelet. Disord."},{"issue":"2","key":"10.1016\/j.bone.2023.116976_bb0120","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/jbmr.1492","article-title":"Mef2c deletion in osteocytes results in increased bone mass","volume":"27","author":"Kramer","year":"2012","journal-title":"J. Bone Miner. Res."},{"issue":"11","key":"10.1016\/j.bone.2023.116976_bb0125","doi-asserted-by":"crossref","first-page":"3778","DOI":"10.1210\/en.2017-00159","article-title":"MEF2C interacts with c-FOS in PTH-stimulated Mmp13 gene expression in osteoblastic cells","volume":"158","author":"Nakatani","year":"2017","journal-title":"Endocrinology"},{"issue":"9","key":"10.1016\/j.bone.2023.116976_bb0130","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1002\/jbmr.2240","article-title":"Dlx5 and mef2 regulate a novel runx2 enhancer for osteoblast-specific expression","volume":"29","author":"Kawane","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2023.116976_bb0135","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.gene.2018.06.079","article-title":"Global gene expression analysis identifies Mef2c as a potential player in Wnt16-mediated transcriptional regulation","volume":"675","author":"Sebastian","year":"2018","journal-title":"Gene"},{"issue":"1","key":"10.1016\/j.bone.2023.116976_bb0140","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nn.2467","article-title":"A robust and high-throughput Cre reporting and characterization system for the whole mouse brain","volume":"13","author":"Madisen","year":"2010","journal-title":"Nat. Neurosci."},{"issue":"7","key":"10.1016\/j.bone.2023.116976_bb0145","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1387\/ijdb.041816fl","article-title":"Expression and activity of osteoblast-targeted Cre recombinase transgenes in murine skeletal tissues","volume":"48","author":"Liu","year":"2004","journal-title":"Int. J. Dev. Biol."},{"issue":"5317","key":"10.1016\/j.bone.2023.116976_bb0150","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1126\/science.276.5317.1404","article-title":"Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C","volume":"276","author":"Lin","year":"1997","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.bone.2023.116976_bb0155","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1359\/jbmr.080216","article-title":"Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength","volume":"23","author":"Li","year":"2008","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2023.116976_bb0160","doi-asserted-by":"crossref","first-page":"938075","DOI":"10.3389\/fimmu.2022.938075","article-title":"Single-cell RNA-Seq reveals changes in immune landscape in post-traumatic osteoarthritis","volume":"13","author":"Sebastian","year":"2022","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.bone.2023.116976_bb0165","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12051307","article-title":"Single-cell transcriptomic analysis of tumor-derived fibroblasts and normal tissue-resident fibroblasts reveals fibroblast heterogeneity in breast cancer","volume":"12","author":"Sebastian","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"5","key":"10.1016\/j.bone.2023.116976_bb0170","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"issue":"12","key":"10.1016\/j.bone.2023.116976_bb0175","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"issue":"W1","key":"10.1016\/j.bone.2023.116976_bb0180","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"8","key":"10.1016\/j.bone.2023.116976_bb0185","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/nprot.2009.97","article-title":"Mapping identifiers for the integration of genomic datasets with the R\/bioconductor package biomaRt","volume":"4","author":"Durinck","year":"2009","journal-title":"Nat. Protoc."},{"issue":"9","key":"10.1016\/j.bone.2023.116976_bb0190","doi-asserted-by":"crossref","first-page":"e0215495","DOI":"10.1371\/journal.pone.0215495","article-title":"CiiiDER: a tool for predicting and analysing transcription factor binding sites","volume":"14","author":"Gearing","year":"2019","journal-title":"PLoS One"},{"issue":"D1","key":"10.1016\/j.bone.2023.116976_bb0195","doi-asserted-by":"crossref","first-page":"D165","DOI":"10.1093\/nar\/gkab1113","article-title":"JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles","volume":"50","author":"Castro-Mondragon","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"Web Server issue","key":"10.1016\/j.bone.2023.116976_bb0200","doi-asserted-by":"crossref","first-page":"W305","DOI":"10.1093\/nar\/gkp427","article-title":"ToppGene suite for gene list enrichment analysis and candidate gene prioritization","volume":"37","author":"Chen","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"7","key":"10.1016\/j.bone.2023.116976_bb0205","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1101\/gr.3437105","article-title":"Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease","volume":"15","author":"Loots","year":"2005","journal-title":"Genome Res."},{"issue":"4","key":"10.1016\/j.bone.2023.116976_bb0210","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.bone.2009.06.010","article-title":"Identification of differentially expressed genes between osteoblasts and osteocytes","volume":"45","author":"Paic","year":"2009","journal-title":"Bone"},{"issue":"12","key":"10.1016\/j.bone.2023.116976_bb0215","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1359\/jbmr.070804","article-title":"Control of the SOST bone enhancer by PTH using MEF2 transcription factors","volume":"22","author":"Leupin","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2023.116976_bb0220","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1146\/annurev.cellbio.042308.113308","article-title":"Genetic control of bone formation","volume":"25","author":"Karsenty","year":"2009","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"5","key":"10.1016\/j.bone.2023.116976_bb0225","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0092-8674(00)80257-3","article-title":"Osf2\/Cbfa1: a transcriptional activator of osteoblast differentiation","volume":"89","author":"Ducy","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.bone.2023.116976_bb0230","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1196\/annals.1402.018","article-title":"Osteocytes as dynamic multifunctional cells","volume":"1116","author":"Bonewald","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"9","key":"10.1016\/j.bone.2023.116976_bb0235","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1007\/s00198-010-1194-5","article-title":"Osteocyte: the unrecognized side of bone tissue","volume":"21","author":"Rochefort","year":"2010","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2023.116976_bb0240","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/00003086-199010000-00032","article-title":"In vivo osteochondrogenic potential of cultured cells derived from the periosteum","volume":"259","author":"Nakahara","year":"1990","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.bone.2023.116976_bb0245","doi-asserted-by":"crossref","first-page":"101594","DOI":"10.1016\/j.bonr.2022.101594","article-title":"Cell energy metabolism and bone formation","volume":"16","author":"Sautchuk","year":"2022","journal-title":"Bone Rep."},{"issue":"11","key":"10.1016\/j.bone.2023.116976_bb0250","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1002\/jbmr.2877","article-title":"Targeting of mesenchymal stromal cells by Cre-recombinase transgenes commonly used to target osteoblast lineage cells","volume":"31","author":"Zhang","year":"2016","journal-title":"J. Bone Miner. Res."},{"issue":"6","key":"10.1016\/j.bone.2023.116976_bb0255","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nmeth.4292","article-title":"Normalizing single-cell RNA sequencing data: challenges and opportunities","volume":"14","author":"Vallejos","year":"2017","journal-title":"Nat. Methods"},{"issue":"3","key":"10.1016\/j.bone.2023.116976_bb0260","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrg3833","article-title":"Computational and analytical challenges in single-cell transcriptomics","volume":"16","author":"Stegle","year":"2015","journal-title":"Nat. Rev. Genet."},{"issue":"1","key":"10.1016\/j.bone.2023.116976_bb0265","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s42255-020-00321-3","article-title":"Metabolic regulation of skeletal cell fate and function in physiology and disease","volume":"3","author":"van Gastel","year":"2021","journal-title":"Nat. Metab."},{"issue":"2","key":"10.1016\/j.bone.2023.116976_bb0270","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1089\/scd.2015.0193","article-title":"Energy metabolism in mesenchymal stem cells during osteogenic differentiation","volume":"25","author":"Shum","year":"2016","journal-title":"Stem Cells Dev."},{"issue":"4","key":"10.1016\/j.bone.2023.116976_bb0275","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.cmet.2019.01.016","article-title":"Glutamine metabolism regulates proliferation and lineage allocation in skeletal stem cells","volume":"29","author":"Yu","year":"2019","journal-title":"Cell Metab."},{"issue":"3","key":"10.1016\/j.bone.2023.116976_bb0280","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1089\/scd.2020.0141","article-title":"Energy metabolism during osteogenic differentiation: the role of Akt","volume":"30","author":"Smith","year":"2021","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.bone.2023.116976_bb0285","doi-asserted-by":"crossref","first-page":"116257","DOI":"10.1016\/j.bone.2021.116257","article-title":"NAD(P)H autofluorescence lifetime imaging enables single cell analyses of cellular metabolism of osteoblasts in vitro and in vivo via two-photon microscopy","volume":"154","author":"Schilling","year":"2022","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.bone.2023.116976_bb0290","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1038\/s41467-018-07316-5","article-title":"Glucose metabolism induced by Bmp signaling is essential for murine skeletal development","volume":"9","author":"Lee","year":"2018","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.bone.2023.116976_bb0295","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1083\/jcb.100.2.598","article-title":"Immunohistochemical localization of short chain cartilage collagen (type X) in avian tissues","volume":"100","author":"Schmid","year":"1985","journal-title":"J. Cell Biol."},{"issue":"4 Pt 1","key":"10.1016\/j.bone.2023.116976_bb0300","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1083\/jcb.109.4.1849","article-title":"Comparative studies of type X collagen expression in normal and rachitic chicken epiphyseal cartilage","volume":"109","author":"Kwan","year":"1989","journal-title":"J. Cell Biol."},{"issue":"3","key":"10.1016\/j.bone.2023.116976_bb0305","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1083\/jcb.117.3.687","article-title":"Domains of type X collagen: alteration of cartilage matrix by fibril association and proteoglycan accumulation","volume":"117","author":"Chen","year":"1992","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bone.2023.116976_bb0310","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1749-6632.1990.tb17918.x","article-title":"Hypertrophic cartilage matrix. Type X collagen, supramolecular assembly, and calcification","volume":"580","author":"Schmid","year":"1990","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"1","key":"10.1016\/j.bone.2023.116976_bb0315","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1601-6343.2004.00308.x","article-title":"The role of type X collagen in facilitating and regulating endochondral ossification of articular cartilage","volume":"8","author":"Shen","year":"2005","journal-title":"Orthod. Craniofacial Res."},{"issue":"23","key":"10.1016\/j.bone.2023.116976_bb0320","doi-asserted-by":"crossref","first-page":"13521","DOI":"10.1016\/S0021-9258(18)77378-X","article-title":"Differential susceptibility of type X collagen to cleavage by two mammalian interstitial collagenases and 72-kDa type IV collagenase","volume":"265","author":"Welgus","year":"1990","journal-title":"J. Biol. Chem."},{"issue":"24","key":"10.1016\/j.bone.2023.116976_bb0325","doi-asserted-by":"crossref","first-page":"13029","DOI":"10.1016\/S0021-9258(17)38833-6","article-title":"Coordinate regulation of collagen and alkaline phosphatase levels in chick embryo chondrocytes","volume":"260","author":"Habuchi","year":"1985","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bone.2023.116976_bb0330","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/03008209709160211","article-title":"Role of type X collagen on experimental mineralization of eggshell membranes","volume":"36","author":"Arias","year":"1997","journal-title":"Connect. Tissue Res."},{"issue":"1","key":"10.1016\/j.bone.2023.116976_bb0335","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/ng0993-79","article-title":"A type X collagen mutation causes Schmid metaphyseal chondrodysplasia","volume":"5","author":"Warman","year":"1993","journal-title":"Nat. Genet."},{"issue":"3","key":"10.1016\/j.bone.2023.116976_bb0340","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.mam.2005.01.003","article-title":"Transcriptional regulation of chondrocyte maturation: potential involvement of transcription factors in OA pathogenesis","volume":"26","author":"Drissi","year":"2005","journal-title":"Mol. Asp. Med."},{"issue":"5","key":"10.1016\/j.bone.2023.116976_bb0345","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/ar3117","article-title":"Hypertrophic differentiation of chondrocytes in osteoarthritis: the developmental aspect of degenerative joint disorders","volume":"12","author":"Dreier","year":"2010","journal-title":"Arthritis Res. Ther."},{"issue":"2","key":"10.1016\/j.bone.2023.116976_bb0350","first-page":"169","article-title":"Amino acid substitutions of conserved residues in the carboxyl-terminal domain of the alpha 1(X) chain of type X collagen occur in two unrelated families with metaphyseal chondrodysplasia type Schmid","volume":"54","author":"Wallis","year":"1994","journal-title":"Am. J. Hum. Genet."},{"issue":"2","key":"10.1016\/j.bone.2023.116976_bb0355","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1083\/jcb.136.2.459","article-title":"Abnormal compartmentalization of cartilage matrix components in mice lacking collagen X: implications for function","volume":"136","author":"Kwan","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bone.2023.116976_bb0360","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.bone.2018.12.001","article-title":"Deletion of OPN in BSP knockout mice does not correct bone hypomineralization but results in high bone turnover","volume":"120","author":"Bouleftour","year":"2019","journal-title":"Bone"},{"key":"10.1016\/j.bone.2023.116976_bb0365","doi-asserted-by":"crossref","first-page":"101621","DOI":"10.1016\/j.bonr.2022.101621","article-title":"Deletion of osteopontin or bone sialoprotein induces opposite bone responses to mechanical stimulation in mice","volume":"17","author":"Maalouf","year":"2022","journal-title":"Bone Rep."},{"issue":"5","key":"10.1016\/j.bone.2023.116976_bb0370","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095144","article-title":"Skeletal development of mice lacking bone sialoprotein (BSP)\u2014impairment of long bone growth and progressive establishment of high trabecular bone mass","volume":"9","author":"Bouleftour","year":"2014","journal-title":"PLoS One"},{"issue":"5708","key":"10.1016\/j.bone.2023.116976_bb0375","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1126\/science.1104343","article-title":"Mitochondrial dysfunction and type 2 diabetes","volume":"307","author":"Lowell","year":"2005","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.bone.2023.116976_bb0380","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/EC-14-0092","article-title":"Mitochondrial dysfunction and insulin resistance: an update","volume":"4","author":"Montgomery","year":"2015","journal-title":"Endocr. Connect."},{"key":"10.1016\/j.bone.2023.116976_bb0385","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.redox.2017.01.013","article-title":"Mitochondrial dynamics in type 2 diabetes: pathophysiological implications","volume":"11","author":"Rovira-Llopis","year":"2017","journal-title":"Redox Biol."},{"issue":"4","key":"10.1016\/j.bone.2023.116976_bb0390","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00198-006-0253-4","article-title":"Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes\u2014a meta-analysis","volume":"18","author":"Vestergaard","year":"2007","journal-title":"Osteoporos. Int."},{"issue":"5","key":"10.1016\/j.bone.2023.116976_bb0395","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nrendo.2011.233","article-title":"Bone, sweet bone\u2014osteoporotic fractures in diabetes mellitus","volume":"8","author":"Hamann","year":"2012","journal-title":"Nat. Rev. Endocrinol."},{"issue":"12","key":"10.1016\/j.bone.2023.116976_bb0400","doi-asserted-by":"crossref","DOI":"10.3390\/cells9122630","article-title":"Deciphering the relevance of bone ECM signaling","volume":"9","author":"Alcorta-Sevillano","year":"2020","journal-title":"Cells"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328223003095?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328223003095?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T18:07:59Z","timestamp":1757614079000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328223003095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":80,"alternative-id":["S8756328223003095"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2023.116976","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mef2c regulates bone mass through Sost-dependent and -independent mechanisms","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2023.116976","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116976"}}