{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:08:10Z","timestamp":1779250090402,"version":"3.51.4"},"reference-count":126,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Forschung, Technologie und Raumfahrt","doi-asserted-by":"publisher","award":["01ZX2210A"],"award-info":[{"award-number":["01ZX2210A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Forschung, Technologie und Raumfahrt","doi-asserted-by":"publisher","award":["01ZX1910B"],"award-info":[{"award-number":["01ZX1910B"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Forschung, Technologie und Raumfahrt","doi-asserted-by":"publisher","award":["01ZX1910A"],"award-info":[{"award-number":["01ZX1910A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Forschung, Technologie und Raumfahrt","doi-asserted-by":"publisher","award":["01ZX2210B"],"award-info":[{"award-number":["01ZX2210B"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Forschung, Technologie und Raumfahrt","doi-asserted-by":"publisher","award":["01ZX1910"],"award-info":[{"award-number":["01ZX1910"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Forschung, Technologie und Raumfahrt","doi-asserted-by":"publisher","award":["01ZX2210"],"award-info":[{"award-number":["01ZX2210"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010412","name":"Fraunhofer-Institut f\u00fcr Zelltherapie und Immunologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bone.2026.117901","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T06:34:13Z","timestamp":1776234853000},"page":"117901","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Proteomic profiling links increased mast cell activity in regenerating callus to impaired scaffold-guided bone regeneration in diabetic rats"],"prefix":"10.1016","volume":"209","author":[{"given":"Vivien","family":"Wiltzsch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela B.","family":"Dias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes R.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer A.","family":"Kirwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrina S.P.","family":"Poh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Kalkhof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2026.117901_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ocl.2009.07.003","article-title":"Bone defects caused by high-energy injuries, bone loss, infected nonunions, and nonunions","volume":"41","author":"Wiese","year":"2010","journal-title":"Orthop. Clin. North Am."},{"key":"10.1016\/j.bone.2026.117901_bb0010","doi-asserted-by":"crossref","DOI":"10.1097\/OI9.0000000000000258","article-title":"Management of aseptic nonunions and severe bone defects: let us get this thing healed!","volume":"6","author":"Nauth","year":"2023","journal-title":"OTA Int."},{"issue":"Suppl. 5","key":"10.1016\/j.bone.2026.117901_bb0015","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1097\/BOT.0000000000000978","article-title":"Size matters: defining critical in bone defect size!","volume":"31","author":"Schemitsch","year":"2017","journal-title":"J. Orthop. Trauma"},{"key":"10.1016\/j.bone.2026.117901_bb0020","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00590-017-2063-0","article-title":"Treatment of critical-sized bone defects: clinical and tissue engineering perspectives","volume":"28","author":"Roddy","year":"2018","journal-title":"Eur. J. Orthop. Surg. Traumatol."},{"key":"10.1016\/j.bone.2026.117901_bb0025","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1007\/s00402-020-03525-0","article-title":"Management of critical-sized bone defects in the treatment of fracture-related infection: a systematic review and pooled analysis","volume":"141","author":"Bezstarosti","year":"2020","journal-title":"Arch. Orthop. Trauma Surg."},{"key":"10.1016\/j.bone.2026.117901_bb0030","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1007\/s00590-024-04050-1","article-title":"The management of critical bone defects: outcomes of a systematic approach","volume":"34","author":"Tsang","year":"2024","journal-title":"Eur. J. Orthop. Surg. Traumatol."},{"key":"10.1016\/j.bone.2026.117901_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2021.109119","article-title":"IDF Diabetes Atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"Sun","year":"2022","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.bone.2026.117901_bb0040","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.bone.2017.02.014","article-title":"TNF\u03b1 contributes to diabetes impaired angiogenesis in fracture healing","volume":"99","author":"Lim","year":"2017","journal-title":"Bone"},{"key":"10.1016\/j.bone.2026.117901_bb0045","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s11914-015-0286-8","article-title":"Diabetes and its effect on bone and fracture healing","volume":"13","author":"Jiao","year":"2015","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bone.2026.117901_bb0050","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00011-010-0246-9","article-title":"Inflammation as death or life signal in diabetic fracture healing","volume":"60","author":"R\u00f6szer","year":"2011","journal-title":"Inflamm. Res."},{"issue":"Suppl. 1","key":"10.1016\/j.bone.2026.117901_bb0055","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1007\/s40520-015-0422-4","article-title":"Impaired healing of fragility fractures in type 2 diabetes: clinical and radiographic assessments and serum cytokine levels","volume":"27","author":"Liuni","year":"2015","journal-title":"Aging Clin. Exp. Res."},{"key":"10.1016\/j.bone.2026.117901_bb0060","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1111\/ans.15878","article-title":"Do patients with diabetes have an increased risk of impaired fracture healing? A systematic review and meta-analysis","volume":"90","author":"Ding","year":"2020","journal-title":"ANZ J. Surg."},{"key":"10.1016\/j.bone.2026.117901_bb0065","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrrheum.2014.164","article-title":"Fracture healing: mechanisms and interventions","volume":"11","author":"Einhorn","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bone.2026.117901_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/jfb14070341","article-title":"The concept of scaffold-guided bone regeneration for the treatment of long bone defects: current clinical application and future perspective","volume":"14","author":"Laubach","year":"2023","journal-title":"J. Funct. Biomater."},{"key":"10.1016\/j.bone.2026.117901_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2025.113604","article-title":"Additively manufactured stochastic and gyroid scaffold design towards osseointegration and bone regeneration in a rabbit femur model","volume":"250","author":"Kanwar","year":"2025","journal-title":"Mater. Des."},{"key":"10.1016\/j.bone.2026.117901_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11020325","article-title":"Scaffold guided bone regeneration for the treatment of large segmental defects in long bones","volume":"11","author":"Schulze","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.bone.2026.117901_bb0085","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.copbio.2021.12.002","article-title":"Enabling technologies towards personalization of scaffolds for large bone defect regeneration","volume":"74","author":"Poh","year":"2022","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.bone.2026.117901_bb0090","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3389\/fbioe.2020.00061","article-title":"Reconstruction of large skeletal defects: current clinical therapeutic strategies and future directions using 3D printing","volume":"8","author":"Vidal","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bone.2026.117901_bb0095","doi-asserted-by":"crossref","DOI":"10.3390\/jfb15090243","article-title":"Polycaprolactone in bone tissue engineering: a comprehensive review of innovations in scaffold fabrication and surface modifications","volume":"15","author":"Liang","year":"2024","journal-title":"J. Funct. Biomater."},{"key":"10.1016\/j.bone.2026.117901_bb0100","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1016\/S0142-9612(00)00121-6","article-title":"Scaffolds in tissue engineering bone and cartilage","volume":"21","author":"Hutmacher","year":"2000","journal-title":"Biomaterials"},{"key":"10.1016\/j.bone.2026.117901_bb0105","article-title":"Bone tissue engineering techniques, advances and scaffolds for treatment of bone defects","volume":"17","author":"Alonzo","year":"2021","journal-title":"Curr. Opin. Biomed. Eng."},{"key":"10.1016\/j.bone.2026.117901_bb0110","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3390\/jfb13030103","article-title":"Immunomodulation effect of biomaterials on bone formation","volume":"13","author":"Zhao","year":"2022","journal-title":"J. Funct. Biomater."},{"key":"10.1016\/j.bone.2026.117901_bb0115","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jot.2022.04.004","article-title":"Clinical translation of a patient-specific scaffold-guided bone regeneration concept in four cases with large long bone defects","volume":"34","author":"Laubach","year":"2022","journal-title":"J. Orthop. Translat."},{"key":"10.1016\/j.bone.2026.117901_bb0120","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/clr.13031","article-title":"The effect of experimental diabetes and glycaemic control on guided bone regeneration: histology and gene expression analyses","volume":"29","author":"Retzepi","year":"2018","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.bone.2026.117901_bb0125","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.2147\/IJN.S449290","article-title":"The dual angiogenesis effects via Nrf2\/HO-1 signaling pathway of melatonin nanocomposite scaffold on promoting diabetic bone defect repair","volume":"19","author":"Chen","year":"2024","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.bone.2026.117901_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.compositesb.2024.111771","article-title":"Self-adaptive bioactive scaffolds orchestrate diabetic microenvironment remodeling and vascularized bone regeneration","volume":"286","author":"Cai","year":"2024","journal-title":"Compos. Part B Eng."},{"key":"10.1016\/j.bone.2026.117901_bb0135","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.7150\/thno.97335","article-title":"Bioinspired soft-hard combined system with mild photothermal therapeutic activity promotes diabetic bone defect healing via synergetic effects of immune activation and angiogenesis","volume":"14","author":"Wu","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.bone.2026.117901_bb0140","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.actbio.2025.05.007","article-title":"Endogenous dysregulated energy and amino acid metabolism delay scaffold-guided large volume bone regeneration in a diabetic rat model with leptin receptor deficiency","volume":"199","author":"Dias","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bone.2026.117901_bb0145","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jproteome.4c01060","article-title":"Systematic comparison of bone proteome extraction methods to allow for integrated proteomics-metabolomics correlation","author":"Wiltzsch","year":"2025","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bone.2026.117901_bb0150","doi-asserted-by":"crossref","DOI":"10.3390\/metabo12050453","article-title":"A comparison of solvent-based extraction methods to assess the central carbon metabolites in mouse bone and muscle","volume":"12","author":"Dias","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.bone.2026.117901_bb0155","series-title":"Microbial Proteomics","first-page":"3","article-title":"Filter-aided sample preparation for proteome analysis","author":"Wi\u015bniewski","year":"2018"},{"key":"10.1016\/j.bone.2026.117901_bb0160","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1038\/nprot.2016.136","article-title":"The MaxQuant computational platform for mass spectrometry-based shotgun proteomics","volume":"11","author":"Tyanova","year":"2016","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bone.2026.117901_bb0165","doi-asserted-by":"crossref","DOI":"10.1038\/s41540-023-00311-7","article-title":"Proteomic meta-study harmonization, mechanotyping and drug repurposing candidate prediction with ProHarMeD","volume":"9","author":"Adamowicz","year":"2023","journal-title":"NPJ Syst. Biol. Appl."},{"key":"10.1016\/j.bone.2026.117901_bb0170","doi-asserted-by":"crossref","first-page":"10241","DOI":"10.1021\/acs.analchem.0c00136","article-title":"Concepts and software package for efficient quality control in targeted metabolomics studies: MeTaQuaC","volume":"92","author":"Kuhring","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bone.2026.117901_bb0175","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1074\/mcp.TIR119.001646","article-title":"DEqMS: a method for accurate variance estimation in differential protein expression analysis","volume":"19","author":"Zhu","year":"2020","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.bone.2026.117901_bb0180","doi-asserted-by":"crossref","first-page":"34570","DOI":"10.1021\/acsami.3c06263","article-title":"Superiority of triply periodic minimal surface gyroid structure to strut-based grid structure in both strength and bone regeneration","volume":"15","author":"Hayashi","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bone.2026.117901_bb0185","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.1016\/j.biomaterials.2005.02.002","article-title":"Porosity of 3D biomaterial scaffolds and osteogenesis","volume":"26","author":"Karageorgiou","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.bone.2026.117901_bb0190","doi-asserted-by":"crossref","DOI":"10.1002\/jbm.a.37978","article-title":"Gyroid-structured scaffolds guide uniform ossification and modulate vascular morphology during rat calvarial bone defect regeneration","volume":"113","author":"Xian","year":"2025","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.bone.2026.117901_bb0195","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1302\/2046-3758.135.BJR-2023-0323.R1","article-title":"Fracture haematoma proteomics","volume":"13","author":"Groven","year":"2024","journal-title":"Bone Joint Res."},{"key":"10.1016\/j.bone.2026.117901_bb0200","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/jre.12498","article-title":"Protein expression during early stages of bone regeneration under hydrophobic and hydrophilic titanium domes. A pilot study","volume":"53","author":"Calciolari","year":"2018","journal-title":"J. Periodontal Res."},{"key":"10.1016\/j.bone.2026.117901_bb0205","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-75527-2","article-title":"Proteomics of regenerated tissue in response to a titanium implant with a bioactive surface in a rat tibial defect model","volume":"10","author":"Boteanu","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bone.2026.117901_bb0210","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jot.2020.10.004","article-title":"Molecular mechanisms of osteogenesis and antibacterial activity of Cu-bearing Ti alloy in a bone defect model with infection in vivo","volume":"27","author":"Yang","year":"2020","journal-title":"J. Orthop. Translat."},{"key":"10.1016\/j.bone.2026.117901_bb0215","doi-asserted-by":"crossref","DOI":"10.1007\/s10565-025-09995-5","article-title":"Repair mechanisms of bone system tissues based on comprehensive perspective of multi-omics","volume":"41","author":"Yu","year":"2025","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.bone.2026.117901_bb0220","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.tem.2017.11.008","article-title":"The metabolic microenvironment steers bone tissue regeneration","volume":"29","author":"Loeffler","year":"2018","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.bone.2026.117901_bb0225","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cmet.2022.04.010","article-title":"The crosstalk between bone remodeling and energy metabolism: a translational perspective","volume":"34","author":"Karsenty","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.bone.2026.117901_bb0230","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1016\/j.cell.2015.05.029","article-title":"Glucose uptake and Runx2 synergize to orchestrate osteoblast differentiation and bone formation","volume":"161","author":"Wei","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.bone.2026.117901_bb0235","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1184463","article-title":"Metabolic regulation by biomaterials in osteoblast","volume":"11","author":"Kang","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bone.2026.117901_bb0240","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s42003-023-04652-1","article-title":"A comprehensive molecular profiling approach reveals metabolic alterations that steer bone tissue regeneration","volume":"6","author":"L\u00f6ffler","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.bone.2026.117901_bb0245","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/jsre.1993.1114","article-title":"Role of ornithine as a proline precursor in healing wounds","volume":"55","author":"Albina","year":"1993","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.bone.2026.117901_bb0250","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/stmcls\/sxab011","article-title":"Impaired bone fracture healing in type 2 diabetes is caused by defective functions of skeletal progenitor cells","volume":"40","author":"Figeac","year":"2022","journal-title":"Stem Cells"},{"key":"10.1016\/j.bone.2026.117901_bb0255","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17040590","article-title":"Matrilin-3 role in cartilage development and osteoarthritis","volume":"17","author":"Muttigi","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bone.2026.117901_bb0260","doi-asserted-by":"crossref","first-page":"821","DOI":"10.3904\/kjim.2022.015","article-title":"Benefits of lumican on human bone health: clinical evidence using bone marrow aspirates","volume":"37","author":"Lee","year":"2022","journal-title":"Kor. J. Intern. Med."},{"key":"10.1016\/j.bone.2026.117901_bb0265","article-title":"Lumican inhibits osteoclastogenesis and bone resorption by suppressing Akt activity","volume":"22","author":"Lee","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bone.2026.117901_bb0270","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.31062","article-title":"Periodontal ligament-associated protein-1 knockout mice regulate the differentiation of osteoclasts and osteoblasts through TGF-\u03b21\/Smad signaling pathway","volume":"239","author":"Liu","year":"2024","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bone.2026.117901_bb0275","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1042\/BJ20090542","article-title":"Asporin competes with decorin for collagen binding, binds calcium and promotes osteoblast collagen mineralization","volume":"423","author":"Kalamajski","year":"2009","journal-title":"Biochem. J."},{"key":"10.1016\/j.bone.2026.117901_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2024.100664","article-title":"PCPE2: expression of multifunctional extracellular glycoprotein associated with diverse cellular functions","volume":"65","author":"Thomas","year":"2024","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bone.2026.117901_bb0285","doi-asserted-by":"crossref","first-page":"8020","DOI":"10.1038\/s41467-023-43401-0","article-title":"Identification of PCPE-2 as the endogenous specific inhibitor of human BMP-1\/tolloid-like proteinases","volume":"14","author":"Vadon-Le Goff","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bone.2026.117901_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2023.166693","article-title":"ANKRD1 activates the Wnt signaling pathway by modulating CAV3 expression and thus promotes BMSC osteogenic differentiation and bone formation in ovariectomized mice","volume":"1869","author":"Zhang","year":"2023","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.bone.2026.117901_bb0295","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/236238","article-title":"Topically applied connective tissue growth factor\/CCN2 improves diabetic preclinical cutaneous wound healing: potential role for CTGF in human diabetic foot ulcer healing","volume":"2015","author":"Henshaw","year":"2015","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.bone.2026.117901_bb0300","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jot.2022.04.002","article-title":"MFG-E8 promotes tendon-bone healing by regualting macrophage efferocytosis and M2 polarization after anterior cruciate ligament reconstruction","volume":"34","author":"Geng","year":"2022","journal-title":"J. Orthop. Translat."},{"key":"10.1016\/j.bone.2026.117901_bb0305","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1007\/s12026-016-8868-9","article-title":"Immunological characterization of the early human fracture hematoma","volume":"64","author":"Hoff","year":"2016","journal-title":"Immunol. Res."},{"key":"10.1016\/j.bone.2026.117901_bb0310","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41584-022-00887-0","article-title":"The decisive early phase of bone regeneration","volume":"19","author":"Duda","year":"2023","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bone.2026.117901_bb0315","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/S0736-0266(02)00066-9","article-title":"The effects of blood glucose control upon fracture healing in the BB Wistar rat with diabetes mellitus","volume":"20","author":"Beam","year":"2002","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bone.2026.117901_bb0320","doi-asserted-by":"crossref","first-page":"E1220","DOI":"10.1152\/ajpendo.00378.2011","article-title":"Delayed bone regeneration and low bone mass in a rat model of insulin-resistant type 2 diabetes mellitus is due to impaired osteoblast function","volume":"301","author":"Hamann","year":"2011","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2026.117901_bb0325","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1210\/en.2002-220072","article-title":"Diabetes interferes with the bone formation by affecting the expression of transcription factors that regulate osteoblast differentiation","volume":"144","author":"Lu","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2026.117901_bb0330","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrrheum.2012.1","article-title":"Fracture healing under healthy and inflammatory conditions","volume":"8","author":"Claes","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bone.2026.117901_bb0335","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1210\/js.2019-00160","article-title":"Advanced glycation end products (AGEs), receptor for AGEs, diabetes, and bone: review of the literature","volume":"3","author":"Asadipooya","year":"2019","journal-title":"J. Endocr. Soc."},{"key":"10.1016\/j.bone.2026.117901_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103618","article-title":"Coronin 1a-mediated F-actin disassembly controls effector function in murine neutrophils","volume":"82","author":"Shaverskyi","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.bone.2026.117901_bb0345","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1182\/blood-2016-11-749622","article-title":"Coronin 1A, a novel player in integrin biology, controls neutrophil trafficking in innate immunity","volume":"130","author":"Pick","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.bone.2026.117901_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2024.117021","article-title":"Is there a role for N1-N2 neutrophil phenotypes in bone regeneration? A systematic review","volume":"181","author":"Lu","year":"2024","journal-title":"Bone"},{"key":"10.1016\/j.bone.2026.117901_bb0355","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3389\/fimmu.2017.00081","article-title":"Neutrophil extracellular traps and its implications in inflammation: an overview","volume":"8","author":"Delgado-Rizo","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bone.2026.117901_bb0360","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/nri.2017.105","article-title":"Neutrophil extracellular traps in immunity and disease","volume":"18","author":"Papayannopoulos","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bone.2026.117901_bb0365","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/nm.3887","article-title":"Diabetes primes neutrophils to undergo NETosis, which impairs wound healing","volume":"21","author":"Wong","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.bone.2026.117901_bb0370","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00592-014-0676-x","article-title":"NETosis is induced by high glucose and associated with type 2 diabetes","volume":"52","author":"Menegazzo","year":"2015","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.bone.2026.117901_bb0375","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.2337\/db15-0863","article-title":"NETosis delays diabetic wound healing in mice and humans","volume":"65","author":"Fadini","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.bone.2026.117901_bb0380","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.tem.2015.07.004","article-title":"NETs and traps delay wound healing in diabetes","volume":"26","author":"Roth Flach","year":"2015","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.bone.2026.117901_bb0385","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1202463","article-title":"Diabetes-associated neutrophil NETosis: pathogenesis and interventional target of diabetic complications","volume":"14","author":"Zhu","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.bone.2026.117901_bb0390","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.614347","article-title":"Therapeutic targeting of neutrophil extracellular traps improves primary and secondary intention wound healing in mice","volume":"12","author":"Heuer","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bone.2026.117901_bb0395","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1186\/s12967-024-05875-4","article-title":"Disulfiram-loaded nanovesicles hydrogel promotes healing of diabetic wound","volume":"22","author":"Sun","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bone.2026.117901_bb0400","article-title":"Innovative bio-based hydrogel microspheres micro-cage for neutrophil extracellular traps scavenging in diabetic wound healing","volume":"11","author":"Xiao","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.bone.2026.117901_bb0405","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1182\/blood.2021014966","article-title":"S100A8\/A9 drives the formation of procoagulant platelets through GPIb\u03b1","volume":"140","author":"Colicchia","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.bone.2026.117901_bb0410","doi-asserted-by":"crossref","DOI":"10.1177\/03946320251338661","article-title":"Synergistic inhibition of CitH3 and S100A8\/A9: a novel therapeutic strategy for mitigating sepsis-induced inflammation and lung injury","volume":"39","author":"Dong","year":"2025","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.bone.2026.117901_bb0415","doi-asserted-by":"crossref","DOI":"10.3390\/cells11020236","article-title":"S100A8\/A9 is a marker for the release of neutrophil extracellular traps and induces neutrophil activation","volume":"11","author":"Sprenkeler","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.bone.2026.117901_bb0420","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1161\/CIRCRESAHA.110.223545","article-title":"Oxidative stress and diabetic complications","volume":"107","author":"Giacco","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.bone.2026.117901_bb0425","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1172\/JCI92450","article-title":"Neutrophil-derived S100 calcium-binding proteins A8\/A9 promote reticulated thrombocytosis and atherogenesis in diabetes","volume":"127","author":"Kraakman","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bone.2026.117901_bb0430","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1096\/fj.04-2377fje","article-title":"The arachidonic acid-binding protein S100A8\/A9 promotes NADPH oxidase activation by interaction with p67phox and Rac-2","volume":"19","author":"Kerkhoff","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.bone.2026.117901_bb0435","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1042\/BJ20140778","article-title":"The antimicrobial peptide LL-37 facilitates the formation of neutrophil extracellular traps","volume":"464","author":"Neumann","year":"2014","journal-title":"Biochem. J."},{"key":"10.1016\/j.bone.2026.117901_bb0440","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41423-018-0024-0","article-title":"NETosis, complement, and coagulation: a triangular relationship","volume":"16","author":"de Bont","year":"2018","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.bone.2026.117901_bb0445","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/imcb.12344","article-title":"Ficolin A derived from local macrophages and neutrophils protects against lipopolysaccharide-induced acute lung injury by activating complement","volume":"98","author":"Wu","year":"2020","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.bone.2026.117901_bb0450","doi-asserted-by":"crossref","first-page":"4456","DOI":"10.1182\/blood-2010-01-263590","article-title":"Efficient osteoclast differentiation requires local complement activation","volume":"116","author":"Tu","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bone.2026.117901_bb0455","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081341","article-title":"Complement C3 and C5 deficiency affects fracture healing","volume":"8","author":"Ehrnthaller","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2026.117901_bb0460","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1164\/rccm.201003-0452OC","article-title":"Urokinase-type plasminogen activator inhibits efferocytosis of neutrophils","volume":"182","author":"Yang","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bone.2026.117901_bb0465","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1432-1033.1976.tb10875.x","article-title":"Identification and some properties of a new fast-reacting plasmin inhibitor in human plasma","volume":"69","author":"Collen","year":"1976","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bone.2026.117901_bb0470","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.883545","article-title":"The influence of uremic high cystatin C concentration on neutrophil apoptosis and selected neutrophil functions isolated from healthy subjects","volume":"18","author":"Majewska","year":"2012","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.bone.2026.117901_bb0475","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2022.101500","article-title":"SERPINA3C ameliorates adipose tissue inflammation through the Cathepsin G\/Integrin\/AKT pathway","volume":"61","author":"Li","year":"2022","journal-title":"Mol. Metab."},{"key":"10.1016\/j.bone.2026.117901_bb0480","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1359\/jbmr.070115","article-title":"Diminished bone formation during diabetic fracture healing is related to the premature resorption of cartilage associated with increased osteoclast activity","volume":"22","author":"Kayal","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2026.117901_bb0485","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3389\/fimmu.2020.00163","article-title":"The role of mast cells in bone metabolism and bone disorders","volume":"11","author":"Ragipoglu","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bone.2026.117901_bb0490","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s12016-019-08769-2","article-title":"Mast cell biology at molecular level: a comprehensive review","volume":"58","author":"Elieh Ali Komi","year":"2020","journal-title":"Clin. Rev. Allerg. Immunol."},{"key":"10.1016\/j.bone.2026.117901_bb0495","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1007\/s11914-024-00869-z","article-title":"Osteoimmunology of fracture healing","volume":"22","author":"Molitoris","year":"2024","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bone.2026.117901_bb0500","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1097\/00005131-199509060-00005","article-title":"Fracture healing and mast cells","volume":"9","author":"Banovac","year":"1995","journal-title":"J. Orthop. Trauma"},{"key":"10.1016\/j.bone.2026.117901_bb0505","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jdermsci.2007.09.009","article-title":"Mast cells: versatile regulators of inflammation, tissue remodeling, host defense and homeostasis","volume":"49","author":"Galli","year":"2008","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.bone.2026.117901_bb0510","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1002\/jbmr.3234","article-title":"Mast cells are critical regulators of bone fracture-induced inflammation and osteoclast formation and activity","volume":"32","author":"Kroner","year":"2017","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2026.117901_bb0515","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.2353\/ajpath.2009.080871","article-title":"Histamine promotes osteoclastogenesis through the differential expression of histamine receptors on osteoclasts and osteoblasts","volume":"174","author":"Biosse-Duplan","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bone.2026.117901_bb0520","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.bone.2005.07.026","article-title":"Mast cell activation and degranulation occur early during induction of periosteal bone resorption","volume":"38","author":"Fouilloux","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.bone.2026.117901_bb0525","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00223-021-00921-5","article-title":"Enhanced bone remodeling after fracture priming","volume":"110","author":"Ramirez-GarciaLuna","year":"2022","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2026.117901_bb0530","doi-asserted-by":"crossref","first-page":"209","DOI":"10.22203\/eCM.v028a14","article-title":"Defective bone repair in mast cell deficient mice with c-Kit loss of function","volume":"28","author":"Behrends","year":"2014","journal-title":"Eur. Cell. Mater."},{"key":"10.1016\/j.bone.2026.117901_bb0535","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/jbmr.4455","article-title":"Mast cells trigger disturbed bone healing in osteoporotic mice","volume":"37","author":"Fischer","year":"2022","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2026.117901_bb0540","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.883707","article-title":"Mast cells drive systemic inflammation and compromised bone repair after trauma","volume":"13","author":"Ragipoglu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bone.2026.117901_bb0545","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1111\/all.14413","article-title":"Mast cells and complement system: ancient interactions between components of innate immunity","volume":"75","author":"Elieh Ali Komi","year":"2020","journal-title":"Allergy"},{"key":"10.1016\/j.bone.2026.117901_bb0550","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1161\/CIRCRESAHA.117.310978","article-title":"Multifunctional role of chymase in acute and chronic tissue injury and remodeling","volume":"122","author":"Dell\u2019Italia","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.bone.2026.117901_bb0555","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.matbio.2022.07.005","article-title":"Mast cell chymase has a negative impact on human osteoblasts","volume":"112","author":"Lind","year":"2022","journal-title":"Matrix Biol."},{"key":"10.1016\/j.bone.2026.117901_bb0560","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.663357","article-title":"Fibronectin in fracture healing: biological mechanisms and regenerative avenues","volume":"9","author":"Klavert","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bone.2026.117901_bb0565","doi-asserted-by":"crossref","first-page":"42","DOI":"10.4041\/kjod.2020.50.1.42","article-title":"The effect of cetirizine, a histamine 1 receptor antagonist, on bone remodeling after calvarial suture expansion","volume":"50","author":"Hwang","year":"2020","journal-title":"Kor. J. Orthod."},{"key":"10.1016\/j.bone.2026.117901_bb0570","doi-asserted-by":"crossref","first-page":"e323","DOI":"10.1016\/j.ajodo.2009.11.013","article-title":"Effect of cetirizine, a histamine (H(1)) receptor antagonist, on bone modeling during orthodontic tooth movement in rats","volume":"139","author":"Meh","year":"2011","journal-title":"Am. J. Orthod. Dentofacial Orthop."},{"key":"10.1016\/j.bone.2026.117901_bb0575","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/(SICI)1097-4652(199710)173:1<10::AID-JCP2>3.0.CO;2-M","article-title":"H1 and H2 histamine receptors modulate osteoclastic resorption by different pathways: evidence obtained by using receptor antagonists in a rat synchronized resorption model","volume":"173","author":"Dobigny","year":"1997","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bone.2026.117901_bb0580","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1254\/jphs.92.43","article-title":"The histamine H2-receptor antagonist, cimetidine, inhibits the articular osteopenia in rats with adjuvant-induced arthritis by suppressing the osteoclast differentiation induced by histamine","volume":"92","author":"Yamaura","year":"2003","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.bone.2026.117901_bb0585","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.2337\/db15-0340","article-title":"Mast cells regulate wound healing in diabetes","volume":"65","author":"Tellechea","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.bone.2026.117901_bb0590","article-title":"Blockade of mast cell activation reduces cutaneous scar formation","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2026.117901_bb0595","doi-asserted-by":"crossref","first-page":"9291","DOI":"10.1074\/jbc.M410396200","article-title":"A key role for mast cell chymase in the activation of pro-matrix metalloprotease-9 and pro-matrix metalloprotease-2","volume":"280","author":"Tchougounova","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2026.117901_bb0600","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.cellbi.2006.04.007","article-title":"Induction of lactoferrin and IL-8 release from human neutrophils by tryptic enzymes via proteinase activated receptor-2","volume":"30","author":"Wang","year":"2006","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.bone.2026.117901_bb0605","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1159\/000444881","article-title":"Circulating neutrophil extracellular trap levels in well-controlled type 2 diabetes and pathway involved in their formation induced by high-dose glucose","volume":"83","author":"Miyoshi","year":"2016","journal-title":"Pathobiology"},{"key":"10.1016\/j.bone.2026.117901_bb0610","doi-asserted-by":"crossref","DOI":"10.3390\/mps8020042","article-title":"Quantification of circulating cell-free DNA as a NETosis marker in trauma patients with type 2 diabetes mellitus","volume":"8","author":"Sahin","year":"2025","journal-title":"Methods Protoc."},{"key":"10.1016\/j.bone.2026.117901_bb0615","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2025.110274","article-title":"Diabetic retinopathy features in lund MetS rats","volume":"252","author":"Canz","year":"2025","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bone.2026.117901_bb0620","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-42379-5","article-title":"Leptin receptor gene deficiency minimally affects osseointegration in rats","volume":"13","author":"Jolic","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bone.2026.117901_bb0625","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2023.116747","article-title":"Bone structure and composition in a hyperglycemic, obese, and leptin receptor-deficient rat: microscale characterization of femur and calvarium","volume":"172","author":"Micheletti","year":"2023","journal-title":"Bone"},{"key":"10.1016\/j.bone.2026.117901_bb0630","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1111\/imcb.12824","article-title":"The evolving role of mast cells in wound healing: insights from recent research and diverse models","volume":"102","author":"Guth","year":"2024","journal-title":"Immunol. Cell Biol."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328226001274?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328226001274?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T03:34:32Z","timestamp":1779248072000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328226001274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":126,"alternative-id":["S8756328226001274"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2026.117901","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteomic profiling links increased mast cell activity in regenerating callus to impaired scaffold-guided bone regeneration in diabetic rats","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2026.117901","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117901"}}