{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:18:04Z","timestamp":1792019884571,"version":"4.4.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","award":["72978"],"award-info":[{"award-number":["72978"]}],"id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.bone.2025.117622","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T23:26:25Z","timestamp":1756769185000},"page":"117622","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["The role of probiotics in modulating RANKL in osteoporosis: A systematic review of animal interventional studies and RCTs"],"prefix":"10.1016","volume":"201","author":[{"given":"Fatemeh","family":"Hamedi-Kalajahi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Alizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorayya","family":"Kheirouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bone.2025.117622_bb0005","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev-pathol-011110-130203","article-title":"Disorders of bone remodeling","volume":"6","author":"Feng","year":"2011","journal-title":"Ann. Rev. Pathol. Mech. Dis."},{"key":"10.1016\/j.bone.2025.117622_bb0010","series-title":"Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism","first-page":"393","article-title":"Osteoporosis: an overview","author":"McClung","year":"2018"},{"issue":"1","key":"10.1016\/j.bone.2025.117622_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.6118\/jmm.24000","article-title":"The 2024 guidelines for osteoporosis - Korean Society of Menopause: part I","volume":"30","author":"Lee","year":"2024","journal-title":"J. Menopausal Med."},{"issue":"8","key":"10.1016\/j.bone.2025.117622_bb0020","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/jbmr.5650110802","article-title":"Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis","volume":"11","author":"Pacifici","year":"1996","journal-title":"J. Bone Miner. Res."},{"issue":"9773","key":"10.1016\/j.bone.2025.117622_bb0025","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/S0140-6736(10)62349-5","article-title":"Osteoporosis: now and the future","volume":"377","author":"Rachner","year":"2011","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.bone.2025.117622_bb0030","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1172\/JCI200317215","article-title":"Role of RANK ligand in mediating increased bone resorption in early postmenopausal women","volume":"111","author":"Eghbali-Fatourechi","year":"2003","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.bone.2025.117622_bb0035","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.berh.2006.10.004","article-title":"Osteoporosis: strategies for prevention and management","volume":"21","author":"Keen","year":"2007","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"issue":"4","key":"10.1016\/j.bone.2025.117622_bb0040","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1111\/os.13009","article-title":"Comprehensive interventions including vitamin D effectively reduce the risk of falls in elderly osteoporotic patients","volume":"13","author":"Feng","year":"2021","journal-title":"Orthop. Surg."},{"issue":"7","key":"10.1016\/j.bone.2025.117622_bb0045","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1002\/jbmr.3122","article-title":"Impact of calcium and two doses of vitamin D on bone metabolism in the elderly: a randomized controlled trial","volume":"32","author":"Rahme","year":"2017","journal-title":"J. Bone Miner. Res."},{"issue":"5","key":"10.1016\/j.bone.2025.117622_bb0050","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.3390\/nu11051157","article-title":"Role of calcium and low-fat dairy foods in weight-loss outcomes revisited: results from the randomized trial of effects on bone and body composition in overweight\/obese postmenopausal women","volume":"11","author":"Ilich","year":"2019","journal-title":"Nutrients"},{"issue":"6","key":"10.1016\/j.bone.2025.117622_bb0055","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/joim.12825","article-title":"Effect of increasing doses of vitamin D on bone mineral density and serum N-terminal telopeptide in elderly women: a randomized controlled trial","volume":"284","author":"Smith","year":"2018","journal-title":"J. Intern. Med."},{"issue":"9322","key":"10.1016\/j.bone.2025.117622_bb0060","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/S0140-6736(02)08827-X","article-title":"Treatment of postmenopausal osteoporosis","volume":"359","author":"Delmas","year":"2002","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.bone.2025.117622_bb0065","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/S2213-8587(17)30188-2","article-title":"Osteoporosis treatment: recent developments and ongoing challenges","volume":"5","author":"Khosla","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"2","key":"10.1016\/j.bone.2025.117622_bb0070","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.abb.2008.03.018","article-title":"Functions of RANKL\/RANK\/OPG in bone modeling and remodeling","volume":"473","author":"Boyce","year":"2008","journal-title":"Arch. Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.bone.2025.117622_bb0075","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41598-017-00563-4","article-title":"Prevalence of polymorphisms in OPG, RANKL and RANK as potential markers for Charcot arthropathy development","volume":"7","author":"Bruhn-Olszewska","year":"2017","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.bone.2025.117622_bb0080","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1172\/JCI128521","article-title":"The gut-bone axis: how bacterial metabolites bridge the distance","volume":"129","author":"Zaiss","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bone.2025.117622_bb0085","series-title":"Handbook on Immunosenescence: Basic Understanding and Clinical Applications","first-page":"1329","article-title":"Osteoporosis, inflammation and ageing","author":"Ginaldi","year":"2009"},{"issue":"4","key":"10.1016\/j.bone.2025.117622_bb0090","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.BAD-0015-2016","article-title":"The potential of probiotics as a therapy for osteoporosis","volume":"5","author":"Collins","year":"2017","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.bone.2025.117622_bb0095","series-title":"Understanding the Gut-Bone Signaling Axis: Mechanisms and Therapeutic Implications","first-page":"225","article-title":"Probiotics in gut-bone signaling","author":"Schepper","year":"2017"},{"issue":"3","key":"10.1016\/j.bone.2025.117622_bb0100","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.anaerobe.2008.02.001","article-title":"Human-derived probiotic Lactobacillus reuteri demonstrate antimicrobial activities targeting diverse enteric bacterial pathogens","volume":"14","author":"Spinler","year":"2008","journal-title":"Anaerobe"},{"issue":"9","key":"10.1016\/j.bone.2025.117622_bb0105","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.3390\/nu13093001","article-title":"Probiotic supplementation and micronutrient status in healthy subjects: a systematic review of clinical trials","volume":"13","author":"Barkhidarian","year":"2021","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.bone.2025.117622_bb0110","article-title":"Effect of probiotics supplementation on bone mineral content and bone mass density","volume":"2014","author":"Parvaneh","year":"2014","journal-title":"Sci. World J."},{"issue":"2","key":"10.1016\/j.bone.2025.117622_bb0115","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s12602-023-10065-7","article-title":"Protective effects of the postbiotic Lactobacillus plantarum MD35 on bone loss in an ovariectomized mice model","volume":"16","author":"Myeong","year":"2024","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"10.1016\/j.bone.2025.117622_bb0120","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.875788","article-title":"Bifidobacterium longum ameliorates ovariectomy-induced bone loss via enhancing anti-osteoclastogenic and immunomodulatory potential of regulatory B cells (Bregs)","volume":"13","author":"Sapra","year":"2022","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.bone.2025.117622_bb0125","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.idairyj.2009.06.009","article-title":"Effects of a Lactobacillus casei 393 fermented milk product on bone metabolism in ovariectomised rats","volume":"19","author":"Kim","year":"2009","journal-title":"Int. Dairy J."},{"key":"10.1016\/j.bone.2025.117622_bb0130","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s12602-018-9443-6","article-title":"Supportive role of probiotic strains in protecting rats from ovariectomy-induced cortical bone loss","volume":"11","author":"Montazeri-Najafabady","year":"2019","journal-title":"Probiotics Antimicrob. Proteins"},{"issue":"3","key":"10.1016\/j.bone.2025.117622_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0092368","article-title":"Probiotics protect mice from ovariectomy-induced cortical bone loss","volume":"9","author":"Ohlsson","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.bone.2025.117622_bb0140","first-page":"171","article-title":"Probiotic Lactobacillus acidophilus prevents bone loss in aged osteoporosis in rats; the possible implication of NLRP3 Inflammasome","volume":"43","author":"Allam","year":"2023","journal-title":"Bull. Egypt. Soc. Physiol. Sci."},{"issue":"4","key":"10.1016\/j.bone.2025.117622_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0153180","article-title":"Lactobacillus reuteri 6475 increases bone density in intact females only under an inflammatory setting","volume":"11","author":"Collins","year":"2016","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.bone.2025.117622_bb0150","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/jre.13256","article-title":"Probiotics enhance alveolar bone microarchitecture, intestinal morphology and estradiol levels in osteoporotic animals","volume":"59","author":"Lucateli","year":"2024","journal-title":"J. Periodontal Res."},{"issue":"4","key":"10.1016\/j.bone.2025.117622_bb0155","doi-asserted-by":"crossref","first-page":"712","DOI":"10.5851\/kosfa.2023.e29","article-title":"Preliminary study on effect of Lactiplantibacillus plantarum on osteoporosis in the ovariectomized rat","volume":"43","author":"Jin","year":"2023","journal-title":"Food Sci. Anim. Resour."},{"issue":"2","key":"10.1016\/j.bone.2025.117622_bb0160","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3340\/jkns.2021.0098","article-title":"The effect of genetically modified Lactobacillus plantarum carrying bone morphogenetic protein 2 gene on an ovariectomized rat","volume":"65","author":"Jin","year":"2022","journal-title":"J. Kor. Neurosurg. Soc."},{"key":"10.1016\/j.bone.2025.117622_bb0165","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.bone.2025.117622_bb0170","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bonr.2018.02.001","article-title":"Lactobacillus acidophilus inhibits bone loss and increases bone heterogeneity in osteoporotic mice via modulating Treg-Th17 cell balance","volume":"8","author":"Dar","year":"2018","journal-title":"Bone Rep."},{"issue":"19","key":"10.1016\/j.bone.2025.117622_bb0175","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.3390\/foods13193115","article-title":"Evaluation of functional components of Lactobacillus plantarum AR495 on ovariectomy-induced osteoporosis in mice and RAW264. 7 cells","volume":"13","author":"Chen","year":"2024","journal-title":"Foods"},{"issue":"1","key":"10.1016\/j.bone.2025.117622_bb0180","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2190304","article-title":"Lactobacillus rhamnosus GG ameliorates osteoporosis in ovariectomized rats by regulating the Th17\/Treg balance and gut microbiota structure","volume":"15","author":"Guo","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.bone.2025.117622_bb0185","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1041647","article-title":"Effect of Lactobacillus casei fermented milk on fracture healing in osteoporotic mice","volume":"13","author":"Guo","year":"2022","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.bone.2025.117622_bb0190","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-02089-6","article-title":"Anti-osteoporotic potential of a probiotic mixture containing Limosilactobacillus reuteri and Weissella cibaria in ovariectomized rats","volume":"15","author":"Hossain","year":"2025","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bone.2025.117622_bb0195","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/fsn3.3747","article-title":"The supplementation of Rothia as a potential preventive approach for bone loss in mice with ovariectomy-induced osteoporosis","volume":"12","author":"Li","year":"2024","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.bone.2025.117622_bb0200","doi-asserted-by":"crossref","first-page":"11593","DOI":"10.2147\/IJN.S473270","article-title":"Lactiplantibacillus plantarum P101 ameliorates TiO2 NP-induced bone injury in young rats by remodeling the gut microbiota and inhibiting the production of pro-inflammatory cytokines","author":"Xie","year":"2024","journal-title":"Int. J. Nanomedicine"},{"issue":"3","key":"10.1016\/j.bone.2025.117622_bb0205","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3390\/biology11030359","article-title":"Anti-osteoporotic effect of lactobacillus brevis AR281 in an ovariectomized mouse model mediated by inhibition of osteoclast differentiation","volume":"11","author":"Yu","year":"2022","journal-title":"Biology"},{"key":"10.1016\/j.bone.2025.117622_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115710","article-title":"Bacteroides vulgatus diminishes colonic microbiota dysbiosis ameliorating lumbar bone loss in ovariectomized mice","volume":"142","author":"Yuan","year":"2021","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.bone.2025.117622_bb0215","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1002\/fft2.359","article-title":"Lactobacillus plantarum AR495 improves bone health of ovariectomized mice by improving gut microbiota","volume":"5","author":"Zhang","year":"2024","journal-title":"Food Front."},{"issue":"4","key":"10.1016\/j.bone.2025.117622_bb0220","doi-asserted-by":"crossref","first-page":"950","DOI":"10.3390\/microorganisms11040950","article-title":"The preventive effects of probiotic prevotella histicola on the bone loss of mice with ovariectomy-mediated osteoporosis","volume":"11","author":"Zhang","year":"2023","journal-title":"Microorganisms"},{"issue":"10","key":"10.1016\/j.bone.2025.117622_bb0225","first-page":"5697","article-title":"The relationship between intestinal flora changes and osteoporosis in rats with inflammatory bowel disease and the improvement effect of probiotics","volume":"24","author":"Zhong","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"11","key":"10.1016\/j.bone.2025.117622_bb0230","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1002\/jcp.24636","article-title":"Probiotic L. reuteri treatment prevents bone loss in a menopausal ovariectomized mouse model","volume":"229","author":"Britton","year":"2014","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.bone.2025.117622_bb0235","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/lam.13525","article-title":"Cell-free culture supernatant of Lactobacillus curvatus Wikim38 inhibits RANKL-induced osteoclast differentiation and ameliorates bone loss in ovariectomized mice","volume":"73","author":"Jang","year":"2021","journal-title":"Lett. Appl. Microbiol."},{"issue":"4","key":"10.1016\/j.bone.2025.117622_bb0240","doi-asserted-by":"crossref","first-page":"673","DOI":"10.3390\/microorganisms9040673","article-title":"Probiotic Propionibacterium freudenreichii MJ2 enhances osteoblast differentiation and mineralization by increasing the OPG\/RANKL ratio","volume":"9","author":"Yeom","year":"2021","journal-title":"Microorganisms"},{"issue":"15","key":"10.1016\/j.bone.2025.117622_bb0245","doi-asserted-by":"crossref","first-page":"6929","DOI":"10.1039\/D3FO00681F","article-title":"The probiotic Lactiplantibacillus plantarum attenuates ovariectomy-induced osteoporosis through osteoimmunological signaling","volume":"14","author":"Tsai","year":"2023","journal-title":"Food Funct."},{"issue":"7","key":"10.1016\/j.bone.2025.117622_bb0250","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.3390\/nu12071914","article-title":"Lactobacillus plantarum GKM3 and Lactobacillus paracasei GKS6 supplementation ameliorates bone loss in ovariectomized mice by promoting osteoblast differentiation and inhibiting osteoclast formation","volume":"12","author":"Yang","year":"2020","journal-title":"Nutrients"},{"issue":"7","key":"10.1016\/j.bone.2025.117622_bb0255","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/07315724.2017.1318724","article-title":"Effects of a multispecies probiotic supplement on bone health in osteopenic postmenopausal women: a randomized, double-blind, controlled trial","volume":"36","author":"Jafarnejad","year":"2017","journal-title":"J. Am. Coll. Nutr."},{"issue":"3","key":"10.1016\/j.bone.2025.117622_bb0260","doi-asserted-by":"crossref","first-page":"909","DOI":"10.3945\/ajcn.117.153353","article-title":"Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial","volume":"106","author":"Lambert","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bone.2025.117622_bb0265","doi-asserted-by":"crossref","DOI":"10.29219\/fnr.v67.9064","article-title":"Lactobacillus plantarum LP45 inhibits the RANKL\/OPG signaling pathway and prevents glucocorticoid-induced osteoporosis","volume":"67","author":"Jiang","year":"2023","journal-title":"Food Nutr. Res."},{"key":"10.1016\/j.bone.2025.117622_bb0270","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1146\/annurev-cellbio-101512-122347","article-title":"Mitogen-activated protein kinase pathways in osteoblasts","volume":"29","author":"Greenblatt","year":"2013","journal-title":"Annu. Rev. Cell Dev. Biol."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328225002340?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328225002340?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T08:01:11Z","timestamp":1780300871000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328225002340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":54,"alternative-id":["S8756328225002340"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2025.117622","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of probiotics in modulating RANKL in osteoporosis: A systematic review of animal interventional studies and RCTs","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2025.117622","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117622"}}