{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T02:09:57Z","timestamp":1772503797299,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T00:00:00Z","timestamp":1745020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973633"],"award-info":[{"award-number":["81973633"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174119"],"award-info":[{"award-number":["82174119"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017547","name":"Jiangsu Association for Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019595","name":"Youth and Middle-aged Scientific and Technological Innovation Leading Talents Program of the Corps","doi-asserted-by":"publisher","award":["QT20230101268"],"award-info":[{"award-number":["QT20230101268"]}],"id":[{"id":"10.13039\/501100019595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.bone.2025.117489","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T19:28:12Z","timestamp":1744658892000},"page":"117489","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Rhizoma Drynariae-derived EV-like particles alleviate osteoporosis by promoting osteogenic differentiation in BMSCs through the activation of the hsa_circ_0001275\/miR-422a pathway"],"prefix":"10.1016","volume":"196","author":[{"given":"Jiawen","family":"Shen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzhen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyue","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fubin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianxin","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongxiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0500-5295","authenticated-orcid":false,"given":"Kewei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bone.2025.117489_bb0005","doi-asserted-by":"crossref","first-page":"182","DOI":"10.7326\/M22-0684","article-title":"Effectiveness and safety of treatments to prevent fractures in people with low bone mass or primary osteoporosis: a living systematic review and network Meta-analysis for the American College of Physicians[J]","volume":"176","author":"Ayers","year":"2023","journal-title":"Ann. Intern. Med."},{"issue":"1","key":"10.1016\/j.bone.2025.117489_bb0010","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2174\/1381612826666200707130246","article-title":"The roles of LncRNAs in osteogenesis, Adipogenesis and osteoporosis[J]","volume":"27","author":"Guo","year":"2021","journal-title":"Curr. Pharm. Des."},{"issue":"4","key":"10.1016\/j.bone.2025.117489_bb0015","article-title":"Prevalence of osteoporosis and fracture in China: the China osteoporosis prevalence study[J]","volume":"8","author":"Wang","year":"2021","journal-title":"JAMA Netw. Open"},{"issue":"15\u201316","key":"10.1016\/j.bone.2025.117489_bb0020","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1111\/jocn.16101","article-title":"Effect of exercise on bone mineral density among patients with osteoporosis and osteopenia: a systematic review and network meta-analysis[J]","volume":"31","author":"Zhang","year":"2022","journal-title":"J. Clin. Nurs."},{"issue":"1","key":"10.1016\/j.bone.2025.117489_bb0025","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/s41392-023-01354-2","article-title":"OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2[J]","volume":"8","author":"Zhu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"2","key":"10.1016\/j.bone.2025.117489_bb0030","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1002\/jcp.30625","article-title":"CircRNA-miRNA networks in regulating bone disease[J]","volume":"237","author":"Huang","year":"2022","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bone.2025.117489_bb0035","doi-asserted-by":"crossref","first-page":"3249737","DOI":"10.1155\/2022\/3249737","article-title":"Identification of circRNA expression profiles in BMSCs from glucocorticoid-induced osteoporosis model[J]","volume":"2022","author":"Chen","year":"2022","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.bone.2025.117489_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109844","article-title":"CircRNA hsa_circ_0006859 inhibits the osteogenic differentiation of BMSCs and aggravates osteoporosis by targeting miR-642b-5p\/miR-483-3p and upregulating EFNA2\/DOCK3[J]","volume":"116","author":"Yin","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"6","key":"10.1016\/j.bone.2025.117489_bb0045","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1042\/CS20220833","article-title":"CircRBM23 regulates the switch between osteogenesis and adipogenesis of mesenchymal stem cells via sponging miR-338-3p[J]","volume":"137","author":"Gao","year":"2023","journal-title":"Clin. Sci. (Lond.)"},{"issue":"5","key":"10.1016\/j.bone.2025.117489_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0097098","article-title":"MiR-422a as a potential cellular microRNA biomarker for postmenopausal osteoporosis[J]","volume":"9","author":"Cao","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.bone.2025.117489_bb0055","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1159\/000489657","article-title":"Hsa_Circ_0001275: a potential novel diagnostic biomarker for postmenopausal osteoporosis[J]","volume":"46","author":"Zhao","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"5","key":"10.1016\/j.bone.2025.117489_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0252126","article-title":"Knockdown of hsa_circ_0001275 reverses dexamethasone-induced osteoblast growth inhibition via mediation of miR-377\/CDKN1B axis[J]","volume":"16","author":"Xu","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2025.117489_bb0065","series-title":"Expression Profile of Circular RNA in Postmenopausal Osteoporosis and Screening of Potential Molecular Markers[D]","author":"K Z.","year":"2018"},{"issue":"1","key":"10.1016\/j.bone.2025.117489_bb0070","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/jre.13209","article-title":"LncRNA JHDM1D-AS1 promotes osteogenic differentiation of periodontal ligament cells by targeting miR-532-5p to activate IGF1R signaling[J]","volume":"59","author":"Zhong","year":"2024","journal-title":"J. Periodontal Res."},{"issue":"1","key":"10.1016\/j.bone.2025.117489_bb0075","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/jcmm.17065","article-title":"Exosomal hsa_circ_0125310 promotes cell proliferation and fibrosis in diabetic nephropathy via sponging miR-422a and targeting the IGF1R\/p38 axis[J]","volume":"26","author":"Zhu","year":"2022","journal-title":"J. Cell. Mol. Med."},{"issue":"5","key":"10.1016\/j.bone.2025.117489_bb0080","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1016\/j.apsb.2024.02.005","article-title":"Rhizoma Drynariae-derived nanovesicles reverse osteoporosis by potentiating osteogenic differentiation of human bone marrow mesenchymal stem cells via targeting ERalpha signaling[J]","volume":"14","author":"Zhao","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bone.2025.117489_bb0085","doi-asserted-by":"crossref","first-page":"5700","DOI":"10.12659\/MSM.915170","article-title":"Network pharmacology-based pharmacological mechanism of the Chinese medicine Rhizoma drynariae against osteoporosis[J]","volume":"25","author":"Gan","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.bone.2025.117489_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111480","article-title":"Total flavonoids of rhizoma drynariae ameliorates bone formation and mineralization in BMP-Smad signaling pathway induced large tibial defect rats[J]","volume":"138","author":"Sun","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bone.2025.117489_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113379","article-title":"Effect of flavonoids from Rhizoma Drynariae on osteoporosis rats and osteocytes[J]","volume":"153","author":"Jin","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.bone.2025.117489_bb0100","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2022.5167","article-title":"Total flavonoids of Rhizoma Drynariae enhances CD31(hi)Emcn(hi) vessel formation and subsequent bone regeneration in rat models of distraction osteogenesis by activating PDGF-BB\/VEGF\/RUNX2\/OSX signaling axis[J]","volume":"50","author":"Shen","year":"2022","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bone.2025.117489_bb0105","doi-asserted-by":"crossref","unstructured":"X S, B W, Z P, et al. A polysaccharide from the dried rhizome of Drynaria fortunei (Kunze) J. Sm. prevents ovariectomized (OVX)-induced osteoporosis in rats[J]. J Cell Mol Med, 2020,24(6):3692\u20133700.","DOI":"10.1111\/jcmm.15072"},{"issue":"24","key":"10.1016\/j.bone.2025.117489_bb0110","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202207826","article-title":"Plant-derived vesicle-like nanoparticles as promising biotherapeutic tools: present and future[J]","volume":"35","author":"Feng","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bone.2025.117489_bb0115","doi-asserted-by":"crossref","unstructured":"Zhao Q, Wang T, Wang H, et al. Consensus statement on research and application of Chinese herbal medicine derived extracellular vesicles-like particles (2023 edition) [J]. Chin Herb Med, 2024,16(1):3\u201312.","DOI":"10.1016\/j.chmed.2023.11.002"},{"issue":"3","key":"10.1016\/j.bone.2025.117489_bb0120","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/mt.2013.190","article-title":"Targeted drug delivery to intestinal macrophages by bioactive nanovesicles released from grapefruit[J]","volume":"22","author":"Wang","year":"2014","journal-title":"Mol. Ther."},{"issue":"Database issue","key":"10.1016\/j.bone.2025.117489_bb0125","doi-asserted-by":"crossref","first-page":"D92","DOI":"10.1093\/nar\/gkt1248","article-title":"starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data[J]","volume":"42","author":"Li","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bone.2025.117489_bb0130","series-title":"Bancroft\u2019s Theory and Practice of Histological Techniques[M]","author":"Kim Suvarna","year":"2013"},{"issue":"2","key":"10.1016\/j.bone.2025.117489_bb0135","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13551","article-title":"NAP1L2 drives mesenchymal stem cell senescence and suppresses osteogenic differentiation[J]","volume":"21","author":"Hu","year":"2022","journal-title":"Aging Cell"},{"issue":"13","key":"10.1016\/j.bone.2025.117489_bb0140","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.2174\/1386207326666230223165730","article-title":"Total flavonoids from Rhizoma Drynariae (Gusuibu) alleviates diabetic osteoporosis by activating BMP2\/Smad signaling pathway[J]","volume":"26","author":"Fang","year":"2023","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"10.1016\/j.bone.2025.117489_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113379","article-title":"Effect of flavonoids from Rhizoma Drynariae on osteoporosis rats and osteocytes[J]","volume":"153","author":"Jin","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bone.2025.117489_bb0150","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12860-015-0056-6","article-title":"Dexamethasone in osteogenic medium strongly induces adipocyte differentiation of mouse bone marrow stromal cells and increases osteoblast differentiation[J]","volume":"16","author":"Ghali","year":"2015","journal-title":"BMC Cell Biol."},{"issue":"1","key":"10.1016\/j.bone.2025.117489_bb0155","doi-asserted-by":"crossref","first-page":"2350751","DOI":"10.1080\/21623945.2024.2350751","article-title":"Isolation and adipogenic differentiation of murine mesenchymal stem cells harvested from macrophage-depleted bone marrow and adipose tissue[J]","volume":"13","author":"Siddiqui","year":"2024","journal-title":"Adipocyte"},{"issue":"1","key":"10.1016\/j.bone.2025.117489_bb0160","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1186\/s13287-020-02058-y","article-title":"circAKT3 positively regulates osteogenic differentiation of human dental pulp stromal cells via miR-206\/CX43 axis[J]","volume":"11","author":"Zhang","year":"2020","journal-title":"Stem Cell Res Ther"},{"issue":"8","key":"10.1016\/j.bone.2025.117489_bb0165","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1302\/2046-3758.108.BJR-2020-0127.R2","article-title":"Hsa_circ_0066523 promotes the proliferation and osteogenic differentiation of bone mesenchymal stem cells by repressing PTEN[J]","volume":"10","author":"Xin","year":"2021","journal-title":"Bone Joint Res"},{"issue":"2","key":"10.1016\/j.bone.2025.117489_bb0170","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/cbin.11502","article-title":"Involvement of circRNA_0007059 in the regulation of postmenopausal osteoporosis by promoting the microRNA-378\/BMP-2 axis[J]","volume":"45","author":"Liu","year":"2021","journal-title":"Cell Biol. Int."},{"issue":"7","key":"10.1016\/j.bone.2025.117489_bb0175","first-page":"3459","article-title":"CircRNA_0048211 protects postmenopausal osteoporosis through targeting miRNA-93-5p to regulate BMP2[J]","volume":"24","author":"Qiao","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"1","key":"10.1016\/j.bone.2025.117489_bb0180","doi-asserted-by":"crossref","first-page":"3824","DOI":"10.1080\/21655979.2021.1949514","article-title":"Circular RNA circ_0000020 promotes osteogenic differentiation to reduce osteoporosis via sponging microRNA miR-142-5p to up-regulate bone morphogenetic protein BMP2[J]","volume":"12","author":"Zhou","year":"2021","journal-title":"Bioengineered"},{"issue":"24","key":"10.1016\/j.bone.2025.117489_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13246383","article-title":"hsa_circ_0001275 is one of a number of circRNAs dysregulated in enzalutamide resistant prostate Cancer and confers enzalutamide resistance in vitro[J]","volume":"13","author":"Lim","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"26","key":"10.1016\/j.bone.2025.117489_bb0190","doi-asserted-by":"crossref","first-page":"42173","DOI":"10.18632\/oncotarget.15025","article-title":"Circulating microRNA-422a is associated with lymphatic metastasis in lung cancer[J]","volume":"8","author":"Wu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bone.2025.117489_bb0195","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3389\/fcell.2020.00623","article-title":"Synonymous mutations of porcine Igf1r extracellular domain affect differentiation and mineralization in MC3T3-E1 cells[J]","volume":"8","author":"Wang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.bone.2025.117489_bb0200","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/jor.23767","article-title":"IGF-1 signaling mediated cell-specific skeletal mechano-transduction[J]","volume":"36","author":"Tian","year":"2018","journal-title":"J. Orthop. Res."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328225001012?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328225001012?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:47:43Z","timestamp":1762660063000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328225001012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":40,"alternative-id":["S8756328225001012"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2025.117489","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rhizoma Drynariae-derived EV-like particles alleviate osteoporosis by promoting osteogenic differentiation in BMSCs through the activation of the hsa_circ_0001275\/miR-422a pathway","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2025.117489","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117489"}}