{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:58:24Z","timestamp":1789567104560,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:00:00Z","timestamp":1709596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.bone.2024.117056","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T14:40:46Z","timestamp":1708699246000},"page":"117056","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Abaloparatide promotes bone repair of vertebral defects in ovariectomized rats by increasing bone formation"],"prefix":"10.1016","volume":"182","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8002-7331","authenticated-orcid":false,"given":"Akito","family":"Makino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoka","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomaya","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideko","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimasa","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohisa","family":"Miyakoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Amizuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bone.2024.117056_bb0005","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1007\/s00198-017-3909-3","article-title":"Worldwide prevalence and incidence of osteoporotic vertebral fractures","volume":"28","author":"Ballane","year":"2017","journal-title":"Osteoporos. Int."},{"issue":"9","key":"10.1016\/j.bone.2024.117056_bb0010","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1007\/s00198-009-1121-9","article-title":"Effects of bone mineral density of the lumbar spine and prevalent vertebral fractures on the risk of immobility","volume":"21","author":"Shiraki","year":"2010","journal-title":"Osteoporos. Int."},{"issue":"11","key":"10.1016\/j.bone.2024.117056_bb0015","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1001\/archinte.159.11.1215","article-title":"Vertebral fractures and mortality in older women: a prospective study. Study of Osteoporotic Fractures Research Group","volume":"159","author":"Kado","year":"1999","journal-title":"Arch Intern Med"},{"issue":"7","key":"10.1016\/j.bone.2024.117056_bb0020","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1359\/jbmr.2003.18.7.1254","article-title":"Association between vertebral fracture and increased mortality in osteoporotic patients","volume":"18","author":"Jalava","year":"2003","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.bone.2024.117056_bb0025","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1359\/jbmr.090731","article-title":"Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures","volume":"25","author":"Aspenberg","year":"2010","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2024.117056_bb0030","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1210\/en.2015-1726","article-title":"Binding selectivity of abaloparatide for PTH-type-1-receptor conformations and effects on downstream signaling","volume":"157","author":"Hattersley","year":"2016","journal-title":"Endocrinology"},{"issue":"7","key":"10.1016\/j.bone.2024.117056_bb0035","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1001\/jama.2016.11136","article-title":"Effect of abaloparatide vs placebo on new vertebral fractures in postmenopausal women with osteoporosis: a randomized clinical trial","volume":"316","author":"Miller","year":"2016","journal-title":"JAMA"},{"issue":"11","key":"10.1016\/j.bone.2024.117056_bb0040","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1359\/jbmr.2002.17.11.2038","article-title":"Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34)","volume":"17","author":"Nakajima","year":"2002","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.bone.2024.117056_bb0045","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/jor.24254","article-title":"Abaloparatide, a PTH receptor agonist with homology to PTHrP, enhances callus bridging and biomechanical properties in rats with femoral fracture","volume":"37","author":"Lanske","year":"2019","journal-title":"J. Orthop. Res."},{"issue":"5","key":"10.1016\/j.bone.2024.117056_bb0050","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00774-014-0617-3","article-title":"Healing of bisphosphonate-associated atypical femoral fractures in patients with osteoporosis: a comparison between treatment with and without teriparatide","volume":"33","author":"Miyakoshi","year":"2015","journal-title":"J. Bone Miner. Metab."},{"issue":"1","key":"10.1016\/j.bone.2024.117056_bb0055","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bone.2007.08.041","article-title":"Intermittent administration of human parathyroid hormone enhances bone formation and union at the site of cancellous bone osteotomy in normal and ovariectomized rats","volume":"42","author":"Nozaka","year":"2008","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.bone.2024.117056_bb0060","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12891-017-1509-1","article-title":"Effect of teriparatide (rh-PTH 1-34) versus bisphosphonate on the healing of osteoporotic vertebral compression fracture: a retrospective comparative study","volume":"18","author":"Iwata","year":"2017","journal-title":"BMC Musculoskelet. Disord."},{"issue":"5","key":"10.1016\/j.bone.2024.117056_bb0065","doi-asserted-by":"crossref","first-page":"763","DOI":"10.31616\/asj.2018.0311","article-title":"Effects of weekly teriparatide administration for vertebral stability and bony union in patients with acute osteoporotic vertebral fractures","volume":"13","author":"Kitaguchi","year":"2019","journal-title":"Asian Spine J"},{"issue":"43","key":"10.1016\/j.bone.2024.117056_bb0070","doi-asserted-by":"crossref","first-page":"73559","DOI":"10.18632\/oncotarget.20611","article-title":"Effect of osteoporosis induced by ovariectomy on vertebral bone defect\/fracture in rat","volume":"8","author":"Shen","year":"2017","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.bone.2024.117056_bb0075","doi-asserted-by":"crossref","DOI":"10.1177\/2309499018770349","article-title":"Osteoporotic effect on bone repair in lumbar vertebral body defects in a rat model","volume":"26","author":"Sakata","year":"2018","journal-title":"J. Orthop. Surg. (Hong Kong)"},{"issue":"7","key":"10.1016\/j.bone.2024.117056_bb0080","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol."},{"issue":"6","key":"10.1016\/j.bone.2024.117056_bb0085","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/S8756-3282(02)00728-7","article-title":"Effect of feeding on bone turnover markers and its impact on biological variability of measurements","volume":"30","author":"Clowes","year":"2002","journal-title":"Bone"},{"issue":"4","key":"10.1016\/j.bone.2024.117056_bb0090","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/8756-3282(92)90078-B","article-title":"Trabecular bone pattern factor\u2014a new parameter for simple quantification of bone microarchitecture","volume":"13","author":"Hahn","year":"1992","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.bone.2024.117056_bb0095","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00223-018-0422-4","article-title":"Abaloparatide exerts bone anabolic effects with less stimulation of bone resorption-related factors: a comparison with Teriparatide","volume":"103","author":"Makino","year":"2018","journal-title":"Calcif. Tissue Int."},{"issue":"3","key":"10.1016\/j.bone.2024.117056_bb0100","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1172\/JCI3265","article-title":"Vitamin D3 differentially regulates parathyroid hormone\/parathyroid hormone-related peptide receptor expression in bone and cartilage","volume":"103","author":"Amizuka","year":"1999","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.bone.2024.117056_bb0105","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.bone.2013.08.008","article-title":"Altered distribution of bone matrix proteins and defective bone mineralization in klotho-deficient mice","volume":"57","author":"Sasaki","year":"2013","journal-title":"Bone"},{"issue":"4","key":"10.1016\/j.bone.2024.117056_bb0110","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1093\/oxfordjournals.jbchem.a022505","article-title":"A general method for rapid purification of soluble versions of glycosylphosphatidylinositol-anchored proteins expressed in insect cells: an application for human tissue-nonspecific alkaline phosphatase","volume":"126","author":"Oda","year":"1999","journal-title":"J. Biochem."},{"issue":"7","key":"10.1016\/j.bone.2024.117056_bb0115","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1210\/en.2015-2028","article-title":"Frequency of teriparatide administration affects the histological pattern of bone formation in young adult male mice","volume":"157","author":"Yamamoto","year":"2016","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.bone.2024.117056_bb0120","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jbmr.1805","article-title":"Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR histomorphometry nomenclature committee","volume":"28","author":"Dempster","year":"2013","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2024.117056_bb0125","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/nrm3254","article-title":"Building strong bones: molecular regulation of the osteoblast lineage","volume":"13","author":"Long","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"9","key":"10.1016\/j.bone.2024.117056_bb0130","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1359\/jbmr.090413","article-title":"Intermittent PTH administration stimulates pre-osteoblastic proliferation without leading to enhanced bone formation in osteoclast-less c-fos(-\/-) mice","volume":"24","author":"Luiz de Freitas","year":"2009","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2024.117056_bb0135","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/jbmr.3003","article-title":"One year of abaloparatide, a selective activator of the PTH1 receptor, increased bone formation and bone mass in osteopenic ovariectomized rats without increasing bone resorption","volume":"32","author":"Varela","year":"2017","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2024.117056_bb0140","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.bone.2018.10.012","article-title":"Abaloparatide, a novel osteoanabolic PTHrP analog, increases cortical and trabecular bone mass and architecture in orchiectomized rats by increasing bone formation without increasing bone resorption","volume":"120","author":"Chandler","year":"2019","journal-title":"Bone"},{"key":"10.1016\/j.bone.2024.117056_bb0145","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.bone.2016.11.027","article-title":"One year of abaloparatide, a selective peptide activator of the PTH1 receptor, increased bone mass and strength in ovariectomized rats","volume":"95","author":"Varela","year":"2017","journal-title":"Bone"},{"issue":"5","key":"10.1016\/j.bone.2024.117056_bb0150","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.bone.2007.06.025","article-title":"Enhancement of graft bone healing by intermittent administration of human parathyroid hormone (1-34) in a rat spinal arthrodesis model","volume":"41","author":"Abe","year":"2007","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.bone.2024.117056_bb0155","doi-asserted-by":"crossref","DOI":"10.1002\/jsp2.1132","article-title":"Effects of systemically administered abaloparatide, an osteoanabolic PTHrP analog, as an adjuvant therapy for spinal fusion in rats","volume":"4","author":"Arlt","year":"2021","journal-title":"JOR Spine"},{"issue":"6","key":"10.1016\/j.bone.2024.117056_bb0160","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1002\/jbmr.2152","article-title":"Tissue-level mechanisms responsible for the increase in bone formation and bone volume by sclerostin antibody","volume":"29","author":"Ominsky","year":"2014","journal-title":"J. Bone Miner. Res."},{"issue":"3","key":"10.1016\/j.bone.2024.117056_bb0165","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.bone.2011.05.022","article-title":"Eldecalcitol, a second-generation vitamin D analog, drives bone minimodeling and reduces osteoclastic number in trabecular bone of ovariectomized rats","volume":"49","author":"de Freitas","year":"2011","journal-title":"Bone"},{"issue":"21","key":"10.1016\/j.bone.2024.117056_bb0170","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1101\/gad.1017802","article-title":"The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6","volume":"16","author":"Akiyama","year":"2002","journal-title":"Genes Dev."},{"issue":"1","key":"10.1016\/j.bone.2024.117056_bb0175","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF00301875","article-title":"Effect of ovariectomy on longitudinal bone growth in the rat","volume":"164","author":"Stenstr\u00f6m","year":"1982","journal-title":"Anat Embryol (Berl)"},{"issue":"2","key":"10.1016\/j.bone.2024.117056_bb0180","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/jbmr.5650020206","article-title":"The effects of ovariectomy and 17 beta-estradiol on cortical bone histomorphometry in growing rats","volume":"2","author":"Turner","year":"1987","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2024.117056_bb0185","first-page":"89","article-title":"Ovariectomized rat model of osteoporosis: a practical guide","volume":"19","author":"Yousefzadeh","year":"2020","journal-title":"EXCLI J."},{"issue":"20","key":"10.1016\/j.bone.2024.117056_bb0190","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1097\/00007632-199810150-00011","article-title":"Vertebral pseudarthrosis in the osteoporotic spine","volume":"23","author":"Hasegawa","year":"1998","journal-title":"Spine (Phila Pa 1976)"},{"issue":"2","key":"10.1016\/j.bone.2024.117056_bb0195","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/JPER.22-0211","article-title":"Abaloparatide outperforms teriparatide in protecting against alveolar bone loss in experimental periodontitis","volume":"94","author":"Li","year":"2023","journal-title":"J. Periodontol."},{"key":"10.1016\/j.bone.2024.117056_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2022.116417","article-title":"Anti-sclerostin antibodies and abaloparatide have additive effects when used as a countermeasure against disuse osteopenia in female rats","volume":"160","author":"Brent","year":"2022","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.bone.2024.117056_bb0205","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S8756-3282(98)00072-6","article-title":"Withdrawal of parathyroid hormone treatment causes rapid resorption of newly formed vertebral cancellous and endocortical bone in old rats","volume":"23","author":"Ejersted","year":"1998","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.bone.2024.117056_bb0210","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1056\/NEJMoa050336","article-title":"One year of alendronate after one year of parathyroid hormone (1-84) for osteoporosis","volume":"353","author":"Black","year":"2005","journal-title":"N. Engl. J. Med."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328224000450?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328224000450?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T18:07:47Z","timestamp":1757614067000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328224000450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":42,"alternative-id":["S8756328224000450"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2024.117056","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Abaloparatide promotes bone repair of vertebral defects in ovariectomized rats by increasing bone formation","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2024.117056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117056"}}