{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T07:36:55Z","timestamp":1775029015715,"version":"3.50.1"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004012","name":"Jane and Aatos Erkko Fundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004012","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["347445"],"award-info":[{"award-number":["347445"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["353755"],"award-info":[{"award-number":["353755"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.bone.2026.117814","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T08:18:31Z","timestamp":1770193111000},"page":"117814","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Activin-A has dual roles in osteoclast formation and foreign body giant cell differentiation from human CD14+ monocytes"],"prefix":"10.1016","volume":"206","author":[{"given":"Elina","family":"Kylm\u00e4oja","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sami","family":"Kauppinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faleh","family":"Abushahba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikko","family":"Finnil\u00e4","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikko","family":"Ritala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petri","family":"Lehenkari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha","family":"Tuukkanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teun J.","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ton","family":"Schoenmaker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2026.117814_bb0005","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.873226","article-title":"Multinucleated giant cells: current insights in phenotype, biological activities, and mechanism of formation","volume":"10","author":"Ahmadzadeh","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bone.2026.117814_bb0010","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1084\/jem.20050645","article-title":"DC-STAMP is essential for cell\u2013cell fusion in osteoclasts and foreign body giant cells","volume":"202","author":"Yagi","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bone.2026.117814_bb0015","article-title":"The foreign body giant cell cannot resorb bone, but dissolves hydroxyapatite like osteoclasts","volume":"10","author":"Harkel","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.bone.2026.117814_bb0020","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1002\/jcb.24518","article-title":"Foreign body giant cells and osteoclasts are TRAP positive, have podosome-belts and both require OC-STAMP for cell fusion","volume":"114","author":"Khan","year":"2013","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bone.2026.117814_bb0025","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.actbio.2016.09.029","article-title":"Giant cells around bone biomaterials: osteoclasts or multi-nucleated giant cells?","volume":"46","author":"Miron","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bone.2026.117814_bb0030","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.216267","article-title":"Common signalling pathways in macrophage and osteoclast multinucleation","volume":"131","author":"Pereira","year":"2018","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bone.2026.117814_bb0035","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202357070","article-title":"Multinucleation resets human macrophages for specialized functions at the expense of their identity","volume":"24","author":"Ahmadzadeh","year":"2023","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bone.2026.117814_bb0040","doi-asserted-by":"crossref","first-page":"1683872","DOI":"10.3389\/fimmu.2025.1683872","article-title":"Macrophages and osteoclasts: similarity and divergence between bone phagocytes","volume":"16","author":"Halper","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bone.2026.117814_bb0045","series-title":"Cellular and Molecular Mechanisms of Bone Remodeling * Cells Involved in Bone Remodeling","author":"Raggatt","year":"2010"},{"key":"10.1016\/j.bone.2026.117814_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41413-022-00219-8","article-title":"Bone remodeling: an operational process ensuring survival and bone mechanical competence","volume":"10","author":"Bolamperti","year":"2022","journal-title":"Bone Res."},{"key":"10.1016\/j.bone.2026.117814_bb0055","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.3390\/ma8095269","article-title":"Macrophages, foreign body giant cells and their response to implantable biomaterials","volume":"8","author":"Sheikh","year":"2015","journal-title":"Materials"},{"key":"10.1016\/j.bone.2026.117814_bb0060","doi-asserted-by":"crossref","first-page":"7441","DOI":"10.1016\/j.biomaterials.2014.05.048","article-title":"Osteoclast resorption of beta-tricalcium phosphate controlled by surface architecture","volume":"35","author":"Davison","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.bone.2026.117814_bb0065","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/ar.20748","article-title":"Detailed process of bone remodeling after achievement of osseointegration in a rat implantation model","volume":"292","author":"Haga","year":"2009","journal-title":"Anat. Rec."},{"key":"10.1016\/j.bone.2026.117814_bb0070","series-title":"Basis of Bone Metabolism Around Dental Implants During Osseointegration and Peri-implant Bone Loss","author":"Insua","year":"2017"},{"key":"10.1016\/j.bone.2026.117814_bb0075","first-page":"61","article-title":"Biology of implant osseointegration","volume":"9","author":"Mavrogenis","year":"2009","journal-title":"J. Musculoskelet. Neuronal Interact."},{"key":"10.1016\/j.bone.2026.117814_bb0080","series-title":"Foreign Body Reaction to Biomaterials: On Mechanisms for Buildup and Breakdown of Osseointegration","author":"Trindade","year":"2014"},{"key":"10.1016\/j.bone.2026.117814_bb0085","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1021\/acsbiomaterials.8b00252","article-title":"The foreign body response demystified","volume":"5","author":"Chandorkar","year":"2019","journal-title":"ACS Biomater Sci. Eng."},{"key":"10.1016\/j.bone.2026.117814_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/polym15051313","article-title":"Mechanisms of foreign body giant cell formation in response to implantable biomaterials","volume":"15","author":"Eslami-Kaliji","year":"2023","journal-title":"Polymers"},{"key":"10.1016\/j.bone.2026.117814_bb0095","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1002\/jbm.a.37599","article-title":"Friend or foe? Inflammation and the foreign body response to orthopedic biomaterials","volume":"112","author":"Gibon","year":"2024","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.bone.2026.117814_bb0100","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1152\/physrev.00002.2018","article-title":"Activin A in mammalian physiology","volume":"99","author":"Bloise","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bone.2026.117814_bb0105","first-page":"250","article-title":"Activin-A binding and biochemical effects in osteoblast-enriched cultures from fetal-rat parietal bone","volume":"11","author":"Centrella","year":"1991","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bone.2026.117814_bb0110","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1096\/fj.07-8080com","article-title":"The activin A-follistatin system: potent regulator of human extracellular matrix mineralization","volume":"21","author":"Eijken","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.bone.2026.117814_bb0115","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1210\/endo.143.1.8580","article-title":"Inhibin suppresses and activin stimulates osteoblastogenesis and osteoclastogenesis in murine bone marrow cultures","volume":"143","author":"Gaddy-Kurten","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2026.117814_bb0120","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1074\/mcp.M112.024927","article-title":"Activin A suppresses osteoblast mineralization capacity by altering extracellular matrix (ECM) composition and impairing matrix vesicle (MV) production","volume":"12","author":"Alves","year":"2013","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.bone.2026.117814_bb0125","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1006\/bbrc.2000.2075","article-title":"Activin A is an essential cofactor for osteoclast induction","volume":"268","author":"Fuller","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bone.2026.117814_bb0130","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1006\/bbrc.1993.2006","article-title":"Activin enhances osteoclast-like cell formation in vitro","volume":"195","author":"Sakai","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bone.2026.117814_bb0135","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/jcb.10613","article-title":"Activin A stimulates IkappaB-alpha\/NFkappaB and RANK expression for osteoclast differentiation, but not AKT survival pathway in osteoclast precursors","volume":"90","author":"Sugatani","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bone.2026.117814_bb0140","doi-asserted-by":"crossref","first-page":"6974","DOI":"10.1002\/jcb.26906","article-title":"Mechanisms involved in enhancement of osteoclast formation by activin-A","volume":"119","author":"Kajita","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bone.2026.117814_bb0145","doi-asserted-by":"crossref","first-page":"17818","DOI":"10.1074\/jbc.RA119.009521","article-title":"Activin A receptor type 1-mediated BMP signaling regulates RANKL-induced osteoclastogenesis via canonical SMAD-signaling pathway","volume":"294","author":"Omi","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2026.117814_bb0150","doi-asserted-by":"crossref","first-page":"14233","DOI":"10.1016\/S0021-9258(19)49702-0","article-title":"Bovine bone activin enhances bone morphogenetic protein-induced ectopic bone formation","volume":"267","author":"Ogawa","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2026.117814_bb0155","first-page":"683","article-title":"Activin A inhibits RANKL-mediated osteoclast formation, movement and function in murine bone marrow macrophage cultures","volume":"128","author":"Fowler","year":"2015","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bone.2026.117814_bb0160","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0898-6568(01)00221-2","article-title":"Role of TGF-\u03b2 family in osteoclastogenesis induced by RANKL","volume":"14","author":"Koseki","year":"2002","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bone.2026.117814_bb0165","doi-asserted-by":"crossref","first-page":"7082","DOI":"10.1073\/pnas.0711263105","article-title":"A soluble activin Type IIA receptor induces bone formation and improves skeletal integrity","volume":"105","author":"Pearsall","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bone.2026.117814_bb0170","doi-asserted-by":"crossref","first-page":"16239","DOI":"10.1073\/pnas.0705971104","article-title":"Activin A is a critical component of the inflammatory response, and its binding protein, follistatin, reduces mortality in endotoxemia","volume":"104","author":"Jones","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bone.2026.117814_bb0175","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1210\/endo.141.5.7531","article-title":"Activin A release into the circulation is an early event in systemic inflammation and precedes the release of follistatin","volume":"141","author":"Jones","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2026.117814_bb0180","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/sj.bjp.0702626","article-title":"Induction of prostanoid, nitric oxide, and cytokine formation in rat bone marrow derived macrophages by activin A","volume":"127","author":"N\u00fcsing","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bone.2026.117814_bb0185","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1432-1033.1995.tb20368.x","article-title":"Activin A and retinoic acid synergize in cyclooxygenase-1 and thromboxane synthase induction during differentiation of J774.1 macrophages","volume":"227","author":"N\u00fcsing","year":"1995","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bone.2026.117814_bb0190","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1189\/jlb.72.2.347","article-title":"Potent induction of activin A secretion from monocytes and bone marrow stromal fibroblasts by cognate interaction with activated T cells","volume":"72","author":"Abe","year":"2002","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bone.2026.117814_bb0195","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.mce.2011.10.009","article-title":"The roles of activin A and its binding protein, follistatin, in inflammation and tissue repair","volume":"359","author":"de Kretser","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.bone.2026.117814_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2019.102314","article-title":"Activin-A in the regulation of immunity in health and disease","volume":"104","author":"Morianos","year":"2019","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.bone.2026.117814_bb0205","article-title":"Different immunoregulation roles of activin A compared with TGF-\u03b2","volume":"13","author":"Li","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bone.2026.117814_bb0210","series-title":"Activin A Skews Macrophage Polarization by Promoting a Proinflammatory Phenotype and Inhibiting the Acquisition of Anti-inflammatory Macrophage Markers","author":"Sierra-Filardi","year":"2011"},{"key":"10.1016\/j.bone.2026.117814_bb0215","doi-asserted-by":"crossref","first-page":"10238","DOI":"10.1002\/jcp.27693","article-title":"The effect of Activin-A on periodontal ligament fibroblasts-mediated osteoclast formation in healthy donors and in patients with fibrodysplasia ossificans progressiva","volume":"234","author":"Schoenmaker","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bone.2026.117814_bb0220","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.00501","article-title":"Activin-A induces fewer, but larger osteoclasts from monocytes in both healthy controls and Fibrodysplasia Ossificans Progressiva patients","volume":"11","author":"Schoenmaker","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.bone.2026.117814_bb0225","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24076822","article-title":"Transcriptomic differences underlying the activin-A induced large osteoclast formation in both healthy control and fibrodysplasia ossificans progressiva osteoclasts","volume":"24","author":"Schoenmaker","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bone.2026.117814_bb0230","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1177\/1120700018757940","article-title":"Projections of hip arthroplasty in OECD countries up to 2050","volume":"28","author":"Pabinger","year":"2018","journal-title":"Hip Int."},{"key":"10.1016\/j.bone.2026.117814_bb0235","doi-asserted-by":"crossref","DOI":"10.3390\/biom12050654","article-title":"Osteoblast attachment on titanium coated with hydroxyapatite by atomic layer deposition","volume":"12","author":"Kylm\u00e4oja","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.bone.2026.117814_bb0240","doi-asserted-by":"crossref","first-page":"887","DOI":"10.3390\/nano15120887","article-title":"Impact of atomic layer-deposited hydroxyapatite-coated titanium on expression of focal adhesion molecules of human gingival fibroblasts","volume":"15","author":"Areid","year":"2025","journal-title":"Nanomaterials"},{"key":"10.1016\/j.bone.2026.117814_bb0245","doi-asserted-by":"crossref","DOI":"10.1177\/08853282251313503","article-title":"Gingival keratinocyte adhesion on atomic layer-deposited hydroxyapatite coated titanium","volume":"39","author":"Abushahba","year":"2025","journal-title":"J. Biomater. Appl."},{"key":"10.1016\/j.bone.2026.117814_bb0250","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.actbio.2020.11.024","article-title":"Atomic layer deposition on dental materials: processing conditions and surface functionalization to improve physical, chemical, and clinical properties - a review","volume":"121","author":"Hashemi Astaneh","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bone.2026.117814_bb0255","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1080\/14686996.2019.1599694","article-title":"New development of atomic layer deposition: processes, methods and applications","volume":"20","author":"Oviroh","year":"2019","journal-title":"Sci. Technol. Adv. Mater."},{"key":"10.1016\/j.bone.2026.117814_bb0260","series-title":"Hydroxyapatite (Hap) for Biomedical Applications","first-page":"143","article-title":"Hydroxyapatite coatings for metallic implants","author":"Bose","year":"2015"},{"key":"10.1016\/j.bone.2026.117814_bb0265","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S1988-8856(08)70080-4","article-title":"Hydroxyapatite coatings in prosthetic joints","volume":"52","author":"Faig-Mart\u00ed","year":"2008","journal-title":"Revista Espa\u00f1ola de Cirug\u00eda Ortop\u00e9dica y Traumatolog\u00eda (English Edition)"},{"key":"10.1016\/j.bone.2026.117814_bb0270","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1002\/jbm.1056","article-title":"Material fundamentals and clinical performance of plasma-sprayed hydroxyapatite coatings: a review","volume":"58","author":"Sun","year":"2001","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.bone.2026.117814_bb0275","doi-asserted-by":"crossref","DOI":"10.1116\/1.4889975","article-title":"Preparation and bioactive properties of nanocrystalline hydroxyapatite thin films obtained by conversion of atomic layer deposited calcium carbonate","volume":"9","author":"Holopainen","year":"2014","journal-title":"Biointerphases"},{"key":"10.1016\/j.bone.2026.117814_bb0280","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.tsf.2003.10.152","article-title":"Growth of calcium carbonate by the atomic layer chemical vapour deposition technique","volume":"450","author":"Nilsen","year":"2004","journal-title":"Thin Solid Films"},{"key":"10.1016\/j.bone.2026.117814_bb0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bone.2026.117814_bb0290","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1109\/TSMC.1979.4310076","article-title":"Threshold selection method from gray-level histograms","volume":"SMC-9","author":"Otsu","year":"1979","journal-title":"IEEE Trans. Syst. Man Cybern."},{"key":"10.1016\/j.bone.2026.117814_bb0295","author":"D'Errico"},{"key":"10.1016\/j.bone.2026.117814_bb0300","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.3390\/molecules28083611","article-title":"Monocyte differentiation on atomic layer-deposited (ALD) hydroxyapatite coating on titanium substrate","volume":"28","author":"Kylm\u00e4oja","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.bone.2026.117814_bb0305","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1177\/0022034515616760","article-title":"Topography influences adherent cell regulation of osteoclastogenesis","volume":"95","author":"Nagasawa","year":"2016","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.bone.2026.117814_bb0310","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/jbm.a.30202","article-title":"Wear particles and surface topographies are modulators of osteoclastogenesis in vitro","volume":"72","author":"Sommer","year":"2005","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.bone.2026.117814_bb0315","doi-asserted-by":"crossref","first-page":"9917","DOI":"10.1074\/jbc.M706415200","article-title":"Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an interleukin-1-mediated autocrine mechanism","volume":"283","author":"Yao","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2026.117814_bb0320","doi-asserted-by":"crossref","first-page":"43","DOI":"10.11613\/BM.2013.007","article-title":"Osteoimmunology and the influence of pro-inflammatory cytokines on osteoclasts","volume":"23","author":"Zupan","year":"2013","journal-title":"Biochem. Med. (Zagreb.)"},{"key":"10.1016\/j.bone.2026.117814_bb0325","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.0105-2896.2005.00336.x","article-title":"Osteoclast precursors, RANKL\/RANK, and immunology","volume":"208","author":"Xing","year":"2005","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bone.2026.117814_bb0330","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01408","article-title":"Immune function and diversity of osteoclasts in normal and pathological conditions","volume":"10","author":"Madel","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bone.2026.117814_bb0335","doi-asserted-by":"crossref","first-page":"4877","DOI":"10.1016\/j.biomaterials.2004.01.003","article-title":"Regulation of osteoclast activity in peri-implant tissues","volume":"25","author":"Haynes","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.bone.2026.117814_bb0340","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1002\/jcp.25220","article-title":"Different blood-borne human osteoclast precursors respond in distinct ways to IL-17A","volume":"231","author":"Sprangers","year":"2016","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.bone.2026.117814_bb0345","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41413-022-00206-z","article-title":"Specific Inflammatory Osteoclast Precursors Induced During Chronic Inflammation Give Rise to Highly Active Osteoclasts Associated With Inflammatory Bone Loss","volume":"10","author":"Meirow","year":"2022","journal-title":"Bone Res."},{"key":"10.1016\/j.bone.2026.117814_bb0350","doi-asserted-by":"crossref","DOI":"10.1038\/s41413-022-00206-z","article-title":"Specific inflammatory osteoclast precursors induced during chronic inflammation give rise to highly active osteoclasts associated with inflammatory bone loss","volume":"10","author":"Meirow","year":"2022","journal-title":"Bone Res."},{"key":"10.1016\/j.bone.2026.117814_bb0355","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13758-012-0034-x","article-title":"Response of osteoclasts to titanium surfaces with increasing surface roughness: an in vitro study","volume":"7","author":"Brinkmann","year":"2012","journal-title":"Biointerphases"},{"key":"10.1016\/j.bone.2026.117814_bb0360","doi-asserted-by":"crossref","first-page":"739","DOI":"10.4012\/dmj.26.739","article-title":"Titanium surface roughness accelerates RANKL-dependent differentiation in the osteoclast precursor cell line, RAW264.7","volume":"26","author":"Makihira","year":"2007","journal-title":"Dent. Mater. J."},{"key":"10.1016\/j.bone.2026.117814_bb0365","doi-asserted-by":"crossref","first-page":"281","DOI":"10.22203\/eCM.v027a20","article-title":"Submicron-scale surface architecture of tricalcium phosphate directs osteogenesis in vitro and in vivo","volume":"27","author":"Davison","year":"2014","journal-title":"Eur. Cell. Mater."},{"key":"10.1016\/j.bone.2026.117814_bb0370","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1007\/s41779-022-00806-2","article-title":"A review on the behavioral responses of osteoclast and osteoblast cells on the near-surface of the bioceramic coating: roles of ions released, solubility, and pH","volume":"58","author":"Mohammed Mohammed","year":"2022","journal-title":"J. Aust. Ceram. Soc."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328226000402?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328226000402?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T05:21:23Z","timestamp":1775020883000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328226000402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":74,"alternative-id":["S8756328226000402"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2026.117814","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activin-A has dual roles in osteoclast formation and foreign body giant cell differentiation from human CD14+ monocytes","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2026.117814","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117814"}}