{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:59:12Z","timestamp":1788580752338,"version":"build-2803163510"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K07838"],"award-info":[{"award-number":["18K07838"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21H02881"],"award-info":[{"award-number":["21H02881"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K07835"],"award-info":[{"award-number":["21K07835"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.bone.2024.117044","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T13:41:33Z","timestamp":1707226893000},"page":"117044","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Complex intrinsic abnormalities in osteoblast lineage cells of X-linked hypophosphatemia: Analysis of human iPS cell models generated by CRISPR\/Cas9-mediated gene ablation"],"prefix":"10.1016","volume":"181","author":[{"given":"Tatsuro","family":"Nakanishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miwa","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Tachikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayu","family":"Ueta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Ozono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshimi","family":"Michigami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.bone.2024.117044_bb0005","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1002\/jbmr.340","article-title":"A clinician\u2019s guide to X-linked hypophosphatemia","volume":"26","author":"Carpenter","year":"2011","journal-title":"J. Bone Miner. Res."},{"issue":"7","key":"10.1016\/j.bone.2024.117044_bb0010","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41581-019-0152-5","article-title":"Clinical practice recommendations for the diagnosis and management of X-linked hypophosphataemia","volume":"15","author":"Haffner","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.bone.2024.117044_bb0015","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1005189","article-title":"Osteocytes and the pathogenesis of hypophosphatemic rickets","volume":"13","author":"Yamazaki","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"11","key":"10.1016\/j.bone.2024.117044_bb0020","doi-asserted-by":"crossref","first-page":"6500","DOI":"10.1073\/pnas.101545198","article-title":"Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia","volume":"98","author":"Shimada","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.bone.2024.117044_bb0025","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/humu.24296","article-title":"Novel PHEX gene locus-specific database: comprehensive characterization of vast number of variants associated with X-linked hypophosphatemia (XLH)","volume":"43","author":"Sarafrazi","year":"2022","journal-title":"Hum. Mutat."},{"issue":"3","key":"10.1016\/j.bone.2024.117044_bb0030","doi-asserted-by":"crossref","first-page":"498","DOI":"10.3390\/endocrines3030040","article-title":"Pathogenic variants of the PHEX gene","volume":"3","author":"Ohata","year":"2022","journal-title":"Endocrines"},{"key":"10.1016\/j.bone.2024.117044_bb0035","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.bone.2017.07.026","article-title":"Tissue-specific mineralization defects in the periodontium of the Hyp mouse model of X-linked hypophosphatemia","volume":"103","author":"Coyac","year":"2017","journal-title":"Bone"},{"issue":"4","key":"10.1016\/j.bone.2024.117044_bb0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0093840","article-title":"Dysregulated gene expression in the primary osteoblasts and osteocytes isolated from hypophosphatemic Hyp mice","volume":"9","author":"Miyagawa","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bone.2024.117044_bb0045","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1046\/j.1523-1755.2000.00807.x","article-title":"PHEX gene and hypophosphatemia","volume":"57","author":"Drezner","year":"2000","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.bone.2024.117044_bb0050","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.bone.2004.04.002","article-title":"FGF23 is processed by proprotein convertases but not by PHEX","volume":"35","author":"Benet-Pages","year":"2004","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.bone.2024.117044_bb0055","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1172\/JCI119276","article-title":"Pex\/PEX tissue distribution and evidence for a deletion in the 3\u2019 region of the Pex gene in X-linked hypophosphatemic mice","volume":"99","author":"Beck","year":"1997","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.bone.2024.117044_bb0060","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1681\/ASN.2005111185","article-title":"Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D","volume":"17","author":"Liu","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"issue":"2","key":"10.1016\/j.bone.2024.117044_bb0065","first-page":"722","article-title":"Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia","volume":"118","author":"Yuan","year":"2008","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.bone.2024.117044_bb0070","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1002\/jbmr.1766","article-title":"Proteolytic processing of osteopontin by PHEX and accumulation of osteopontin fragments in Hyp mouse bone, the murine model of X-linked hypophosphatemia","volume":"28","author":"Barros","year":"2013","journal-title":"J. Bone Miner. Res."},{"issue":"10","key":"10.1016\/j.bone.2024.117044_bb0075","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1002\/jbmr.4101","article-title":"Genetic ablation of Osteopontin in Osteomalacic Hyp mice partially rescues the deficient mineralization without correcting hypophosphatemia","volume":"35","author":"Hoac","year":"2020","journal-title":"J. Bone Miner. Res."},{"issue":"8","key":"10.1016\/j.bone.2024.117044_bb0080","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1096\/fj.10-177816","article-title":"Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling","volume":"25","author":"Martin","year":"2011","journal-title":"FASEB J."},{"issue":"8","key":"10.1016\/j.bone.2024.117044_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0104154","article-title":"Osteocyte-specific deletion of Fgfr1 suppresses FGF23","volume":"9","author":"Xiao","year":"2014","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.bone.2024.117044_bb0090","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/s41551-019-0410-7","article-title":"In vitro bone-like nodules generated from patient-derived iPSCs recapitulate pathological bone phenotypes","volume":"3","author":"Kawai","year":"2019","journal-title":"Nat. Biomed. Eng."},{"issue":"50","key":"10.1016\/j.bone.2024.117044_bb0095","doi-asserted-by":"crossref","first-page":"15438","DOI":"10.1073\/pnas.1510540112","article-title":"Neofunction of ACVR1 in fibrodysplasia ossificans progressiva","volume":"112","author":"Hino","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.bone.2024.117044_bb0100","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1002\/jcb.25742","article-title":"Extracellular phosphate induces the expression of dentin matrix protein 1 through the FGF receptor in osteoblasts","volume":"118","author":"Nishino","year":"2017","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bone.2024.117044_bb0105","doi-asserted-by":"crossref","first-page":"116430","DOI":"10.1016\/j.bone.2022.116430","article-title":"Growth-related skeletal changes and alterations in phosphate metabolism","volume":"161","author":"Michigami","year":"2022","journal-title":"Bone"},{"key":"10.1016\/j.bone.2024.117044_bb0110","doi-asserted-by":"crossref","first-page":"116036","DOI":"10.1016\/j.bone.2021.116036","article-title":"Clonal osteoblastic cell lines with CRISPR\/Cas9-mediated ablation of Pit1 or Pit2 show enhanced mineralization despite reduced osteogenic gene expression","volume":"151","author":"Yamazaki","year":"2021","journal-title":"Bone"},{"key":"10.1016\/j.bone.2024.117044_bb0115","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41413-018-0029-4","article-title":"Alpl prevents bone ageing sensitivity by specifically regulating senescence and differentiation in mesenchymal stem cells","volume":"6","author":"Liu","year":"2018","journal-title":"Bone Res."},{"issue":"5","key":"10.1016\/j.bone.2024.117044_bb0120","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11926-016-0574-z","article-title":"The role of ANK in calcium pyrophosphate deposition disease","volume":"18","author":"Mitton-Fitzgerald","year":"2016","journal-title":"Curr. Rheumatol. Rep."},{"issue":"7","key":"10.1016\/j.bone.2024.117044_bb0125","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.tibs.2019.01.010","article-title":"ENPP1 in the regulation of mineralization and beyond","volume":"44","author":"Roberts","year":"2019","journal-title":"Trends Biochem. Sci."},{"issue":"1","key":"10.1016\/j.bone.2024.117044_bb0130","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/jbm4.10021","article-title":"Parathyroid hormone signaling in osteocytes","volume":"2","author":"Wein","year":"2018","journal-title":"JBMR Plus"},{"key":"10.1016\/j.bone.2024.117044_bb0135","doi-asserted-by":"crossref","first-page":"833221","DOI":"10.3389\/fendo.2021.833221","article-title":"PTH1R actions on bone using the cAMP\/protein kinase a pathway","volume":"12","author":"Martin","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"4","key":"10.1016\/j.bone.2024.117044_bb0140","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1152\/physrev.00022.2017","article-title":"Phosphate as a signaling molecule and its sensing mechanism","volume":"98","author":"Michigami","year":"2018","journal-title":"Physiol. Rev."},{"issue":"5","key":"10.1016\/j.bone.2024.117044_bb0145","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1002\/jcb.22842","article-title":"Both FGF23 and extracellular phosphate activate Raf\/MEK\/ERK pathway via FGF receptors in HEK293 cells","volume":"111","author":"Yamazaki","year":"2010","journal-title":"J. Cell. Biochem."},{"issue":"5","key":"10.1016\/j.bone.2024.117044_bb0150","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.bone.2010.08.006","article-title":"Signaling of extracellular inorganic phosphate up-regulates cyclin D1 expression in proliferating chondrocytes via the Na+\/Pi cotransporter Pit-1 and Raf\/MEK\/ERK pathway","volume":"47","author":"Kimata","year":"2010","journal-title":"Bone"},{"issue":"15","key":"10.1016\/j.bone.2024.117044_bb0155","doi-asserted-by":"crossref","first-page":"8352","DOI":"10.1073\/pnas.140021997","article-title":"Phosphate is a specific signal for induction of osteopontin gene expression","volume":"97","author":"Beck","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.bone.2024.117044_bb0160","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s40610-019-0111-8","article-title":"FGF23 synthesis and activity","volume":"5","author":"Noonan","year":"2019","journal-title":"Curr. Mol. Biol. Rep."},{"key":"10.1016\/j.bone.2024.117044_bb0165","doi-asserted-by":"crossref","first-page":"967774","DOI":"10.3389\/fendo.2022.967774","article-title":"Roles of osteocytes in phosphate metabolism","volume":"13","author":"Michigami","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"21","key":"10.1016\/j.bone.2024.117044_bb0170","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1056\/NEJMoa1714641","article-title":"Burosumab therapy in children with X-linked hypophosphatemia","volume":"378","author":"Carpenter","year":"2018","journal-title":"N. Engl. J. Med."},{"issue":"10189","key":"10.1016\/j.bone.2024.117044_bb0175","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1016\/S0140-6736(19)30654-3","article-title":"Burosumab versus conventional therapy in children with X-linked hypophosphataemia: a randomised, active-controlled, open-label, phase 3 trial","volume":"393","author":"Imel","year":"2019","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.bone.2024.117044_bb0180","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2021-001714","article-title":"Burosumab treatment in adults with X-linked hypophosphataemia: 96-week patient-reported outcomes and ambulatory function from a randomised phase 3 trial and open-label extension","volume":"7","author":"Briot","year":"2021","journal-title":"RMD Open"},{"issue":"2","key":"10.1016\/j.bone.2024.117044_bb0185","doi-asserted-by":"crossref","first-page":"R57","DOI":"10.1530\/JME-20-0089","article-title":"FGF23-related hypophosphatemic rickets\/osteomalacia: diagnosis and new treatment","volume":"66","author":"Fukumoto","year":"2021","journal-title":"J. Mol. Endocrinol."},{"issue":"7","key":"10.1016\/j.bone.2024.117044_bb0190","doi-asserted-by":"crossref","DOI":"10.1210\/clinem\/dgaa242","article-title":"Enthesopathy, osteoarthritis, and mobility in X-linked Hypophosphatemia1","volume":"105","author":"Imel","year":"2020","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.bone.2024.117044_bb0195","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.bone.2008.02.014","article-title":"Clinical usefulness of measurement of fibroblast growth factor 23 (FGF23) in hypophosphatemic patients: proposal of diagnostic criteria using FGF23 measurement","volume":"42","author":"Endo","year":"2008","journal-title":"Bone"},{"issue":"8","key":"10.1016\/j.bone.2024.117044_bb0200","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1007\/s00198-013-2286-9","article-title":"High bone mineral apparent density in children with X-linked hypophosphatemia","volume":"24","author":"Beck-Nielsen","year":"2013","journal-title":"Osteoporos. Int."},{"issue":"5","key":"10.1016\/j.bone.2024.117044_bb0205","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1007\/s00774-023-01442-x","article-title":"Evaluation of the trabecular bone score in 35 children and adults with X-linked hypophosphatemic rickets","volume":"41","author":"de Paula Colares Neto","year":"2023","journal-title":"J. Bone Miner. Metab."},{"issue":"4","key":"10.1016\/j.bone.2024.117044_bb0210","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s00223-012-9672-8","article-title":"The role of phosphatases in the initiation of skeletal mineralization","volume":"93","author":"Millan","year":"2013","journal-title":"Calcif. Tissue Int."},{"issue":"4","key":"10.1016\/j.bone.2024.117044_bb0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1002427","article-title":"Excessive Osteocytic Fgf23 secretion contributes to pyrophosphate accumulation and mineralization defect in Hyp mice","volume":"14","author":"Murali","year":"2016","journal-title":"PLoS Biol."},{"issue":"1","key":"10.1016\/j.bone.2024.117044_bb0220","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/jbmr.2606","article-title":"FGF23 regulates bone mineralization in a 1,25(OH)2 D3 and Klotho-independent manner","volume":"31","author":"Murali","year":"2016","journal-title":"J. Bone Miner. Res."},{"issue":"20","key":"10.1016\/j.bone.2024.117044_bb0225","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.162138","article-title":"Spatial metabolomics reveals upregulation of several pyrophosphate-producing pathways in cortical bone of Hyp mice","volume":"7","author":"Buck","year":"2022","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.bone.2024.117044_bb0230","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bone.2004.09.015","article-title":"Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE-ASARM motif: a model for impaired mineralization in X-linked rickets (HYP)","volume":"36","author":"Rowe","year":"2005","journal-title":"Bone"},{"key":"10.1016\/j.bone.2024.117044_bb0235","doi-asserted-by":"crossref","first-page":"115447","DOI":"10.1016\/j.bone.2020.115447","article-title":"Biological stenciling of mineralization in the skeleton: local enzymatic removal of inhibitors in the extracellular matrix","volume":"138","author":"Reznikov","year":"2020","journal-title":"Bone"},{"issue":"43","key":"10.1016\/j.bone.2024.117044_bb0240","doi-asserted-by":"crossref","first-page":"41921","DOI":"10.1074\/jbc.M304470200","article-title":"Osteopontin regulation by inorganic phosphate is ERK1\/2-, protein kinase C-, and proteasome-dependent","volume":"278","author":"Beck","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.bone.2024.117044_bb0245","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23105776","article-title":"Whole aspect of Runx2 functions in skeletal development","volume":"23","author":"Komori","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bone.2024.117044_bb0250","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1679\/aohc.71.131","article-title":"Inhibition of the terminal differentiation of odontoblasts and their transdifferentiation into osteoblasts in Runx2 transgenic mice","volume":"71","author":"Miyazaki","year":"2008","journal-title":"Arch. Histol. Cytol."},{"issue":"11","key":"10.1016\/j.bone.2024.117044_bb0255","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1359\/jbmr.2002.17.11.1931","article-title":"Cell-type-dependent up-regulation of in vitro mineralization after overexpression of the osteoblast-specific transcription factor Runx2\/Cbfal","volume":"17","author":"Byers","year":"2002","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.bone.2024.117044_bb0260","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.yexcr.2004.07.031","article-title":"Runx2\/Cbfa1 stimulates transdifferentiation of primary skeletal myoblasts into a mineralizing osteoblastic phenotype","volume":"300","author":"Gersbach","year":"2004","journal-title":"Exp. Cell Res."},{"issue":"23","key":"10.1016\/j.bone.2024.117044_bb0265","doi-asserted-by":"crossref","first-page":"11418","DOI":"10.1073\/pnas.1815166116","article-title":"Activation of unliganded FGF receptor by extracellular phosphate potentiates proteolytic protection of FGF23 by its O-glycosylation","volume":"116","author":"Takashi","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.bone.2024.117044_bb0270","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1023\/A:1023633704132","article-title":"The role of ATF\/CREB family members in cell growth, survival and apoptosis","volume":"8","author":"Persengiev","year":"2003","journal-title":"Apoptosis"},{"issue":"6","key":"10.1016\/j.bone.2024.117044_bb0275","article-title":"Transcriptional regulation of BMP2 expression by the PTH-CREB signaling pathway in osteoblasts","volume":"6","author":"Zhang","year":"2011","journal-title":"PLoS One"},{"issue":"16","key":"10.1016\/j.bone.2024.117044_bb0280","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1089\/scd.2018.0023","article-title":"Zinc promotes osteoblast differentiation in human mesenchymal stem cells via activation of the cAMP-PKA-CREB signaling pathway","volume":"27","author":"Park","year":"2018","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.bone.2024.117044_bb0285","doi-asserted-by":"crossref","first-page":"583105","DOI":"10.3389\/fendo.2020.583105","article-title":"Inhibition of Y1 receptor promotes osteogenesis in bone marrow stromal cells via cAMP\/PKA\/CREB pathway","volume":"11","author":"Yu","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"9","key":"10.1016\/j.bone.2024.117044_bb0290","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1172\/JCI24918","article-title":"Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34","volume":"115","author":"Miao","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.bone.2024.117044_bb0295","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/jbmr.3291","article-title":"Autocrine and paracrine regulation of the murine skeleton by osteocyte-derived parathyroid hormone-related protein","volume":"33","author":"Ansari","year":"2018","journal-title":"J. Bone Miner. Res."},{"issue":"8","key":"10.1016\/j.bone.2024.117044_bb0300","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1002\/jbmr.3167","article-title":"Osteocytes acidify their microenvironment in response to PTHrP in vitro and in lactating mice in vivo","volume":"32","author":"Jahn","year":"2017","journal-title":"J. Bone Miner. Res."},{"issue":"4\u20135","key":"10.1016\/j.bone.2024.117044_bb0305","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/BF02405074","article-title":"Relation between hypomineralized periosteocytic lesions and bone mineralization in vitamin D-resistant rickets","volume":"35","author":"Marie","year":"1983","journal-title":"Calcif. Tissue Int."},{"issue":"Pt 3","key":"10.1016\/j.bone.2024.117044_bb0310","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1042\/bj3550707","article-title":"Characterization of PHEX endopeptidase catalytic activity: identification of parathyroid-hormone-related peptide107-139 as a substrate and osteocalcin, PPi and phosphate as inhibitors","volume":"355","author":"Boileau","year":"2001","journal-title":"Biochem. J."},{"issue":"3","key":"10.1016\/j.bone.2024.117044_bb0315","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1210\/jcem-59-3-556","article-title":"Specific internalization and action of 1,25-dihydroxyvitamin D3 in cultured dermal fibroblasts from patients with X-linked hypophosphatemia","volume":"59","author":"Adams","year":"1984","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.bone.2024.117044_bb0320","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1177\/0022034517728497","article-title":"Defective mineralization in X-linked hypophosphatemia dental pulp cell cultures","volume":"97","author":"Coyac","year":"2018","journal-title":"J. Dent. Res."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328224000334?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328224000334?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:47:02Z","timestamp":1762660022000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328224000334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":64,"alternative-id":["S8756328224000334"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2024.117044","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Complex intrinsic abnormalities in osteoblast lineage cells of X-linked hypophosphatemia: Analysis of human iPS cell models generated by CRISPR\/Cas9-mediated gene ablation","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2024.117044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117044"}}