{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:35:38Z","timestamp":1791434138722,"version":"4.3.3"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bone.2026.117857","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T17:05:28Z","timestamp":1773162328000},"page":"117857","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Paget's disease of bone: Clinical and epidemiological characterisation of the population of a Portuguese tertiary centre"],"prefix":"10.1016","volume":"208","author":[{"given":"Ana Rita","family":"Lopes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Och\u00f4a Matos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Pereira da Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Travessa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"Tenazinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00edlvia","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Barros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Rita","family":"Cruz-Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Carlos","family":"Romeu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2026.117857_bb0005","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2023.1131182","article-title":"Paget\u2019s disease: a review of the epidemiology, etiology, genetics, and treatment","volume":"14","author":"Banaganapalli","year":"2023","journal-title":"Front. Genet."},{"issue":"3","key":"10.1016\/j.bone.2026.117857_bb0010","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1359\/jbmr.2002.17.3.465","article-title":"Incidence and natural history of Paget\u2019s disease of bone in England and Wales","volume":"17","author":"Van Staa","year":"2002","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2026.117857_bb0015","series-title":"Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism","first-page":"659","article-title":"Paget\u2019s disease of bone","author":"Siris","year":"2013"},{"issue":"4","key":"10.1016\/j.bone.2026.117857_bb0020","doi-asserted-by":"crossref","first-page":"390","DOI":"10.2174\/1573397117666210908102615","article-title":"Complications of Paget bone disease: a study of 69 patients","volume":"17","author":"Miladi","year":"2021","journal-title":"Curr. Rheumatol. Rev."},{"issue":"6","key":"10.1016\/j.bone.2026.117857_bb0025","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1007\/s40618-024-02318-1","article-title":"Diagnosis and treatment of Paget\u2019s disease of bone: position paper from the Italian Society of Osteoporosis, Mineral Metabolism and Skeletal Diseases (SIOMMMS)","volume":"47","author":"Rendina","year":"2024","journal-title":"J. Endocrinol. Investig."},{"issue":"7","key":"10.1016\/j.bone.2026.117857_bb0030","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1056\/NEJMcp1204713","article-title":"Paget\u2019s disease of bone","volume":"368","author":"Ralston","year":"2013","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.bone.2026.117857_bb0035","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s12018-016-9226-0","article-title":"Clinical and genetic advances in Paget\u2019s disease of bone: a review","volume":"15","author":"Alonso","year":"2017","journal-title":"Clin. Rev. Bone Miner. Metab."},{"issue":"5","key":"10.1016\/j.bone.2026.117857_bb0040","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/jbmr.5650060511","article-title":"Familial aggregation of Paget\u2019s disease of bone","volume":"6","author":"Siris","year":"1991","journal-title":"J. Bone Miner. Res."},{"issue":"Suppl. 2","key":"10.1016\/j.bone.2026.117857_bb0045","article-title":"Sequestosome 1: mutation frequencies, haplotypes, and phenotypes in familial Paget\u2019s disease of bone","volume":"22","author":"Morissette","year":"2007","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.bone.2026.117857_bb0050","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/jbmr.5650100421","article-title":"Frequency and characteristics of familial aggregation of Paget\u2019s disease of bone","volume":"10","author":"Morales-Piga","year":"1995","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2026.117857_bb0055","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.932065","article-title":"Update on the pathogenesis and genetics of Paget\u2019s disease of bone","volume":"10","author":"Gennari","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"8","key":"10.1016\/j.bone.2026.117857_bb0060","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1002\/jbmr.4090","article-title":"A new gene for susceptibility to Paget\u2019s disease of bone and for multisystem proteinopathy","volume":"35","author":"Ralston","year":"2020","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2026.117857_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2023.116721","article-title":"Decline in clinical severity of Paget\u2019s disease of bone: comparison between a contemporary cohort and a historical cohort","volume":"170","author":"Gendron","year":"2023","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.bone.2026.117857_bb0070","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.bone.2013.04.024","article-title":"Epidemiology of Paget\u2019s disease of bone: a systematic review and meta-analysis of secular changes","volume":"55","author":"Corral-Gudino","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.bone.2026.117857_bb0075","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.65715","article-title":"Epigenetic analysis of Paget\u2019s disease of bone identifies differentially methylated loci that predict disease status","volume":"10","author":"Diboun","year":"2021","journal-title":"Elife"},{"issue":"12","key":"10.1016\/j.bone.2026.117857_bb0080","first-page":"767","article-title":"Ultrastructural characteristics of osteoclasts in Paget\u2019s disease","volume":"41","author":"Rebel","year":"1974","journal-title":"Rev. Rhum. Mal. Osteoartic."},{"issue":"4","key":"10.1016\/j.bone.2026.117857_bb0085","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1359\/jbmr.070103","article-title":"Multicenter blinded analysis of RT-PCR detection methods for paramyxoviruses in relation to Paget\u2019s disease of bone","volume":"22","author":"Ralston","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2026.117857_bb0090","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/00003086-198403000-00044","article-title":"Evidence for both respiratory syncytial virus and measles virus antigens in the osteoclasts of patients with Paget\u2019s disease of bone","volume":"183","author":"Mills","year":"1984","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"8461","key":"10.1016\/j.bone.2026.117857_bb0095","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0140-6736(85)90852-9","article-title":"Past pets and Paget\u2019s disease","volume":"326","author":"O\u2019Driscoll","year":"1985","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.bone.2026.117857_bb0100","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1359\/JBMR.050322","article-title":"Characteristics and familial aggregation of Paget\u2019s disease of bone in Italy","volume":"20","author":"Merlotti","year":"2005","journal-title":"J. Bone Miner. Res."},{"issue":"3","key":"10.1016\/j.bone.2026.117857_bb0105","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/00001648-199705000-00004","article-title":"Cattle, pets, and Paget\u2019s disease of bone","volume":"8","author":"L\u00f3pez-Abente","year":"1997","journal-title":"Epidemiology"},{"issue":"3","key":"10.1016\/j.bone.2026.117857_bb0110","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S8756-3282(02)00833-5","article-title":"Paget\u2019s disease of bone in Lancashire and arsenic pesticide in cotton mill wastewater: a speculative hypothesis","volume":"31","author":"Lever","year":"2002","journal-title":"Bone"},{"issue":"4","key":"10.1016\/j.bone.2026.117857_bb0115","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.jbspin.2011.07.005","article-title":"Epidemiogenetic study of French families with Paget\u2019s disease of bone","volume":"79","author":"Michou","year":"2012","journal-title":"Joint Bone Spine"},{"issue":"4","key":"10.1016\/j.bone.2026.117857_bb0120","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/0049-0172(94)90037-X","article-title":"Epidemiological aspects of Paget\u2019s disease: family history and relationship to other medical conditions","volume":"23","author":"Siris","year":"1994","journal-title":"Semin. Arthritis Rheum."},{"issue":"4","key":"10.1016\/j.bone.2026.117857_bb0125","first-page":"226","article-title":"Distribution of Paget\u2019s disease in England, Wales and Scotland and a possible relationship with vitamin D deficiency in childhood","volume":"28","author":"Barker","year":"1974","journal-title":"Br. J. Prev. Soc. Med."},{"issue":"4","key":"10.1016\/j.bone.2026.117857_bb0130","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/jbmr.3657","article-title":"Diagnosis and management of Paget\u2019s disease of bone in adults: a clinical guideline","volume":"34","author":"Ralston","year":"2019","journal-title":"J. Bone Miner. Res."},{"issue":"Suppl. 2","key":"10.1016\/j.bone.2026.117857_bb0135","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1007\/BF02561369","article-title":"Clinical efficacy of salmon calcitonin in Paget\u2019s disease of bone","volume":"49","author":"Singer","year":"1991","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2026.117857_bb0140","article-title":"Paget\u2019s disease of bone: clinical and epidemiological characterization of 65 patients","volume":"20","author":"Reis","year":"1993","journal-title":"Rev. Esp. Reum."},{"key":"10.1016\/j.bone.2026.117857_bb0145","series-title":"Managing the Global Epidemic of Obesity. Report of the World Health Organization (WHO) Consultation on Obesity","author":"International Obesity Task Force","year":"1997"},{"key":"10.1016\/j.bone.2026.117857_bb0150","series-title":"International Standard Classification of Occupations, ISCO-08","author":"International Labour Organization","year":"2012"},{"issue":"3","key":"10.1016\/j.bone.2026.117857_bb0155","first-page":"271","article-title":"Cardiac output in osteitis deformans","volume":"12","author":"Howarth","year":"1953","journal-title":"Clin. Sci."},{"key":"10.1016\/j.bone.2026.117857_bb0160","series-title":"INE Portugal","author":"Instituto Nacional de Estat\u00edstica (INE)","year":"2025"},{"issue":"12","key":"10.1016\/j.bone.2026.117857_bb0165","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1359\/jbmr.060822","article-title":"Evidence for increased clinical severity of familial and sporadic Paget\u2019s disease of bone in Campania, southern Italy","volume":"21","author":"Rendina","year":"2006","journal-title":"J. Bone Miner. Res."},{"issue":"5","key":"10.1016\/j.bone.2026.117857_bb0170","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00223-014-9904-1","article-title":"Clinical presentation of Paget\u2019s disease: evaluation of a contemporary cohort and systematic review","volume":"95","author":"Tan","year":"2014","journal-title":"Calcif. Tissue Int."},{"issue":"3","key":"10.1016\/j.bone.2026.117857_bb0175","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.reuma.2008.11.005","article-title":"Characteristics of Paget\u2019s disease of bone in Spain: data from the Spanish Paget\u2019s Register","volume":"5","author":"Del Pino-Montes","year":"2009","journal-title":"Reumatol. Clin."},{"issue":"2","key":"10.1016\/j.bone.2026.117857_bb0180","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00198-012-1954-5","article-title":"Secular changes in Paget\u2019s disease: contrasting changes in the number of new referrals and in disease severity in two neighboring regions of Spain","volume":"24","author":"Corral-Gudino","year":"2013","journal-title":"Osteoporos. Int."},{"issue":"3","key":"10.1016\/j.bone.2026.117857_bb0185","doi-asserted-by":"crossref","first-page":"156","DOI":"10.5152\/eurjrheum.2020.20139","article-title":"Clinical and demographic aspects of Paget disease of bone: a multicentric study from Turkey","volume":"8","author":"Gogas Yavuz","year":"2021","journal-title":"Eur. J. Rheumatol."},{"issue":"3","key":"10.1016\/j.bone.2026.117857_bb0190","doi-asserted-by":"crossref","DOI":"10.1093\/jbmrpl\/ziae171","article-title":"Epidemiology of Paget\u2019s disease of bone in South Korea","volume":"9","author":"Park","year":"2024","journal-title":"JBMR Plus."},{"issue":"9","key":"10.1016\/j.bone.2026.117857_bb0195","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1056\/NEJMoa044241","article-title":"Comparison of a single infusion of zoledronic acid with risedronate for Paget\u2019s disease","volume":"353","author":"Reid","year":"2005","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.bone.2026.117857_bb0200","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1002\/jbmr.438","article-title":"A single infusion of zoledronic acid produces sustained remissions in Paget disease: data to 6.5 years","volume":"26","author":"Reid","year":"2011","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.bone.2026.117857_bb0205","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1007\/s12020-024-03791-7","article-title":"Long-term effectiveness of zoledronic acid in patients with Paget\u2019s disease of bone - a retrospective cohort study","volume":"85","author":"Ayalon-Dangur","year":"2024","journal-title":"Endocrine"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328226000839?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328226000839?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T20:28:57Z","timestamp":1784233737000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328226000839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":41,"alternative-id":["S8756328226000839"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2026.117857","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Paget's disease of bone: Clinical and epidemiological characterisation of the population of a Portuguese tertiary centre","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2026.117857","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117857"}}