{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:55:41Z","timestamp":1789181741758,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010249","name":"School of Medicine, Indiana University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010249","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006377","name":"Purdue University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006377","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.bone.2024.117173","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T07:37:02Z","timestamp":1718782622000},"page":"117173","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Estrogen deficiency induces changes in bone matrix bound water that do not closely correspond with bone turnover"],"prefix":"10.1016","volume":"186","author":[{"given":"Corinne E.","family":"Metzger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Olayooye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Landon Y.","family":"Tak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oli","family":"Culpepper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alec N.","family":"LaPlant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Jalaie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pearl-Marie","family":"Andoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wikum","family":"Bandara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia N.","family":"Reul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew A.","family":"Tomaschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel K.","family":"Surowiec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bone.2024.117173_bb0005","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/BOR.0000000000000518","article-title":"Fracture prediction and prevention: will newer technologies help?","volume":"30","author":"Chang","year":"2018","journal-title":"Curr. Opin. Rheumatol."},{"issue":"10","key":"10.1016\/j.bone.2024.117173_bb0010","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1001\/archinte.164.10.1108","article-title":"Bone mineral density thresholds for pharmacological intervention to prevent fractures","volume":"164","author":"Siris","year":"2004","journal-title":"Arch. Intern. Med."},{"issue":"1","key":"10.1016\/j.bone.2024.117173_bb0015","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bone.2003.10.001","article-title":"Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study","volume":"34","author":"Schuit","year":"2004","journal-title":"Bone"},{"issue":"5","key":"10.1016\/j.bone.2024.117173_bb0020","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1210\/jc.2004-1568","article-title":"Hip fracture in women without osteoporosis","volume":"90","author":"Wainwright","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2024.117173_bb0025","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bone.2016.12.016","article-title":"Use of dual-energy X-ray absorptiometry (DXA) for diagnosis and fracture risk assessment; WHO-criteria, T- and Z-score, and reference databases","volume":"104","author":"Dimai","year":"2017","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.bone.2024.117173_bb0030","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S8756-3282(01)00491-4","article-title":"Understanding bone strength: size isn\u2019t everything","volume":"29","author":"van der Meulen","year":"2001","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.bone.2024.117173_bb0035","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.bone.2006.06.001","article-title":"A biomechanical perspective on bone quality","volume":"39","author":"Hernandez","year":"2006","journal-title":"Bone"},{"issue":"4","key":"10.1016\/j.bone.2024.117173_bb0040","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1084\/jem.186.4.489","article-title":"Estrogen inhibits bone resorption by directly inducing apoptosis of the bone-resorbing osteoclasts","volume":"186","author":"Kameda","year":"1997","journal-title":"J. Exp. Med."},{"issue":"38","key":"10.1016\/j.bone.2024.117173_bb0045","doi-asserted-by":"crossref","first-page":"15087","DOI":"10.1073\/pnas.0703610104","article-title":"Oxidative stress causes bone loss in estrogen-deficient mice through enhanced bone marrow dendritic cell activation","volume":"104","author":"Grassi","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"5","key":"10.1016\/j.bone.2024.117173_bb0050","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1172\/JCI28550","article-title":"Estrogen deficiency and bone loss: an inflammatory tale","volume":"116","author":"Weitzmann","year":"2006","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.bone.2024.117173_bb0055","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1172\/JCI11066","article-title":"Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha","volume":"106","author":"Cenci","year":"2000","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.bone.2024.117173_bb0060","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1093\/gerona\/glt071","article-title":"Age- and menopause-related bone loss compromise cortical and trabecular microstructure","volume":"68","author":"Seeman","year":"2013","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"issue":"3","key":"10.1016\/j.bone.2024.117173_bb0065","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1359\/jbmr.081108","article-title":"Hip fractures and the contribution of cortical versus trabecular bone to femoral neck strength","volume":"24","author":"Holzer","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2024.117173_bb0070","article-title":"Bone hydration: how we can evaluate it, what can it tell us, and is it an effective therapeutic target?","volume":"16","author":"Surowiec","year":"2022","journal-title":"Bone Rep"},{"key":"10.1016\/j.bone.2024.117173_bb0075","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jmbbm.2012.08.013","article-title":"Partial removal of pore and loosely bound water by low-energy drying decreases cortical bone toughness in young and old donors","volume":"22","author":"Nyman","year":"2013","journal-title":"J. Mech. Behav. Biomed. Mater."},{"issue":"3","key":"10.1016\/j.bone.2024.117173_bb0080","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/jbm4.10030","article-title":"Age-related deterioration of bone toughness is related to diminishing amount of matrix glycosaminoglycans (gags)","volume":"2","author":"Wang","year":"2018","journal-title":"JBMR Plus"},{"key":"10.1016\/j.bone.2024.117173_bb0085","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.bone.2019.06.017","article-title":"Organic matrix quality discriminates between age- and BMD-matched fracturing versus non-fracturing post-menopausal women: a pilot study","volume":"127","author":"Rokidi","year":"2019","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.bone.2024.117173_bb0090","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1258\/175404507780796325","article-title":"Skin ageing","volume":"13","author":"Calleja-Agius","year":"2007","journal-title":"Menopause Int."},{"issue":"8","key":"10.1016\/j.bone.2024.117173_bb0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0220846","article-title":"Inflammatory cytokines via up-regulation of aquaporins deteriorated the pathogenesis of early osteoarthritis","volume":"14","author":"Tan","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2024.117173_bb0100","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.567417","article-title":"Quantitative ultrashort echo time (UTE) magnetic resonance imaging of bone: an update","volume":"11","author":"Ma","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"10.1016\/j.bone.2024.117173_bb0105","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jbmr.1805","article-title":"Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee","volume":"28","author":"Dempster","year":"2013","journal-title":"J. Bone Miner. Res."},{"issue":"7","key":"10.1016\/j.bone.2024.117173_bb0110","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/nbm.3305","article-title":"Bi-component T2 * analysis of bound and pore bone water fractions fails at high field strengths","volume":"28","author":"Seifert","year":"2015","journal-title":"NMR Biomed."},{"key":"10.1016\/j.bone.2024.117173_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2024.117031","article-title":"A comprehensive set of ultrashort echo time magnetic resonance imaging biomarkers to assess cortical bone health: a feasibility study at clinical field strength","volume":"181","author":"Jacobson","year":"2024","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.bone.2024.117173_bb0120","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1359\/jbmr.081259","article-title":"Inbred strain-specific response to biglycan deficiency in the cortical bone of C57BL6\/129 and C3H\/He mice","volume":"24","author":"Wallace","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2024.117173_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2023.116805","article-title":"Ex vivo exposure to calcitonin or raloxifene improves mechanical properties of diseased bone through non-cell mediated mechanisms","volume":"173","author":"Surowiec","year":"2023","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.bone.2024.117173_bb0130","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/jmri.25955","article-title":"Usefulness of sweep imaging with Fourier transform for evaluation of cortical bone in diabetic rats","volume":"48","author":"Minami","year":"2018","journal-title":"J. Magn. Reson. Imaging"},{"issue":"3","key":"10.1016\/j.bone.2024.117173_bb0140","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.bone.2011.11.029","article-title":"Ultrashort echo time (UTE) imaging with bi-component analysis: bound and free water evaluation of bovine cortical bone subject to sequential drying","volume":"50","author":"Biswas","year":"2012","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.bone.2024.117173_bb0145","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/mrm.28140","article-title":"T(1) measurement of bound water in cortical bone using 3D adiabatic inversion recovery ultrashort echo time (3D IR-UTE) Cones imaging","volume":"84","author":"Guo","year":"2020","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.bone.2024.117173_bb0150","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.bone.2019.05.038","article-title":"Volumetric mapping of bound and pore water as well as collagen protons in cortical bone using 3D ultrashort echo time cones MR imaging techniques","volume":"127","author":"Jerban","year":"2019","journal-title":"Bone"},{"key":"10.1016\/j.bone.2024.117173_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115774","article-title":"MRI-derived porosity index is associated with whole-bone stiffness and mineral density in human cadaveric femora","volume":"143","author":"Jones","year":"2021","journal-title":"Bone"},{"issue":"24","key":"10.1016\/j.bone.2024.117173_bb0165","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1001\/jama.280.24.2077","article-title":"Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial","volume":"280","author":"Cummings","year":"1998","journal-title":"Jama"},{"issue":"1","key":"10.1016\/j.bone.2024.117173_bb0170","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s001980050010","article-title":"Randomized trial of the effects of risedronate on vertebral fractures in women with established postmenopausal osteoporosis. Vertebral Efficacy with Risedronate Therapy (VERT) Study Group","volume":"11","author":"Reginster","year":"2000","journal-title":"Osteoporos. Int."},{"issue":"19","key":"10.1016\/j.bone.2024.117173_bb0175","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1056\/NEJM200105103441904","article-title":"Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis","volume":"344","author":"Neer","year":"2001","journal-title":"N. Engl. J. Med."},{"issue":"7","key":"10.1016\/j.bone.2024.117173_bb0180","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1001\/jama.2016.11136","article-title":"Effect of abaloparatide vs placebo on new vertebral fractures in postmenopausal women with osteoporosis: a randomized clinical trial","volume":"316","author":"Miller","year":"2016","journal-title":"Jama"},{"issue":"16","key":"10.1016\/j.bone.2024.117173_bb0185","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1056\/NEJMoa1607948","article-title":"Romosozumab treatment in postmenopausal women with osteoporosis","volume":"375","author":"Cosman","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.bone.2024.117173_bb0190","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/s12916-015-0494-1","article-title":"How effective are common medications: a perspective based on meta-analyses of major drugs","volume":"13","author":"Leucht","year":"2015","journal-title":"BMC Med."},{"issue":"7","key":"10.1016\/j.bone.2024.117173_bb0195","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/nrendo.2015.71","article-title":"Short-term and long-term effects of osteoporosis therapies","volume":"11","author":"Reid","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"issue":"7","key":"10.1016\/j.bone.2024.117173_bb0200","first-page":"637","article-title":"Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial","volume":"282","author":"Ettinger","year":"1999","journal-title":"Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators. Jama"},{"issue":"8","key":"10.1016\/j.bone.2024.117173_bb0205","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1002\/jbmr.2470","article-title":"In vivo UTE-MRI reveals positive effects of raloxifene on skeletal-bound water in skeletally mature beagle dogs","volume":"30","author":"Allen","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2024.117173_bb0210","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.bone.2014.01.009","article-title":"Bone cell-independent benefits of raloxifene on the skeleton: a novel mechanism for improving bone material properties","volume":"61","author":"Gallant","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.bone.2024.117173_bb0215","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.bone.2014.07.021","article-title":"Molecular spectroscopic identification of the water compartments in bone","volume":"67","author":"Unal","year":"2014","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.bone.2024.117173_bb0220","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10439-005-8965-8","article-title":"Nuclear magnetic resonance studies of bone water","volume":"33","author":"Wehrli","year":"2005","journal-title":"Ann. Biomed. Eng."},{"issue":"10","key":"10.1016\/j.bone.2024.117173_bb0225","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1039\/C9AN02491C","article-title":"Near infrared spectroscopic assessment of loosely and tightly bound cortical bone water","volume":"145","author":"Ailavajhala","year":"2020","journal-title":"Analyst"},{"issue":"3","key":"10.1016\/j.bone.2024.117173_bb0230","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF02308895","article-title":"Thermogravimetric analysis of human femur bone","volume":"3","author":"Lim","year":"1975","journal-title":"J. Biol. Phys."},{"issue":"5","key":"10.1016\/j.bone.2024.117173_bb0235","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jsbmb.2004.12.039","article-title":"Attainment of peak bone mass and bone turnover rate in relation to estrous cycle, pregnancy and lactation in colony-bred Sprague-Dawley rats: suitability for studies on pathophysiology of bone and therapeutic measures for its management","volume":"94","author":"Sengupta","year":"2005","journal-title":"J. Steroid Biochem. Mol. Biol."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328224001625?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328224001625?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T12:38:29Z","timestamp":1747312709000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328224001625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":45,"alternative-id":["S8756328224001625"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2024.117173","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Estrogen deficiency induces changes in bone matrix bound water that do not closely correspond with bone turnover","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2024.117173","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117173"}}