{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T15:47:47Z","timestamp":1787932067229,"version":"build-2784847793"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"am","delay-in-days":290,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K15973"],"award-info":[{"award-number":["23K15973"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJSP2132"],"award-info":[{"award-number":["JPMJSP2132"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.bone.2024.117200","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T18:37:21Z","timestamp":1721068641000},"page":"117200","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Role of sclerostin deletion in bisphosphonate-induced osteonecrosis of the jaw"],"prefix":"10.1016","volume":"187","author":[{"given":"Fuminori","family":"Nakashima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurika","family":"Ninomiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saki","family":"Hatano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Furutama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Memida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikihito","family":"Kajiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisa","family":"Shukunami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Ouhara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyoshi","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bone.2024.117200_bb0005","doi-asserted-by":"crossref","DOI":"10.1111\/ecc.12452","article-title":"Health resource utilisation associated with skeletal-related events in patients with bone metastases secondary to solid tumours: regional comparisons in an observational study","volume":"26","author":"Duran","year":"2017","journal-title":"Eur J Cancer Care (Engl)"},{"issue":"35","key":"10.1016\/j.bone.2024.117200_bb0010","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.1200\/JCO.2017.75.4614","article-title":"Role of bone-modifying agents in metastatic breast cancer: an American Society of Clinical Oncology-Cancer Care Ontario focused guideline update","volume":"35","author":"Van Poznak","year":"2017","journal-title":"J. Clin. Oncol."},{"issue":"6","key":"10.1016\/j.bone.2024.117200_bb0015","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1002\/jbmr.4049","article-title":"Osteoporosis management in the era of COVID-19","volume":"35","author":"Yu","year":"2020","journal-title":"J. Bone Miner. Res."},{"issue":"5","key":"10.1016\/j.bone.2024.117200_bb0020","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.joms.2022.02.008","article-title":"American association of oral and maxillofacial surgeons\u2019 position paper on medication-related osteonecrosis of the jaws-2022 update","volume":"80","author":"Ruggiero","year":"2022","journal-title":"J. Oral Maxillofac. Surg."},{"issue":"3","key":"10.1016\/j.bone.2024.117200_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11030806","article-title":"The role of sclerostin in bone diseases","volume":"11","author":"Vasiliadis","year":"2022","journal-title":"J. Clin. Med."},{"issue":"5","key":"10.1016\/j.bone.2024.117200_bb0030","doi-asserted-by":"crossref","first-page":"E478","DOI":"10.1073\/pnas.1409857112","article-title":"Osteocytes mediate the anabolic actions of canonical Wnt\/\u03b2-catenin signaling in bone","volume":"112","author":"Tu","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bone.2024.117200_bb0035","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bone.2016.10.008","article-title":"Sclerostin's role in bone's adaptive response to mechanical loading","volume":"96","author":"Galea","year":"2017","journal-title":"Bone"},{"issue":"5","key":"10.1016\/j.bone.2024.117200_bb0040","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/hmg\/10.5.537","article-title":"Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)","volume":"10","author":"Balemans","year":"2001","journal-title":"Hum. Mol. Genet."},{"issue":"6","key":"10.1016\/j.bone.2024.117200_bb0045","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1359\/jbmr.080216","article-title":"Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength","volume":"23","author":"Li","year":"2008","journal-title":"J. Bone Miner. Res."},{"issue":"10","key":"10.1016\/j.bone.2024.117200_bb0050","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1002\/jbmr.2259","article-title":"Sclerostin deficiency is linked to altered bone composition","volume":"29","author":"Hassler","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2024.117200_bb0055","article-title":"Sclerostin modulates mineralization degree and stiffness profile in the fibrocartilaginous enthesis for mechanical tissue integrity","volume":"12","author":"Yambe","year":"2024","journal-title":"Frontiers, Frontiers in Cell and Developmental Biology"},{"issue":"16","key":"10.1016\/j.bone.2024.117200_bb0060","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1056\/NEJMoa1607948","article-title":"Romosozumab treatment in postmenopausal women with osteoporosis","volume":"375","author":"Cosman","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.bone.2024.117200_bb0065","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1002\/jbmr.3735","article-title":"Bone-forming and antiresorptive effects of romosozumab in postmenopausal women with osteoporosis: bone histomorphometry and microcomputed tomography analysis after 2 and 12 months of treatment","volume":"34","author":"Chavassieux","year":"2019","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2024.117200_bb0070","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/jbmr.4457","article-title":"Modeling-based bone formation after 2months of romosozumab treatment: results from the FRAME clinical trial","volume":"37","author":"Eriksen","year":"2022","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2024.117200_bb0075","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.bonr.2018.03.002","article-title":"Differential time-dependent transcriptional changes in the osteoblast lineage in cortical bone associated with sclerostin antibody treatment in ovariectomized rats","volume":"8","author":"Taylor","year":"2018","journal-title":"Bone Rep"},{"key":"10.1016\/j.bone.2024.117200_bb0080","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.bone.2017.11.003","article-title":"Dampening of the bone formation response following repeat dosing with sclerostin antibody in mice is associated with up-regulation of Wnt antagonists","volume":"107","author":"Holdsworth","year":"2018","journal-title":"Bone"},{"key":"10.1016\/j.bone.2024.117200_bb0085","doi-asserted-by":"crossref","first-page":"1017391","DOI":"10.3389\/fphar.2022.1017391","article-title":"Real-world study of antiresorptive-related osteonecrosis of jaw based on the US food and drug administration adverse event reporting system database","volume":"13","author":"Peng","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bone.2024.117200_bb0090","series-title":"Oral and Maxillofacial Surgery Cases","article-title":"Romosozumab-associated medication-related osteonecrosis of the jaw","author":"Palla","year":"2023"},{"issue":"1","key":"10.1016\/j.bone.2024.117200_bb0095","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/jbmr.3581","article-title":"Clinically relevant doses of sclerostin antibody do not induce osteonecrosis of the jaw (ONJ) in rats with experimental periodontitis","volume":"34","author":"Hadaya","year":"2019","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2024.117200_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2022.103172","article-title":"Effectiveness of antimicrobial photodynamic therapy mediated by butyl toluidine blue in preventing medication-related osteonecrosis of the jaws in rats","volume":"40","author":"Ervolino","year":"2022","journal-title":"Photodiagn. Photodyn. Ther."},{"issue":"7","key":"10.1016\/j.bone.2024.117200_bb0105","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1002\/jbmr.4614","article-title":"Long-term ligature-induced periodontitis exacerbates development of bisphosphonate-related osteonecrosis of the jaw in mice","volume":"37","author":"Williams","year":"2022","journal-title":"J. Bone Miner. Res."},{"issue":"10","key":"10.1016\/j.bone.2024.117200_bb0110","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1016\/j.ajpath.2018.06.019","article-title":"Removal of pre-existing periodontal inflammatory condition before tooth extraction ameliorates medication-related osteonecrosis of the jaw-like lesion in mice","volume":"188","author":"Kim","year":"2018","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bone.2024.117200_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2023.105875","article-title":"Rodents as an animal model for studying tooth extraction-related medication-related osteonecrosis of the jaw: assessment of outcomes","volume":"159","author":"Hadad","year":"2024","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.bone.2024.117200_bb0120","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.bone.2015.01.011","article-title":"Evaluation of the therapeutic effects of conditioned media from mesenchymal stem cells in a rat bisphosphonate-related osteonecrosis of the jaw-like model","volume":"74","author":"Ogata","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.bone.2024.117200_bb0125","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.886411","article-title":"Porphyromonas gingivalis induces bisphosphonate-related osteonecrosis of the femur in mice","volume":"12","author":"Wu","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1","key":"10.1016\/j.bone.2024.117200_bb0130","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41368-022-00182-4","article-title":"Establishment and assessment of rodent models of medication-related osteonecrosis of the jaw (MRONJ)","volume":"14","author":"Yan","year":"2022","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.bone.2024.117200_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2021.115945","article-title":"Local RANKL delivery improves socket healing in bisphosphonate treated rats","volume":"148","author":"Soundia","year":"2021","journal-title":"Bone"},{"key":"10.1016\/j.bone.2024.117200_bb0140","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.bone.2014.07.027","article-title":"Spontaneous osteonecrosis of the jaws in the maxilla of mice on antiresorptive treatment: a novel ONJ mouse model","volume":"68","author":"de Molon","year":"2014","journal-title":"Bone"},{"issue":"28","key":"10.1016\/j.bone.2024.117200_bb0145","doi-asserted-by":"crossref","first-page":"17349","DOI":"10.1074\/jbc.M115.652305","article-title":"Osteonecrosis of the jaw developed in mice: disease variants regulated by \u03b3\u03b4 T cells in oral mucosal barrier immunity","volume":"290","author":"Park","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.bone.2024.117200_bb0150","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1002\/jcp.22942","article-title":"Brain-derived neurotrophic factor induces migration of endothelial cells through a TrkB-ERK-integrin \u03b1V\u03b23-FAK cascade","volume":"227","author":"Matsuda","year":"2012","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.bone.2024.117200_bb0155","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s12967-022-03417-4","article-title":"Sclerostin is a promising therapeutic target for oral inflammation and regenerative dentistry","volume":"20","author":"Liao","year":"2022","journal-title":"J. Transl. Med."},{"issue":"6","key":"10.1016\/j.bone.2024.117200_bb0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0214173","article-title":"Medication-related osteonecrosis of the jaws after tooth extraction in senescent female mice treated with zoledronic acid: microtomographic, histological and immunohistochemical characterization","volume":"14","author":"Biguetti","year":"2019","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.bone.2024.117200_bb0165","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.201900226","article-title":"Investigation of sustained BMP delivery in the prevention of medication-related osteonecrosis of the jaw (MRONJ) in a rat model","volume":"19","author":"Brierly","year":"2019","journal-title":"Macromol. Biosci."},{"issue":"12","key":"10.1016\/j.bone.2024.117200_bb0170","doi-asserted-by":"crossref","first-page":"7895","DOI":"10.1007\/s00520-021-06361-z","article-title":"Bone turnover markers can predict healing time in medication-related osteonecrosis of the jaw","volume":"29","author":"Schubert","year":"2021","journal-title":"Support Care Cancer"},{"issue":"4","key":"10.1016\/j.bone.2024.117200_bb0175","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.gendis.2022.07.011","article-title":"Wnt signaling: essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders","volume":"10","author":"Vlashi","year":"2023","journal-title":"Genes Dis"},{"issue":"39","key":"10.1016\/j.bone.2024.117200_bb0180","doi-asserted-by":"crossref","first-page":"20602","DOI":"10.1074\/jbc.M116.735795","article-title":"Plasticity of myeloid cells during oral barrier wound healing and the development of bisphosphonate-related osteonecrosis of the jaw","volume":"291","author":"Sun","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.bone.2024.117200_bb0185","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1177\/0022034511420430","article-title":"A role of oral bacteria in bisphosphonate-induced osteonecrosis of the jaw","volume":"90","author":"Mawardi","year":"2011","journal-title":"J. Dent. Res."},{"issue":"1","key":"10.1016\/j.bone.2024.117200_bb0190","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12903-022-02678-1","article-title":"Low-level laser therapy prevents medication-related osteonecrosis of the jaw-like lesions via IL-1RA-mediated primary gingival wound healing","volume":"23","author":"Zheng","year":"2023","journal-title":"BMC Oral Health"},{"issue":"2","key":"10.1016\/j.bone.2024.117200_bb0195","doi-asserted-by":"crossref","DOI":"10.3390\/cells13020137","article-title":"Sclerostin alters tumor cell characteristics of Oral squamous cell carcinoma and may be a key player in local bone invasion","volume":"13","author":"Schirmer","year":"2024","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.bone.2024.117200_bb0200","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00223-016-0231-6","article-title":"Effects of SOST gene silencing on proliferation, apoptosis, invasion, and migration of human osteosarcoma cells through the Wnt\/\u03b2-catenin signaling pathway","volume":"100","author":"Zou","year":"2017","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2024.117200_bb0205","article-title":"Sclerostin suppression facilitates uveal melanoma progression through activating Wnt\/\u03b2-catenin signaling","volume":"12","author":"Wang","year":"2022","journal-title":"Front. Oncol."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328224001893?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328224001893?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T04:31:00Z","timestamp":1728448260000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328224001893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":41,"alternative-id":["S8756328224001893"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2024.117200","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of sclerostin deletion in bisphosphonate-induced osteonecrosis of the jaw","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2024.117200","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117200"}}