{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:41:18Z","timestamp":1792726878619,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272955"],"award-info":[{"award-number":["82272955"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.bone.2025.117510","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T15:48:04Z","timestamp":1746200884000},"page":"117510","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Label-free rapid diagnosis of jaw osteonecrosis via the intersection of Raman spectroscopy and deep learning"],"prefix":"10.1016","volume":"197","author":[{"given":"Xiaobo","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangjun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZhongXu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingzhi","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhining","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2025.117510_bb0005","first-page":"128","article-title":"[Interpretation of medication-related osteonecrosis of the jaw: MASCC\/ISOO\/ASCO clinical practice guideline], Zhonghua Kou Qiang Yi Xue Za Zhi Zhonghua Kouqiang Yixue Zazhi Chin","volume":"57","author":"Chen","year":"2022","journal-title":"J. Stomatol."},{"key":"10.1016\/j.bone.2025.117510_bb0010","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jds.2017.12.003","article-title":"Clinical analysis of medication related osteonecrosis of the jaws: a growing severe complication in China","volume":"13","author":"Wang","year":"2018","journal-title":"J. Dent. Sci."},{"key":"10.1016\/j.bone.2025.117510_bb0015","first-page":"245","article-title":"Mechanism, prevention, and treatment for medication-related osteonecrosis of the jaws, Hua Xi Kou Qiang Yi Xue Za Zhi Huaxi Kouqiang Yixue Zazhi West China","volume":"39","author":"Pan","year":"2021","journal-title":"J. Stomatol."},{"key":"10.1016\/j.bone.2025.117510_bb0020","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.critrevonc.2015.08.010","article-title":"Oral toxicity management in head and neck cancer patients treated with chemotherapy and radiation: dental pathologies and osteoradionecrosis (part 1) literature review and consensus statement","volume":"97","author":"Buglione","year":"2016","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.bone.2025.117510_bb0025","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1200\/JCO.23.01951","article-title":"Development and standardization of an osteoradionecrosis classification system in head and neck cancer: implementation of a risk-based model","volume":"42","author":"Watson","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bone.2025.117510_bb0030","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1016\/j.ijom.2016.06.016","article-title":"Osteoradionecrosis and medication-related osteonecrosis of the jaw: similarities and differences","volume":"45","author":"Grisar","year":"2016","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.bone.2025.117510_bb0035","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.ijrobp.2020.12.043","article-title":"Osteoradionecrosis: exposing the evidence not the bone","volume":"109","author":"Frankart","year":"2021","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.bone.2025.117510_bb0040","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/idj.12318","article-title":"Osteoradionecrosis of the jaws: definition, epidemiology, staging and clinical and radiological findings. A concise review","volume":"68","author":"Chronopoulos","year":"2018","journal-title":"Int. Dent. J."},{"key":"10.1016\/j.bone.2025.117510_bb0045","article-title":"Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy","volume":"2019","author":"El-Rabbany","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.bone.2025.117510_bb0050","article-title":"Interventions for managing medication-related osteonecrosis of the jaw","volume":"7","author":"Beth-Tasdogan","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.bone.2025.117510_bb0055","first-page":"195","article-title":"Conservative Management of Medication-Related Osteonecrosis of the Jaws (MRONJ): a retrospective cohort study","volume":"10","author":"Varoni","year":"2021","journal-title":"Antibiot. Basel Switz."},{"key":"10.1016\/j.bone.2025.117510_bb0060","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/cncr.33948","article-title":"Exposed bone in patients with head and neck cancer treated with radiation therapy: an analysis of the Observational Study of Dental Outcomes in Head and Neck Cancer Patients (OraRad)","volume":"128","author":"Treister","year":"2022","journal-title":"Cancer"},{"key":"10.1016\/j.bone.2025.117510_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115490","article-title":"Raman and Fourier transform infrared imaging for characterization of bone material properties","volume":"139","author":"Taylor","year":"2020","journal-title":"Bone"},{"key":"10.1016\/j.bone.2025.117510_bb0070","unstructured":"Raman spectroscopic detection of changes in bioapatite in mouse femora as a function of age and in vitro fluoride treatment - PubMed, (n.d.). https:\/\/pubmed.ncbi.nlm.nih.gov\/11351499\/ (accessed July 31, 2024)."},{"key":"10.1016\/j.bone.2025.117510_bb0075","doi-asserted-by":"crossref","DOI":"10.1126\/science.aao2189","article-title":"Fractal-like hierarchical organization of bone begins at the nanoscale","volume":"360","author":"Reznikov","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.bone.2025.117510_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2024.107105","article-title":"Noninvasive surface-enhanced Raman spectroscopy outperforms combined positive score in predicting sensitivity to neoadjuvant immunotherapy in head and neck squamous cell carcinoma","volume":"159","author":"Yang","year":"2024","journal-title":"Oral Oncol."},{"key":"10.1016\/j.bone.2025.117510_bb0085","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2024.1480279","article-title":"Intraoperative rapid assessment of the deep muscle surgical margin of tongue squamous cell carcinoma via Raman spectroscopy","volume":"12","author":"Li","year":"2024","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bone.2025.117510_bb0090","doi-asserted-by":"crossref","first-page":"4977","DOI":"10.2147\/IJN.S167996","article-title":"Surface-enhanced Raman spectroscopy of blood serum based on gold nanoparticles for tumor stages detection and histologic grades classification of oral squamous cell carcinoma","volume":"13","author":"Xue","year":"2018","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.bone.2025.117510_bb0095","first-page":"3081","article-title":"Raman spectroscopic analysis to detect reduced bone quality after sciatic neurectomy in mice","volume":"23","author":"Ishimaru","year":"2018","journal-title":"Mol. Basel Switz."},{"key":"10.1016\/j.bone.2025.117510_bb0100","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00223-021-00825-4","article-title":"Measures of bone mineral carbonate content and mineral maturity\/crystallinity for FT-IR and Raman spectroscopic imaging differentially relate to physical-chemical properties of carbonate-substituted hydroxyapatite","volume":"109","author":"Taylor","year":"2021","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2025.117510_bb0105","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1007\/s00198-017-4019-y","article-title":"Vibrational spectroscopic techniques to assess bone quality","volume":"28","author":"Paschalis","year":"2017","journal-title":"Osteoporos. Int. J. Establ. Result Coop. Eur. Found. Osteoporos. Natl. Osteoporos. Found. USA"},{"key":"10.1016\/j.bone.2025.117510_bb0110","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1177\/00037028221109244","article-title":"Irradiation induced biochemical changes in human mandibular bone: a Raman spectroscopic study","volume":"76","author":"Reddy Padala","year":"2022","journal-title":"Appl. Spectrosc."},{"key":"10.1016\/j.bone.2025.117510_bb0115","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-66857-6","article-title":"Classification of osteoarthritic and healthy cartilage using deep learning with Raman spectra","volume":"14","author":"Kok","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bone.2025.117510_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.freeradbiomed.2024.10.308","article-title":"Taurine ameliorates radiation-induced oxidative stress in bone marrow mesenchymal stromal cells and promotes osteogenesis","author":"Chen","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bone.2025.117510_bb0125","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3390\/cancers12020419","article-title":"Patient derived models to study head and neck cancer radiation response","volume":"12","author":"Cosper","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.bone.2025.117510_bb0130","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.freeradbiomed.2023.06.022","article-title":"Menaquinone-4 prevents medication-related osteonecrosis of the jaw through the SIRT1 signaling-mediated inhibition of cellular metabolic stresses-induced osteoblast apoptosis","volume":"206","author":"Cui","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bone.2025.117510_bb0135","doi-asserted-by":"crossref","DOI":"10.3791\/64855","article-title":"The establishment of a murine mandibular molar extraction socket healing model","author":"Yu","year":"2023","journal-title":"J. Vis. Exp. JoVE"},{"key":"10.1016\/j.bone.2025.117510_bb0140","doi-asserted-by":"crossref","first-page":"7464","DOI":"10.1039\/D1AN01560E","article-title":"Compositional assessment of bone by Raman spectroscopy","volume":"146","author":"Unal","year":"2021","journal-title":"Analyst"},{"key":"10.1016\/j.bone.2025.117510_bb0145","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/05704920701551530","article-title":"Raman spectroscopy of biological tissues","volume":"42","author":"Movasaghi","year":"2007","journal-title":"Appl. Spectrosc. Rev."},{"key":"10.1016\/j.bone.2025.117510_bb0150","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ijom.2011.12.016","article-title":"Suppurative osteomyelitis, bisphosphonate induced osteonecrosis, osteoradionecrosis: a blinded histopathologic comparison and its implications for the mechanism of each disease","volume":"41","author":"Marx","year":"2012","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.bone.2025.117510_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2022.106056","article-title":"Osteoradionecrosis after postoperative radiotherapy for oral cavity cancer: a retrospective cohort study","volume":"133","author":"M\u00f6ring","year":"2022","journal-title":"Oral Oncol."},{"key":"10.1016\/j.bone.2025.117510_bb0160","unstructured":"Medication-related osteonecrosis of the jaw (MRONJ): a review of pathogenesis hypothesis and therapy strategies - PubMed, (n.d.). https:\/\/pubmed.ncbi.nlm.nih.gov\/38155341\/ (accessed April 11, 2025)."},{"key":"10.1016\/j.bone.2025.117510_bb0165","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nrrheum.2011.181","article-title":"Epidemiology and pathogenesis of osteonecrosis of the jaw","volume":"8","author":"Reid","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bone.2025.117510_bb0170","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.radonc.2021.11.021","article-title":"Hyperbaric oxygen treatment of mandibular osteoradionecrosis: combined data from the two randomized clinical trials DAHANCA-21 and NWHHT2009-1","volume":"166","author":"Forner","year":"2022","journal-title":"Radiother. Oncol. J. Eur. Soc. Ther. Radiol. Oncol."},{"key":"10.1016\/j.bone.2025.117510_bb0175","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1007\/s00784-018-2385-2","article-title":"Bone mineralization and vascularization in bisphosphonate-related osteonecrosis of the jaw: an experimental study in the rat","volume":"22","author":"K\u00fcn-Darbois","year":"2018","journal-title":"Clin. Oral Investig."},{"key":"10.1016\/j.bone.2025.117510_bb0180","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1111\/odi.14721","article-title":"Raman spectroscopy and U-Net deep neural network in antiresorptive drug-related osteonecrosis of the jaw","volume":"30","author":"Matthies","year":"2024","journal-title":"Oral Dis."},{"key":"10.1016\/j.bone.2025.117510_bb0185","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1099889","article-title":"The feasibility of discriminating BRONJ lesion bone with Raman spectroscopy","volume":"14","author":"Xia","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bone.2025.117510_bb0190","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2019.00587","article-title":"Therapeutic irradiation: consequences for bone and bone marrow adipose tissue","volume":"10","author":"Costa","year":"2019","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bone.2025.117510_bb0195","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s00223-021-00916-2","article-title":"Occlusal trauma and bisphosphonate-related osteonecrosis of the jaw in mice","volume":"110","author":"Mine","year":"2022","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2025.117510_bb0200","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.bone.2009.10.006","article-title":"Increased matrix mineralization in the immature femoral head following ischemic osteonecrosis","volume":"46","author":"Hofstaetter","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.bone.2025.117510_bb0205","unstructured":"Biologic and pathologic aspects of osteocytes in the setting of medication-related osteonecrosis of the jaw (MRONJ) - PubMed, (n.d.). https:\/\/pubmed.ncbi.nlm.nih.gov\/34487892\/ (accessed December 13, 2024)."},{"key":"10.1016\/j.bone.2025.117510_bb0210","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jssc.2017.07.025","article-title":"Carbonate substitution in the mineral component of bone: discriminating the structural changes, simultaneously imposed by carbonate in A and B sites of apatite","volume":"255","author":"Madupalli","year":"2017","journal-title":"J. Solid State Chem."},{"key":"10.1016\/j.bone.2025.117510_bb0215","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1366\/00037020360695964","article-title":"Osteoradionecrosis (ORN) of the mandible: a laser Raman spectroscopic study","volume":"57","author":"Lakshmi","year":"2003","journal-title":"Appl. Spectrosc."},{"key":"10.1016\/j.bone.2025.117510_bb0220","unstructured":"Rapid diagnosis of diabetes based on ResNet and Raman spectroscopy - PubMed, (n.d.). https:\/\/pubmed.ncbi.nlm.nih.gov\/35817371\/ (accessed December 14, 2024)."},{"key":"10.1016\/j.bone.2025.117510_bb0225","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1038\/s41598-022-22204-1","article-title":"Rapid diagnosis of membranous nephropathy based on serum and urine Raman spectroscopy combined with deep learning methods","volume":"13","author":"Zhang","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bone.2025.117510_bb0230","unstructured":"Indigenous microbiota protects development of medication-related osteonecrosis induced by periapical disease in mice - PubMed, (n.d.). https:\/\/pubmed.ncbi.nlm.nih.gov\/35307731\/ (accessed July 30, 2024)."},{"key":"10.1016\/j.bone.2025.117510_bb0235","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1007\/s12015-020-10034-5","article-title":"Mesenchymal stem cell therapy for osteoradionecrosis of the mandible: a systematic review of preclinical and human studies","volume":"16","author":"Gundestrup","year":"2020","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.bone.2025.117510_bb0240","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.3390\/microorganisms10061135","article-title":"A journey into animal models of human osteomyelitis: a review","volume":"10","author":"Meroni","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.bone.2025.117510_bb0245","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb9265","article-title":"Human and mouse bones physiologically integrate in a humanized mouse model while maintaining species-specific ultrastructure","volume":"6","author":"Moreno-Jim\u00e9nez","year":"2020","journal-title":"Sci. Adv."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632822500122X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632822500122X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T15:51:26Z","timestamp":1747756286000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S875632822500122X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":49,"alternative-id":["S875632822500122X"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2025.117510","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Label-free rapid diagnosis of jaw osteonecrosis via the intersection of Raman spectroscopy and deep learning","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2025.117510","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117510"}}