{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T06:09:54Z","timestamp":1774418994895,"version":"3.50.1"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["101123"],"award-info":[{"award-number":["101123"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["110140"],"award-info":[{"award-number":["110140"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.bone.2025.117472","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T21:49:51Z","timestamp":1742852991000},"page":"117472","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The GWAS candidate far upstream element binding protein 3 (FUBP3) is required for normal skeletal growth, and adult bone mass and strength in mice"],"prefix":"10.1016","volume":"195","author":[{"given":"Laura M.","family":"Watts","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penny C.","family":"Sparkes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah F.","family":"Dewhurst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siobhan E.","family":"Guilfoyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea S.","family":"Pollard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Komla-Ebri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie C.","family":"Butterfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham R.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.H. Duncan","family":"Bassett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2025.117472_bb0005","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/jbmr.5650110414","article-title":"The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twins","volume":"11","author":"Arden","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2025.117472_bb0010","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1172\/JCI107476","article-title":"Genetic factors in determining bone mass","volume":"52","author":"Smith","year":"1973","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bone.2025.117472_bb0015","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1375\/136905203770326402","article-title":"Heritability of adult body height: a comparative study of twin cohorts in eight countries","volume":"6","author":"Silventoinen","year":"2003","journal-title":"Twin Res."},{"key":"10.1016\/j.bone.2025.117472_bb0020","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s00198-014-2655-z","article-title":"The clinical diagnosis of osteoporosis: a position statement from the National Bone Health Alliance Working Group","volume":"25","author":"Siris","year":"2014","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2025.117472_bb0025","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S8756-3282(01)00614-7","article-title":"Epidemiology of fractures in England and Wales","volume":"29","author":"van Staa","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.bone.2025.117472_bb0030","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bone.2003.10.001","article-title":"Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam study","volume":"34","author":"Schuit","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.bone.2025.117472_bb0035","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1007\/s00198-006-0172-4","article-title":"An estimate of the worldwide prevalence and disability associated with osteoporotic fractures","volume":"17","author":"Johnell","year":"2006","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2025.117472_bb0040","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/S0140-6736(02)08657-9","article-title":"Epidemiology and outcomes of osteoporotic fractures","volume":"359","author":"Cummings","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.bone.2025.117472_bb0045","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ng.2249","article-title":"Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture","volume":"44","author":"Estrada","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bone.2025.117472_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004423","article-title":"Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment","volume":"10","author":"Kemp","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bone.2025.117472_bb0055","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1136\/jmedgenet-2018-105437","article-title":"Multitrait genome association analysis identifies new susceptibility genes for human anthropometric variation in the GCAT cohort","volume":"55","author":"Galv\u00e1n-Femen\u00eda","year":"2018","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.bone.2025.117472_bb0060","unstructured":"L. Yengo, S. Vedantam, E. Marouli, J. Sidorenko, E. Bartell, S. Sakaue, M. Graff, A.U. Eliasen, Y. Jiang, S. Raghavan, J. Miao, J.D. Arias, S.E. Graham, R.E. Mukamel, C.N. Spracklen, X. Yin, S.-H. Chen, T. Ferreira, H.H. Highland, Y. Ji, T. Karaderi, K. Lin, K. L\u00fcll, D.E. Malden, C. Medina-Gomez, M. Machado, A. Moore, S. R\u00fceger, X. Sim, S. Vrieze, T.S. Ahluwalia, M. Akiyama, M.A. Allison, M. Alvarez, M.K. Andersen, A. Ani, V. Appadurai, L. Arbeeva, S. Bhaskar, L.F. Bielak, S. Bollepalli, L.L. Bonnycastle, J. Bork-Jensen, J.P. Bradfield, Y. Bradford, P.S. Braund, J.A. Brody, K.S. Burgdorf, B.E. Cade, H. Cai, Q. Cai, A. Campbell, M. Ca\u00f1adas-Garre, E. Catamo, J.-F. Chai, X. Chai, L.-C. Chang, Y.-C. Chang, C.-H. Chen, A. Chesi, S.H. Choi, R.-H. Chung, M. Cocca, M.P. Concas, C. Couture, G. Cuellar-Partida, R. Danning, E.W. Daw, F. Degenhard, G.E. Delgado, A. Delitala, A. Demirkan, X. Deng, P. Devineni, A. Dietl, M. Dimitriou, L. Dimitrov, R. Dorajoo, A.B. Ekici, J.E. Engmann, Z. Fairhurst-Hunter, A.-E. Farmaki, J.D. Faul, J.-C. Fernandez-Lopez, L. Forer, M. Francescatto, S. Freitag-Wolf, C. Fuchsberger, T.E. Galesloot, Y. Gao, Z. Gao, F. Geller, O. Giannakopoulou, F. Giulianini, A.P. Gjesing, A. Goel, S.D. Gordon, M. Gorski, J. Grove, X. Guo, S. Gustafsson, J. Haessler, T.F. Hansen, A.S. Havulinna, S.J. Haworth, J. He, N. Heard-Costa, P. Hebbar, G. Hindy, Y.-L.A. Ho, E. Hofer, E. Holliday, K. Horn, W.E. Hornsby, J.-J. Hottenga, H. Huang, J. Huang, A. Huerta-Chagoya, J.E. Huffman, Y.-J. Hung, S. Huo, M.Y. Hwang, H. Iha, D.D. Ikeda, M. Isono, A.U. Jackson, S. J\u00e4ger, I.E. Jansen, I. Johansson, J.B. Jonas, A. Jonsson, T. J\u00f8rgensen, I.-P. Kalafati, M. Kanai, S. Kanoni, L.L. K\u00e5rhus, A. Kasturiratne, T. Katsuya, T. Kawaguchi, R.L. Kember, K.A. Kentistou, H.-N. Kim, Y.J. Kim, M.E. Kleber, M.J. Knol, A. Kurbasic, M. Lauzon, P. Le, R. Lea, J.-Y. Lee, H.L. Leonard, S.A. Li, X. Li, X. Li, J. Liang, H. Lin, S.-Y. Lin, J. Liu, X. Liu, K.S. Lo, J. Long, L. Lores-Motta, J. Luan, V. Lyssenko, L.-P. Lyytik\u00e4inen, A. Mahajan, V. Mamakou, M. Mangino, A. Manichaikul, J. Marten, M. Mattheisen, L. Mavarani, A.F. McDaid, K. Meidtner, T.L. Melendez, J.M. Mercader, Y. Milaneschi, J.E. Miller, I.Y. Millwood, P.P. Mishra, R.E. Mitchell, L.T. M\u00f8llehave, A. Morgan, S. Mucha, M. Munz, M. Nakatochi, C.P. Nelson, M. Nethander, C.W. Nho, A.A. Nielsen, I.M. Nolte, S.S. Nongmaithem, R. Noordam, I. Ntalla, T. Nutile, A. Pandit, P. Christofidou, K. P\u00e4rna, M. Pauper, E.R.B. Petersen, L. V Petersen, N. Pitk\u00e4nen, O. Pola\u0161ek, A. Poveda, M.H. Preuss, S. Pyarajan, L.M. Raffield, H. Rakugi, J. Ramirez, A. Rasheed, D. Raven, N.W. Rayner, C. Riveros, R. Rohde, D. Ruggiero, S.E. Ruotsalainen, K.A. Ryan, M. Sabater-Lleal, R. Saxena, M. Scholz, A. Sendamarai, B. Shen, J. Shi, J.H. Shin, C. Sidore, C.M. Sitlani, R.C. Slieker, R.A.J. Smit, A. V Smith, J.A. Smith, L.J. Smyth, L. Southam, V. Steinthorsdottir, L. Sun, F. Takeuchi, D.S.P. Tallapragada, K.D. Taylor, B.O. Tayo, C. Tcheandjieu, N. Terzikhan, P. Tesolin, A. Teumer, E. Theusch, D.J. Thompson, G. Thorleifsson, P.R.H.J. Timmers, S. Trompet, C. Turman, S. Vaccargiu, S.W. van der Laan, P.J. van der Most, J.B. van Klinken, J. van Setten, S.S. Verma, N. Verweij, Y. Veturi, C.A. Wang, C. Wang, L. Wang, Z. Wang, H.R. Warren, W. Bin Wei, A.R. Wickremasinghe, M. Wielscher, K.L. Wiggins, B.S. Winsvold, A. Wong, Y. Wu, M. Wuttke, R. Xia, T. Xie, K. Yamamoto, J. Yang, J. Yao, H. Young, N.A. Yousri, L. Yu, L. Zeng, W. Zhang, X. Zhang, J.-H. Zhao, W. Zhao, W. Zhou, M.E. Zimmermann, M. Zoledziewska, L.S. Adair, H.H.H. Adams, C.A. Aguilar-Salinas, F. Al-Mulla, D.K. Arnett, F.W. Asselbergs, B.O. \u00c5svold, J. Attia, B. Banas, S. Bandinelli, D.A. Bennett, T. Bergler, D. Bharadwaj, G. Biino, H. Bisgaard, E. Boerwinkle, C.A. B\u00f6ger, K. B\u00f8nnelykke, D.I. Boomsma, A.D. B\u00f8rglum, J.B. Borja, C. Bouchard, D.W. Bowden, I. Brandslund, B. Brumpton, J.E. Buring, M.J. Caulfield, J.C. Chambers, G.R. Chandak, S.J. Chanock, N. Chaturvedi, Y.-D.I. Chen, Z. Chen, C.-Y. Cheng, I.E. Christophersen, M. Ciullo, J.W. Cole, F.S. Collins, R.S. Cooper, M. Cruz, F. Cucca, L.A. Cupples, M.J. Cutler, S.M. Damrauer, T.M. Dantoft, G.J. de Borst, L.C.P.G.M. de Groot, P.L. De Jager, D.P. V de Kleijn, H. Janaka de Silva, G. V Dedoussis, A.I. den Hollander, S. Du, D.F. Easton, P.J.M. Elders, A.H. Eliassen, P.T. Ellinor, S. Elmst\u00e5hl, J. Erdmann, M.K. Evans, D. Fatkin, B. Feenstra, M.F. Feitosa, L. Ferrucci, I. Ford, M. Fornage, A. Franke, P.W. Franks, B.I. Freedman, P. Gasparini, C. Gieger, G. Girotto, M.E. Goddard, Y.M. Golightly, C. Gonzalez-Villalpando, P. Gordon-Larsen, H. Grallert, S.F.A. Grant, N. Grarup, L. Griffiths, V. Gudnason, C. Haiman, H. Hakonarson, T. Hansen, C.A. Hartman, A.T. Hattersley, C. Hayward, S.R. Heckbert, C.-K. Heng, C. Hengstenberg, A.W. Hewitt, H. Hishigaki, C.B. Hoyng, P.L. Huang, W. Huang, S.C. Hunt, K. Hveem, E. Hypp\u00f6nen, W.G. Iacono, S. Ichihara, M.A. Ikram, C.R. Isasi, R.D. Jackson, M.-R. Jarvelin, Z.-B. Jin, K.-H. J\u00f6ckel, P.K. Joshi, P. Jousilahti, J.W. Jukema, M. K\u00e4h\u00f6nen, Y. Kamatani, K.D. Kang, J. Kaprio, S.L.R. Kardia, F. Karpe, N. Kato, F. Kee, T. Kessler, A. V Khera, C.C. Khor, L.A.L.M. Kiemeney, B.-J. Kim, E.K. Kim, H.-L. Kim, P. Kirchhof, M. Kivimaki, W.-P. Koh, H.A. Koistinen, G.D. Kolovou, J.S. Kooner, C. Kooperberg, A. K\u00f6ttgen, P. Kovacs, A. Kraaijeveld, P. Kraft, R.M. Krauss, M. Kumari, Z. Kutalik, M. Laakso, L.A. Lange, C. Langenberg, L.J. Launer, L. Le Marchand, H. Lee, N.R. Lee, T. Lehtim\u00e4ki, H. Li, L. Li, W. Lieb, X. Lin, L. Lind, A. Linneberg, C.-T. Liu, J. Liu, M. Loeffler, B. London, S.A. Lubitz, S.J. Lye, D.A. Mackey, R. M\u00e4gi, P.K.E. Magnusson, G.M. Marcus, P.M. Vidal, N.G. Martin, W. M\u00e4rz, F. Matsuda, R.W. McGarrah, M. McGue, A.J. McKnight, S.E. Medland, D. Mellstr\u00f6m, A. Metspalu, B.D. Mitchell, P. Mitchell, D.O. Mook-Kanamori, A.D. Morris, L.A. Mucci, P.B. Munroe, M.A. Nalls, S. Nazarian, A.E. Nelson, M.J. Neville, C. Newton-Cheh, C.S. Nielsen, M.M. N\u00f6then, C. Ohlsson, A.J. Oldehinkel, L. Orozco, K. Pahkala, P. Pajukanta, C.N.A. Palmer, E.J. Parra, C. Pattaro, O. Pedersen, C.E. Pennell, B.W.J.H. Penninx, L. Perusse, A. Peters, P.A. Peyser, D.J. Porteous, D. Posthuma, C. Power, P.P. Pramstaller, M.A. Province, Q. Qi, J. Qu, D.J. Rader, O.T. Raitakari, S. Ralhan, L.S. Rallidis, D.C. Rao, S. Redline, D.F. Reilly, A.P. Reiner, S.Y. Rhee, P.M. Ridker, M. Rienstra, S. Ripatti, M.D. Ritchie, D.M. Roden, F.R. Rosendaal, J.I. Rotter, I. Rudan, F. Rutters, C. Sabanayagam, D. Saleheen, V. Salomaa, N.J. Samani, D.K. Sanghera, N. Sattar, B. Schmidt, H. Schmidt, R. Schmidt, M.B. Schulze, H. Schunkert, L.J. Scott, R.J. Scott, P. Sever, E.J. Shiroma, M.B. Shoemaker, X.-O. Shu, E.M. Simonsick, M. Sims, J.R. Singh, A.B. Singleton, M.F. Sinner, J.G. Smith, H. Snieder, T.D. Spector, M.J. Stampfer, K.J. Stark, D.P. Strachan, L.M. \u2018t Hart, Y. Tabara, H. Tang, J.-C. Tardif, T.A. Thanaraj, N.J. Timpson, A. T\u00f6njes, A. Tremblay, T. Tuomi, J. Tuomilehto, M.-T. Tusi\u00e9-Luna, A.G. Uitterlinden, R.M. van Dam, P. van der Harst, N. Van der Velde, C.M. van Duijn, N.M. van Schoor, V. Vitart, U. V\u00f6lker, P. Vollenweider, H. V\u00f6lzke, N.H. Wacher-Rodarte, M. Walker, Y.X. Wang, N.J. Wareham, R.M. Watanabe, H. Watkins, D.R. Weir, T.M. Werge, E. Widen, L.R. Wilkens, G. Willemsen, W.C. Willett, J.F. Wilson, T.-Y. Wong, J.-T. Woo, A.F. Wright, J.-Y. Wu, H. Xu, C.S. Yajnik, M. Yokota, J.-M. Yuan, E. Zeggini, B.S. Zemel, W. Zheng, X. Zhu, J.M. Zmuda, A.B. Zonderman, J.-A. Zwart, 23andMe Research Team, VA Million Veteran Program, DiscovEHR (DiscovEHR and MyCode Community Health Initiative), eMERGE (Electronic Medical Records and Genomics Network), Lifelines Cohort Study, PRACTICAL Consortium, Understanding Society Scientific Group, D.I. Chasman, Y.S. Cho, I.M. Heid, M.I. McCarthy, M.C.Y. Ng, C.J. O'Donnell, F. Rivadeneira, U. Thorsteinsdottir, Y. V Sun, E.S. Tai, M. Boehnke, P. Deloukas, A.E. Justice, C.M. Lindgren, R.J.F. Loos, K.L. Mohlke, K.E. North, K. Stefansson, R.G. Walters, T.W. Winkler, K.L. Young, P.-R. Loh, J. Yang, T. Esko, T.L. Assimes, A. Auton, G.R. Abecasis, C.J. Willer, A.E. Locke, S.I. Berndt, G. Lettre, T.M. Frayling, Y. Okada, A.R. Wood, P.M. Visscher, J.N. Hirschhorn, A saturated map of common genetic variants associated with human height., Nature 610 (2022) 704\u2013712. doi:https:\/\/doi.org\/10.1038\/s41586-022-05275-y."},{"key":"10.1016\/j.bone.2025.117472_bb0065","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ajhg.2017.12.005","article-title":"Life-course genome-wide association study meta-analysis of total body BMD and assessment of age-specific effects","volume":"102","author":"Medina-gomez","year":"2018","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bone.2025.117472_bb0070","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1038\/ng.3949","article-title":"Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis","volume":"49","author":"Kemp","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bone.2025.117472_bb0075","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41588-018-0302-x","article-title":"An atlas of genetic influences on osteoporosis in humans and mice","volume":"51","author":"Morris","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bone.2025.117472_bb0080","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.k3225","article-title":"Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study","author":"Trajanoska","year":"2018","journal-title":"BMJ"},{"key":"10.1016\/j.bone.2025.117472_bb0085","article-title":"Identification of 613 new loci associated with heel bone mineral density and a polygenic risk score for bone mineral density, osteoporosis and fracture","volume":"13","author":"Kim","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2025.117472_bb0090","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/nature09410","article-title":"Hundreds of variants clustered in genomic loci and biological pathways affect human height","volume":"467","author":"Allen","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.bone.2025.117472_bb0095","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/ng.3097","article-title":"Defining the role of common variation in the genomic and biological architecture of adult human height","volume":"46","author":"Wood","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bone.2025.117472_bb0100","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/ng.2606","article-title":"Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture","volume":"45","author":"Berndt","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bone.2025.117472_bb0105","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.tig.2016.10.008","article-title":"Mining the unknown: assigning function to noncoding single nucleotide polymorphisms","volume":"33","author":"Nishizaki","year":"2017","journal-title":"Trends Genet."},{"key":"10.1016\/j.bone.2025.117472_bb0110","doi-asserted-by":"crossref","first-page":"424","DOI":"10.3389\/fgene.2020.00424","article-title":"From GWAS to function: using functional genomics to identify the mechanisms underlying complex diseases","volume":"11","author":"Cano-Gamez","year":"2020","journal-title":"Front. Genet."},{"key":"10.1016\/j.bone.2025.117472_bb0115","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3389\/fgene.2013.00280","article-title":"A review of post-GWAS prioritization approaches","volume":"4","author":"Hou","year":"2013","journal-title":"Front. Genet."},{"key":"10.1016\/j.bone.2025.117472_bb0120","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1242\/dmm.000414","article-title":"Mouse models and the interpretation of human GWAS in type 2 diabetes and obesity","volume":"4","author":"Cox","year":"2011","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.bone.2025.117472_bb0125","doi-asserted-by":"crossref","first-page":"6584","DOI":"10.1128\/MCB.00754-06","article-title":"FBPs are calibrated molecular tools to adjust gene expression","volume":"26","author":"Chung","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bone.2025.117472_bb0130","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1038\/sj.emboj.7601101","article-title":"The FUSE\/FBP\/FIR\/TFIIH system is a molecular machine programming a pulse of c-myc expression","volume":"25","author":"Liu","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.bone.2025.117472_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0169852","article-title":"Upregulation of far upstream element-binding protein 1 (FUBP1) promotes tumor proliferation and tumorigenesis of clear cell renal cell carcinoma","volume":"12","author":"Duan","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2025.117472_bb0140","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1007\/s13277-015-4263-8","article-title":"Far upstream element-binding protein 1 (FUBP1) is a potential c-Myc regulator in esophageal squamous cell carcinoma (ESCC) and its expression promotes ESCC progression","volume":"37","author":"Yang","year":"2016","journal-title":"Tumour Biol."},{"key":"10.1016\/j.bone.2025.117472_bb0145","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1126\/science.1210557","article-title":"Mutations in CIC and FUBP1 contribute to human oligodendroglioma","volume":"333","author":"Bettegowda","year":"2011","journal-title":"Science (80)"},{"key":"10.1016\/j.bone.2025.117472_bb0150","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.ajpath.2015.10.028","article-title":"Far upstream element binding protein plays a crucial role in embryonic development, hematopoiesis, and stabilizing Myc expression levels","volume":"186","author":"Zhou","year":"2016","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bone.2025.117472_bb0155","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.molcel.2004.05.002","article-title":"A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery","volume":"14","author":"Gherzi","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bone.2025.117472_bb0160","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1101\/gad.11.8.1023","article-title":"A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer","volume":"11","author":"Min","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.bone.2025.117472_bb0165","doi-asserted-by":"crossref","first-page":"8388","DOI":"10.1128\/MCB.01493-07","article-title":"Functional analysis of KSRP interaction with the AU-rich element of Interleukin-8 and identification of inflammatory mRNA targets","volume":"27","author":"Winzen","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bone.2025.117472_bb0170","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.celrep.2012.10.020","article-title":"Bone morphogenetic protein\/SMAD signaling orients cell fate decision by impairing KSRP-dependent microRNA maturation","volume":"2","author":"Pasero","year":"2012","journal-title":"Cell Rep."},{"key":"10.1016\/j.bone.2025.117472_bb0175","doi-asserted-by":"crossref","first-page":"903","DOI":"10.3892\/ijo.2016.3601","article-title":"Overexpression of KH-type splicing regulatory protein regulates proliferation, migration, and implantation ability of osteosarcoma","volume":"49","author":"Pruksakorn","year":"2016","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bone.2025.117472_bb0180","article-title":"Sequential and coordinated actions of c-Myc and N-Myc control appendicular skeletal development","volume":"6","author":"Zhou","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2025.117472_bb0185","doi-asserted-by":"crossref","first-page":"9645","DOI":"10.1016\/S0021-9258(18)98398-5","article-title":"Expression and role of c-myc in chondrocytes undergoing endochondral ossification","volume":"268","author":"Iwamoto","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2025.117472_bb0190","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.cell.2014.12.016","article-title":"Reduced expression of MYC increases longevity and enhances healthspan","volume":"160","author":"Hofmann","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.bone.2025.117472_bb0195","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.aaz1776","article-title":"The GTEx Consortium atlas of genetic regulatory effects across human tissues","volume":"369","author":"GTEx Consortium","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.bone.2025.117472_bb0200","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1093\/nar\/gkq1295","article-title":"FUBP3 interacts with FGF9 3\u2032 microsatellite and positively regulates FGF9 translation","volume":"39","author":"Gau","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bone.2025.117472_bb0205","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1002\/humu.23292","article-title":"FGF9 mutation causes craniosynostosis along with multiple synostoses","volume":"38","author":"Rodriguez-Zabala","year":"2017","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.bone.2025.117472_bb0210","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ydbio.2016.01.008","article-title":"A combined series of Fgf9 and Fgf18 mutant alleles identifies unique and redundant roles in skeletal development","volume":"411","author":"Hung","year":"2016","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bone.2025.117472_bb0215","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ajhg.2009.06.007","article-title":"Multiple synostoses syndrome is due to a missense mutation in exon 2 of FGF9 gene","volume":"85","author":"Wu","year":"2009","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bone.2025.117472_bb0220","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ydbio.2007.04.048","article-title":"FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod","volume":"307","author":"Hung","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bone.2025.117472_bb0225","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2019.00934","article-title":"High fidelity of mouse models mimicking human genetic skeletal disorders","volume":"10","author":"Brommage","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)."},{"key":"10.1016\/j.bone.2025.117472_bb0230","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1093\/bioinformatics\/btq419","article-title":"LocusZoom: regional visualization of genome-wide association scan results","volume":"26","author":"Pruim","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bone.2025.117472_bb0235","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature10163","article-title":"A conditional knockout resource for the genome-wide study of mouse gene function","volume":"474","author":"Skarnes","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bone.2025.117472_bb0240","series-title":"Pre-Clinical Model. Tech. Protoc","first-page":"303","article-title":"Description of ovariectomy protocol in mice","author":"Souza","year":"2019"},{"key":"10.1016\/j.bone.2025.117472_bb0245","series-title":"Bone Res. Protoc","first-page":"559","article-title":"Quantitative X-ray imaging of mouse bone by faxitron","author":"Butterfield","year":"2019"},{"key":"10.1016\/j.bone.2025.117472_bb0250","series-title":"Lect. Notes Comput. Sci","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1007\/978-3-540-24768-5_100","article-title":"Kolmogorov-Smirnov test for image comparison","author":"Demidenko","year":"2004"},{"key":"10.1016\/j.bone.2025.117472_bb0255","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/978-1-4939-8997-3_28","article-title":"Analysis of bone architecture in rodents using micro-computed tomography","volume":"1914","author":"Van \u2019t Hof","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bone.2025.117472_bb0260","doi-asserted-by":"crossref","first-page":"7604","DOI":"10.1073\/pnas.0911346107","article-title":"Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts","volume":"107","author":"Bassett","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bone.2025.117472_bb0265","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1210\/en.2014-1943","article-title":"Thyrostimulin regulates osteoblastic bone formation during early skeletal development","volume":"156","author":"Bassett","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2025.117472_bb0270","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jbmr.1805","article-title":"Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee","volume":"28","author":"Dempster","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2025.117472_bb0275","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bone.2017.03.051","article-title":"Open source software for semi-automated histomorphometry of bone resorption and formation parameters","volume":"99","author":"Van \u2019t Hof","year":"2017","journal-title":"Bone"},{"key":"10.1016\/j.bone.2025.117472_bb0280","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.1093\/hmg\/ddy271","article-title":"Meta-analysis of genome-wide association studies for height and body mass index in \u223c700000 individuals of European ancestry","volume":"27","author":"Yengo","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bone.2025.117472_bb0285","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000888","article-title":"Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS","volume":"6","author":"Nicolae","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bone.2025.117472_bb0290","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009190","article-title":"Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density","volume":"16","author":"Swan","year":"2020","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bone.2025.117472_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2020.02.015","article-title":"Integrating mouse and human genetic data to move beyond GWAS and identify causal genes in cholesterol metabolism","volume":"31","author":"Li","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.bone.2025.117472_bb0300","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0261572","article-title":"In vivo identification and validation of novel potential predictors for human cardiovascular diseases","volume":"16","author":"Hammouda","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2025.117472_bb0305","first-page":"74","article-title":"The landscape of GWAS validation; systematic review identifying 309 validated non-coding variants across 130 human diseases","volume":"15","author":"Alsheikh","year":"2022","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.bone.2025.117472_bb0310","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.1038\/s41467-019-10936-0","article-title":"Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits","volume":"10","author":"Porcu","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bone.2025.117472_bb0315","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1101\/gr.160283.113","article-title":"Identifying multiple causative genes at a single GWAS locus","volume":"23","author":"Flister","year":"2013","journal-title":"Genome Res."},{"key":"10.1016\/j.bone.2025.117472_bb0320","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1101\/gad.8.4.465","article-title":"A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif","volume":"8","author":"Duncan","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/j.bone.2025.117472_bb0325","doi-asserted-by":"crossref","first-page":"4620","DOI":"10.1021\/bi9021445","article-title":"Quantitative characterization of the interactions among c-myc transcriptional regulators FUSE, FBP, and FIR","volume":"49","author":"Hsiao","year":"2010","journal-title":"Biochemistry"},{"key":"10.1016\/j.bone.2025.117472_bb0330","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1242\/dev.000703","article-title":"Activities of N-Myc in the developing limb link control of skeletal size with digit separation","volume":"134","author":"Ota","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.bone.2025.117472_bb0335","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1359\/jbmr.2002.17.5.763","article-title":"C-myc is required for osteoclast differentiation","volume":"17","author":"Battaglino","year":"2002","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2025.117472_bb0340","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/jcp.1041520118","article-title":"The proto-oncogene C-myc is involved in cell differentiation as well as cell proliferation: studies on growth plate chondrocytes in situ","volume":"152","author":"Farquharson","year":"1992","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bone.2025.117472_bb0345","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s42003-020-01264-x","article-title":"FUBP1 and FUBP2 enforce distinct epigenetic setpoints for MYC expression in primary single murine cells","volume":"3","author":"Zheng","year":"2020","journal-title":"Commun. Biol."},{"key":"10.1016\/j.bone.2025.117472_bb0350","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1128\/MCB.05073-11","article-title":"Posttranscriptional control of type I interferon genes by KSRP in the innate immune response against viral infection","volume":"31","author":"Lin","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bone.2025.117472_bb0355","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.2337\/db13-1901","article-title":"KSRP ablation enhances brown fat gene program in white adipose tissue through reduced miR-150 expression","volume":"63","author":"Chou","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.bone.2025.117472_bb0360","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature14878","article-title":"Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture","volume":"526","author":"Zheng","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bone.2025.117472_bb0365","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.bone.2018.02.027","article-title":"Joint study of two genome-wide association meta-analyses identified 20p12.1 and 20q13.33 for bone mineral density","volume":"110","author":"Pei","year":"2018","journal-title":"Bone"},{"key":"10.1016\/j.bone.2025.117472_bb0370","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1359\/jbmr.1999.14.5.821","article-title":"Prevalent vertebral deformities predict hip fractures and new vertebral deformities but not wrist fractures","volume":"14","author":"Black","year":"1999","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2025.117472_bb0375","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/jbmr.5650070214","article-title":"Incidence of clinically diagnosed vertebral fractures: a population-based study in Rochester, Minnesota, 1985-1989","volume":"7","author":"Cooper","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2025.117472_bb0380","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1002\/jbmr.5650110719","article-title":"The prevalence of vertebral deformity in European men and women: the european vertebral osteoporosis study","volume":"11","author":"O\u2019Neill","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2025.117472_bb0385","first-page":"1","article-title":"Age-related changes in trabecular and cortical bone microstructure","volume":"2013","author":"Chen","year":"2013","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.bone.2025.117472_bb0390","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1016\/S0020-1383(16)47003-8","article-title":"Bone mechanical properties and changes with osteoporosis","volume":"47","author":"Osterhoff","year":"2016","journal-title":"Injury"},{"key":"10.1016\/j.bone.2025.117472_bb0395","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/jor.23339","article-title":"Different bone remodeling levels of trabecular and cortical bone in response to changes in Wnt\/\u03b2-catenin signaling in mice","volume":"35","author":"Li","year":"2017","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2025.117472_bb0400","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1002\/ajmg.a.63132","article-title":"Nosology of genetic skeletal disorders: 2023 revision","volume":"191","author":"Unger","year":"2023","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.bone.2025.117472_bb0405","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1038\/ng.166","article-title":"Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia","volume":"40","author":"Rock","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bone.2025.117472_bb0410","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1001\/jama.285.6.785","article-title":"Osteoporosis prevention, diagnosis and therapy","volume":"285","author":"Klibanski","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.bone.2025.117472_bb0415","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1093\/gerona\/glt046","article-title":"The relevance of mouse models for investigating age-related bone loss in humans","volume":"68","author":"Jilka","year":"2013","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.bone.2025.117472_bb0420","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/BF02553699","article-title":"Intersample variation in bone histomorphometry: comparison between parameter values measured on two contiguous transiliac bone biopsies","volume":"37","author":"Chavassieux","year":"1985","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2025.117472_bb0425","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/S0344-0338(89)80240-7","article-title":"Sensitivity of bone histomorphometry in the diagnosis of metabolic bone diseases","volume":"185","author":"Ballanti","year":"1989","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.bone.2025.117472_bb0430","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/8756-3282(92)90198-6","article-title":"Combined inter-observer and inter-method variation in bone histomorphometry","volume":"13","author":"Wright","year":"1992","journal-title":"Bone"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328225000845?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328225000845?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T05:18:40Z","timestamp":1774415920000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328225000845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":86,"alternative-id":["S8756328225000845"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2025.117472","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The GWAS candidate far upstream element binding protein 3 (FUBP3) is required for normal skeletal growth, and adult bone mass and strength in mice","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2025.117472","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117472"}}