{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T00:11:12Z","timestamp":1794442272117,"version":"4.9.1"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HF20C0020"],"award-info":[{"award-number":["HF20C0020"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.bone.2025.117644","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T16:01:38Z","timestamp":1757779298000},"page":"117644","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Clinical evidence linking osteoporosis and the gut microbiome in postmenopausal females: A systematic review"],"prefix":"10.1016","volume":"201","author":[{"given":"Kyungjae","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hojun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bone.2025.117644_bb0005","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s44324-024-00010-9","article-title":"Bone metabolism \u2013 an underappreciated player","volume":"2","author":"Choi","year":"2024","journal-title":"npj Metab. Health Dis."},{"key":"10.1016\/j.bone.2025.117644_bb0010","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.821429","article-title":"New advances in improving bone health based on specific gut microbiota","volume":"12","author":"Yan","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1","key":"10.1016\/j.bone.2025.117644_bb0015","article-title":"The global prevalence of osteoporosis in the world: a comprehensive systematic review and meta-analysis","volume":"16","author":"Salari","year":"2021","journal-title":"J. Orthop. Surg. Res."},{"issue":"1","key":"10.1016\/j.bone.2025.117644_bb0020","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1186\/s13018-021-02821-8","article-title":"Global prevalence of osteoporosis among the world older adults: a comprehensive systematic review and meta-analysis","volume":"16","author":"Salari","year":"2021","journal-title":"J. Orthop. Surg. Res."},{"issue":"4","key":"10.1016\/j.bone.2025.117644_bb0025","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s40520-021-01817-y","article-title":"Pathophysiology and treatment of osteoporosis: challenges for clinical practice in older people","volume":"33","author":"Barnsley","year":"2021","journal-title":"Aging Clin. Exp. Res."},{"issue":"2","key":"10.1016\/j.bone.2025.117644_bb0030","first-page":"92","article-title":"Osteoporosis: a review of treatment options","volume":"43","author":"Tu","year":"2018","journal-title":"P T"},{"issue":"3","key":"10.1016\/j.bone.2025.117644_bb0035","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1517\/14740338.2016.1136287","article-title":"Safety issues and adverse reactions with osteoporosis management","volume":"15","author":"Rossini","year":"2016","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1016\/j.bone.2025.117644_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108168","article-title":"Advances in pathogenesis and therapeutic strategies for osteoporosis","volume":"237","author":"Song","year":"2022","journal-title":"Pharmacol. Ther."},{"issue":"8","key":"10.1016\/j.bone.2025.117644_bb0045","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1055\/s-0032-1328883","article-title":"The adverse effects of estrogen and selective estrogen receptor modulators on hemostasis and thrombosis","volume":"38","author":"Artero","year":"2012","journal-title":"Semin. Thromb. Hemost."},{"issue":"9","key":"10.1016\/j.bone.2025.117644_bb0050","doi-asserted-by":"crossref","DOI":"10.1002\/jbm4.10665","article-title":"Teriparatide and osteosarcoma risk: history, science, elimination of boxed warning, and other label updates","volume":"6","author":"Krege","year":"2022","journal-title":"JBMR Plus"},{"issue":"1","key":"10.1016\/j.bone.2025.117644_bb0055","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10010152","article-title":"Denosumab discontinuation and the rebound phenomenon: a narrative review","volume":"10","author":"Anastasilakis","year":"2021","journal-title":"J. Clin. Med."},{"issue":"1","key":"10.1016\/j.bone.2025.117644_bb0060","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00198-011-1676-0","article-title":"Calcitonin for treating acute and chronic pain of recent and remote osteoporotic vertebral compression fractures: a systematic review and meta-analysis","volume":"23","author":"Knopp-Sihota","year":"2012","journal-title":"Osteoporos. Int."},{"issue":"12","key":"10.1016\/j.bone.2025.117644_bb0065","article-title":"Cardiac arrhythmia and heart failure shortly after starting romosozumab for osteoporosis: a case-based review","volume":"15","author":"Alnaqbi","year":"2023","journal-title":"Cureus"},{"issue":"3","key":"10.1016\/j.bone.2025.117644_bb0070","doi-asserted-by":"crossref","first-page":"207","DOI":"10.14797\/mdcj-15-3-207","article-title":"Vitamin D and calcium supplements: helpful, harmful, or neutral for cardiovascular risk?","volume":"15","author":"Heravi","year":"2019","journal-title":"Methodist Debakey Cardiovasc. J."},{"issue":"5","key":"10.1016\/j.bone.2025.117644_bb0075","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s13238-020-00814-7","article-title":"The role of the gut microbiome and its metabolites in metabolic diseases","volume":"12","author":"Wu","year":"2021","journal-title":"Protein Cell"},{"issue":"20","key":"10.1016\/j.bone.2025.117644_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph192013076","article-title":"Gut microbiome: the interplay of an \u201cinvisible organ\u201d with herbal medicine and its derived compounds in chronic metabolic disorders","volume":"19","author":"Lim","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.bone.2025.117644_bb0085","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.maturitas.2017.06.025","article-title":"Estrogen–gut microbiome axis: physiological and clinical implications","volume":"103","author":"Baker","year":"2017","journal-title":"Maturitas"},{"issue":"1","key":"10.1016\/j.bone.2025.117644_bb0090","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/s41598-019-57106-2","article-title":"Intestinal barrier function is maintained with aging \u2013 a comprehensive study in healthy subjects and irritable bowel syndrome patients","volume":"10","author":"Wilms","year":"2020","journal-title":"Sci. Rep."},{"issue":"42","key":"10.1016\/j.bone.2025.117644_bb0095","doi-asserted-by":"crossref","first-page":"4750","DOI":"10.3748\/wjg.v24.i42.4750","article-title":"Gut microbiota in common elderly diseases affecting activities of daily living","volume":"24","author":"Shimizu","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bone.2025.117644_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115317","article-title":"The role of gut microbiota in bone homeostasis","volume":"135","author":"Behera","year":"2020","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.bone.2025.117644_bb0105","doi-asserted-by":"crossref","first-page":"e154","DOI":"10.1016\/S2665-9913(19)30068-2","article-title":"Probiotic treatment using a mix of three Lactobacillus strains for lumbar spine bone loss in postmenopausal women: a randomised, double-blind, placebo-controlled, multicentre trial","volume":"1","author":"Jansson","year":"2019","journal-title":"Lancet Rheumatol."},{"issue":"7","key":"10.1016\/j.bone.2025.117644_bb0110","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/07315724.2017.1318724","article-title":"Effects of a multispecies probiotic supplement on bone health in osteopenic postmenopausal women: a randomized, double-blind, controlled trial","volume":"36","author":"Jafarnejad","year":"2017","journal-title":"J. Am. Coll. Nutr."},{"issue":"3","key":"10.1016\/j.bone.2025.117644_bb0115","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/joim.12805","article-title":"Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: a randomized, placebo-controlled, double-blind, clinical trial","volume":"284","author":"Nilsson","year":"2018","journal-title":"J. Intern. Med."},{"issue":"3","key":"10.1016\/j.bone.2025.117644_bb0120","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2020-041393","article-title":"Probiotic supplements and bone health in postmenopausal women: a meta-analysis of randomised controlled trials","volume":"11","author":"Yu","year":"2021","journal-title":"BMJ Open"},{"key":"10.1016\/j.bone.2025.117644_bb0125","article-title":"Effects of probiotic supplementation on bone health in postmenopausal women: a systematic review and meta-analysis","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.bone.2025.117644_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106930","article-title":"Estrogen deficiency induces bone loss through the gut microbiota","volume":"196","author":"Guan","year":"2023","journal-title":"Pharmacol. Res."},{"issue":"7","key":"10.1016\/j.bone.2025.117644_bb0135","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23071517","article-title":"Commensal microbiota enhance both osteoclast and osteoblast activities","volume":"23","author":"Uchida","year":"2018","journal-title":"Molecules"},{"issue":"7413","key":"10.1016\/j.bone.2025.117644_bb0140","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nature11400","article-title":"Antibiotics in early life alter the murine colonic microbiome and adiposity","volume":"488","author":"Cho","year":"2012","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.bone.2025.117644_bb0145","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1002\/jbmr.1588","article-title":"The gut microbiota regulates bone mass in mice","volume":"27","author":"Sj\u00f6gren","year":"2012","journal-title":"J. Bone Miner. Res."},{"issue":"7","key":"10.1016\/j.bone.2025.117644_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med."},{"issue":"1","key":"10.1016\/j.bone.2025.117644_bb0155","doi-asserted-by":"crossref","first-page":"14.10.1","DOI":"10.1002\/cpbi.11","article-title":"Using MetaboAnalyst 3.0 for comprehensive metabolomics data analysis","volume":"55","author":"Xia","year":"2016","journal-title":"Curr. Protoc. Bioinformatics"},{"issue":"8","key":"10.1016\/j.bone.2025.117644_bb0160","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12081639","article-title":"Revisiting fold-change calculation: preference for median or geometric mean over arithmetic mean-based methods","volume":"12","author":"L\u00f6tsch","year":"2024","journal-title":"Biomedicines"},{"issue":"4","key":"10.1016\/j.bone.2025.117644_bb0165","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1093\/ajcn\/nqab194","article-title":"An emerging role of Prevotella histicola on estrogen deficiency-induced bone loss through the gut microbiota-bone axis in postmenopausal women and in ovariectomized mice","volume":"114","author":"Wang","year":"2021","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bone.2025.117644_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115951","article-title":"Glycolithocholic acid increases the frequency of circulating Tregs through constitutive androstane receptor to alleviate postmenopausal osteoporosis","volume":"219","author":"Cai","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bone.2025.117644_bb0175","article-title":"Gut microbiome signature are correlated with bone mineral density alterations in the Chinese elders","volume":"12","author":"Wang","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"9","key":"10.1016\/j.bone.2025.117644_bb0180","doi-asserted-by":"crossref","first-page":"8583","DOI":"10.18632\/aging.103168","article-title":"Gut microbiota and metabolite alterations associated with reduced bone mineral density or bone metabolic indexes in postmenopausal osteoporosis","volume":"12","author":"He","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.bone.2025.117644_bb0185","article-title":"Identifying microbial signatures for patients with postmenopausal osteoporosis using gut microbiota analyses and feature selection approaches","volume":"14","author":"Huang","year":"2023","journal-title":"Front. Microbiol."},{"issue":"2","key":"10.1016\/j.bone.2025.117644_bb0190","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms11020234","article-title":"Inferring bacterial community interactions and functionalities associated with osteopenia and osteoporosis in Taiwanese postmenopausal women","volume":"11","author":"Kuo","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.bone.2025.117644_bb0195","doi-asserted-by":"crossref","DOI":"10.46471\/gigabyte.12","article-title":"Linking gut microbiome to bone mineral density: a shotgun metagenomic dataset from 361 elderly women","volume":"2021","author":"Wang","year":"2021","journal-title":"GigaByte"},{"issue":"3","key":"10.1016\/j.bone.2025.117644_bb0200","doi-asserted-by":"crossref","DOI":"10.1002\/jbm4.10452","article-title":"The gut microbiome is altered in postmenopausal women with osteoporosis and osteopenia","volume":"5","author":"Rettedal","year":"2021","journal-title":"JBMR Plus"},{"issue":"1","key":"10.1016\/j.bone.2025.117644_bb0205","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/s12866-023-02927-5","article-title":"The potential of Klebsiella and Escherichia-Shigella and amino acids metabolism to monitor patients with postmenopausal osteoporosis in northwest China","volume":"23","author":"Liang","year":"2023","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.bone.2025.117644_bb0210","article-title":"Changes in the composition of gut and vaginal microbiota in patients with postmenopausal osteoporosis","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bone.2025.117644_bb0215","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.17416","article-title":"Gut microbiota alterations in postmenopausal women with osteoporosis and osteopenia from Shanghai, China","volume":"12","author":"Ji","year":"2024","journal-title":"PeerJ"},{"issue":"1","key":"10.1016\/j.bone.2025.117644_bb0220","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1186\/s12891-024-07904-1","article-title":"Osteoporosis in postmenopausal women is associated with disturbances in gut microbiota and migration of peripheral immune cells","volume":"25","author":"Ma","year":"2024","journal-title":"BMC Musculoskelet. Disord."},{"issue":"1","key":"10.1016\/j.bone.2025.117644_bb0225","doi-asserted-by":"crossref","DOI":"10.1080\/09513590.2025.2465587","article-title":"Clinical correlation between intestinal flora profiles and the incidence of postmenopausal osteoporosis","volume":"41","author":"Zhu","year":"2025","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.bone.2025.117644_bb0230","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2025.1627519","article-title":"Gut microbiota changes in postmenopausal women with low bone density linked to serum amino acid metabolism","volume":"15","author":"Becerra-Cervera","year":"2025","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1","key":"10.1016\/j.bone.2025.117644_bb0235","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1186\/s40001-025-02795-x","article-title":"Mapping gut microbiota and metabolite alterations in patients with postmenopausal osteoporosis in the Beijing Community of China","volume":"30","author":"Wang","year":"2025","journal-title":"Eur. J. Med. Res."},{"issue":"4","key":"10.1016\/j.bone.2025.117644_bb0240","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s00223-024-01260-x","article-title":"The characteristics of gut microbiota and its relation with diet in postmenopausal osteoporosis","volume":"115","author":"Chen","year":"2024","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2025.117644_bb0245","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.796025","article-title":"The power of microbiome studies: some considerations on which alpha and beta metrics to use and how to report results","volume":"12","author":"Kers","year":"2022","journal-title":"Front. Microbiol."},{"issue":"417","key":"10.1016\/j.bone.2025.117644_bb0250","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1080\/01621459.1992.10475194","article-title":"Estimating the number of classes via sample coverage","volume":"87","author":"Chao","year":"1992","journal-title":"J. Am. Stat. Assoc."},{"issue":"5","key":"10.1016\/j.bone.2025.117644_bb0255","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1128\/AEM.01996-06","article-title":"Quantitative and qualitative beta diversity measures lead to different insights into factors that structure microbial communities","volume":"73","author":"Lozupone","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"issue":"6","key":"10.1016\/j.bone.2025.117644_bb0260","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/2041-210X.12029","article-title":"Separating the two components of abundance-based dissimilarity: balanced changes in abundance vs. abundance gradients","volume":"4","author":"Baselga","year":"2013","journal-title":"Methods Ecol. Evol."},{"issue":"5","key":"10.1016\/j.bone.2025.117644_bb0270","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1163\/18762891-20230038","article-title":"Quantitative assessment of urinary equol levels, equol-producing bacteria, and the faecal microbiota in healthy Japanese individuals","volume":"14","author":"Kodera","year":"2023","journal-title":"Benefic. Microbes"},{"key":"10.1016\/j.bone.2025.117644_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154509","article-title":"Equol exerts a protective effect on postmenopausal osteoporosis by upregulating OPG\/RANKL pathway","volume":"108","author":"Ni","year":"2023","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.bone.2025.117644_bb0280","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.toxlet.2005.02.011","article-title":"Estrogenic and genotoxic potential of equol and two hydroxylated metabolites of Daidzein in cultured human Ishikawa cells","volume":"158","author":"Lehmann","year":"2005","journal-title":"Toxicol. Lett."},{"issue":"15","key":"10.1016\/j.bone.2025.117644_bb0285","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241512063","article-title":"Equol and resveratrol improve bone turnover biomarkers in postmenopausal women: a clinical trial","volume":"24","author":"Corbi","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bone.2025.117644_bb0290","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1129904","article-title":"Bifidobacterium-derived short-chain fatty acids and indole compounds attenuate nonalcoholic fatty liver disease by modulating gut-liver axis","volume":"14","author":"Yoon","year":"2023","journal-title":"Front. Microbiol."},{"issue":"1","key":"10.1016\/j.bone.2025.117644_bb0295","doi-asserted-by":"crossref","first-page":"5160","DOI":"10.1038\/s41467-023-40874-x","article-title":"Gut microbiota and fecal short chain fatty acids differ with adiposity and country of origin: the METS-microbiome study","volume":"14","author":"Ecklu-Mensah","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bone.2025.117644_bb0300","article-title":"Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bone.2025.117644_bb0305","doi-asserted-by":"crossref","first-page":"6436","DOI":"10.1038\/s41598-020-63475-w","article-title":"Gut metagenomic and short chain fatty acids signature in hypertension: a cross-sectional study","volume":"10","author":"Calder\u00f3n-P\u00e9rez","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bone.2025.117644_bb0310","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41467-017-02490-4","article-title":"Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss","volume":"9","author":"Lucas","year":"2018","journal-title":"Nat. Commun."},{"issue":"44","key":"10.1016\/j.bone.2025.117644_bb0315","doi-asserted-by":"crossref","first-page":"24400","DOI":"10.1021\/acs.jafc.4c04456","article-title":"Butyrate inhibits the HDAC8\/NF-\u03baB pathway to enhance Slc26a3 expression and improve the intestinal epithelial barrier to relieve colitis","volume":"72","author":"Peng","year":"2024","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.bone.2025.117644_bb0320","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2430424","article-title":"Butyrate reduces epithelial barrier dysfunction induced by the foodborne mycotoxin deoxynivalenol in cell monolayers derived from pig jejunum organoids","volume":"16","author":"Alberge","year":"2024","journal-title":"Gut Microbes"},{"issue":"7480","key":"10.1016\/j.bone.2025.117644_bb0325","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature12721","article-title":"Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells","volume":"504","author":"Furusawa","year":"2013","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.bone.2025.117644_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2018.10.013","article-title":"The microbial metabolite butyrate stimulates bone formation via T regulatory cell-mediated regulation of WNT10B expression","volume":"49","author":"Tyagi","year":"2018","journal-title":"Immunity"},{"issue":"47","key":"10.1016\/j.bone.2025.117644_bb0335","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000040554","article-title":"Gut microbiota and short-chain fatty acids signatures in postmenopausal osteoporosis patients: a retrospective study","volume":"103","author":"Li","year":"2024","journal-title":"Medicine (Baltimore)"},{"issue":"5","key":"10.1016\/j.bone.2025.117644_bb0340","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s00198-019-04855-5","article-title":"Gut microbiota composition and bone mineral loss-epidemiologic evidence from individuals in Wuhan, China","volume":"30","author":"Li","year":"2019","journal-title":"Osteoporos. Int."},{"issue":"2","key":"10.1016\/j.bone.2025.117644_bb0345","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/19490976.2016.1270809","article-title":"Linking dietary patterns with gut microbial composition and function","volume":"8","author":"Sheflin","year":"2017","journal-title":"Gut Microbes"},{"issue":"2","key":"10.1016\/j.bone.2025.117644_bb0350","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/ismej.2012.104","article-title":"Gut microbiome composition is linked to whole grain-induced immunological improvements","volume":"7","author":"Mart\u00ednez","year":"2013","journal-title":"ISME J."},{"issue":"5","key":"10.1016\/j.bone.2025.117644_bb0355","doi-asserted-by":"crossref","DOI":"10.3390\/nu13051655","article-title":"Dietary fibre modulates the gut microbiota","volume":"13","author":"Cronin","year":"2021","journal-title":"Nutrients"},{"issue":"17","key":"10.1016\/j.bone.2025.117644_bb0360","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25179366","article-title":"A comprehensive review of the triangular relationship among diet-gut microbiota-inflammation","volume":"25","author":"Randeni","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.bone.2025.117644_bb0365","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms10122507","article-title":"Dietary fiber intake and gut microbiota in human health","volume":"10","author":"Fu","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.bone.2025.117644_bb0370","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4137\/IJTR.S2129","article-title":"L-tryptophan: basic metabolic functions, behavioral research and therapeutic indications","volume":"2","author":"Richard","year":"2009","journal-title":"Int. J. Tryptophan Res."},{"issue":"10","key":"10.1016\/j.bone.2025.117644_bb0375","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100702R","article-title":"Tryptophan-derived serotonin-kynurenine balance in immune activation and intestinal inflammation","volume":"35","author":"Haq","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.bone.2025.117644_bb0380","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2018.00013","article-title":"Impact of the gut microbiota on intestinal immunity mediated by tryptophan metabolism","volume":"8","author":"Gao","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1","key":"10.1016\/j.bone.2025.117644_bb0385","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41413-023-00264-x","article-title":"Modulation of bone remodeling by the gut microbiota: a new therapy for osteoporosis","volume":"11","author":"Lyu","year":"2023","journal-title":"Bone Res."},{"issue":"6","key":"10.1016\/j.bone.2025.117644_bb0390","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/nm.4102","article-title":"CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands","volume":"22","author":"Lamas","year":"2016","journal-title":"Nat. Med."},{"issue":"36","key":"10.1016\/j.bone.2025.117644_bb0395","article-title":"Microbial tryptophan metabolites ameliorate ovariectomy-induced bone loss by repairing intestinal AhR-mediated gut-bone signaling pathway","volume":"11","author":"Chen","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.bone.2025.117644_bb0400","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jot.2022.08.003","article-title":"Fecal microbiota transplantation ameliorates bone loss in mice with ovariectomy-induced osteoporosis via modulating gut microbiota and metabolic function","volume":"37","author":"Zhang","year":"2022","journal-title":"J. Orthop. Translat."},{"issue":"4","key":"10.1016\/j.bone.2025.117644_bb0405","doi-asserted-by":"crossref","DOI":"10.1172\/JCI143137","article-title":"Ovariectomy induces bone loss via microbial-dependent trafficking of intestinal TNF+ T cells and Th17 cells","volume":"131","author":"Yu","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"12","key":"10.1016\/j.bone.2025.117644_bb0410","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1084\/jem.20061775","article-title":"Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction","volume":"203","author":"Sato","year":"2006","journal-title":"J. Exp. Med."},{"issue":"9","key":"10.1016\/j.bone.2025.117644_bb0415","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1002\/jbmr.2228","article-title":"Enhanced immunoprotective effects by anti-IL-17 antibody translates to improved skeletal parameters under estrogen deficiency compared with anti-RANKL and anti-TNF-\u03b1 antibodies","volume":"29","author":"Tyagi","year":"2014","journal-title":"J. Bone Miner. Res."},{"issue":"5","key":"10.1016\/j.bone.2025.117644_bb0420","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1359\/jbmr.070207","article-title":"Effect of blockade of TNF-alpha and interleukin-1 action on bone resorption in early postmenopausal women","volume":"22","author":"Charatcharoenwitthaya","year":"2007","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.bone.2025.117644_bb0425","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms12040764","article-title":"Age-dependent differences in postprandial bile-acid metabolism and the role of the gut microbiome","volume":"12","author":"Majait","year":"2024","journal-title":"Microorganisms"},{"key":"10.1016\/j.bone.2025.117644_bb0430","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116313","article-title":"Bile acid metabolism in health and ageing-related diseases","volume":"225","author":"Li","year":"2024","journal-title":"Biochem. Pharmacol."},{"issue":"4","key":"10.1016\/j.bone.2025.117644_bb0435","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41579-022-00805-x","article-title":"Bile acids and the gut microbiota: metabolic interactions and impacts on disease","volume":"21","author":"Collins","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"issue":"1","key":"10.1016\/j.bone.2025.117644_bb0440","doi-asserted-by":"crossref","first-page":"10432","DOI":"10.1038\/s41598-022-13640-0","article-title":"Profiling gut microbiota and bile acid metabolism in critically ill children","volume":"12","author":"Kean","year":"2022","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.bone.2025.117644_bb0445","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/jbmr.3652","article-title":"Dual targeting of bile acid receptor-1 (TGR5) and farnesoid X receptor (FXR) prevents estrogen-dependent bone loss in mice","volume":"34","author":"Li","year":"2019","journal-title":"J. Bone Miner. Res."},{"issue":"6","key":"10.1016\/j.bone.2025.117644_bb0450","doi-asserted-by":"crossref","first-page":"G550","DOI":"10.1152\/ajpgi.00256.2016","article-title":"Ursodeoxycholic acid and lithocholic acid exert anti-inflammatory actions in the colon","volume":"312","author":"Ward","year":"2017","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"10","key":"10.1016\/j.bone.2025.117644_bb0460","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025637","article-title":"The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis","volume":"6","author":"Cipriani","year":"2011","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.bone.2025.117644_bb0465","doi-asserted-by":"crossref","first-page":"4193","DOI":"10.1039\/D4FO00404C","article-title":"Folic acid supplementation prevents high body fat-induced bone loss through TGR5 signaling pathways","volume":"15","author":"Zhang","year":"2024","journal-title":"Food Funct."},{"issue":"5","key":"10.1016\/j.bone.2025.117644_bb0470","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1016\/j.apsb.2021.12.011","article-title":"Bile acid coordinates microbiota homeostasis and systemic immunometabolism in cardiometabolic diseases","volume":"12","author":"Guan","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.bone.2025.117644_bb0475","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1038\/s41467-021-21744-w","article-title":"Hyocholic acid species as novel biomarkers for metabolic disorders","volume":"12","author":"Zheng","year":"2021","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.bone.2025.117644_bb0480","doi-asserted-by":"crossref","DOI":"10.1177\/0300060521999555","article-title":"Association of dyslipidaemia with osteoporosis in postmenopausal women","volume":"49","author":"Zhang","year":"2021","journal-title":"J. Int. Med. Res."},{"issue":"3","key":"10.1016\/j.bone.2025.117644_bb0485","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1210\/jc.2013-3338","article-title":"Association between insulin resistance and bone mass in men","volume":"99","author":"Shin","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2025.117644_bb0490","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.725341","article-title":"An integrated metabolomic study of osteoporosis: discovery and quantification of hyocholic acids as candidate markers","volume":"12","author":"Deng","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"9912","key":"10.1016\/j.bone.2025.117644_bb0495","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0140-6736(13)61647-5","article-title":"Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis","volume":"383","author":"Reid","year":"2014","journal-title":"Lancet (London, England)"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632822500256X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632822500256X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T08:02:02Z","timestamp":1780300922000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S875632822500256X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":97,"alternative-id":["S875632822500256X"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2025.117644","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical evidence linking osteoporosis and the gut microbiome in postmenopausal females: A systematic review","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2025.117644","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117644"}}