{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:50:41Z","timestamp":1786985441942,"version":"build-2736575974"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100008056","name":"Florencio Fiorini Faoundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008056","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.bone.2025.117455","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T12:48:30Z","timestamp":1741956510000},"page":"117455","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Impact of vascular calcifications on the risk of fractures in patients with chronic kidney disease"],"prefix":"10.1016","volume":"195","author":[{"given":"Alejandro","family":"Godoy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Paula","family":"Dionisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anyelo","family":"Cardozo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pehu\u00e9n","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Porta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Tabares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Chiurchiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"de Arteaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"de la Fuente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Douthat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Ang\u00e9lica","family":"Rivoira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2025.117455_bb0005","first-page":"S16","article-title":"Epidemiology of cardiovascular disease in chronic renal disease","volume":"9","author":"Foley","year":"1998","journal-title":"J. Am. Soc. Nephrol."},{"issue":"113","key":"10.1016\/j.bone.2025.117455_bb0010","first-page":"S1","article-title":"KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and BoneDisorder (CKD-MBD)","author":"KDIGO","year":"2009","journal-title":"Kidney Int. Suppl."},{"key":"10.1016\/j.bone.2025.117455_bb0015","first-page":"2077","article-title":"Signaling pathways involved in vascular smooth muscle cell calcification during hyperphosphatemia","volume":"76","author":"Voelkl","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bone.2025.117455_bb0020","doi-asserted-by":"crossref","first-page":"F891","DOI":"10.1152\/ajprenal.00163.2014","article-title":"A current understanding of vascular calcification in CKD","volume":"307","author":"Paloian","year":"2014","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bone.2025.117455_bb0025","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1093\/ckj\/sfw145","article-title":"Is chronic kidney disease-mineral and bone disorder associated with the presence of endothelial progenitor cells with a calcifying phenotype?","volume":"10","author":"Cianciolo","year":"2017","journal-title":"Clin. Kidney J."},{"key":"10.1016\/j.bone.2025.117455_bb0030","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.semnephrol.2018.02.004","article-title":"Updates on the mechanisms and the care of cardiovascular calcification in chronic kidney disease","volume":"38","author":"H\u00e9naut","year":"2018","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.bone.2025.117455_bb0035","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s00223-020-00777-1","article-title":"Chronic kidney disease\u2014mineral and bone disorders: pathogenesis and management","volume":"108","author":"Cannata-And\u00eda","year":"2021","journal-title":"Calcif. Tissue Int."},{"issue":"1","key":"10.1016\/j.bone.2025.117455_bb0040","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/ndt\/gfn466","article-title":"Vascular calcifications, vertebral fractures and mortality in haemodialysis patients","volume":"24","author":"Rodr\u00edguez-Garc\u00eda","year":"2008","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bone.2025.117455_bb0045","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/TP.0000000000003226","article-title":"Bone mineral density and aortic calcification: evidence for a bone-vascular axis after kidney transplantation","volume":"105","author":"Sotomayor","year":"2021","journal-title":"Transplantation"},{"key":"10.1016\/j.bone.2025.117455_bb0050","doi-asserted-by":"crossref","DOI":"10.1002\/jbmr.4203","article-title":"Chronic kidney disease-induced vascular calcification impairs bone metabolism","author":"Mace","year":"2020","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2025.117455_bb0055","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4081\/nr.2009.e4","article-title":"Does vascular calcification correlate with pulse wave velocity in hemodialysis patients?","volume":"1","author":"Di Iorio","year":"2009","journal-title":"Nephrol. Rev."},{"issue":"8","key":"10.1016\/j.bone.2025.117455_bb0060","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/sj.ki.5002164","article-title":"Association of pulse wave velocity with vascular and valvular calcification in hemodialysis patients","volume":"71","author":"Raggi","year":"2007","journal-title":"Kidney Int."},{"issue":"6","key":"10.1016\/j.bone.2025.117455_bb0065","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1744-9987.2011.00979.x","article-title":"Vascular calcification in patients with chronic kidney disease","volume":"15","author":"Nitta","year":"2011","journal-title":"Ther. Apher. Dial."},{"issue":"18","key":"10.1016\/j.bone.2025.117455_bb0070","doi-asserted-by":"crossref","first-page":"6846","DOI":"10.3390\/ijms21186846","article-title":"Osteoporosis in patients with chronic kidney diseases: a systemic review","volume":"21","author":"Hsu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bone.2025.117455_bb0075","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1093\/ndt\/gfh217","article-title":"A simple vascular calcification score predicts cardiovascular risk in haemodialysis patients","volume":"19","author":"Adragao","year":"2004","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bone.2025.117455_bb0080","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0021-9150(97)00106-8","article-title":"New indices to classify location, severity and progression of calcific lesions in the abdominal aorta: a 25-year follow-up study","volume":"132","author":"Kauppila","year":"1997","journal-title":"Atherosclerosis"},{"issue":"1","key":"10.1016\/j.bone.2025.117455_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/07853890.2020.1794538","article-title":"Comparing oscillometric and tonometric methods to assess pulse wave velocity: a population-based study","volume":"53","author":"Del Giorno","year":"2021","journal-title":"Ann. Med."},{"issue":"1","key":"10.1016\/j.bone.2025.117455_bb0090","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1161\/ATVBAHA.122.317332","article-title":"Molecular mechanisms of vascular health: insights from vascular aging and calcification","volume":"43","author":"Sutton","year":"2023","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bone.2025.117455_bb0095","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1161\/ATVBAHA.120.313131","article-title":"Arterial stiffness: a focus on vascular calcification and its link to bone mineralization","volume":"40","author":"Chen","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bone.2025.117455_bb0100","doi-asserted-by":"crossref","DOI":"10.1177\/00045632211025567","article-title":"Assessing bone formation in patients with chronic kidney disease using procollagen type I N-terminal propeptide (PINP): the choice of assay makes a difference","author":"Tridimas","year":"2021","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.bone.2025.117455_bb0105","article-title":"D\u00edaz de Barboza G, Dionisi MP, Tolosa de Talamoni N. Emerging concepts on the FGF23 regulation and activity","volume":"6","author":"Rivoira","year":"2024","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bone.2025.117455_bb0110","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nrneph.2017.60","article-title":"Alkaline phosphatase: a novel treatment target for cardiovascular disease in CKD","volume":"13","author":"Haarhaus","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.bone.2025.117455_bb0115","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.3390\/nu14102124","article-title":"Alkaline phosphatase: an old friend as treatment target for cardiovascular and mineral bone disorders in chronic kidney disease","volume":"14","author":"Haarhaus","year":"2022","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.bone.2025.117455_bb0120","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s00223-020-00779-z","article-title":"Bone fragility fractures in CKD patients","volume":"108","author":"Pimentel","year":"2021","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2025.117455_bb0125","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/nep.13593","article-title":"Bone turnover markers predict type of bone histomorphometry and bone mineral density in Asian chronic haemodialysis patients","volume":"25","author":"Laowalert","year":"2020","journal-title":"Nephrology (Carlton)"},{"issue":"4S","key":"10.1016\/j.bone.2025.117455_bb0130","first-page":"S117","article-title":"KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"105","author":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group","year":"2024","journal-title":"Kidney Int."},{"issue":"6","key":"10.1016\/j.bone.2025.117455_bb0135","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/j.ekir.2021.03.874","article-title":"Longitudinal bone loss occurs at the radius in CKD","volume":"6","author":"Cailleaux","year":"2021","journal-title":"Kidney Int. Rep."},{"issue":"1","key":"10.1016\/j.bone.2025.117455_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0190410","article-title":"The higher mortality associated with low serum albumin is dependent on systemic inflammation in end-stage kidney disease","volume":"13","author":"Alves","year":"2018","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.bone.2025.117455_bb0145","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.7150\/ijms.39158","article-title":"Hypoalbuminemia differently affects the serum bone turnover markers in hemodialysis patients","volume":"16","author":"Zheng","year":"2019","journal-title":"Int. J. Med. Sci."},{"issue":"3","key":"10.1016\/j.bone.2025.117455_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.xkme.2022.100408","article-title":"Malnutrition-inflammation complex syndrome and bone fractures and cardiovascular disease events in patients undergoing hemodialysis: the Q-cohort study","volume":"4","author":"Yamada","year":"2022","journal-title":"Kidney Med."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328225000675?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328225000675?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T05:17:56Z","timestamp":1774415876000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328225000675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":30,"alternative-id":["S8756328225000675"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2025.117455","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of vascular calcifications on the risk of fractures in patients with chronic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2025.117455","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117455"}}