{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:01:07Z","timestamp":1775606467638,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.bone.2024.117284","type":"journal-article","created":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T15:21:35Z","timestamp":1728746495000},"page":"117284","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The role of AKR1B10 in osteogenic differentiation of mesenchymal stem cells and atrophic nonunion"],"prefix":"10.1016","volume":"190","author":[{"given":"Jie","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runze","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6221-7743","authenticated-orcid":false,"given":"Weiming","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2024.117284_bb0005","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/jbmr.3626","article-title":"Periosteal mesenchymal progenitor dysfunction and Extraskeletally-derived fibrosis contribute to atrophic fracture nonunion","volume":"34","author":"Wang","year":"2019","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2024.117284_bb0010","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.3892\/mmr.2014.2024","article-title":"MicroRNA-125b suppresses the proliferation and osteogenic differentiation of human bone marrow-derived mesenchymal stem cells","volume":"9","author":"Chen","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bone.2024.117284_bb0015","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1302\/2046-3758.57.2000587","article-title":"Mesenchymal stem cell implantation in atrophic nonunion of the long bones: a translational study","volume":"5","author":"Ismail","year":"2016","journal-title":"Bone Joint Res"},{"issue":"Pt 3","key":"10.1016\/j.bone.2024.117284_bb0020","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1042\/bj3260625","article-title":"Comparative anatomy of the aldo-keto reductase superfamily","volume":"326","author":"Jez","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/j.bone.2024.117284_bb0025","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1210\/er.2018-00089","article-title":"Structural and functional biology of aldo-keto reductase steroid-transforming enzymes","volume":"40","author":"Penning","year":"2019","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.bone.2024.117284_bb0030","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1186\/s13287-021-02425-3","article-title":"Aldo-keto reductase family 1 member C1 regulates the osteogenic differentiation of human ASCs by targeting the progesterone receptor","volume":"12","author":"Liu","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.bone.2024.117284_bb0035","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s13287-016-0375-3","article-title":"TGFbeta-induced switch from adipogenic to osteogenic differentiation of human mesenchymal stem cells: identification of drug targets for prevention of fat cell differentiation","volume":"7","author":"van Zoelen","year":"2016","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.bone.2024.117284_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101963","article-title":"LRRc17 controls BMSC senescence via mitophagy and inhibits the therapeutic effect of BMSCs on ovariectomy-induced bone loss","volume":"43","author":"Liu","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.bone.2024.117284_bb0045","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.255273","article-title":"AKR1B10 negatively regulates autophagy through reducing GAPDH upon glucose starvation in colon cancer","volume":"134","author":"Li","year":"2021","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bone.2024.117284_bb0050","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0736-0266(02)00209-7","article-title":"Development of an atrophic nonunion model and comparison to a closed healing fracture in rat femur","volume":"21","author":"Kokubu","year":"2003","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2024.117284_bb0055","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"10.1016\/j.bone.2024.117284_bb0060","article-title":"Bone marrow mesenchymal stromal cells: identification, classification, and differentiation","volume":"9","author":"Gao","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bone.2024.117284_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122106","article-title":"Split dCas12a activator for lncRNA H19 activation to enhance BMSC differentiation and promote calvarial bone healing","volume":"297","author":"Kieu Nguyen","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.bone.2024.117284_bb0070","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.ymthe.2019.11.029","article-title":"Coactivation of endogenous Wnt10b and Foxc2 by CRISPR activation enhances BMSC osteogenesis and promotes calvarial bone regeneration","volume":"28","author":"Hsu","year":"2020","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bone.2024.117284_bb0075","first-page":"4091","article-title":"Comparison of the effects of minimally invasive percutaneous pedicle screws osteosynthesis and open surgery on repairing the pain, inflammation and recovery of thoracolumbar vertebra fracture","volume":"14","author":"Gong","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.bone.2024.117284_bb0080","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1302\/2046-3758.26.2000165","article-title":"Existence of mesenchymal stem cellsin sites of atrophic nonunion","volume":"2","author":"Ismail","year":"2013","journal-title":"Bone Joint Res"},{"key":"10.1016\/j.bone.2024.117284_bb0085","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1186\/s13287-021-02581-6","article-title":"Knockdown of SERPINB2 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the Wnt\/beta-catenin signalling pathway","volume":"12","author":"Hang","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.bone.2024.117284_bb0090","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41572-021-00289-8","article-title":"Non-union bone fractures","volume":"7","author":"Wildemann","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.bone.2024.117284_bb0095","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jot.2018.05.002","article-title":"Molecular pathogenesis of fracture nonunion","volume":"14","author":"Ding","year":"2018","journal-title":"J Orthop Translat"},{"key":"10.1016\/j.bone.2024.117284_bb0100","first-page":"33","article-title":"Bone marrow in patients with pseudarthrosis. A study of progenitor cells by in vitro cloning","volume":"83","author":"Hernigou","year":"1997","journal-title":"Rev. Chir. Orthop. Reparatrice Appar. Mot."},{"key":"10.1016\/j.bone.2024.117284_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/cells8080784","article-title":"Mesenchymal stem cell migration and tissue repair","volume":"8","author":"Fu","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.bone.2024.117284_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21249759","article-title":"Clinical application of bone marrow mesenchymal stem\/stromal cells to repair skeletal tissue","volume":"21","author":"Arthur","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bone.2024.117284_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21030708","article-title":"An update on the progress of isolation, culture, storage, and clinical application of human bone marrow mesenchymal stem\/stromal cells","volume":"21","author":"Chu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bone.2024.117284_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2005.06.017","article-title":"The BMP signaling and in vivo bone formation","volume":"357","author":"Cao","year":"2005","journal-title":"Gene"},{"key":"10.1016\/j.bone.2024.117284_bb0125","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1359\/jbmr.060303","article-title":"HES1 cooperates with pRb to activate RUNX2-dependent transcription","volume":"21","author":"Lee","year":"2006","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2024.117284_bb0130","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1139\/bcb-2022-0108","article-title":"Effects of aldo-keto reductase family 1 member A on osteoblast differentiation associated with lactate production in MC3T3-E1 preosteoblastic cells","volume":"100","author":"Kuo","year":"2022","journal-title":"Biochem. Cell Biol."},{"key":"10.1016\/j.bone.2024.117284_bb0135","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jot.2017.03.002","article-title":"Mesenchymal stem cells homing to improve bone healing","volume":"9","author":"Lin","year":"2017","journal-title":"J Orthop Translat"},{"key":"10.1016\/j.bone.2024.117284_bb0140","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s00223-007-9020-6","article-title":"Number and proliferative capacity of human mesenchymal stem cells are modulated positively in multiple trauma patients and negatively in atrophic nonunions","volume":"80","author":"Seebach","year":"2007","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2024.117284_bb0145","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.bone.2013.01.005","article-title":"Decreased pool of mesenchymal stem cells is associated with altered chemokines serum levels in atrophic nonunion fractures","volume":"53","author":"Mathieu","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.bone.2024.117284_bb0150","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.molimm.2023.11.006","article-title":"Immunomodulation by mesenchymal stem cells during osteogenic differentiation: clinical implications during bone regeneration","volume":"164","author":"Mahajan","year":"2023","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.bone.2024.117284_bb0155","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrrheum.2012.1","article-title":"Fracture healing under healthy and inflammatory conditions","volume":"8","author":"Claes","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bone.2024.117284_bb0160","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s11914-018-0423-2","article-title":"The role of the immune cells in fracture healing","volume":"16","author":"Baht","year":"2018","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bone.2024.117284_bb0165","doi-asserted-by":"crossref","first-page":"1250309","DOI":"10.3389\/fimmu.2023.1250309","article-title":"Distinct defects in early innate and late adaptive immune responses typify impaired fracture healing in diet-induced obesity","volume":"14","author":"Khajuria","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bone.2024.117284_bb0170","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20222007","article-title":"AKR1B10 regulates M2 macrophage polarization to promote the malignant phenotype of gastric cancer","volume":"43","author":"Wu","year":"2023","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.bone.2024.117284_bb0175","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9091178","article-title":"Autophagy, mesenchymal stem cell differentiation, and secretion","volume":"9","author":"Menshikov","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.bone.2024.117284_bb0180","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/cr.2011.200","article-title":"Autophagy is required for self-renewal and differentiation of adult human stem cells","volume":"22","author":"Salemi","year":"2012","journal-title":"Cell Res."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328224002734?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328224002734?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,29]],"date-time":"2024-12-29T04:10:12Z","timestamp":1735445412000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328224002734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":36,"alternative-id":["S8756328224002734"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2024.117284","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of AKR1B10 in osteogenic differentiation of mesenchymal stem cells and atrophic nonunion","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2024.117284","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117284"}}